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Nonalcoholic Fatty Liver Disease Is Associated With Coronary Artery Calcification Development: A Longitudinal Study

Context: Nonalcoholic fatty liver disease (NAFLD) is associated with coronary artery calcification (CAC) in cross-sectional studies. However, whether NAFLD itself affects CAC development or progression remains unknown. Objective: This study investigated the longitudinal association between NAFLD and... Full description

Journal Title: The journal of clinical endocrinology and metabolism 2016, Vol.101 (8), p.3134-3143
Main Author: Park, Hyo Eun
Other Authors: Kwak, Min-Sun , Kim, Donghee , Kim, Min-Kyung , Cha, Myung-jin , Choi, Su-Yeon
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: United States: Endocrine Society
ID: ISSN: 0021-972X
Link: https://www.ncbi.nlm.nih.gov/pubmed/27253666
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title: Nonalcoholic Fatty Liver Disease Is Associated With Coronary Artery Calcification Development: A Longitudinal Study
format: Article
creator:
  • Park, Hyo Eun
  • Kwak, Min-Sun
  • Kim, Donghee
  • Kim, Min-Kyung
  • Cha, Myung-jin
  • Choi, Su-Yeon
subjects:
  • Abridged Index Medicus
  • Aged
  • Calcinosis - complications
  • Calcinosis - diagnosis
  • Calcinosis - epidemiology
  • Calcinosis - pathology
  • Coronary Artery Disease - complications
  • Coronary Artery Disease - diagnosis
  • Coronary Artery Disease - epidemiology
  • Coronary Artery Disease - pathology
  • Disease Progression
  • Female
  • Humans
  • Liver - diagnostic imaging
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Non-alcoholic Fatty Liver Disease - complications
  • Non-alcoholic Fatty Liver Disease - diagnosis
  • Non-alcoholic Fatty Liver Disease - epidemiology
  • Retrospective Studies
  • Severity of Illness Index
  • Ultrasonography
ispartof: The journal of clinical endocrinology and metabolism, 2016, Vol.101 (8), p.3134-3143
description: Context: Nonalcoholic fatty liver disease (NAFLD) is associated with coronary artery calcification (CAC) in cross-sectional studies. However, whether NAFLD itself affects CAC development or progression remains unknown. Objective: This study investigated the longitudinal association between NAFLD and CAC score. Design and Setting: This study is a longitudinal cohort study performed in a healthcare center. Participants: Among 1732 subjects who underwent serial CAC evaluation, we evaluated 846 subjects with NAFLD and 886 subjects without NAFLD, as diagnosed via ultrasonography. Main Outcome Measures: CAC score was compared at baseline and follow-up. In subjects without calcification (CAC score = 0) at baseline, any incidental calcification (CAC score >0) at follow-up was defined as development of CAC. In subjects with CAC (CAC score > 0) at baseline, confirmed CAC aggravation was defined as progression. Logistic regression analysis was performed. Results: More subjects with NAFLD than without showed CAC development or progression (48.8 vs 38.4%; P < .001). The impact of NAFLD on a change in CAC score significantly differed according to the CAC score at baseline. In subjects without calcification at baseline, NAFLD significantly affected the development of calcification (odds ratio, 1.49; 95% confidence interval, 1.01–2.21; P = .045) after adjusting for traditional metabolic risk factors. However, in subjects with baseline CAC, NAFLD did not significantly affect progression (P = .734). Additionally, the severity of NAFLD was important. The severity of NAFLD was dose-dependently associated with the development of CAC (P for trend = .043). Conclusions: NAFLD plays a role in the early development of CAC, but not the progression. Ultrasonographic severity of NAFLD is dose-dependently associated with CAC development in subjects with a CAC score of 0 at baseline, independent of traditional risk factors. We investigated the association between NAFLD and CAC. NAFLD significantly affected the development of CAC, but not the progression. The severity of NAFLD was also associated with CAC development.
language: eng
source:
identifier: ISSN: 0021-972X
fulltext: no_fulltext
issn:
  • 0021-972X
  • 1945-7197
url: Link


