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The anxiolytic effect of essential oil of Cananga odorata exposure on mice and determination of its major active constituents

Essential oil from Cananga odorata (ylang-ylang essential oil, YYO) is usually used in reducing blood pressure, improving cognitive functioning in aromatherapy in human. Few reports showed its effect on anxiety behaviors. To investigate the anxiolytic effects of YYO exposure on anxiety animal models... Full description

Journal Title: Phytomedicine (Stuttgart) 2016-12-15, Vol.23 (14), p.1727-1734
Main Author: Zhang, Nan
Other Authors: Zhang, Lei , Feng, Linyin , Yao, Lei
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: Germany: Elsevier GmbH
ID: ISSN: 0944-7113
Link: https://www.ncbi.nlm.nih.gov/pubmed/27912874
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title: The anxiolytic effect of essential oil of Cananga odorata exposure on mice and determination of its major active constituents
format: Article
creator:
  • Zhang, Nan
  • Zhang, Lei
  • Feng, Linyin
  • Yao, Lei
subjects:
  • Acyclic Monoterpenes
  • Animals
  • Anti-Anxiety Agents - pharmacology
  • Anti-Anxiety Agents - therapeutic use
  • Antianxiety agents
  • Anxiety
  • Anxiety - drug therapy
  • Anxiety - metabolism
  • Anxiolytic effect
  • Aromatherapy
  • Behavior, Animal - drug effects
  • Benzoates - pharmacology
  • Benzoates - therapeutic use
  • Benzyl Alcohol - pharmacology
  • Benzyl Alcohol - therapeutic use
  • Benzyl benzoate
  • Brain - drug effects
  • Brain - metabolism
  • Cananga - chemistry
  • Cananga odorata
  • Care and treatment
  • Dopamine
  • Dopamine - metabolism
  • Essences and essential oils
  • Female
  • Health aspects
  • Humans
  • Hydroxyindoleacetic Acid - metabolism
  • Magnoliidae
  • Male
  • Medicine, Botanic
  • Medicine, Herbal
  • Mice, Inbred ICR
  • Monoterpenes - pharmacology
  • Monoterpenes - therapeutic use
  • Oils, Volatile - chemistry
  • Oils, Volatile - pharmacology
  • Oils, Volatile - therapeutic use
  • Phytotherapy
  • Plant Extracts - chemistry
  • Plant Extracts - pharmacology
  • Plant Extracts - therapeutic use
  • Plant Oils - chemistry
  • Plant Oils - pharmacology
  • Plant Oils - therapeutic use
  • Serotonin
  • Serotonin - metabolism
ispartof: Phytomedicine (Stuttgart), 2016-12-15, Vol.23 (14), p.1727-1734
description: Essential oil from Cananga odorata (ylang-ylang essential oil, YYO) is usually used in reducing blood pressure, improving cognitive functioning in aromatherapy in human. Few reports showed its effect on anxiety behaviors. To investigate the anxiolytic effects of YYO exposure on anxiety animal models, determine the major active constituents and investigate the change of neurotransmitters after odor exposure. ICR mice were subjected to three anxiety models including open field, elevated plus maze and light-dark box tests after acute and chronic YYO exposure. Main constituents of YYO were defined using GC/MS. These compounds were then tested on the male mice separately on three anxiety models. The monoamines neurotransmitters and their metabolites were analyzed after acute odor exposure and elevated plus maze test. YYO exposure only showed significant anxiolytic effect on the male mice. It increased the time that mice visited open arms and light box area in elevated plus maze and light-dark box tests after acute and chronic YYO exposures. Three main constituents of YYO, benzyl benzoate, linalool and benzyl alcohol showed anxiolytic effect on the male mice individually. YYO exposure brought changes of neurotransmitters on the male mice more significantly than the female mice. It decreased the dopamine (DA) concentration in the striatum and increased the 5-hydroxytryptamine (5-HT) concentration in the hippocampus of the male mice. The major constituent benzyl benzoate changed neurotransmitters concentration in accordance with the YYO. Moreover, it decreased the ratio of 5-HIAA/5-HT in the hippocampus. Both acute and chronic YYO exposure showed anxiolytic effect on the male mice. YYO and its major constituent benzyl benzoate might act on the 5-HTnergic and DAnergic pathways. [Display omitted]
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0944-7113
fulltext: fulltext
issn:
  • 0944-7113
  • 1618-095X
url: Link


