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Placental antioxidant enzyme status and lipid peroxidation in pregnant women with type 1 diabetes: The effect of vitamin C and E supplementation

Abstract Aim In view of the increased rates of pre-eclampsia observed in diabetic pregnancy and the lack of ex vivo data on placental biomarkers of oxidative stress in T1 diabetic pregnancy, the aim of the current investigation was to examine placental antioxidant enzyme status and lipid peroxidatio... Full description

Journal Title: Journal of diabetes and its complications 2016, Vol.30 (1), p.109-114
Main Author: Johnston, Philip C
Other Authors: McCance, David R , Holmes, Valerie A , Young, Ian S , McGinty, Ann
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: United States: Elsevier Inc
ID: ISSN: 1056-8727
Link: https://www.ncbi.nlm.nih.gov/pubmed/26597598
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title: Placental antioxidant enzyme status and lipid peroxidation in pregnant women with type 1 diabetes: The effect of vitamin C and E supplementation
format: Article
creator:
  • Johnston, Philip C
  • McCance, David R
  • Holmes, Valerie A
  • Young, Ian S
  • McGinty, Ann
subjects:
  • Antioxidant status
  • Antioxidants
  • Ascorbic Acid - blood
  • Ascorbic Acid - metabolism
  • Ascorbic Acid - therapeutic use
  • Biomarkers - blood
  • Biomarkers - metabolism
  • Cohort Studies
  • Diabetes
  • Diabetes Mellitus, Type 1 - blood
  • Diabetes Mellitus, Type 1 - complications
  • Diabetes Mellitus, Type 1 - diet therapy
  • Diabetes Mellitus, Type 1 - metabolism
  • Diet therapy
  • Dietary Supplements
  • Endocrinology & Metabolism
  • Enzymes
  • Female
  • Fetal Blood
  • Gynecology
  • Humans
  • Hypertension
  • Laboratories
  • Lipid Peroxidation
  • Lipids
  • Maternal Nutritional Physiological Phenomena
  • Northern Ireland - epidemiology
  • Obstetrics
  • Oxidative Stress
  • Oxidoreductases - chemistry
  • Oxidoreductases - metabolism
  • Pathogenesis
  • Placenta
  • Placenta - enzymology
  • Placenta - metabolism
  • Pre-eclampsia
  • Pre-Eclampsia - epidemiology
  • Pre-Eclampsia - prevention & control
  • Preeclampsia
  • Pregnancy
  • Pregnancy in Diabetics - blood
  • Pregnancy in Diabetics - diet therapy
  • Pregnancy in Diabetics - enzymology
  • Pregnancy in Diabetics - metabolism
  • Pregnancy, High-Risk - blood
  • Pregnancy, High-Risk - metabolism
  • Pregnant women
  • Risk
  • Type 1 diabetes
  • Type 1 diabetes mellitus
  • Vitamin C
  • Vitamin C and E supplementation
  • Vitamin E
  • Vitamin E - blood
  • Vitamin E - metabolism
  • Vitamin E - therapeutic use
ispartof: Journal of diabetes and its complications, 2016, Vol.30 (1), p.109-114
description: Abstract Aim In view of the increased rates of pre-eclampsia observed in diabetic pregnancy and the lack of ex vivo data on placental biomarkers of oxidative stress in T1 diabetic pregnancy, the aim of the current investigation was to examine placental antioxidant enzyme status and lipid peroxidation in pregnant women with type 1 diabetes. A further objective of the study was to investigate the putative impact of vitamin C and E supplementation on antioxidant enzyme activity and lipid peroxidation in type 1 diabetic placentae. Methods The current study measured levels of antioxidant enzyme [glutathione peroxidase (Gpx), glutathione reductase (Gred), superoxide dismutase (SOD) and catalase] activity and degree of lipid peroxidation (aqueous phase hydroperoxides and 8-iso-prostaglandin F2α) in matched central and peripheral samples from placentae of DAPIT (n = 57) participants. Levels of vitamin C and E were assessed in placentae and cord blood. Results Peripheral placentae demonstrated significant increases in Gpx and Gred activities in pre-eclamptic in comparison to non-pre-eclamptic women. Vitamin C and E supplementation had no significant effect on cord blood or placental levels of these vitamins, nor on placental antioxidant enzyme activity or degree of lipid peroxidation in comparison to placebo-supplementation. Conclusion The finding that maternal supplementation with vitamin C/E does not augment cord or placental levels of these vitamins is likely to explain the lack of effect of such supplementation on placental indices including antioxidant enzymes or markers of lipid peroxidation.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 1056-8727
fulltext: fulltext
issn:
  • 1056-8727
  • 1873-460X
url: Link


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titlePlacental antioxidant enzyme status and lipid peroxidation in pregnant women with type 1 diabetes: The effect of vitamin C and E supplementation
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creatorJohnston, Philip C ; McCance, David R ; Holmes, Valerie A ; Young, Ian S ; McGinty, Ann
creatorcontribJohnston, Philip C ; McCance, David R ; Holmes, Valerie A ; Young, Ian S ; McGinty, Ann