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titleNonalcoholic Fatty Liver Disease Is Associated With Coronary Artery Calcification Development: A Longitudinal Study
creatorPark, Hyo Eun ; Kwak, Min-Sun ; Kim, Donghee ; Kim, Min-Kyung ; Cha, Myung-jin ; Choi, Su-Yeon
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descriptionContext: Nonalcoholic fatty liver disease (NAFLD) is associated with coronary artery calcification (CAC) in cross-sectional studies. However, whether NAFLD itself affects CAC development or progression remains unknown. Objective: This study investigated the longitudinal association between NAFLD and CAC score. Design and Setting: This study is a longitudinal cohort study performed in a healthcare center. Participants: Among 1732 subjects who underwent serial CAC evaluation, we evaluated 846 subjects with NAFLD and 886 subjects without NAFLD, as diagnosed via ultrasonography. Main Outcome Measures: CAC score was compared at baseline and follow-up. In subjects without calcification (CAC score = 0) at baseline, any incidental calcification (CAC score >0) at follow-up was defined as development of CAC. In subjects with CAC (CAC score > 0) at baseline, confirmed CAC aggravation was defined as progression. Logistic regression analysis was performed. Results: More subjects with NAFLD than without showed CAC development or progression (48.8 vs 38.4%; P < .001). The impact of NAFLD on a change in CAC score significantly differed according to the CAC score at baseline. In subjects without calcification at baseline, NAFLD significantly affected the development of calcification (odds ratio, 1.49; 95% confidence interval, 1.01–2.21; P = .045) after adjusting for traditional metabolic risk factors. However, in subjects with baseline CAC, NAFLD did not significantly affect progression (P = .734). Additionally, the severity of NAFLD was important. The severity of NAFLD was dose-dependently associated with the development of CAC (P for trend = .043). Conclusions: NAFLD plays a role in the early development of CAC, but not the progression. Ultrasonographic severity of NAFLD is dose-dependently associated with CAC development in subjects with a CAC score of 0 at baseline, independent of traditional risk factors. We investigated the association between NAFLD and CAC. NAFLD significantly affected the development of CAC, but not the progression. The severity of NAFLD was also associated with CAC development.
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descriptionContext: Nonalcoholic fatty liver disease (NAFLD) is associated with coronary artery calcification (CAC) in cross-sectional studies. However, whether NAFLD itself affects CAC development or progression remains unknown. Objective: This study investigated the longitudinal association between NAFLD and CAC score. Design and Setting: This study is a longitudinal cohort study performed in a healthcare center. Participants: Among 1732 subjects who underwent serial CAC evaluation, we evaluated 846 subjects with NAFLD and 886 subjects without NAFLD, as diagnosed via ultrasonography. Main Outcome Measures: CAC score was compared at baseline and follow-up. In subjects without calcification (CAC score = 0) at baseline, any incidental calcification (CAC score >0) at follow-up was defined as development of CAC. In subjects with CAC (CAC score > 0) at baseline, confirmed CAC aggravation was defined as progression. Logistic regression analysis was performed. Results: More subjects with NAFLD than without showed CAC development or progression (48.8 vs 38.4%; P < .001). The impact of NAFLD on a change in CAC score significantly differed according to the CAC score at baseline. In subjects without calcification at baseline, NAFLD significantly affected the development of calcification (odds ratio, 1.49; 95% confidence interval, 1.01–2.21; P = .045) after adjusting for traditional metabolic risk factors. However, in subjects with baseline CAC, NAFLD did not significantly affect progression (P = .734). Additionally, the severity of NAFLD was important. The severity of NAFLD was dose-dependently associated with the development of CAC (P for trend = .043). Conclusions: NAFLD plays a role in the early development of CAC, but not the progression. Ultrasonographic severity of NAFLD is dose-dependently associated with CAC development in subjects with a CAC score of 0 at baseline, independent of traditional risk factors. We investigated the association between NAFLD and CAC. NAFLD significantly affected the development of CAC, but not the progression. The severity of NAFLD was also associated with CAC development.
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notesThis work was supported by the Seoul National University Hospital Research Fund, Grants 0420140670 (no. 2014-0670) and 0420130960 (no. 2013-1243). The funding organizations had no role in the design or conduct of the study; in the collection, management, analysis, or interpretation of the data; or in the preparation, review, or approval of the manuscript.
abstractContext: Nonalcoholic fatty liver disease (NAFLD) is associated with coronary artery calcification (CAC) in cross-sectional studies. However, whether NAFLD itself affects CAC development or progression remains unknown. Objective: This study investigated the longitudinal association between NAFLD and CAC score. Design and Setting: This study is a longitudinal cohort study performed in a healthcare center. Participants: Among 1732 subjects who underwent serial CAC evaluation, we evaluated 846 subjects with NAFLD and 886 subjects without NAFLD, as diagnosed via ultrasonography. Main Outcome Measures: CAC score was compared at baseline and follow-up. In subjects without calcification (CAC score = 0) at baseline, any incidental calcification (CAC score >0) at follow-up was defined as development of CAC. In subjects with CAC (CAC score > 0) at baseline, confirmed CAC aggravation was defined as progression. Logistic regression analysis was performed. Results: More subjects with NAFLD than without showed CAC development or progression (48.8 vs 38.4%; P < .001). The impact of NAFLD on a change in CAC score significantly differed according to the CAC score at baseline. In subjects without calcification at baseline, NAFLD significantly affected the development of calcification (odds ratio, 1.49; 95% confidence interval, 1.01–2.21; P = .045) after adjusting for traditional metabolic risk factors. However, in subjects with baseline CAC, NAFLD did not significantly affect progression (P = .734). Additionally, the severity of NAFLD was important. The severity of NAFLD was dose-dependently associated with the development of CAC (P for trend = .043). Conclusions: NAFLD plays a role in the early development of CAC, but not the progression. Ultrasonographic severity of NAFLD is dose-dependently associated with CAC development in subjects with a CAC score of 0 at baseline, independent of traditional risk factors. We investigated the association between NAFLD and CAC. NAFLD significantly affected the development of CAC, but not the progression. The severity of NAFLD was also associated with CAC development.
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doi10.1210/jc.2016-1525
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