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Epithelial mesenchymal transition (EMT) and non-small cell lung cancer (NSCLC): a mutual association with airway disease

NSCLC is a leading cause of morbidity and mortality worldwide. It includes adeno- and squamous cell carcinoma. In the background, COPD and smoking play a vital role in development of NSCLC. Local progression and metastasis of NSCLC has been associated with various mechanisms, but in particular by a... Full description

Journal Title: Medical oncology (Northwood London, England), 2017, Vol.34 (3), p.45-45
Main Author: Mahmood, Malik Quasir
Other Authors: Ward, Chris , Muller, Hans Konrad , Sohal, Sukhwinder Singh , Walters, Eugene Haydn
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: New York: Springer US
ID: ISSN: 1357-0560
Link: https://www.ncbi.nlm.nih.gov/pubmed/28197929
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title: Epithelial mesenchymal transition (EMT) and non-small cell lung cancer (NSCLC): a mutual association with airway disease
format: Article
creator:
  • Mahmood, Malik Quasir
  • Ward, Chris
  • Muller, Hans Konrad
  • Sohal, Sukhwinder Singh
  • Walters, Eugene Haydn
subjects:
  • Aged
  • Analysis
  • Antigens, CD - biosynthesis
  • Antigens, CD - genetics
  • Biomarkers, Tumor - biosynthesis
  • Biomarkers, Tumor - genetics
  • Cadherins - biosynthesis
  • Cadherins - genetics
  • Carcinoma, Non-Small-Cell Lung - blood supply
  • Carcinoma, Non-Small-Cell Lung - genetics
  • Carcinoma, Non-Small-Cell Lung - metabolism
  • Carcinoma, Non-Small-Cell Lung - pathology
  • Collagen
  • Epithelial-Mesenchymal Transition - physiology
  • Female
  • Genetic Heterogeneity
  • Hematology
  • Humans
  • Intermediate filament proteins
  • Internal Medicine
  • Lung cancer
  • Lung cancer, Non-small cell
  • Lung diseases, Obstructive
  • Lung Diseases, Obstructive - genetics
  • Lung Diseases, Obstructive - metabolism
  • Lung Diseases, Obstructive - pathology
  • Lung Neoplasms - blood supply
  • Lung Neoplasms - genetics
  • Lung Neoplasms - metabolism
  • Lung Neoplasms - pathology
  • Male
  • Medical colleges
  • Medicine
  • Medicine & Public Health
  • Middle Aged
  • Oncology
  • Original Paper
  • Pathology
  • Receptor, Epidermal Growth Factor - biosynthesis
  • Receptor, Epidermal Growth Factor - genetics
  • S100 Calcium-Binding Protein A4 - biosynthesis
  • S100 Calcium-Binding Protein A4 - genetics
  • Squamous cell carcinoma
  • Stem cells
  • Vimentin - biosynthesis
  • Vimentin - genetics
ispartof: Medical oncology (Northwood, London, England), 2017, Vol.34 (3), p.45-45
description: NSCLC is a leading cause of morbidity and mortality worldwide. It includes adeno- and squamous cell carcinoma. In the background, COPD and smoking play a vital role in development of NSCLC. Local progression and metastasis of NSCLC has been associated with various mechanisms, but in particular by a process called epithelial mesenchymal transition (EMT), which is implicated in COPD pathogenesis. In this study, we have investigated whether expression of EGFR (activation marker) and S100A4, vimentin and N-cadherin (as EMT) is different both in central and leading edge of NSCLC and to what extent related to EMT activity of both small and large airways, stage and differentiation of NSCLC. We have investigated EMT biomarkers (S100A4, vimentin, and N-cadherin), an epithelial activation marker (EGFR) and a vascularity marker (Type-IV collagen) in surgically resected tissue from patients with NSCLC (adeno- and squamous cell carcinoma), and compared them with expression in the corresponding non-tumorous airways. EGFR, S100A4, vimentin, N-cadherin expression was higher in tumor cells located at the peripheral leading edge of NSCLC when compared with centrally located tumor cells of same subjects ( P  
language: eng
source:
identifier: ISSN: 1357-0560
fulltext: no_fulltext
issn:
  • 1357-0560
  • 1559-131X
url: Link


