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The reciprocal interaction between LV remodelling and allograft outcomes in kidney transplant recipients

ObjectiveThis study aimed to investigate the incidence and related clinical factors of LV hypertrophy (LVH) regression after kidney transplantation and its effect on graft outcome.MethodsAmong the 3373 kidney transplant recipients who were enrolled in a multicentre cohort from 1997 to 2012, a total... Full description

Journal Title: Heart (British Cardiac Society) 2015, Vol.101 (22), p.1826-1833
Main Author: An, Jung Nam
Other Authors: Kim, Young Hoon , Park, Jun-Bean , Hwang, Jin Ho , Yoo, Kyung Don , Park, Jae Yoon , Kim, Clara Tammy , Kim, Hack-Lyoung , Kim, Yong-Jin , Han, Duck-Jong , Lim, Chun Soo , Kim, Yon Su , Lee, Jung Pyo
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: England: British Medical Association
ID: ISSN: 1355-6037
Link: https://www.ncbi.nlm.nih.gov/pubmed/26416838
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title: The reciprocal interaction between LV remodelling and allograft outcomes in kidney transplant recipients
format: Article
creator:
  • An, Jung Nam
  • Kim, Young Hoon
  • Park, Jun-Bean
  • Hwang, Jin Ho
  • Yoo, Kyung Don
  • Park, Jae Yoon
  • Kim, Clara Tammy
  • Kim, Hack-Lyoung
  • Kim, Yong-Jin
  • Han, Duck-Jong
  • Lim, Chun Soo
  • Kim, Yon Su
  • Lee, Jung Pyo
subjects:
  • Abridged Index Medicus
  • Allografts - physiology
  • Analysis
  • Clinical outcomes
  • Female
  • Graft Rejection - etiology
  • Graft Rejection - physiopathology
  • Health aspects
  • Heart attacks
  • Hemoglobinopathies - complications
  • Homografts
  • Humans
  • Hypertension - complications
  • Hypertrophy, Left Ventricular - physiopathology
  • Hypertrophy, Left Ventricular - surgery
  • Kidney Failure, Chronic - complications
  • Kidney Failure, Chronic - physiopathology
  • Kidney Failure, Chronic - surgery
  • Kidney Transplantation
  • Kidneys
  • Male
  • Medical records
  • Middle Aged
  • Mortality
  • Organ transplant recipients
  • Postoperative Complications
  • Recovery of Function
  • Remission Induction
  • Retrospective Studies
  • Transplantation
  • Transplantation, Homologous
  • Treatment Outcome
  • Ventricular Remodeling - physiology
ispartof: Heart (British Cardiac Society), 2015, Vol.101 (22), p.1826-1833
description: ObjectiveThis study aimed to investigate the incidence and related clinical factors of LV hypertrophy (LVH) regression after kidney transplantation and its effect on graft outcome.MethodsAmong the 3373 kidney transplant recipients who were enrolled in a multicentre cohort from 1997 to 2012, a total of 767 patients who underwent echocardiography before and after transplantation were included in this study followed for a median of 7.5 years.ResultsLVH regression steadily increased from 7.4% at 1 year to 35.4% at 5 years over the 5-year post-transplantation period. The probability of LVH regression decreased in the patients who received a kidney transplant due to end-stage renal disease of unknown aetiology (p=0.041) or who underwent pretransplant haemodialysis (p=0.020). The probability of LVH regression also decreased as the pretransplant LV mass index (p
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 1355-6037
fulltext: fulltext
issn:
  • 1355-6037
  • 1468-201X
url: Link


