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Self-reported influenza vaccination and protective serum antibody titers in a cohort of COPD patients

Abstract Background COPD patients are advised vaccination against seasonal influenza, yet few studies have evaluated the protective antibody titers obtained in this patient group. Aims 1) To describe protective titers in COPD patients who self-reported influenza vaccination compared with vaccinated... Full description

Journal Title: Respiratory medicine 2016, Vol.115, p.53-59
Main Author: Eagan, T.M
Other Authors: Hardie, J.A , Jul-Larsen, Å , Grydeland, T.B , Bakke, P.S , Cox, R.J
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: England: Elsevier Ltd
ID: ISSN: 0954-6111
Link: https://www.ncbi.nlm.nih.gov/pubmed/27215504
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title: Self-reported influenza vaccination and protective serum antibody titers in a cohort of COPD patients
format: Article
creator:
  • Eagan, T.M
  • Hardie, J.A
  • Jul-Larsen, Å
  • Grydeland, T.B
  • Bakke, P.S
  • Cox, R.J
subjects:
  • Adult
  • Aged
  • Analysis
  • Antibodies, Viral - blood
  • Chronic obstructive pulmonary disease
  • Cohort Studies
  • Comorbidity
  • Confidence intervals
  • COPD
  • Family medical history
  • Female
  • Health risk assessment
  • Hemagglutination Inhibition Tests - methods
  • Humans
  • Influenza
  • Influenza A Virus, H1N1 Subtype - immunology
  • Influenza A Virus, H3N2 Subtype - immunology
  • Influenza vaccines
  • Influenza Vaccines - administration & dosage
  • Influenza Vaccines - immunology
  • Influenza, Human - epidemiology
  • Influenza, Human - prevention & control
  • Influenza, Human - therapy
  • Influenza, Human - virology
  • Lung diseases, Obstructive
  • Male
  • Medical research
  • Medicine, Experimental
  • Middle Aged
  • Mortality
  • Norway - epidemiology
  • Pulmonary Disease, Chronic Obstructive - diagnosis
  • Pulmonary Disease, Chronic Obstructive - immunology
  • Pulmonary Disease, Chronic Obstructive - physiopathology
  • Pulmonary/Respiratory
  • Ratios
  • Seasons
  • Self Report
  • Smoking - immunology
  • Vaccination
  • Vaccination - adverse effects
  • Vaccination - methods
  • Vaccines
ispartof: Respiratory medicine, 2016, Vol.115, p.53-59
description: Abstract Background COPD patients are advised vaccination against seasonal influenza, yet few studies have evaluated the protective antibody titers obtained in this patient group. Aims 1) To describe protective titers in COPD patients who self-reported influenza vaccination compared with vaccinated subjects without COPD and unvaccinated COPD patients, 2) analyze whether clinical parameters predicted influenza-specific antibody titers, and 3) whether antibody titers to influenza A at baseline could predict exacerbation risk or 5 years all-cause mortality. Methods Influenza A (H1N1 and H3N2) titers were measured by haemagglutination inhibition assay in serum from 432 COPD patients and 77 controls in the Bergen COPD Cohort Study, at yearly visits between 2006/09. Titers of 40 or above were considered protective. We examined the variables sex, age, body composition, smoking, GOLD stage, yearly exacerbations, inhaled steroids, and Charlson score as predictive of titers, both univariately and in a multivariable model estimated by generalized estimating equations. The exacerbation incidence rate ratios and mortality hazard ratios were assessed by negative binominal and cox regression models respectively. Results At baseline, 59% of COPD patients reported influenza vaccination during the last season. Levels of predictive titers varied considerably each season, but trended lower in COPD patients compared with controls. Neither sex, age, body composition, smoking, comorbidities, GOLD stage nor use of inhaled steroids consistently predicted titers. Having high titers at baseline did not impact later risk for exacerbations, but seemed to be associated with higher all-cause mortality, even after adjustment for COPD disease characteristics. Conclusion Vaccination coverage for influenza is imperfect for COPD patients in Norway, and there is a concern that immunization is suboptimal.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0954-6111
fulltext: fulltext
issn:
  • 0954-6111
  • 1532-3064
url: Link


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titleSelf-reported influenza vaccination and protective serum antibody titers in a cohort of COPD patients
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creatorEagan, T.M ; Hardie, J.A ; Jul-Larsen, Å ; Grydeland, T.B ; Bakke, P.S ; Cox, R.J
creatorcontribEagan, T.M ; Hardie, J.A ; Jul-Larsen, Å ; Grydeland, T.B ; Bakke, P.S ; Cox, R.J
