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Glucosamine and chondroitin for knee osteoarthritis: a double-blind randomised placebo-controlled clinical trial evaluating single and combination regimens

Objective To determine if the dietary supplements, glucosamine and/or chondroitin, result in reduced joint space narrowing (JSN) and pain among people with symptomatic knee osteoarthritis. Methods A double-blind randomised placebo-controlled clinical trial with 2-year follow-up. 605 participants, ag... Full description

Journal Title: Annals of the rheumatic diseases 2015-05, Vol.74 (5), p.851-858
Main Author: Fransen, Marlene
Other Authors: Agaliotis, Maria , Nairn, Lillias , Votrubec, Milana , Bridgett, Lisa , Su, Steve , Jan, Stephen , March, Lyn , Edmonds, John , Norton, Robyn , Woodward, Mark , Day, Richard
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: England: British Medical Association
ID: ISSN: 0003-4967
Link: https://www.ncbi.nlm.nih.gov/pubmed/24395557
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title: Glucosamine and chondroitin for knee osteoarthritis: a double-blind randomised placebo-controlled clinical trial evaluating single and combination regimens
format: Article
creator:
  • Fransen, Marlene
  • Agaliotis, Maria
  • Nairn, Lillias
  • Votrubec, Milana
  • Bridgett, Lisa
  • Su, Steve
  • Jan, Stephen
  • March, Lyn
  • Edmonds, John
  • Norton, Robyn
  • Woodward, Mark
  • Day, Richard
subjects:
  • Aged
  • Arthritis
  • Care and treatment
  • Chondroitin
  • Chondroitin Sulfates - therapeutic use
  • Clinical trials
  • Dietary Supplements
  • Disease Progression
  • Double-Blind Method
  • Drug Therapy, Combination
  • Female
  • Glucosamine
  • Glucosamine - therapeutic use
  • Humans
  • Knee
  • Knee Joint - diagnostic imaging
  • Male
  • Middle Aged
  • Osteoarthritis
  • Osteoarthritis, Knee - diagnostic imaging
  • Osteoarthritis, Knee - drug therapy
  • Pain management
  • Quality of life
  • Radiography
  • Risk factors
  • Studies
  • Treatment Outcome
  • Usage
ispartof: Annals of the rheumatic diseases, 2015-05, Vol.74 (5), p.851-858
description: Objective To determine if the dietary supplements, glucosamine and/or chondroitin, result in reduced joint space narrowing (JSN) and pain among people with symptomatic knee osteoarthritis. Methods A double-blind randomised placebo-controlled clinical trial with 2-year follow-up. 605 participants, aged 45–75 years, reporting chronic knee pain and with evidence of medial tibio-femoral compartment narrowing (but retaining >2 mm medial joint space width) were randomised to once daily: glucosamine sulfate 1500 mg (n=152), chondroitin sulfate 800 mg (n=151), both dietary supplements (n=151) or matching placebo capsules (n=151). JSN (mm) over 2 years was measured from digitised knee radiographs. Maximum knee pain (0–10) was self-reported in a participant diary for 7 days every 2 months over 1 year. Results After adjusting for factors associated with structural disease progression (gender, body mass index (BMI), baseline structural disease severity and Heberden's nodes), allocation to the dietary supplement combination (glucosamine–chondroitin) resulted in a statistically significant (p=0.046) reduction of 2-year JSN compared to placebo: mean difference 0.10 mm (95% CI 0.002 mm to 0.20 mm); no significant structural effect for the single treatment allocations was detected. All four allocation groups demonstrated reduced knee pain over the first year, but no significant between-group differences (p=0.93) were detected. 34 (6%) participants reported possibly-related adverse medical events over the 2-year follow-up period. Conclusions Allocation to the glucosamine–chondroitin combination resulted in a statistically significant reduction in JSN at 2 years. While all allocation groups demonstrated reduced knee pain over the study period, none of the treatment allocation groups demonstrated significant symptomatic benefit above placebo. Trial Registration ClinicalTrials.gov identifier: NCT00513422; http://www.clinicaltrials.gov
language: eng
source:
identifier: ISSN: 0003-4967
fulltext: no_fulltext
issn:
  • 0003-4967
  • 1468-2060
url: Link


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titleGlucosamine and chondroitin for knee osteoarthritis: a double-blind randomised placebo-controlled clinical trial evaluating single and combination regimens
creatorFransen, Marlene ; Agaliotis, Maria ; Nairn, Lillias ; Votrubec, Milana ; Bridgett, Lisa ; Su, Steve ; Jan, Stephen ; March, Lyn ; Edmonds, John ; Norton, Robyn ; Woodward, Mark ; Day, Richard