descriptionAbstract Aim In view of the increased rates of pre-eclampsia observed in diabetic pregnancy and the lack of ex vivo data on placental biomarkers of oxidative stress in T1 diabetic pregnancy, the aim of the current investigation was to examine placental antioxidant enzyme status and lipid peroxidation in pregnant women with type 1 diabetes. A further objective of the study was to investigate the putative impact of vitamin C and E supplementation on antioxidant enzyme activity and lipid peroxidation in type 1 diabetic placentae. Methods The current study measured levels of antioxidant enzyme [glutathione peroxidase (Gpx), glutathione reductase (Gred), superoxide dismutase (SOD) and catalase] activity and degree of lipid peroxidation (aqueous phase hydroperoxides and 8-iso-prostaglandin F2α) in matched central and peripheral samples from placentae of DAPIT (n = 57) participants. Levels of vitamin C and E were assessed in placentae and cord blood. Results Peripheral placentae demonstrated significant increases in Gpx and Gred activities in pre-eclamptic in comparison to non-pre-eclamptic women. Vitamin C and E supplementation had no significant effect on cord blood or placental levels of these vitamins, nor on placental antioxidant enzyme activity or degree of lipid peroxidation in comparison to placebo-supplementation. Conclusion The finding that maternal supplementation with vitamin C/E does not augment cord or placental levels of these vitamins is likely to explain the lack of effect of such supplementation on placental indices including antioxidant enzymes or markers of lipid peroxidation.
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1EISSN: 1873-460X
2DOI: 10.1016/j.jdiacomp.2015.10.001
3PMID: 26597598
languageeng
publisherUnited States: Elsevier Inc
subjectAntioxidant status ; Antioxidants ; Ascorbic Acid - blood ; Ascorbic Acid - metabolism ; Ascorbic Acid - therapeutic use ; Biomarkers - blood ; Biomarkers - metabolism ; Cohort Studies ; Diabetes ; Diabetes Mellitus, Type 1 - blood ; Diabetes Mellitus, Type 1 - complications ; Diabetes Mellitus, Type 1 - diet therapy ; Diabetes Mellitus, Type 1 - metabolism ; Diet therapy ; Dietary Supplements ; Endocrinology & Metabolism ; Enzymes ; Female ; Fetal Blood ; Gynecology ; Humans ; Hypertension ; Laboratories ; Lipid Peroxidation ; Lipids ; Maternal Nutritional Physiological Phenomena ; Northern Ireland - epidemiology ; Obstetrics ; Oxidative Stress ; Oxidoreductases - chemistry ; Oxidoreductases - metabolism ; Pathogenesis ; Placenta ; Placenta - enzymology ; Placenta - metabolism ; Pre-eclampsia ; Pre-Eclampsia - epidemiology ; Pre-Eclampsia - prevention & control ; Preeclampsia ; Pregnancy ; Pregnancy in Diabetics - blood ; Pregnancy in Diabetics - diet therapy ; Pregnancy in Diabetics - enzymology ; Pregnancy in Diabetics - metabolism ; Pregnancy, High-Risk - blood ; Pregnancy, High-Risk - metabolism ; Pregnant women ; Risk ; Type 1 diabetes ; Type 1 diabetes mellitus ; Vitamin C ; Vitamin C and E supplementation ; Vitamin E ; Vitamin E - blood ; Vitamin E - metabolism ; Vitamin E - therapeutic use
ispartofJournal of diabetes and its complications, 2016, Vol.30 (1), p.109-114
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1McCance, David R
2Holmes, Valerie A
3Young, Ian S
4McGinty, Ann
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1Journal of diabetes and its complications
addtitleJ Diabetes Complications
descriptionAbstract Aim In view of the increased rates of pre-eclampsia observed in diabetic pregnancy and the lack of ex vivo data on placental biomarkers of oxidative stress in T1 diabetic pregnancy, the aim of the current investigation was to examine placental antioxidant enzyme status and lipid peroxidation in pregnant women with type 1 diabetes. A further objective of the study was to investigate the putative impact of vitamin C and E supplementation on antioxidant enzyme activity and lipid peroxidation in type 1 diabetic placentae. Methods The current study measured levels of antioxidant enzyme [glutathione peroxidase (Gpx), glutathione reductase (Gred), superoxide dismutase (SOD) and catalase] activity and degree of lipid peroxidation (aqueous phase hydroperoxides and 8-iso-prostaglandin F2α) in matched central and peripheral samples from placentae of DAPIT (n = 57) participants. Levels of vitamin C and E were assessed in placentae and cord blood. Results Peripheral placentae demonstrated significant increases in Gpx and Gred activities in pre-eclamptic in comparison to non-pre-eclamptic women. Vitamin C and E supplementation had no significant effect on cord blood or placental levels of these vitamins, nor on placental antioxidant enzyme activity or degree of lipid peroxidation in comparison to placebo-supplementation. Conclusion The finding that maternal supplementation with vitamin C/E does not augment cord or placental levels of these vitamins is likely to explain the lack of effect of such supplementation on placental indices including antioxidant enzymes or markers of lipid peroxidation.
