schliessen

Filtern

 

Bibliotheken

Predictive ability of urinary biomarkers for outcome in children with acute kidney injury

Background Urinary neutrophil gelatinase-associated lipocalin (NGAL), N-acetyl-beta-D-glucosaminidase (NAG), and interleukin 18 (IL-18) were found to be useful for early detection of acute kidney injury (AKI). The objective of this study was to determine the predictive ability of biomarkers for mort... Full description

Journal Title: Pediatric nephrology (Berlin West), 2016-07-07, Vol.32 (3), p.521-527
Main Author: Mishra, Om P
Other Authors: Rai, Avinash K , Srivastava, Pradeep , Pandey, Khushaboo , Abhinay, Abhishek , Prasad, Rajniti , Mishra, Rabindra N , Schaefer, Franz
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Berlin/Heidelberg: Springer Berlin Heidelberg
ID: ISSN: 0931-041X
Link: https://www.ncbi.nlm.nih.gov/pubmed/27387432
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: cdi_proquest_miscellaneous_1868305821
title: Predictive ability of urinary biomarkers for outcome in children with acute kidney injury
format: Article
creator:
  • Mishra, Om P
  • Rai, Avinash K
  • Srivastava, Pradeep
  • Pandey, Khushaboo
  • Abhinay, Abhishek
  • Prasad, Rajniti
  • Mishra, Rabindra N
  • Schaefer, Franz
subjects:
  • Acetylglucosaminidase - urine
  • Acute Kidney Injury - diagnosis
  • Acute Kidney Injury - therapy
  • Acute Kidney Injury - urine
  • Adolescent
  • Biomarkers - urine
  • Child
  • Child, Preschool
  • Cross-Sectional Studies
  • Disease Progression
  • Female
  • Humans
  • Infant
  • Interleukin-18 - urine
  • Kidney Failure, Chronic - etiology
  • Kidney Failure, Chronic - urine
  • Length of Stay
  • Lipocalin-2 - urine
  • Male
  • Medicine
  • Medicine & Public Health
  • Nephrology
  • Original Article
  • Pediatrics
  • Peritoneal Dialysis
  • Predictive Value of Tests
  • Prospective Studies
  • Survival Analysis
  • Threshold Limit Values
  • Urology
ispartof: Pediatric nephrology (Berlin, West), 2016-07-07, Vol.32 (3), p.521-527
description: Background Urinary neutrophil gelatinase-associated lipocalin (NGAL), N-acetyl-beta-D-glucosaminidase (NAG), and interleukin 18 (IL-18) were found to be useful for early detection of acute kidney injury (AKI). The objective of this study was to determine the predictive ability of biomarkers for mortality and variation in levels in relation to different stages of AKI, need for dialysis, etiologies, and with duration of hospital stay. Methods Urinary NGAL, NAG, and IL-18 levels were measured in 50 children with AKI and 30 age- and gender-matched healthy controls. AKI was classified as per pediatric Risk, Injury, Failure, Loss, and End-stage (RIFLE) criteria. Results Median NGAL, NAG, and IL-18 values were significantly increased in AKI patients compared with controls ( p  
language: eng
source:
identifier: ISSN: 0931-041X
fulltext: no_fulltext
issn:
  • 0931-041X
  • 1432-198X
url: Link


@attributes
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
RANK2.499503
LOCALfalse
PrimoNMBib
record
control
sourceidgale_proqu