creatorcontribFransen, Marlene ; Agaliotis, Maria ; Nairn, Lillias ; Votrubec, Milana ; Bridgett, Lisa ; Su, Steve ; Jan, Stephen ; March, Lyn ; Edmonds, John ; Norton, Robyn ; Woodward, Mark ; Day, Richard ; LEGS study collaborative group
descriptionObjective To determine if the dietary supplements, glucosamine and/or chondroitin, result in reduced joint space narrowing (JSN) and pain among people with symptomatic knee osteoarthritis. Methods A double-blind randomised placebo-controlled clinical trial with 2-year follow-up. 605 participants, aged 45–75 years, reporting chronic knee pain and with evidence of medial tibio-femoral compartment narrowing (but retaining >2 mm medial joint space width) were randomised to once daily: glucosamine sulfate 1500 mg (n=152), chondroitin sulfate 800 mg (n=151), both dietary supplements (n=151) or matching placebo capsules (n=151). JSN (mm) over 2 years was measured from digitised knee radiographs. Maximum knee pain (0–10) was self-reported in a participant diary for 7 days every 2 months over 1 year. Results After adjusting for factors associated with structural disease progression (gender, body mass index (BMI), baseline structural disease severity and Heberden's nodes), allocation to the dietary supplement combination (glucosamine–chondroitin) resulted in a statistically significant (p=0.046) reduction of 2-year JSN compared to placebo: mean difference 0.10 mm (95% CI 0.002 mm to 0.20 mm); no significant structural effect for the single treatment allocations was detected. All four allocation groups demonstrated reduced knee pain over the first year, but no significant between-group differences (p=0.93) were detected. 34 (6%) participants reported possibly-related adverse medical events over the 2-year follow-up period. Conclusions Allocation to the glucosamine–chondroitin combination resulted in a statistically significant reduction in JSN at 2 years. While all allocation groups demonstrated reduced knee pain over the study period, none of the treatment allocation groups demonstrated significant symptomatic benefit above placebo. Trial Registration ClinicalTrials.gov identifier: NCT00513422; http://www.clinicaltrials.gov
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publisherEngland: British Medical Association
subjectAged ; Arthritis ; Care and treatment ; Chondroitin ; Chondroitin Sulfates - therapeutic use ; Clinical trials ; Dietary Supplements ; Disease Progression ; Double-Blind Method ; Drug Therapy, Combination ; Female ; Glucosamine ; Glucosamine - therapeutic use ; Humans ; Knee ; Knee Joint - diagnostic imaging ; Male ; Middle Aged ; Osteoarthritis ; Osteoarthritis, Knee - diagnostic imaging ; Osteoarthritis, Knee - drug therapy ; Pain management ; Quality of life ; Radiography ; Risk factors ; Studies ; Treatment Outcome ; Usage
ispartofAnnals of the rheumatic diseases, 2015-05, Vol.74 (5), p.851-858
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0Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions
1Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
2Copyright: 2015 Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions
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4Bridgett, Lisa
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6Jan, Stephen
7March, Lyn
8Edmonds, John
9Norton, Robyn
10Woodward, Mark
11Day, Richard
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0Glucosamine and chondroitin for knee osteoarthritis: a double-blind randomised placebo-controlled clinical trial evaluating single and combination regimens
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descriptionObjective To determine if the dietary supplements, glucosamine and/or chondroitin, result in reduced joint space narrowing (JSN) and pain among people with symptomatic knee osteoarthritis. Methods A double-blind randomised placebo-controlled clinical trial with 2-year follow-up. 605 participants, aged 45–75 years, reporting chronic knee pain and with evidence of medial tibio-femoral compartment narrowing (but retaining >2 mm medial joint space width) were randomised to once daily: glucosamine sulfate 1500 mg (n=152), chondroitin sulfate 800 mg (n=151), both dietary supplements (n=151) or matching placebo capsules (n=151). JSN (mm) over 2 years was measured from digitised knee radiographs. Maximum knee pain (0–10) was self-reported in a participant diary for 7 days every 2 months over 1 year. Results After adjusting for factors associated with structural disease progression (gender, body mass index (BMI), baseline structural disease severity and Heberden's nodes), allocation to the dietary supplement combination (glucosamine–chondroitin) resulted in a statistically significant (p=0.046) reduction of 2-year JSN compared to placebo: mean difference 0.10 mm (95% CI 0.002 mm to 0.20 mm); no significant structural effect for the single treatment allocations was detected. All four allocation groups demonstrated reduced knee pain over the first year, but no significant between-group differences (p=0.93) were detected. 