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Functional abolition of carotid body activity restores insulin action and glucose homeostasis in rats: key roles for visceral adipose tissue and the liver

Aims/hypothesis We recently described that carotid body (CB) over-activation is involved in the aetiology of insulin resistance and arterial hypertension in animal models of the metabolic syndrome. Additionally, we have demonstrated that CB activity is increased in animal models of insulin resistanc... Full description

Journal Title: Diabetologia 2016, Vol.60 (1), p.158-168
Main Author: Sacramento, Joana F
Other Authors: Ribeiro, Maria J , Rodrigues, Tiago , Olea, Elena , Melo, Bernardete F , Guarino, Maria P , Fonseca-Pinto, Rui , Ferreira, Cristiana R , Coelho, Joana , Obeso, Ana , Seiça, Raquel , Matafome, Paulo , Conde, Sílvia V
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Berlin/Heidelberg: Springer Berlin Heidelberg
ID: ISSN: 0012-186X
Link: https://www.ncbi.nlm.nih.gov/pubmed/27744526
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title: Functional abolition of carotid body activity restores insulin action and glucose homeostasis in rats: key roles for visceral adipose tissue and the liver
format: Article
creator:
  • Sacramento, Joana F
  • Ribeiro, Maria J
  • Rodrigues, Tiago
  • Olea, Elena
  • Melo, Bernardete F
  • Guarino, Maria P
  • Fonseca-Pinto, Rui
  • Ferreira, Cristiana R
  • Coelho, Joana
  • Obeso, Ana
  • Seiça, Raquel
  • Matafome, Paulo
  • Conde, Sílvia V
subjects:
  • Adipose tissue
  • Adipose tissues
  • Animals
  • Article
  • Blotting, Western
  • Carotid Body - metabolism
  • Carotid sinus nerve
  • Dextrose
  • Evaluation
  • Glucose
  • Glucose - metabolism
  • Glucose homeostasis
  • Homeostasis
  • Homeostasis - physiology
  • Human Physiology
  • Hypertension
  • Insulin
  • Insulin - blood
  • Insulin - metabolism
  • Insulin resistance
  • Insulin Resistance - physiology
  • Insulin sensitivity
  • Internal Medicine
  • Intra-Abdominal Fat - metabolism
  • Liver
  • Liver - metabolism
  • Male
  • Medicine
  • Medicine & Public Health
  • Metabolic Diseases
  • Muscles
  • Rats
  • Rats, Wistar
ispartof: Diabetologia, 2016, Vol.60 (1), p.158-168
description: Aims/hypothesis We recently described that carotid body (CB) over-activation is involved in the aetiology of insulin resistance and arterial hypertension in animal models of the metabolic syndrome. Additionally, we have demonstrated that CB activity is increased in animal models of insulin resistance, and that carotid sinus nerve (CSN) resection prevents the development of insulin resistance and arterial hypertension induced by high-energy diets. Here, we tested whether the functional abolition of CB by CSN transection would reverse pre-established insulin resistance, dyslipidaemia, obesity, autonomic dysfunction and hypertension in animal models of the metabolic syndrome. The effect of CSN resection on insulin signalling pathways and tissue-specific glucose uptake was evaluated in skeletal muscle, adipose tissue and liver. Methods Experiments were performed in male Wistar rats submitted to two high-energy diets: a high-fat diet, representing a model of insulin resistance, hypertension and obesity, and a high-sucrose diet, representing a lean model of insulin resistance and hypertension. Half of each group was submitted to chronic bilateral resection of the CSN. Age-matched control rats were also used. Results CSN resection normalised systemic sympathetic nervous system activity and reversed weight gain induced by high-energy diets. It also normalised plasma glucose and insulin levels, insulin sensitivity lipid profile, arterial pressure and endothelial function by improving glucose uptake by the liver and perienteric adipose tissue. Conclusions/interpretation We concluded that functional abolition of CB activity restores insulin sensitivity and glucose homeostasis by positively affecting insulin signalling pathways in visceral adipose tissue and liver.
language: eng
source:
identifier: ISSN: 0012-186X
fulltext: no_fulltext
issn:
  • 0012-186X
  • 1432-0428
url: Link


