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β-Amyloid, APOE and BDNF Genotype, and Depressive and Anxiety Symptoms in Cognitively Normal Older Women and Men

Objective To examine how β-amyloid (Aβ), APOE and BDNF genotypes, and cortisol relate to depressive and anxiety symptoms in cognitively normal older women and men. Methods Cross-sectional data were analyzed from 423 older adults from the Australian Imaging Biomarkers and Lifestyle study. Analyses of... Full description

Journal Title: The American journal of geriatric psychiatry 2016, Vol.24 (12), p.1191-1195
Main Author: Holmes, Sophie E., Ph.D
Other Authors: Esterlis, Irina, Ph.D , Mazure, Carolyn M., Ph.D , Lim, Yen Ying, Ph.D , Ames, David, M.D , Rainey-Smith, Stephanie, Ph.D , Martins, Ralph N., Ph.D , Salvado, Olivier, Ph.D , Dore, Vincent, Ph.D , Villemagne, Victor L., M.D , Rowe, Christopher C., M.D , Laws, Simon M., Ph.D , Masters, Colin L., M.D , Maruff, Paul, Ph.D , Pietrzak, Robert H., Ph.D., M.P.H
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: England: Elsevier Inc
ID: ISSN: 1064-7481
Link: https://www.ncbi.nlm.nih.gov/pubmed/27742526
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title: β-Amyloid, APOE and BDNF Genotype, and Depressive and Anxiety Symptoms in Cognitively Normal Older Women and Men
format: Article
creator:
  • Holmes, Sophie E., Ph.D
  • Esterlis, Irina, Ph.D
  • Mazure, Carolyn M., Ph.D
  • Lim, Yen Ying, Ph.D
  • Ames, David, M.D
  • Rainey-Smith, Stephanie, Ph.D
  • Martins, Ralph N., Ph.D
  • Salvado, Olivier, Ph.D
  • Dore, Vincent, Ph.D
  • Villemagne, Victor L., M.D
  • Rowe, Christopher C., M.D
  • Laws, Simon M., Ph.D
  • Masters, Colin L., M.D
  • Maruff, Paul, Ph.D
  • Pietrzak, Robert H., Ph.D., M.P.H
subjects:
  • Aged
  • Aged, 80 and over
  • amyloid
  • Amyloid beta-Peptides - genetics
  • anxiety
  • Anxiety - genetics
  • APOE
  • Apolipoproteins E - genetics
  • BDNF
  • Brain-Derived Neurotrophic Factor - genetics
  • Cross-Sectional Studies
  • depression
  • Depression - genetics
  • elderly
  • Female
  • Genetic Association Studies
  • Genetic Markers - genetics
  • Humans
  • Internal Medicine
  • Male
  • Middle Aged
  • Psychiatric Status Rating Scales
ispartof: The American journal of geriatric psychiatry, 2016, Vol.24 (12), p.1191-1195
description: Objective To examine how β-amyloid (Aβ), APOE and BDNF genotypes, and cortisol relate to depressive and anxiety symptoms in cognitively normal older women and men. Methods Cross-sectional data were analyzed from 423 older adults from the Australian Imaging Biomarkers and Lifestyle study. Analyses of covariance evaluated associations between Aβ, APOE and BDNF genotype, and cortisol in relation to severity of depressive and anxiety symptoms. Results Among Aβ+ older adults, APOE ε4 carriage was associated with greater severity of anxiety symptoms (d = 0.55); and in the full sample, APOE ε4 carriage was linked to greater severity of depressive (d = 0.26) and anxiety (d = 0.21) symptoms. Among Aβ+ women, ε4 carriers reported greater anxiety symptoms than non-ε4 carriers (d = 0.83), and female BDNF rs6265 Val66 Met allele carriers reported greater depressive symptoms (d = 0.29). Conclusion Sex moderated the relationship between Aβ, APOE genotype, and BDNF genotype in predicting severity of anxiety and depressive symptoms in cognitively normal older adults.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 1064-7481
fulltext: fulltext
issn:
  • 1064-7481
  • 1545-7214
url: Link


