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Exercise Training Reduces Liver Fat and Increases Rates of VLDL Clearance But Not VLDL Production in NAFLD

Context: Randomized controlled trials in nonalcoholic fatty liver disease (NAFLD) have shown that regular exercise, even without calorie restriction, reduces liver steatosis. A previous study has shown that 16 weeks of supervised exercise training in NAFLD did not affect total very low-density lipop... Full description

Journal Title: The journal of clinical endocrinology and metabolism 2016-11, Vol.101 (11), p.4219-4228
Main Author: Shojaee-Moradie, F
Other Authors: Cuthbertson, D. J , Barrett, M , Jackson, N. C , Herring, R , Thomas, E. L , Bell, J , Kemp, G. J , Wright, J , Umpleby, A. M
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: United States: Endocrine Society
ID: ISSN: 0021-972X
Link: https://www.ncbi.nlm.nih.gov/pubmed/27583475
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title: Exercise Training Reduces Liver Fat and Increases Rates of VLDL Clearance But Not VLDL Production in NAFLD
format: Article
creator:
  • Shojaee-Moradie, F
  • Cuthbertson, D. J
  • Barrett, M
  • Jackson, N. C
  • Herring, R
  • Thomas, E. L
  • Bell, J
  • Kemp, G. J
  • Wright, J
  • Umpleby, A. M
subjects:
  • Adiposity
  • Apolipoproteins B - blood
  • Apolipoproteins B - metabolism
  • Exercise Therapy - methods
  • Humans
  • Kinetics
  • Lipoproteins, VLDL - blood
  • Lipoproteins, VLDL - metabolism
  • Liver - metabolism
  • Male
  • Middle Aged
  • Non-alcoholic Fatty Liver Disease - metabolism
  • Non-alcoholic Fatty Liver Disease - therapy
  • Outcome Assessment, Health Care
  • Sedentary Behavior
  • Triglycerides - blood
  • Triglycerides - metabolism
ispartof: The journal of clinical endocrinology and metabolism, 2016-11, Vol.101 (11), p.4219-4228
description: Context: Randomized controlled trials in nonalcoholic fatty liver disease (NAFLD) have shown that regular exercise, even without calorie restriction, reduces liver steatosis. A previous study has shown that 16 weeks of supervised exercise training in NAFLD did not affect total very low-density lipoprotein (VLDL) kinetics. Objective: The objective of the study was to determine the effect of exercise training on intrahepatocellular fat (IHCL) and the kinetics of large triglyceride (TG)-rich VLDL1 and smaller denser VLDL2, which has a lower TG content. Design: This was a 16-week randomized controlled trial. Patients: A total of 27 sedentary patients with NAFLD participated in the trial. Intervention: The intervention was composed of supervised exercise with moderate-intensity aerobic exercise or conventional lifestyle advice (control). Main Outcome: VLDL1 and VLDL2-TG and apolipoprotein B (apoB) kinetics were investigated using stable isotopes before and after the intervention. Results: In the exercise group, maximal oxygen uptake increased by 31% ± 6% (mean ± SEM) and IHCL decreased from 19.6% (14.8%, 30.0%) to 8.9% (5.4%, 17.3%) (median [interquartile range]) with no significant change in maximal oxygen uptake or IHCL in the control group (change between groups, P < .001 and P = .02, respectively). Exercise training increased VLDL1-TG and apoB fractional catabolic rates, a measure of clearance, (change between groups, P = .02 and P = .01, respectively), and VLDL1-apoB production rate (change between groups, P = .006), with no change in VLDL1-TG production rate. Plasma TG did not change in either group. Conclusion: An increased clearance of VLDL1 may contribute to the significant decrease in liver fat after 16 weeks of exercise in NAFLD. A longer duration or higher-intensity exercise interventions may be needed to lower the plasma TG and VLDL production rate. A 16-week exercise improved fitness and reduced liver fat by 50% in men with NAFLD and increased clearance of both VLDL1 TG and apoB. However the liver continued to export large amounts of VLDL-TG.