34 (6%) participants reported possibly-related adverse medical events over the 2-year follow-up period. Conclusions Allocation to the glucosamine–chondroitin combination resulted in a statistically significant reduction in JSN at 2 years. While all allocation groups demonstrated reduced knee pain over the study period, none of the treatment allocation groups demonstrated significant symptomatic benefit above placebo. Trial Registration ClinicalTrials.gov identifier: NCT00513422; http://www.clinicaltrials.gov
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24Risk factors
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26Treatment Outcome
27Usage
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titleGlucosamine and chondroitin for knee osteoarthritis: a double-blind randomised placebo-controlled clinical trial evaluating single and combination regimens
authorFransen, Marlene ; Agaliotis, Maria ; Nairn, Lillias ; Votrubec, Milana ; Bridgett, Lisa ; Su, Steve ; Jan, Stephen ; March, Lyn ; Edmonds, John ; Norton, Robyn ; Woodward, Mark ; Day, Richard
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1Arthritis
2Care and treatment
3Chondroitin
4Chondroitin Sulfates - therapeutic use
5Clinical trials
6Dietary Supplements
7Disease Progression
8Double-Blind Method
9Drug Therapy, Combination
10Female
11Glucosamine
12Glucosamine - therapeutic use
13Humans
14Knee
15Knee Joint - diagnostic imaging
16Male
17Middle Aged
18Osteoarthritis
19Osteoarthritis, Knee - diagnostic imaging
20Osteoarthritis, Knee - drug therapy
21Pain management
22Quality of life
23Radiography
24Risk factors
25Studies
26Treatment Outcome
27Usage
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9Norton, Robyn
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8Edmonds, John
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atitleGlucosamine and chondroitin for knee osteoarthritis: a double-blind randomised placebo-controlled clinical trial evaluating single and combination regimens
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abstractObjective To determine if the dietary supplements, glucosamine and/or chondroitin, result in reduced joint space narrowing (JSN) and pain among people with symptomatic knee osteoarthritis. Methods A double-blind randomised placebo-controlled clinical trial with 2-year follow-up. 605 participants, aged 45–75 years, reporting chronic knee pain and with evidence of medial tibio-femoral compartment narrowing (but retaining >2 mm medial joint space width) were randomised to once daily: glucosamine sulfate 1500 mg (n=152), chondroitin sulfate 800 mg (n=151), both dietary supplements (n=151) or matching placebo capsules (n=151). JSN (mm) over 2 years was measured from digitised knee radiographs. Maximum knee pain (0–10) was self-reported in a participant diary for 7 days every 2 months over 1 year. Results After adjusting for factors associated with structural disease progression (gender, body mass index (BMI), baseline structural disease severity and Heberden's nodes), allocation to the dietary supplement combination (glucosamine–chondroitin) resulted in a statistically significant (p=0.046) reduction of 2-year JSN compared to placebo: mean difference 0.10 mm (95% CI 0.002 mm to 0.20 mm); no significant structural effect for the single treatment allocations was detected. All four allocation groups demonstrated reduced knee pain over the first year, but no significant between-group differences (p=0.93) were detected. 34 (6%) participants reported possibly-related adverse medical events over the 2-year follow-up period. Conclusions Allocation to the glucosamine–chondroitin combination resulted in a statistically significant reduction in JSN at 2 years. While all allocation groups demonstrated reduced knee pain over the study period, none of the treatment allocation groups demonstrated significant symptomatic benefit above placebo. Trial Registration ClinicalTrials.gov identifier: NCT00513422; http://www.clinicaltrials.gov
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