Predictive ability of urinary biomarkers for outcome in children with acute kidney injury
Journal Title: | Pediatric nephrology (Berlin West), 2016-07-07, Vol.32 (3), p.521-527 |
Main Author: | Mishra, Om P |
Other Authors: | Rai, Avinash K , Srivastava, Pradeep , Pandey, Khushaboo , Abhinay, Abhishek , Prasad, Rajniti , Mishra, Rabindra N , Schaefer, Franz |
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English |
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Publisher: | Berlin/Heidelberg: Springer Berlin Heidelberg |
ID: | ISSN: 0931-041X |
Link: | https://www.ncbi.nlm.nih.gov/pubmed/27387432 |
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recordid: | cdi_proquest_miscellaneous_1868305821 |
title: | Predictive ability of urinary biomarkers for outcome in children with acute kidney injury |
format: | Article |
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ispartof: | Pediatric nephrology (Berlin, West), 2016-07-07, Vol.32 (3), p.521-527 |
description: | Background Urinary neutrophil gelatinase-associated lipocalin (NGAL), N-acetyl-beta-D-glucosaminidase (NAG), and interleukin 18 (IL-18) were found to be useful for early detection of acute kidney injury (AKI). The objective of this study was to determine the predictive ability of biomarkers for mortality and variation in levels in relation to different stages of AKI, need for dialysis, etiologies, and with duration of hospital stay. Methods Urinary NGAL, NAG, and IL-18 levels were measured in 50 children with AKI and 30 age- and gender-matched healthy controls. AKI was classified as per pediatric Risk, Injury, Failure, Loss, and End-stage (RIFLE) criteria. Results Median NGAL, NAG, and IL-18 values were significantly increased in AKI patients compared with controls ( p |
language: | eng |
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identifier: | ISSN: 0931-041X |
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