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titleThe reciprocal interaction between LV remodelling and allograft outcomes in kidney transplant recipients
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creatorAn, Jung Nam ; Kim, Young Hoon ; Park, Jun-Bean ; Hwang, Jin Ho ; Yoo, Kyung Don ; Park, Jae Yoon ; Kim, Clara Tammy ; Kim, Hack-Lyoung ; Kim, Yong-Jin ; Han, Duck-Jong ; Lim, Chun Soo ; Kim, Yon Su ; Lee, Jung Pyo
creatorcontribAn, Jung Nam ; Kim, Young Hoon ; Park, Jun-Bean ; Hwang, Jin Ho ; Yoo, Kyung Don ; Park, Jae Yoon ; Kim, Clara Tammy ; Kim, Hack-Lyoung ; Kim, Yong-Jin ; Han, Duck-Jong ; Lim, Chun Soo ; Kim, Yon Su ; Lee, Jung Pyo
descriptionObjectiveThis study aimed to investigate the incidence and related clinical factors of LV hypertrophy (LVH) regression after kidney transplantation and its effect on graft outcome.MethodsAmong the 3373 kidney transplant recipients who were enrolled in a multicentre cohort from 1997 to 2012, a total of 767 patients who underwent echocardiography before and after transplantation were included in this study followed for a median of 7.5 years.ResultsLVH regression steadily increased from 7.4% at 1 year to 35.4% at 5 years over the 5-year post-transplantation period. The probability of LVH regression decreased in the patients who received a kidney transplant due to end-stage renal disease of unknown aetiology (p=0.041) or who underwent pretransplant haemodialysis (p=0.020). The probability of LVH regression also decreased as the pretransplant LV mass index (p<0.001) and post-transplant systolic blood pressure increased (p=0.005). Conversely, LVH regression was significantly associated with the highest tertile of the pretransplant haemoglobin level (p=0.029). Furthermore, in the 5th year after transplantation, persistent LVH was independently associated with allograft failure (HR 1.95; 95% CI 1.14 to 3.33; p=0.015) and the LV mass index reliably predicted graft outcome.ConclusionsLVH consistently regressed after kidney transplantation in most patients. Persistent LVH, low haemoglobin levels and elevated blood pressure were associated with an increased risk of allograft failure in kidney transplant recipients.
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0ISSN: 1355-6037
1EISSN: 1468-201X
2DOI: 10.1136/heartjnl-2015-308142
3PMID: 26416838
languageeng
publisherEngland: British Medical Association
subjectAbridged Index Medicus ; Allografts - physiology ; Analysis ; Clinical outcomes ; Female ; Graft Rejection - etiology ; Graft Rejection - physiopathology ; Health aspects ; Heart attacks ; Hemoglobinopathies - complications ; Homografts ; Humans ; Hypertension - complications ; Hypertrophy, Left Ventricular - physiopathology ; Hypertrophy, Left Ventricular - surgery ; Kidney Failure, Chronic - complications ; Kidney Failure, Chronic - physiopathology ; Kidney Failure, Chronic - surgery ; Kidney Transplantation ; Kidneys ; Male ; Medical records ; Middle Aged ; Mortality ; Organ transplant recipients ; Postoperative Complications ; Recovery of Function ; Remission Induction ; Retrospective Studies ; Transplantation ; Transplantation, Homologous ; Treatment Outcome ; Ventricular Remodeling - physiology
ispartofHeart (British Cardiac Society), 2015, Vol.101 (22), p.1826-1833
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0Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing
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1Kim, Young Hoon
2Park, Jun-Bean
3Hwang, Jin Ho
4Yoo, Kyung Don
5Park, Jae Yoon
6Kim, Clara Tammy
7Kim, Hack-Lyoung
8Kim, Yong-Jin
9Han, Duck-Jong
10Lim, Chun Soo
11Kim, Yon Su
12Lee, Jung Pyo
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descriptionObjectiveThis study aimed to investigate the incidence and related clinical factors of LV hypertrophy (LVH) regression after kidney transplantation and its effect on graft outcome.MethodsAmong the 3373 kidney transplant recipients who were enrolled in a multicentre cohort from 1997 to 2012, a total of 767 patients who underwent echocardiography before and after transplantation were included in this study followed for a median of 7.5 years.ResultsLVH regression steadily increased from 7.4% at 1 year to 35.4% at 5 years over the 5-year post-transplantation period. The probability of LVH regression decreased in the patients who received a kidney transplant due to end-stage renal disease of unknown aetiology (p=0.041) or who underwent pretransplant haemodialysis (p=0.020). The probability of LVH regression also decreased as the pretransplant LV mass index (p<0.001) and post-transplant systolic blood pressure increased (p=0.005). Conversely, LVH regression was significantly associated with the highest tertile of the pretransplant haemoglobin level (p=0.029). Furthermore, in the 5th year after transplantation, persistent LVH was independently associated with allograft failure (HR 1.95; 95% CI 1.14 to 3.33; p=0.015) and the LV mass index reliably predicted graft outcome.ConclusionsLVH consistently regressed after kidney transplantation in most patients. Persistent LVH, low haemoglobin levels and elevated blood pressure were associated with an increased risk of allograft failure in kidney transplant recipients.
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1Allografts - physiology
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5Graft Rejection - etiology
6Graft Rejection - physiopathology
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9Hemoglobinopathies - complications
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24Organ transplant recipients
25Postoperative Complications
26Recovery of Function
27Remission Induction
28Retrospective Studies
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31Treatment Outcome
32Ventricular Remodeling - physiology
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titleThe reciprocal interaction between LV remodelling and allograft outcomes in kidney transplant recipients
authorAn, Jung Nam ; Kim, Young Hoon ; Park, Jun-Bean ; Hwang, Jin Ho ; Yoo, Kyung Don ; Park, Jae Yoon ; Kim, Clara Tammy ; Kim, Hack-Lyoung ; Kim, Yong-Jin ; Han, Duck-Jong ; Lim, Chun Soo ; Kim, Yon Su ; Lee, Jung Pyo
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1Allografts - physiology
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3Hwang, Jin Ho
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8Kim, Yong-Jin
9Han, Duck-Jong
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atitleThe reciprocal interaction between LV remodelling and allograft outcomes in kidney transplant recipients
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issue22
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pages1826-1833
issn1355-6037
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abstractObjectiveThis study aimed to investigate the incidence and related clinical factors of LV hypertrophy (LVH) regression after kidney transplantation and its effect on graft outcome.MethodsAmong the 3373 kidney transplant recipients who were enrolled in a multicentre cohort from 1997 to 2012, a total of 767 patients who underwent echocardiography before and after transplantation were included in this study followed for a median of 7.5 years.ResultsLVH regression steadily increased from 7.4% at 1 year to 35.4% at 5 years over the 5-year post-transplantation period. The probability of LVH regression decreased in the patients who received a kidney transplant due to end-stage renal disease of unknown aetiology (p=0.041) or who underwent pretransplant haemodialysis (p=0.020). The probability of LVH regression also decreased as the pretransplant LV mass index (p<0.001) and post-transplant systolic blood pressure increased (p=0.005). Conversely, LVH regression was significantly associated with the highest tertile of the pretransplant haemoglobin level (p=0.029). Furthermore, in the 5th year after transplantation, persistent LVH was independently associated with allograft failure (HR 1.95; 95% CI 1.14 to 3.33; p=0.015) and the LV mass index reliably predicted graft outcome.ConclusionsLVH consistently regressed after kidney transplantation in most patients. Persistent LVH, low haemoglobin levels and elevated blood pressure were associated with an increased risk of allograft failure in kidney transplant recipients.
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pubBritish Medical Association
pmid26416838
doi10.1136/heartjnl-2015-308142