language: eng
source:
identifier: ISSN: 0021-972X
fulltext: no_fulltext
issn:
  • 0021-972X
  • 1945-7197
url: Link


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titleExercise Training Reduces Liver Fat and Increases Rates of VLDL Clearance But Not VLDL Production in NAFLD
creatorShojaee-Moradie, F ; Cuthbertson, D. J ; Barrett, M ; Jackson, N. C ; Herring, R ; Thomas, E. L ; Bell, J ; Kemp, G. J ; Wright, J ; Umpleby, A. M
creatorcontribShojaee-Moradie, F ; Cuthbertson, D. J ; Barrett, M ; Jackson, N. C ; Herring, R ; Thomas, E. L ; Bell, J ; Kemp, G. J ; Wright, J ; Umpleby, A. M
descriptionContext: Randomized controlled trials in nonalcoholic fatty liver disease (NAFLD) have shown that regular exercise, even without calorie restriction, reduces liver steatosis. A previous study has shown that 16 weeks of supervised exercise training in NAFLD did not affect total very low-density lipoprotein (VLDL) kinetics. Objective: The objective of the study was to determine the effect of exercise training on intrahepatocellular fat (IHCL) and the kinetics of large triglyceride (TG)-rich VLDL1 and smaller denser VLDL2, which has a lower TG content. Design: This was a 16-week randomized controlled trial. Patients: A total of 27 sedentary patients with NAFLD participated in the trial. Intervention: The intervention was composed of supervised exercise with moderate-intensity aerobic exercise or conventional lifestyle advice (control). Main Outcome: VLDL1 and VLDL2-TG and apolipoprotein B (apoB) kinetics were investigated using stable isotopes before and after the intervention. Results: In the exercise group, maximal oxygen uptake increased by 31% ± 6% (mean ± SEM) and IHCL decreased from 19.6% (14.8%, 30.0%) to 8.9% (5.4%, 17.3%) (median [interquartile range]) with no significant change in maximal oxygen uptake or IHCL in the control group (change between groups, P < .001 and P = .02, respectively). Exercise training increased VLDL1-TG and apoB fractional catabolic rates, a measure of clearance, (change between groups, P = .02 and P = .01, respectively), and VLDL1-apoB production rate (change between groups, P = .006), with no change in VLDL1-TG production rate. Plasma TG did not change in either group. Conclusion: An increased clearance of VLDL1 may contribute to the significant decrease in liver fat after 16 weeks of exercise in NAFLD. A longer duration or higher-intensity exercise interventions may be needed to lower the plasma TG and VLDL production rate. A 16-week exercise improved fitness and reduced liver fat by 50% in men with NAFLD and increased clearance of both VLDL1 TG and apoB. However the liver continued to export large amounts of VLDL-TG.