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titleThe anxiolytic effect of essential oil of Cananga odorata exposure on mice and determination of its major active constituents
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creatorcontribZhang, Nan ; Zhang, Lei ; Feng, Linyin ; Yao, Lei
descriptionEssential oil from Cananga odorata (ylang-ylang essential oil, YYO) is usually used in reducing blood pressure, improving cognitive functioning in aromatherapy in human. Few reports showed its effect on anxiety behaviors. To investigate the anxiolytic effects of YYO exposure on anxiety animal models, determine the major active constituents and investigate the change of neurotransmitters after odor exposure. ICR mice were subjected to three anxiety models including open field, elevated plus maze and light-dark box tests after acute and chronic YYO exposure. Main constituents of YYO were defined using GC/MS. These compounds were then tested on the male mice separately on three anxiety models. The monoamines neurotransmitters and their metabolites were analyzed after acute odor exposure and elevated plus maze test. YYO exposure only showed significant anxiolytic effect on the male mice. It increased the time that mice visited open arms and light box area in elevated plus maze and light-dark box tests after acute and chronic YYO exposures. Three main constituents of YYO, benzyl benzoate, linalool and benzyl alcohol showed anxiolytic effect on the male mice individually. YYO exposure brought changes of neurotransmitters on the male mice more significantly than the female mice. It decreased the dopamine (DA) concentration in the striatum and increased the 5-hydroxytryptamine (5-HT) concentration in the hippocampus of the male mice. The major constituent benzyl benzoate changed neurotransmitters concentration in accordance with the YYO. Moreover, it decreased the ratio of 5-HIAA/5-HT in the hippocampus. Both acute and chronic YYO exposure showed anxiolytic effect on the male mice. YYO and its major constituent benzyl benzoate might act on the 5-HTnergic and DAnergic pathways. [Display omitted]
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languageeng
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subjectAcyclic Monoterpenes ; Animals ; Anti-Anxiety Agents - pharmacology ; Anti-Anxiety Agents - therapeutic use ; Antianxiety agents ; Anxiety ; Anxiety - drug therapy ; Anxiety - metabolism ; Anxiolytic effect ; Aromatherapy ; Behavior, Animal - drug effects ; Benzoates - pharmacology ; Benzoates - therapeutic use ; Benzyl Alcohol - pharmacology ; Benzyl Alcohol - therapeutic use ; Benzyl benzoate ; Brain - drug effects ; Brain - metabolism ; Cananga - chemistry ; Cananga odorata ; Care and treatment ; Dopamine ; Dopamine - metabolism ; Essences and essential oils ; Female ; Health aspects ; Humans ; Hydroxyindoleacetic Acid - metabolism ; Magnoliidae ; Male ; Medicine, Botanic ; Medicine, Herbal ; Mice, Inbred ICR ; Monoterpenes - pharmacology ; Monoterpenes - therapeutic use ; Oils, Volatile - chemistry ; Oils, Volatile - pharmacology ; Oils, Volatile - therapeutic use ; Phytotherapy ; Plant Extracts - chemistry ; Plant Extracts - pharmacology ; Plant Extracts - therapeutic use ; Plant Oils - chemistry ; Plant Oils - pharmacology ; Plant Oils - therapeutic use ; Serotonin ; Serotonin - metabolism
ispartofPhytomedicine (Stuttgart), 2016-12-15, Vol.23 (14), p.1727-1734
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02016 Elsevier GmbH
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2COPYRIGHT 2016 Urban & Fischer Verlag
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descriptionEssential oil from Cananga odorata (ylang-ylang essential oil, YYO) is usually used in reducing blood pressure, improving cognitive functioning in aromatherapy in human. Few reports showed its effect on anxiety behaviors. To investigate the anxiolytic effects of YYO exposure on anxiety animal models, determine the major active constituents and investigate the change of neurotransmitters after odor exposure. ICR mice were subjected to three anxiety models including open field, elevated plus maze and light-dark box tests after acute and chronic YYO exposure. Main constituents of YYO were defined using GC/MS. These compounds were then tested on the male mice separately on three anxiety models. The monoamines neurotransmitters and their metabolites were analyzed after acute odor