recordidTN_cdi_proquest_miscellaneous_1868305821
sourceformatXML
sourcesystemPC
galeidA551030222
sourcerecordidA551030222
originalsourceidFETCH-LOGICAL-c517t-d3330ea1a1369dbedd43d348abb6169740ba188d054d99e5cbb7c63ad452d4110
addsrcrecordideNqNkl2L1DAUhoso7rj6A7yRgCDedM1328tl8QsW9EJhvQppcrqT2U4yJqnSf2_qqDu7rCK5KKTP-5wmfavqKcEnBOPmVcKYy6bGRNaMc1HP96oV4YzWpGsv7lcr3DFSY04ujqpHKW0wxq1o5cPqiDasbQq4qr58jGCdye4bIN270eUZhQFN0XkdZ9S7sNXxCmJCQ4goTNmELSDnkVm70Ubw6LvLa6TNlAFdOethLm83U5wfVw8GPSZ48ut5XH1-8_rT2bv6_MPb92en57URpMm1ZYxh0EQTJjvbg7WcWcZb3feSyK7huNekbS0W3HYdCNP3jZFMWy6o5YTg4-rl3ruL4esEKautSwbGUXsIU1KklS3DoqX_g1LZkI7_RJ_fQjdhir4cZBEKKmTD5DV1qUdQzg8hR20WqToVgmCGKaWFOrmDKsvC1pngYXBl_0bg2R0BdQi8OADWoMe8TmGcsgs-3TSRPWhiSCnCoHbRlT86K4LV0iG175AqHVJLh9R8PX039VuwfxK_S1OA5pbUuKyX2eUz3fhPNd0nU5H6S4gHt_rX0A-Bid-M
sourcetypeAggregation Database
isCDItrue
recordtypearticle
pqid1865256736
display
typearticle
titlePredictive ability of urinary biomarkers for outcome in children with acute kidney injury
creatorMishra, Om P ; Rai, Avinash K ; Srivastava, Pradeep ; Pandey, Khushaboo ; Abhinay, Abhishek ; Prasad, Rajniti ; Mishra, Rabindra N ; Schaefer, Franz
creatorcontribMishra, Om P ; Rai, Avinash K ; Srivastava, Pradeep ; Pandey, Khushaboo ; Abhinay, Abhishek ; Prasad, Rajniti ; Mishra, Rabindra N ; Schaefer, Franz
descriptionBackground Urinary neutrophil gelatinase-associated lipocalin (NGAL), N-acetyl-beta-D-glucosaminidase (NAG), and interleukin 18 (IL-18) were found to be useful for early detection of acute kidney injury (AKI). The objective of this study was to determine the predictive ability of biomarkers for mortality and variation in levels in relation to different stages of AKI, need for dialysis, etiologies, and with duration of hospital stay. Methods Urinary NGAL, NAG, and IL-18 levels were measured in 50 children with AKI and 30 age- and gender-matched healthy controls. AKI was classified as per pediatric Risk, Injury, Failure, Loss, and End-stage (RIFLE) criteria. Results Median NGAL, NAG, and IL-18 values were significantly increased in AKI patients compared with controls ( p  < 0.001), with significant increase among risk, injury, and failure stages. Nonsurvivors had significantly higher median levels of NGAL ( p  = 0.008) and NAG ( p  = 0.018) than survivors. NGAL had highest area under the curve (AUC) at 0.750 [confidence interval (CI) 0.580–0.920], followed by NAG at 0.724 (CI 0.541–0.907), with sensitivity and specificity of 75 % each; and IL-18 (AUC 0.688, CI 0.511–0.864), with sensitivity 62.5 % and specificity 70.8 %, for predicting mortality. Values were significantly higher in patients who required peritoneal dialysis (PD) than in those in whom it was not indicated. Levels were comparable among different etiologies. Only NGAL level was found to be a significant risk factor associated with longer duration of hospital stay. Conclusions Urinary NGAL and NAG had modest predictive ability for mortality. Children requiring dialysis had significantly raised levels, and the NGAL level had significant association with duration of hospital stay.
