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The effect of bergamot on dyslipidemia

Statins are the most common used lipid lowering drugs but they may cause adverse effects and despite their well-established therapeutic benefits residual cardiovascular (CV) risk remains. The use of other lipid lowering drugs and nutraceuticals alone or as add-on lipid-modifying therapy can be an op... Full description

Journal Title: Phytomedicine (Stuttgart) 2016-10-15, Vol.23 (11), p.1175-1181
Main Author: Giglio, Rosaria Vincenza
Other Authors: Patti, Angelo Maria , Nikolic, Dragana , Li Volti, Giovanni , Al-Rasadi, Khalid , Katsiki, Niki , Mikhailidis, Dimitri P , Montalto, Giuseppe , Ivanova, Ekaterina , Orekhov, Alexander N , Rizzo, Manfredi
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: Germany: Elsevier GmbH
ID: ISSN: 0944-7113
Link: https://www.ncbi.nlm.nih.gov/pubmed/26851838
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title: The effect of bergamot on dyslipidemia
format: Article
creator:
  • Giglio, Rosaria Vincenza
  • Patti, Angelo Maria
  • Nikolic, Dragana
  • Li Volti, Giovanni
  • Al-Rasadi, Khalid
  • Katsiki, Niki
  • Mikhailidis, Dimitri P
  • Montalto, Giuseppe
  • Ivanova, Ekaterina
  • Orekhov, Alexander N
  • Rizzo, Manfredi
subjects:
  • Animals
  • Bergamot
  • Bitter orange
  • Cardiovascular risk
  • Care and treatment
  • Citrus - chemistry
  • Dyslipidemia
  • Dyslipidemias
  • Dyslipidemias - drug therapy
  • Flavonoids - pharmacology
  • Flavonoids - therapeutic use
  • Health aspects
  • Humans
  • Hypolipidemic Agents - pharmacology
  • Hypolipidemic Agents - therapeutic use
  • LDL cholesterol
  • Plant Extracts - pharmacology
  • Plant Extracts - therapeutic use
  • Usage
ispartof: Phytomedicine (Stuttgart), 2016-10-15, Vol.23 (11), p.1175-1181
description: Statins are the most common used lipid lowering drugs but they may cause adverse effects and despite their well-established therapeutic benefits residual cardiovascular (CV) risk remains. The use of other lipid lowering drugs and nutraceuticals alone or as add-on lipid-modifying therapy can be an option in such cases. Several studies have reported health-related properties of the Citrus fruits, among which bergamot (Citrus bergamia Risso) differs from others by particularly high content of certain compounds. This narrative review summarizes the current evidence on the effects of bergamot on lipid parameters based on studies involving animals and humans. This natural supplement may lead to effective lipid-lowering treatment. Its lipid-lowering activity is attributed to different flavonoids. However, the exact mechanisms involved remain unclear. It is expected that ongoing and future studies will confirm the benefit of bergamot in dyslipidemic and other cardiometabolic disorders, potentially leading to reduced overall CV risk.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0944-7113
fulltext: fulltext
issn:
  • 0944-7113
  • 1618-095X
url: Link


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descriptionStatins are the most common used lipid lowering drugs but they may cause adverse effects and despite their well-established therapeutic benefits residual cardiovascular (CV) risk remains. The use of other lipid lowering drugs and nutraceuticals alone or as add-on lipid-modifying therapy can be an option in such cases. Several studies have reported health-related properties of the Citrus fruits, among which bergamot (Citrus bergamia Risso) differs from others by particularly high content of certain compounds. This narrative review summarizes the current evidence on the effects of bergamot on lipid parameters based on studies involving animals and humans. This natural supplement may lead to effective lipid-lowering treatment. Its lipid-lowering activity is attributed to different flavonoids. However, the exact mechanisms involved remain unclear. It is expected that ongoing and future studies will confirm the benefit of bergamot in dyslipidemic and other cardiometabolic disorders, potentially leading to reduced overall CV risk.
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subjectAnimals ; Bergamot ; Bitter orange ; Cardiovascular risk ; Care and treatment ; Citrus - chemistry ; Dyslipidemia ; Dyslipidemias ; Dyslipidemias - drug therapy ; Flavonoids - pharmacology ; Flavonoids - therapeutic use ; Health aspects ; Humans ; Hypolipidemic Agents - pharmacology ; Hypolipidemic Agents - therapeutic use ; LDL cholesterol ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Usage
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descriptionStatins are the most common used lipid lowering drugs but they may cause adverse effects and despite their well-established therapeutic benefits residual cardiovascular (CV) risk remains. The use of other lipid lowering drugs and nutraceuticals alone or as add-on lipid-modifying therapy can be an option in such cases. Several studies have reported health-related properties of the Citrus fruits, among which bergamot (Citrus bergamia Risso) differs from others by particularly high content of certain compounds. This narrative review summarizes the current evidence on the effects of bergamot on lipid parameters based on studies involving animals and humans. This natural supplement may lead to effective lipid-lowering treatment. Its lipid-lowering activity is attributed to different flavonoids. However, the exact mechanisms involved remain unclear. It is expected that ongoing and future studies will confirm the benefit of bergamot in dyslipidemic and other cardiometabolic disorders, potentially leading to reduced overall CV risk.
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abstractStatins are the most common used lipid lowering drugs but they may cause adverse effects and despite their well-established therapeutic benefits residual cardiovascular (CV) risk remains. The use of other lipid lowering drugs and nutraceuticals alone or as add-on lipid-modifying therapy can be an option in such cases. Several studies have reported health-related properties of the Citrus fruits, among which bergamot (Citrus bergamia Risso) differs from others by particularly high content of certain compounds. This narrative review summarizes the current evidence on the effects of bergamot on lipid parameters based on studies involving animals and humans. This natural supplement may lead to effective lipid-lowering treatment. Its lipid-lowering activity is attributed to different flavonoids. However, the exact mechanisms involved remain unclear. It is expected that ongoing and future studies will confirm the benefit of bergamot in dyslipidemic and other cardiometabolic disorders, potentially leading to reduced overall CV risk.
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