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subjectAdiposity ; Apolipoproteins B - blood ; Apolipoproteins B - metabolism ; Exercise Therapy - methods ; Humans ; Kinetics ; Lipoproteins, VLDL - blood ; Lipoproteins, VLDL - metabolism ; Liver - metabolism ; Male ; Middle Aged ; Non-alcoholic Fatty Liver Disease - metabolism ; Non-alcoholic Fatty Liver Disease - therapy ; Outcome Assessment, Health Care ; Sedentary Behavior ; Triglycerides - blood ; Triglycerides - metabolism
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6Bell, J
7Kemp, G. J
8Wright, J
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descriptionContext: Randomized controlled trials in nonalcoholic fatty liver disease (NAFLD) have shown that regular exercise, even without calorie restriction, reduces liver steatosis. A previous study has shown that 16 weeks of supervised exercise training in NAFLD did not affect total very low-density lipoprotein (VLDL) kinetics. Objective: The objective of the study was to determine the effect of exercise training on intrahepatocellular fat (IHCL) and the kinetics of large triglyceride (TG)-rich VLDL1 and smaller denser VLDL2, which has a lower TG content. Design: This was a 16-week randomized controlled trial. Patients: A total of 27 sedentary patients with NAFLD participated in the trial. Intervention: The intervention was composed of supervised exercise with moderate-intensity aerobic exercise or conventional lifestyle advice (control). Main Outcome: VLDL1 and VLDL2-TG and apolipoprotein B (apoB) kinetics were investigated using stable isotopes before and after the intervention. Results: In the exercise group, maximal oxygen uptake increased by 31% ± 6% (mean ± SEM) and IHCL decreased from 19.6% (14.8%, 30.0%) to 8.9% (5.4%, 17.3%) (median [interquartile range]) with no significant change in maximal oxygen uptake or IHCL in the control group (change between groups, P < .001 and P = .02, respectively). Exercise training increased VLDL1-TG and apoB fractional catabolic rates, a measure of clearance, (change between groups, P = .02 and P = .01, respectively), and VLDL1-apoB production rate (change between groups, P = .006), with no change in VLDL1-TG production rate. Plasma TG did not change in either group. Conclusion: An increased clearance of VLDL1 may contribute to the significant decrease in liver fat after 16 weeks of exercise in NAFLD. A longer duration or higher-intensity exercise interventions may be needed to lower the plasma TG and VLDL production rate. A 16-week exercise improved fitness and reduced liver fat by 50% in men with NAFLD and increased clearance of both VLDL1 TG and apoB. However the liver continued to export large amounts of VLDL-TG.
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1Apolipoproteins B - blood
2Apolipoproteins B - metabolism
3Exercise Therapy - methods
4Humans
5Kinetics
6Lipoproteins, VLDL - blood
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8Liver - metabolism
9Male
10Middle Aged
11Non-alcoholic Fatty Liver Disease - metabolism
12Non-alcoholic Fatty Liver Disease - therapy
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14Sedentary Behavior
15Triglycerides - blood
16Triglycerides - metabolism
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14Sedentary Behavior
15Triglycerides - blood
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abstractContext: Randomized controlled trials in nonalcoholic fatty liver disease (NAFLD) have shown that regular exercise, even without calorie restriction, reduces liver steatosis. A previous study has shown that 16 weeks of supervised exercise training in NAFLD did not affect total very low-density lipoprotein (VLDL) kinetics. Objective: The objective of the study was to determine the effect of exercise training on intrahepatocellular fat (IHCL) and the kinetics of large triglyceride (TG)-rich VLDL1 and smaller denser VLDL2, which has a lower TG content. Design: This was a 16-week randomized controlled trial. Patients: A total of 27 sedentary patients with NAFLD participated in the trial. Intervention: The intervention was composed of supervised exercise with moderate-intensity aerobic exercise or conventional lifestyle advice (control). Main Outcome: VLDL1 and VLDL2-TG and apolipoprotein B (apoB) kinetics were investigated using stable isotopes before and after the intervention. Results: In the exercise group, maximal oxygen uptake increased by 31% ± 6% (mean ± SEM) and IHCL decreased from 19.6% (14.8%, 30.0%) to 8.9% (5.4%, 17.3%) (median [interquartile range]) with no significant change in maximal oxygen uptake or IHCL in the control group (change between groups, P < .001 and P = .02, respectively). Exercise training increased VLDL1-TG and apoB fractional catabolic rates, a measure of clearance, (change between groups, P = .02 and P = .01, respectively), and VLDL1-apoB production rate (change between groups, P = .006), with no change in VLDL1-TG production rate. Plasma TG did not change in either group. Conclusion: An increased clearance of VLDL1 may contribute to the significant decrease in liver fat after 16 weeks of exercise in NAFLD. A longer duration or higher-intensity exercise interventions may be needed to lower the plasma TG and VLDL production rate. A 16-week exercise improved fitness and reduced liver fat by 50% in men with NAFLD and increased clearance of both VLDL1 TG and apoB. However the liver continued to export large amounts of VLDL-TG.
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pubEndocrine Society
pmid27583475
doi10.1210/jc.2016-2353
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