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titleβ-Amyloid, APOE and BDNF Genotype, and Depressive and Anxiety Symptoms in Cognitively Normal Older Women and Men
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creatorHolmes, Sophie E., Ph.D ; Esterlis, Irina, Ph.D ; Mazure, Carolyn M., Ph.D ; Lim, Yen Ying, Ph.D ; Ames, David, M.D ; Rainey-Smith, Stephanie, Ph.D ; Martins, Ralph N., Ph.D ; Salvado, Olivier, Ph.D ; Dore, Vincent, Ph.D ; Villemagne, Victor L., M.D ; Rowe, Christopher C., M.D ; Laws, Simon M., Ph.D ; Masters, Colin L., M.D ; Maruff, Paul, Ph.D ; Pietrzak, Robert H., Ph.D., M.P.H
creatorcontribHolmes, Sophie E., Ph.D ; Esterlis, Irina, Ph.D ; Mazure, Carolyn M., Ph.D ; Lim, Yen Ying, Ph.D ; Ames, David, M.D ; Rainey-Smith, Stephanie, Ph.D ; Martins, Ralph N., Ph.D ; Salvado, Olivier, Ph.D ; Dore, Vincent, Ph.D ; Villemagne, Victor L., M.D ; Rowe, Christopher C., M.D ; Laws, Simon M., Ph.D ; Masters, Colin L., M.D ; Maruff, Paul, Ph.D ; Pietrzak, Robert H., Ph.D., M.P.H ; Australian Imaging, Biomarkers, Lifestyle Research Group
descriptionObjective To examine how β-amyloid (Aβ), APOE and BDNF genotypes, and cortisol relate to depressive and anxiety symptoms in cognitively normal older women and men. Methods Cross-sectional data were analyzed from 423 older adults from the Australian Imaging Biomarkers and Lifestyle study. Analyses of covariance evaluated associations between Aβ, APOE and BDNF genotype, and cortisol in relation to severity of depressive and anxiety symptoms. Results Among Aβ+ older adults, APOE ε4 carriage was associated with greater severity of anxiety symptoms (d = 0.55); and in the full sample, APOE ε4 carriage was linked to greater severity of depressive (d = 0.26) and anxiety (d = 0.21) symptoms. Among Aβ+ women, ε4 carriers reported greater anxiety symptoms than non-ε4 carriers (d = 0.83), and female BDNF rs6265 Val66 Met allele carriers reported greater depressive symptoms (d = 0.29). Conclusion Sex moderated the relationship between Aβ, APOE genotype, and BDNF genotype in predicting severity of anxiety and depressive symptoms in cognitively normal older adults.
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subjectAged ; Aged, 80 and over ; amyloid ; Amyloid beta-Peptides - genetics ; anxiety ; Anxiety - genetics ; APOE ; Apolipoproteins E - genetics ; BDNF ; Brain-Derived Neurotrophic Factor - genetics ; Cross-Sectional Studies ; depression ; Depression - genetics ; elderly ; Female ; Genetic Association Studies ; Genetic Markers - genetics ; Humans ; Internal Medicine ; Male ; Middle Aged ; Psychiatric Status Rating Scales
ispartofThe American journal of geriatric psychiatry, 2016, Vol.24 (12), p.1191-1195
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15Australian Imaging, Biomarkers, Lifestyle Research Group
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0β-Amyloid, APOE and BDNF Genotype, and Depressive and Anxiety Symptoms in Cognitively Normal Older Women and Men
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descriptionObjective To examine how β-amyloid (Aβ), APOE and BDNF genotypes, and cortisol relate to depressive and anxiety symptoms in cognitively normal older women and men. Methods Cross-sectional data were analyzed from 423 older adults from the Australian Imaging Biomarkers and Lifestyle study. Analyses of covariance evaluated associations between Aβ, APOE and BDNF genotype, and cortisol in relation to severity of depressive and anxiety symptoms. Results Among Aβ+ older adults, APOE ε4 carriage was associated with greater severity of anxiety symptoms (d = 0.55); and in the full sample, APOE ε4 carriage was linked to greater severity of depressive (d = 0.26) and anxiety (d = 0.21) symptoms. Among Aβ+ women, ε4 carriers reported greater anxiety symptoms than non-ε4 carriers (d = 0.83), and female BDNF rs6265 Val66 Met allele carriers reported greater depressive symptoms (d = 0.29). Conclusion Sex moderated the relationship between Aβ, APOE genotype, and BDNF genotype in predicting severity of anxiety and depressive symptoms in cognitively normal older adults.
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atitleβ-Amyloid, APOE and BDNF Genotype, and Depressive and Anxiety Symptoms in Cognitively Normal Older Women and Men
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abstractObjective To examine how β-amyloid (Aβ), APOE and BDNF genotypes, and cortisol relate to depressive and anxiety symptoms in cognitively normal older women and men. Methods Cross-sectional data were analyzed from 423 older adults from the Australian Imaging Biomarkers and Lifestyle study. Analyses of covariance evaluated associations between Aβ, APOE and BDNF genotype, and cortisol in relation to severity of depressive and anxiety symptoms. Results Among Aβ+ older adults, APOE ε4 carriage was associated with greater severity of anxiety symptoms (d = 0.55); and in the full sample, APOE ε4 carriage was linked to greater severity of depressive (d = 0.26) and anxiety (d = 0.21) symptoms. Among Aβ+ women, ε4 carriers reported greater anxiety symptoms than non-ε4 carriers (d = 0.83), and female BDNF rs6265 Val66 Met allele carriers reported greater depressive symptoms (d = 0.29). Conclusion Sex moderated the relationship between Aβ, APOE genotype, and BDNF genotype in predicting severity of anxiety and depressive symptoms in cognitively normal older adults.
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pmid27742526
doi10.1016/j.jagp.2016.08.007