descriptionAbstract Background COPD patients are advised vaccination against seasonal influenza, yet few studies have evaluated the protective antibody titers obtained in this patient group. Aims 1) To describe protective titers in COPD patients who self-reported influenza vaccination compared with vaccinated subjects without COPD and unvaccinated COPD patients, 2) analyze whether clinical parameters predicted influenza-specific antibody titers, and 3) whether antibody titers to influenza A at baseline could predict exacerbation risk or 5 years all-cause mortality. Methods Influenza A (H1N1 and H3N2) titers were measured by haemagglutination inhibition assay in serum from 432 COPD patients and 77 controls in the Bergen COPD Cohort Study, at yearly visits between 2006/09. Titers of 40 or above were considered protective. We examined the variables sex, age, body composition, smoking, GOLD stage, yearly exacerbations, inhaled steroids, and Charlson score as predictive of titers, both univariately and in a multivariable model estimated by generalized estimating equations. The exacerbation incidence rate ratios and mortality hazard ratios were assessed by negative binominal and cox regression models respectively. Results At baseline, 59% of COPD patients reported influenza vaccination during the last season. Levels of predictive titers varied considerably each season, but trended lower in COPD patients compared with controls. Neither sex, age, body composition, smoking, comorbidities, GOLD stage nor use of inhaled steroids consistently predicted titers. Having high titers at baseline did not impact later risk for exacerbations, but seemed to be associated with higher all-cause mortality, even after adjustment for COPD disease characteristics. Conclusion Vaccination coverage for influenza is imperfect for COPD patients in Norway, and there is a concern that immunization is suboptimal.
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subjectAdult ; Aged ; Analysis ; Antibodies, Viral - blood ; Chronic obstructive pulmonary disease ; Cohort Studies ; Comorbidity ; Confidence intervals ; COPD ; Family medical history ; Female ; Health risk assessment ; Hemagglutination Inhibition Tests - methods ; Humans ; Influenza ; Influenza A Virus, H1N1 Subtype - immunology ; Influenza A Virus, H3N2 Subtype - immunology ; Influenza vaccines ; Influenza Vaccines - administration & dosage ; Influenza Vaccines - immunology ; Influenza, Human - epidemiology ; Influenza, Human - prevention & control ; Influenza, Human - therapy ; Influenza, Human - virology ; Lung diseases, Obstructive ; Male ; Medical research ; Medicine, Experimental ; Middle Aged ; Mortality ; Norway - epidemiology ; Pulmonary Disease, Chronic Obstructive - diagnosis ; Pulmonary Disease, Chronic Obstructive - immunology ; Pulmonary Disease, Chronic Obstructive - physiopathology ; Pulmonary/Respiratory ; Ratios ; Seasons ; Self Report ; Smoking - immunology ; Vaccination ; Vaccination - adverse effects ; Vaccination - methods ; Vaccines
ispartofRespiratory medicine, 2016, Vol.115, p.53-59
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2Jul-Larsen, Å
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4Bakke, P.S
5Cox, R.J
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descriptionAbstract Background COPD patients are advised vaccination against seasonal influenza, yet few studies have evaluated the protective antibody titers obtained in this patient group. Aims 1) To describe protective titers in COPD patients who self-reported influenza vaccination compared with vaccinated subjects without COPD and unvaccinated COPD patients, 2) analyze whether clinical parameters predicted influenza-specific antibody titers, and 3) whether antibody titers to influenza A at baseline could predict exacerbation risk or 5 years all-cause mortality. Methods Influenza A (H1N1 and H3N2) titers were measured by haemagglutination inhibition assay in serum from 432 COPD patients and 77 controls in the Bergen COPD Cohort Study, at yearly visits between 2006/09. Titers of 40 or above were considered protective. We examined the variables sex, age, body composition, smoking, GOLD stage, yearly exacerbations, inhaled steroids, and Charlson score as predictive of titers, both univariately and in a multivariable model estimated by generalized estimating equations. The exacerbation incidence rate ratios and mortality hazard ratios were assessed by negative binominal and cox regression models respectively. Results At baseline, 59% of COPD patients reported influenza vaccination during the last season. Levels of predictive titers varied considerably each season, but trended lower in COPD patients compared with controls. Neither sex, age, body composition, smoking, comorbidities, GOLD stage nor use of inhaled steroids consistently predicted titers. Having high titers at baseline did not impact later risk for exacerbations, but seemed to be associated with higher all-cause mortality, even after adjustment for COPD disease characteristics. Conclusion Vaccination coverage for influenza is imperfect for COPD patients in Norway, and there is a concern that immunization is suboptimal.