identifier
0ISSN: 0931-041X
1EISSN: 1432-198X
2DOI: 10.1007/s00467-016-3445-y
3PMID: 27387432
languageeng
publisherBerlin/Heidelberg: Springer Berlin Heidelberg
subjectAcetylglucosaminidase - urine ; Acute Kidney Injury - diagnosis ; Acute Kidney Injury - therapy ; Acute Kidney Injury - urine ; Adolescent ; Biomarkers - urine ; Child ; Child, Preschool ; Cross-Sectional Studies ; Disease Progression ; Female ; Humans ; Infant ; Interleukin-18 - urine ; Kidney Failure, Chronic - etiology ; Kidney Failure, Chronic - urine ; Length of Stay ; Lipocalin-2 - urine ; Male ; Medicine ; Medicine & Public Health ; Nephrology ; Original Article ; Pediatrics ; Peritoneal Dialysis ; Predictive Value of Tests ; Prospective Studies ; Survival Analysis ; Threshold Limit Values ; Urology
ispartofPediatric nephrology (Berlin, West), 2016-07-07, Vol.32 (3), p.521-527
rights
0IPNA 2016
1COPYRIGHT 2017 Springer
2Pediatric Nephrology is a copyright of Springer, 2017.
lds50peer_reviewed
citedbyFETCH-LOGICAL-c517t-d3330ea1a1369dbedd43d348abb6169740ba188d054d99e5cbb7c63ad452d4110
citesFETCH-LOGICAL-c517t-d3330ea1a1369dbedd43d348abb6169740ba188d054d99e5cbb7c63ad452d4110
links
openurl$$Topenurl_article
thumbnail$$Usyndetics_thumb_exl
backlink$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27387432$$D View this record in MEDLINE/PubMed
search
creatorcontrib
0Mishra, Om P
1Rai, Avinash K
2Srivastava, Pradeep
3Pandey, Khushaboo
4Abhinay, Abhishek
5Prasad, Rajniti
6Mishra, Rabindra N
7Schaefer, Franz
title
0Predictive ability of urinary biomarkers for outcome in children with acute kidney injury
1Pediatric nephrology (Berlin, West)
addtitle
0Pediatr Nephrol
1Pediatr Nephrol
descriptionBackground Urinary neutrophil gelatinase-associated lipocalin (NGAL), N-acetyl-beta-D-glucosaminidase (NAG), and interleukin 18 (IL-18) were found to be useful for early detection of acute kidney injury (AKI). The objective of this study was to determine the predictive ability of biomarkers for mortality and variation in levels in relation to different stages of AKI, need for dialysis, etiologies, and with duration of hospital stay. Methods Urinary NGAL, NAG, and IL-18 levels were measured in 50 children with AKI and 30 age- and gender-matched healthy controls. AKI was classified as per pediatric Risk, Injury, Failure, Loss, and End-stage (RIFLE) criteria. Results Median NGAL, NAG, and IL-18 values were significantly increased in AKI patients compared with controls ( p  < 0.001), with significant increase among risk, injury, and failure stages. Nonsurvivors had significantly higher median levels of NGAL ( p  = 0.008) and NAG ( p  = 0.018) than survivors. NGAL had highest area under the curve (AUC) at 0.750 [confidence interval (CI) 0.580–0.920], followed by NAG at 0.724 (CI 0.541–0.907), with sensitivity and specificity of 75 % each; and IL-18 (AUC 0.688, CI 0.511–0.864), with sensitivity 62.5 % and specificity 70.8 %, for predicting mortality. Values were significantly higher in patients who required peritoneal dialysis (PD) than in those in whom it was not indicated. Levels were comparable among different etiologies. Only NGAL level was found to be a significant risk factor associated with longer duration of hospital stay. Conclusions Urinary NGAL and NAG had modest predictive ability for mortality. Children requiring dialysis had significantly raised levels, and the NGAL level had significant association with duration of hospital stay.