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titleFunctional abolition of carotid body activity restores insulin action and glucose homeostasis in rats: key roles for visceral adipose tissue and the liver
creatorSacramento, Joana F ; Ribeiro, Maria J ; Rodrigues, Tiago ; Olea, Elena ; Melo, Bernardete F ; Guarino, Maria P ; Fonseca-Pinto, Rui ; Ferreira, Cristiana R ; Coelho, Joana ; Obeso, Ana ; Seiça, Raquel ; Matafome, Paulo ; Conde, Sílvia V
creatorcontribSacramento, Joana F ; Ribeiro, Maria J ; Rodrigues, Tiago ; Olea, Elena ; Melo, Bernardete F ; Guarino, Maria P ; Fonseca-Pinto, Rui ; Ferreira, Cristiana R ; Coelho, Joana ; Obeso, Ana ; Seiça, Raquel ; Matafome, Paulo ; Conde, Sílvia V
descriptionAims/hypothesis We recently described that carotid body (CB) over-activation is involved in the aetiology of insulin resistance and arterial hypertension in animal models of the metabolic syndrome. Additionally, we have demonstrated that CB activity is increased in animal models of insulin resistance, and that carotid sinus nerve (CSN) resection prevents the development of insulin resistance and arterial hypertension induced by high-energy diets. Here, we tested whether the functional abolition of CB by CSN transection would reverse pre-established insulin resistance, dyslipidaemia, obesity, autonomic dysfunction and hypertension in animal models of the metabolic syndrome. The effect of CSN resection on insulin signalling pathways and tissue-specific glucose uptake was evaluated in skeletal muscle, adipose tissue and liver. Methods Experiments were performed in male Wistar rats submitted to two high-energy diets: a high-fat diet, representing a model of insulin resistance, hypertension and obesity, and a high-sucrose diet, representing a lean model of insulin resistance and hypertension. Half of each group was submitted to chronic bilateral resection of the CSN. Age-matched control rats were also used. Results CSN resection normalised systemic sympathetic nervous system activity and reversed weight gain induced by high-energy diets. It also normalised plasma glucose and insulin levels, insulin sensitivity lipid profile, arterial pressure and endothelial function by improving glucose uptake by the liver and perienteric adipose tissue. Conclusions/interpretation We concluded that functional abolition of CB activity restores insulin sensitivity and glucose homeostasis by positively affecting insulin signalling pathways in visceral adipose tissue and liver.
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subjectAdipose tissue ; Adipose tissues ; Animals ; Article ; Blotting, Western ; Carotid Body - metabolism ; Carotid sinus nerve ; Dextrose ; Evaluation ; Glucose ; Glucose - metabolism ; Glucose homeostasis ; Homeostasis ; Homeostasis - physiology ; Human Physiology ; Hypertension ; Insulin ; Insulin - blood ; Insulin - metabolism ; Insulin resistance ; Insulin Resistance - physiology ; Insulin sensitivity ; Internal Medicine ; Intra-Abdominal Fat - metabolism ; Liver ; Liver - metabolism ; Male ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Muscles ; Rats ; Rats, Wistar
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1Ribeiro, Maria J
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5Guarino, Maria P
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7Ferreira, Cristiana R
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descriptionAims/hypothesis We recently described that carotid body (CB) over-activation is involved in the aetiology of insulin resistance and arterial hypertension in animal models of the metabolic syndrome. Additionally, we have demonstrated that CB activity is increased in animal models of insulin resistance, and that carotid sinus nerve (CSN) resection prevents the development of insulin resistance and arterial hypertension induced by high-energy diets. Here, we tested whether the functional abolition of CB by CSN transection would reverse pre-established insulin resistance, dyslipidaemia, obesity, autonomic dysfunction and hypertension in animal models of the metabolic syndrome. The effect of CSN resection on insulin signalling pathways and tissue-specific glucose uptake was evaluated in skeletal muscle, adipose tissue and liver. Methods Experiments were performed in male Wistar rats submitted to two high-energy diets: a high-fat diet, representing a model of insulin resistance, hypertension and obesity, and a high-sucrose diet, representing a lean model of insulin resistance and hypertension. Half of each group was submitted to chronic bilateral resection of the CSN. Age-matched control rats were also used. Results CSN resection normalised systemic sympathetic nervous system activity and reversed weight gain induced by high-energy diets. It also normalised plasma glucose and insulin levels, insulin sensitivity lipid profile, arterial pressure and endothelial function by improving glucose uptake by the liver and perienteric adipose tissue. Conclusions/interpretation We concluded that functional abolition of CB activity restores insulin sensitivity and glucose homeostasis by positively affecting insulin signalling pathways in visceral adipose tissue and liver.
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titleFunctional abolition of carotid body activity restores insulin action and glucose homeostasis in rats: key roles for visceral adipose tissue and the liver
authorSacramento, Joana F ; Ribeiro, Maria J ; Rodrigues, Tiago ; Olea, Elena ; Melo, Bernardete F ; Guarino, Maria P ; Fonseca-Pinto, Rui ; Ferreira, Cristiana R ; Coelho, Joana ; Obeso, Ana ; Seiça, Raquel ; Matafome, Paulo ; Conde, Sílvia V
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abstractAims/hypothesis We recently described that carotid body (CB) over-activation is involved in the aetiology of insulin resistance and arterial hypertension in animal models of the metabolic syndrome. Additionally, we have demonstrated that CB activity is increased in animal models of insulin resistance, and that carotid sinus nerve (CSN) resection prevents the development of insulin resistance and arterial hypertension induced by high-energy diets. Here, we tested whether the functional abolition of CB by CSN transection would reverse pre-established insulin resistance, dyslipidaemia, obesity, autonomic dysfunction and hypertension in animal models of the metabolic syndrome. The effect of CSN resection on insulin signalling pathways and tissue-specific glucose uptake was evaluated in skeletal muscle, adipose tissue and liver. Methods Experiments were performed in male Wistar rats submitted to two high-energy diets: a high-fat diet, representing a model of insulin resistance, hypertension and obesity, and a high-sucrose diet, representing a lean model of insulin resistance and hypertension. Half of each group was submitted to chronic bilateral resection of the CSN. Age-matched control rats were also used. Results CSN resection normalised systemic sympathetic nervous system activity and reversed weight gain induced by high-energy diets. It also normalised plasma glucose and insulin levels, insulin sensitivity lipid profile, arterial pressure and endothelial function by improving glucose uptake by the liver and perienteric adipose tissue. Conclusions/interpretation We concluded that functional abolition of CB activity restores insulin sensitivity and glucose homeostasis by positively affecting insulin signalling pathways in visceral adipose tissue and liver.
copBerlin/Heidelberg
pubSpringer Berlin Heidelberg
pmid27744526
doi10.1007/s00125-016-4133-y
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