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1Antioxidants
2Ascorbic Acid - blood
3Ascorbic Acid - metabolism
4Ascorbic Acid - therapeutic use
5Biomarkers - blood
6Biomarkers - metabolism
7Cohort Studies
8Diabetes
9Diabetes Mellitus, Type 1 - blood
10Diabetes Mellitus, Type 1 - complications
11Diabetes Mellitus, Type 1 - diet therapy
12Diabetes Mellitus, Type 1 - metabolism
13Diet therapy
14Dietary Supplements
15Endocrinology & Metabolism
16Enzymes
17Female
18Fetal Blood
19Gynecology
20Humans
21Hypertension
22Laboratories
23Lipid Peroxidation
24Lipids
25Maternal Nutritional Physiological Phenomena
26Northern Ireland - epidemiology
27Obstetrics
28Oxidative Stress
29Oxidoreductases - chemistry
30Oxidoreductases - metabolism
31Pathogenesis
32Placenta
33Placenta - enzymology
34Placenta - metabolism
35Pre-eclampsia
36Pre-Eclampsia - epidemiology
37Pre-Eclampsia - prevention & control
38Preeclampsia
39Pregnancy
40Pregnancy in Diabetics - blood
41Pregnancy in Diabetics - diet therapy
42Pregnancy in Diabetics - enzymology
43Pregnancy in Diabetics - metabolism
44Pregnancy, High-Risk - blood
45Pregnancy, High-Risk - metabolism
46Pregnant women
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48Type 1 diabetes
49Type 1 diabetes mellitus
50Vitamin C
51Vitamin C and E supplementation
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53Vitamin E - blood
54Vitamin E - metabolism
55Vitamin E - therapeutic use
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37Pre-Eclampsia - prevention & control
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41Pregnancy in Diabetics - diet therapy
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atitlePlacental antioxidant enzyme status and lipid peroxidation in pregnant women with type 1 diabetes: The effect of vitamin C and E supplementation
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abstractAbstract Aim In view of the increased rates of pre-eclampsia observed in diabetic pregnancy and the lack of ex vivo data on placental biomarkers of oxidative stress in T1 diabetic pregnancy, the aim of the current investigation was to examine placental antioxidant enzyme status and lipid peroxidation in pregnant women with type 1 diabetes. A further objective of the study was to investigate the putative impact of vitamin C and E supplementation on antioxidant enzyme activity and lipid peroxidation in type 1 diabetic placentae. Methods The current study measured levels of antioxidant enzyme [glutathione peroxidase (Gpx), glutathione reductase (Gred), superoxide dismutase (SOD) and catalase] activity and degree of lipid peroxidation (aqueous phase hydroperoxides and 8-iso-prostaglandin F2α) in matched central and peripheral samples from placentae of DAPIT (n = 57) participants. Levels of vitamin C and E were assessed in placentae and cord blood. Results Peripheral placentae demonstrated significant increases in Gpx and Gred activities in pre-eclamptic in comparison to non-pre-eclamptic women. Vitamin C and E supplementation had no significant effect on cord blood or placental levels of these vitamins, nor on placental antioxidant enzyme activity or degree of lipid peroxidation in comparison to placebo-supplementation. Conclusion The finding that maternal supplementation with vitamin C/E does not augment cord or placental levels of these vitamins is likely to explain the lack of effect of such supplementation on placental indices including antioxidant enzymes or markers of lipid peroxidation.
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pubElsevier Inc
pmid26597598
doi10.1016/j.jdiacomp.2015.10.001