subject
0Acetylglucosaminidase - urine
1Acute Kidney Injury - diagnosis
2Acute Kidney Injury - therapy
3Acute Kidney Injury - urine
4Adolescent
5Biomarkers - urine
6Child
7Child, Preschool
8Cross-Sectional Studies
9Disease Progression
10Female
11Humans
12Infant
13Interleukin-18 - urine
14Kidney Failure, Chronic - etiology
15Kidney Failure, Chronic - urine
16Length of Stay
17Lipocalin-2 - urine
18Male
19Medicine
20Medicine & Public Health
21Nephrology
22Original Article
23Pediatrics
24Peritoneal Dialysis
25Predictive Value of Tests
26Prospective Studies
27Survival Analysis
28Threshold Limit Values
29Urology
issn
00931-041X
11432-198X
fulltextfalse
rsrctypearticle
creationdate2016
recordtypearticle
recordideNqNkl2L1DAUhoso7rj6A7yRgCDedM1328tl8QsW9EJhvQppcrqT2U4yJqnSf2_qqDu7rCK5KKTP-5wmfavqKcEnBOPmVcKYy6bGRNaMc1HP96oV4YzWpGsv7lcr3DFSY04ujqpHKW0wxq1o5cPqiDasbQq4qr58jGCdye4bIN270eUZhQFN0XkdZ9S7sNXxCmJCQ4goTNmELSDnkVm70Ubw6LvLa6TNlAFdOethLm83U5wfVw8GPSZ48ut5XH1-8_rT2bv6_MPb92en57URpMm1ZYxh0EQTJjvbg7WcWcZb3feSyK7huNekbS0W3HYdCNP3jZFMWy6o5YTg4-rl3ruL4esEKautSwbGUXsIU1KklS3DoqX_g1LZkI7_RJ_fQjdhir4cZBEKKmTD5DV1qUdQzg8hR20WqToVgmCGKaWFOrmDKsvC1pngYXBl_0bg2R0BdQi8OADWoMe8TmGcsgs-3TSRPWhiSCnCoHbRlT86K4LV0iG175AqHVJLh9R8PX039VuwfxK_S1OA5pbUuKyX2eUz3fhPNd0nU5H6S4gHt_rX0A-Bid-M
startdate20160707
enddate20160707
creator
0Mishra, Om P
1Rai, Avinash K
2Srivastava, Pradeep
3Pandey, Khushaboo
4Abhinay, Abhishek
5Prasad, Rajniti
6Mishra, Rabindra N
7Schaefer, Franz
general
0Springer Berlin Heidelberg
1Springer
2Springer Nature B.V
scope
0CGR
1CUY
2CVF
3ECM
4EIF
5NPM
6AAYXX
7CITATION
8IOF
93V.
107QP
117RV
127X7
137XB
1488E
158AO
168FI
178FJ
188FK
19ABUWG
20AZQEC
21BENPR
22FYUFA
23GHDGH
24K9-
25K9.
26KB0
27M0R
28M0S
29M1P
30NAPCQ
31PQEST
32PQQKQ
33PQUKI
34PRINS
357X8
sort
creationdate20160707
titlePredictive ability of urinary biomarkers for outcome in children with acute kidney injury
authorMishra, Om P ; Rai, Avinash K ; Srivastava, Pradeep ; Pandey, Khushaboo ; Abhinay, Abhishek ; Prasad, Rajniti ; Mishra, Rabindra N ; Schaefer, Franz
facets
frbrtype5
frbrgroupidcdi_FETCH-LOGICAL-c517t-d3330ea1a1369dbedd43d348abb6169740ba188d054d99e5cbb7c63ad452d4110
rsrctypearticles
prefilterarticles
languageeng
creationdate2016
topic
0Acetylglucosaminidase - urine
1Acute Kidney Injury - diagnosis
2Acute Kidney Injury - therapy
3Acute Kidney Injury - urine
4Adolescent
5Biomarkers - urine
6Child
7Child, Preschool
8Cross-Sectional Studies
9Disease Progression
10Female
11Humans
12Infant
13Interleukin-18 - urine
14Kidney Failure, Chronic - etiology
15Kidney Failure, Chronic - urine
16Length of Stay
17Lipocalin-2 - urine
18Male
19Medicine
20Medicine & Public Health
21Nephrology
22Original Article
23Pediatrics
24Peritoneal Dialysis
25Predictive Value of Tests
26Prospective Studies
27Survival Analysis
28Threshold Limit Values
29Urology
toplevelpeer_reviewed
creatorcontrib
0Mishra, Om P
1Rai, Avinash K
2Srivastava, Pradeep
3Pandey, Khushaboo
4Abhinay, Abhishek
5Prasad, Rajniti
6Mishra, Rabindra N
7Schaefer, Franz
collection
0Medline
1MEDLINE
2MEDLINE (Ovid)
3MEDLINE
4MEDLINE
5PubMed
6CrossRef
7Gale General OneFile
8ProQuest Central (Corporate)
9Calcium & Calcified Tissue Abstracts
10Nursing & Allied Health Database
11Health & Medical Collection
