Relation between resting amygdalar activity and cardiovascular events: a longitudinal and cohort study
| Journal Title: | The Lancet (British edition) 2017, Vol.389 (10071), p.834-845 |
| Main Author: | Tawakol, Ahmed, Dr |
| Other Authors: | Ishai, Amorina, MD , Takx, Richard AP, MD , Figueroa, Amparo L, MD , Ali, Abdelrahman, MD , Kaiser, Yannick, BS , Truong, Quynh A, MD , Solomon, Chloe JE, BS , Calcagno, Claudia, MD , Mani, Venkatesh, PhD , Tang, Cheuk Y, PhD , Mulder, Willem JM, Prof , Murrough, James W, MD , Hoffmann, Udo, Prof , Nahrendorf, Matthias, MD , Shin, Lisa M, PhD , Fayad, Zahi A, Prof , Pitman, Roger K, Prof |
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 Electronic Article
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| Language: |
English |
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| Quelle: | Alma/SFX Local Collection |
| Publisher: | England: Elsevier Ltd |
| ID: | ISSN: 0140-6736 |
| Link: | https://www.ncbi.nlm.nih.gov/pubmed/28088338 |
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| recordid: | cdi_proquest_miscellaneous_1861551902 |
| title: | Relation between resting amygdalar activity and cardiovascular events: a longitudinal and cohort study |
| format: | Article |
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| ispartof: | The Lancet (British edition), 2017, Vol.389 (10071), p.834-845 |
| description: | Summary Background Emotional stress is associated with increased risk of cardiovascular disease. We imaged the amygdala, a brain region involved in stress, to determine whether its resting metabolic activity predicts risk of subsequent cardiovascular events. Methods Individuals aged 30 years or older without known cardiovascular disease or active cancer disorders, who underwent18 F-fluorodexoyglucose PET/CT at Massachusetts General Hospital (Boston, MA, USA) between Jan 1, 2005, and Dec 31, 2008, were studied longitudinally. Amygdalar activity, bone-marrow activity, and arterial inflammation were assessed with validated methods. In a separate cross-sectional study we analysed the relation between perceived stress, amygdalar activity, arterial inflammation, and C-reactive protein. Image analyses and cardiovascular disease event adjudication were done by mutually blinded researchers. Relations between amygdalar activity and cardiovascular disease events were assessed with Cox models, log-rank tests, and mediation (path) analyses. Findings 293 patients (median age 55 years [IQR 45·0–65·5]) were included in the longitudinal study, 22 of whom had a cardiovascular disease event during median follow-up of 3·7 years (IQR 2·7–4·8). Amygdalar activity was associated with increased bone-marrow activity ( r =0·47; p |
| language: | eng |
| source: | Alma/SFX Local Collection |
| identifier: | ISSN: 0140-6736 |
| fulltext: | fulltext |
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| url: | Link |
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