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1Aged
2Analysis
3Antibodies, Viral - blood
4Chronic obstructive pulmonary disease
5Cohort Studies
6Comorbidity
7Confidence intervals
8COPD
9Family medical history
10Female
11Health risk assessment
12Hemagglutination Inhibition Tests - methods
13Humans
14Influenza
15Influenza A Virus, H1N1 Subtype - immunology
16Influenza A Virus, H3N2 Subtype - immunology
17Influenza vaccines
18Influenza Vaccines - administration & dosage
19Influenza Vaccines - immunology
20Influenza, Human - epidemiology
21Influenza, Human - prevention & control
22Influenza, Human - therapy
23Influenza, Human - virology
24Lung diseases, Obstructive
25Male
26Medical research
27Medicine, Experimental
28Middle Aged
29Mortality
30Norway - epidemiology
31Pulmonary Disease, Chronic Obstructive - diagnosis
32Pulmonary Disease, Chronic Obstructive - immunology
33Pulmonary Disease, Chronic Obstructive - physiopathology
34Pulmonary/Respiratory
35Ratios
36Seasons
37Self Report
38Smoking - immunology
39Vaccination
40Vaccination - adverse effects
41Vaccination - methods
42Vaccines
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titleSelf-reported influenza vaccination and protective serum antibody titers in a cohort of COPD patients
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abstractAbstract Background COPD patients are advised vaccination against seasonal influenza, yet few studies have evaluated the protective antibody titers obtained in this patient group. Aims 1) To describe protective titers in COPD patients who self-reported influenza vaccination compared with vaccinated subjects without COPD and unvaccinated COPD patients, 2) analyze whether clinical parameters predicted influenza-specific antibody titers, and 3) whether antibody titers to influenza A at baseline could predict exacerbation risk or 5 years all-cause mortality. Methods Influenza A (H1N1 and H3N2) titers were measured by haemagglutination inhibition assay in serum from 432 COPD patients and 77 controls in the Bergen COPD Cohort Study, at yearly visits between 2006/09. Titers of 40 or above were considered protective. We examined the variables sex, age, body composition, smoking, GOLD stage, yearly exacerbations, inhaled steroids, and Charlson score as predictive of titers, both univariately and in a multivariable model estimated by generalized estimating equations. The exacerbation incidence rate ratios and mortality hazard ratios were assessed by negative binominal and cox regression models respectively. Results At baseline, 59% of COPD patients reported influenza vaccination during the last season. Levels of predictive titers varied considerably each season, but trended lower in COPD patients compared with controls. Neither sex, age, body composition, smoking, comorbidities, GOLD stage nor use of inhaled steroids consistently predicted titers. Having high titers at baseline did not impact later risk for exacerbations, but seemed to be associated with higher all-cause mortality, even after adjustment for COPD disease characteristics. Conclusion Vaccination coverage for influenza is imperfect for COPD patients in Norway, and there is a concern that immunization is suboptimal.
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pubElsevier Ltd
pmid27215504
doi10.1016/j.rmed.2016.04.008
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