12ProQuest Central (purchase pre-March 2016)
13Medical Database (Alumni Edition)
14ProQuest Pharma Collection
15Hospital Premium Collection
16Hospital Premium Collection (Alumni Edition)
17ProQuest Central (Alumni) (purchase pre-March 2016)
18ProQuest Central (Alumni Edition)
19ProQuest Central Essentials
20ProQuest Central
21Health Research Premium Collection
22Health Research Premium Collection (Alumni)
23Consumer Health Database (Alumni Edition)
24ProQuest Health & Medical Complete (Alumni)
25Nursing & Allied Health Database (Alumni Edition)
26Consumer Health Database
27Health & Medical Collection (Alumni Edition)
28Medical Database
29Nursing & Allied Health Premium
30ProQuest One Academic Eastern Edition
31ProQuest One Academic
32ProQuest One Academic UKI Edition
33ProQuest Central China
34MEDLINE - Academic
jtitlePediatric nephrology (Berlin, West)
delivery
delcategoryRemote Search Resource
fulltextno_fulltext
addata
au
0Mishra, Om P
1Rai, Avinash K
2Srivastava, Pradeep
3Pandey, Khushaboo
4Abhinay, Abhishek
5Prasad, Rajniti
6Mishra, Rabindra N
7Schaefer, Franz
formatjournal
genrearticle
ristypeJOUR
atitlePredictive ability of urinary biomarkers for outcome in children with acute kidney injury
jtitlePediatric nephrology (Berlin, West)
stitlePediatr Nephrol
addtitlePediatr Nephrol
date2016-07-07
risdate2016
volume32
issue3
spage521
epage527
pages521-527
issn0931-041X
eissn1432-198X
abstractBackground Urinary neutrophil gelatinase-associated lipocalin (NGAL), N-acetyl-beta-D-glucosaminidase (NAG), and interleukin 18 (IL-18) were found to be useful for early detection of acute kidney injury (AKI). The objective of this study was to determine the predictive ability of biomarkers for mortality and variation in levels in relation to different stages of AKI, need for dialysis, etiologies, and with duration of hospital stay. Methods Urinary NGAL, NAG, and IL-18 levels were measured in 50 children with AKI and 30 age- and gender-matched healthy controls. AKI was classified as per pediatric Risk, Injury, Failure, Loss, and End-stage (RIFLE) criteria. Results Median NGAL, NAG, and IL-18 values were significantly increased in AKI patients compared with controls ( p  < 0.001), with significant increase among risk, injury, and failure stages. Nonsurvivors had significantly higher median levels of NGAL ( p  = 0.008) and NAG ( p  = 0.018) than survivors. NGAL had highest area under the curve (AUC) at 0.750 [confidence interval (CI) 0.580–0.920], followed by NAG at 0.724 (CI 0.541–0.907), with sensitivity and specificity of 75 % each; and IL-18 (AUC 0.688, CI 0.511–0.864), with sensitivity 62.5 % and specificity 70.8 %, for predicting mortality. Values were significantly higher in patients who required peritoneal dialysis (PD) than in those in whom it was not indicated. Levels were comparable among different etiologies. Only NGAL level was found to be a significant risk factor associated with longer duration of hospital stay. Conclusions Urinary NGAL and NAG had modest predictive ability for mortality. Children requiring dialysis had significantly raised levels, and the NGAL level had significant association with duration of hospital stay.
copBerlin/Heidelberg
pubSpringer Berlin Heidelberg
pmid27387432
doi10.1007/s00467-016-3445-y