exposure and elevated plus maze test. YYO exposure only showed significant anxiolytic effect on the male mice. It increased the time that mice visited open arms and light box area in elevated plus maze and light-dark box tests after acute and chronic YYO exposures. Three main constituents of YYO, benzyl benzoate, linalool and benzyl alcohol showed anxiolytic effect on the male mice individually. YYO exposure brought changes of neurotransmitters on the male mice more significantly than the female mice. It decreased the dopamine (DA) concentration in the striatum and increased the 5-hydroxytryptamine (5-HT) concentration in the hippocampus of the male mice. The major constituent benzyl benzoate changed neurotransmitters concentration in accordance with the YYO. Moreover, it decreased the ratio of 5-HIAA/5-HT in the hippocampus. Both acute and chronic YYO exposure showed anxiolytic effect on the male mice. YYO and its major constituent benzyl benzoate might act on the 5-HTnergic and DAnergic pathways. [Display omitted]
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0Acyclic Monoterpenes
1Animals
2Anti-Anxiety Agents - pharmacology
3Anti-Anxiety Agents - therapeutic use
4Antianxiety agents
5Anxiety
6Anxiety - drug therapy
7Anxiety - metabolism
8Anxiolytic effect
9Aromatherapy
10Behavior, Animal - drug effects
11Benzoates - pharmacology
12Benzoates - therapeutic use
13Benzyl Alcohol - pharmacology
14Benzyl Alcohol - therapeutic use
15Benzyl benzoate
16Brain - drug effects
17Brain - metabolism
18Cananga - chemistry
19Cananga odorata
20Care and treatment
21Dopamine
22Dopamine - metabolism
23Essences and essential oils
24Female
25Health aspects
26Humans
27Hydroxyindoleacetic Acid - metabolism
28Magnoliidae
29Male
30Medicine, Botanic
31Medicine, Herbal
32Mice, Inbred ICR
33Monoterpenes - pharmacology
34Monoterpenes - therapeutic use
35Oils, Volatile - chemistry
36Oils, Volatile - pharmacology
37Oils, Volatile - therapeutic use
38Phytotherapy
39Plant Extracts - chemistry
40Plant Extracts - pharmacology
41Plant Extracts - therapeutic use
42Plant Oils - chemistry
43Plant Oils - pharmacology
44Plant Oils - therapeutic use
45Serotonin
46Serotonin - metabolism
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titleThe anxiolytic effect of essential oil of Cananga odorata exposure on mice and determination of its major active constituents
authorZhang, Nan ; Zhang, Lei ; Feng, Linyin ; Yao, Lei
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abstractEssential oil from Cananga odorata (ylang-ylang essential oil, YYO) is usually used in reducing blood pressure, improving cognitive functioning in aromatherapy in human. Few reports showed its effect on anxiety behaviors. To investigate the anxiolytic effects of YYO exposure on anxiety animal models, determine the major active constituents and investigate the change of neurotransmitters after odor exposure. ICR mice were subjected to three anxiety models including open field, elevated plus maze and light-dark box tests after acute and chronic YYO exposure. Main constituents of YYO were defined using GC/MS. These compounds were then tested on the male mice separately on three anxiety models. The monoamines neurotransmitters and their metabolites were analyzed after acute odor exposure and elevated plus maze test. YYO exposure only showed significant anxiolytic effect on the male mice. It increased the time that mice visited open arms and light box area in elevated plus maze and light-dark box tests after acute and chronic YYO exposures. Three main constituents of YYO, benzyl benzoate, linalool and benzyl alcohol showed anxiolytic effect on the male mice individually. YYO exposure brought changes of neurotransmitters on the male mice more significantly than the female mice. It decreased the dopamine (DA) concentration in the striatum and increased the 5-hydroxytryptamine (5-HT) concentration in the hippocampus of the male mice. The major constituent benzyl benzoate changed neurotransmitters concentration in accordance with the YYO. Moreover, it decreased the ratio of 5-HIAA/5-HT in the hippocampus. Both acute and chronic YYO exposure showed anxiolytic effect on the male mice. YYO and its major constituent benzyl benzoate might act on the 5-HTnergic and DAnergic pathways. [Display omitted]
copGermany
pubElsevier GmbH
pmid27912874
doi10.1016/j.phymed.2016.10.017
tpages8