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titleEpithelial mesenchymal transition (EMT) and non-small cell lung cancer (NSCLC): a mutual association with airway disease
creatorMahmood, Malik Quasir ; Ward, Chris ; Muller, Hans Konrad ; Sohal, Sukhwinder Singh ; Walters, Eugene Haydn
creatorcontribMahmood, Malik Quasir ; Ward, Chris ; Muller, Hans Konrad ; Sohal, Sukhwinder Singh ; Walters, Eugene Haydn
descriptionNSCLC is a leading cause of morbidity and mortality worldwide. It includes adeno- and squamous cell carcinoma. In the background, COPD and smoking play a vital role in development of NSCLC. Local progression and metastasis of NSCLC has been associated with various mechanisms, but in particular by a process called epithelial mesenchymal transition (EMT), which is implicated in COPD pathogenesis. In this study, we have investigated whether expression of EGFR (activation marker) and S100A4, vimentin and N-cadherin (as EMT) is different both in central and leading edge of NSCLC and to what extent related to EMT activity of both small and large airways, stage and differentiation of NSCLC. We have investigated EMT biomarkers (S100A4, vimentin, and N-cadherin), an epithelial activation marker (EGFR) and a vascularity marker (Type-IV collagen) in surgically resected tissue from patients with NSCLC (adeno- and squamous cell carcinoma), and compared them with expression in the corresponding non-tumorous airways. EGFR, S100A4, vimentin, N-cadherin expression was higher in tumor cells located at the peripheral leading edge of NSCLC when compared with centrally located tumor cells of same subjects ( P  < 0.01). Type-IV collagen-expressing blood vessels were also more at the leading edge in comparison with central parts of NSCLC. EGFR and S100A4 expression was related to differentiation status ( P  < 0.05) and TNM stage ( P  < 0.05) of NSCLC. Moreover, EMT markers in the leading edge were significantly related to airway EMT activity, while peripheral edge vascularity of squamous cell carcinoma only was significantly related to large airway Rbm vascularity ( P  < 0.05). EGFR- and EMT-related protein expression was markedly high in the peripheral leading edge of NSCLCs and related to tumor characteristics associated with poor prognosis. The relationships between EMT-related tumor biomarker expression and those in the airway epithelium and Rbm provide a background for utility of airway changes in clinical settings.
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subjectAged ; Analysis ; Antigens, CD - biosynthesis ; Antigens, CD - genetics ; Biomarkers, Tumor - biosynthesis ; Biomarkers, Tumor - genetics ; Cadherins - biosynthesis ; Cadherins - genetics ; Carcinoma, Non-Small-Cell Lung - blood supply ; Carcinoma, Non-Small-Cell Lung - genetics ; Carcinoma, Non-Small-Cell Lung - metabolism ; Carcinoma, Non-Small-Cell Lung - pathology ; Collagen ; Epithelial-Mesenchymal Transition - physiology ; Female ; Genetic Heterogeneity ; Hematology ; Humans ; Intermediate filament proteins ; Internal Medicine ; Lung cancer ; Lung cancer, Non-small cell ; Lung diseases, Obstructive ; Lung Diseases, Obstructive - genetics ; Lung Diseases, Obstructive - metabolism ; Lung Diseases, Obstructive - pathology ; Lung Neoplasms - blood supply ; Lung Neoplasms - genetics ; Lung Neoplasms - metabolism ; Lung Neoplasms - pathology ; Male ; Medical colleges ; Medicine ; Medicine & Public Health ; Middle Aged ; Oncology ; Original Paper ; Pathology ; Receptor, Epidermal Growth Factor - biosynthesis ; Receptor, Epidermal Growth Factor - genetics ; S100 Calcium-Binding Protein A4 - biosynthesis ; S100 Calcium-Binding Protein A4 - genetics ; Squamous cell carcinoma ; Stem cells ; Vimentin - biosynthesis ; Vimentin - genetics
ispartofMedical oncology (Northwood, London, England), 2017, Vol.34 (3), p.45-45
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2Muller, Hans Konrad
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descriptionNSCLC is a leading cause of morbidity and mortality worldwide. It includes adeno- and squamous cell carcinoma. In the background, COPD and smoking play a vital role in development of NSCLC. Local progression and metastasis of NSCLC has been associated with various mechanisms, but in particular by a process called epithelial mesenchymal transition (EMT), which is implicated in COPD pathogenesis. In this study, we have investigated whether expression of EGFR (activation marker) and S100A4, vimentin and N-cadherin (as EMT) is different both in central and leading edge of NSCLC and to what extent related to EMT activity of both small and large airways, stage and differentiation of NSCLC. We have investigated EMT biomarkers (S100A4, vimentin, and N-cadherin), an epithelial activation marker (EGFR) and a vascularity marker (Type-IV collagen) in surgically resected tissue from patients with NSCLC (adeno- and squamous cell carcinoma), and compared them with expression in the corresponding non-tumorous airways. EGFR, S100A4, vimentin, N-cadherin expression was higher in tumor cells located at the peripheral leading edge of NSCLC when compared with centrally located tumor cells of same subjects ( P  < 0.01). Type-IV collagen-expressing blood vessels were also more at the leading edge in comparison with central parts of NSCLC. EGFR and S100A4 expression was related to differentiation status ( P  < 0.05) and TNM stage ( P  < 0.05) of NSCLC. Moreover, EMT markers in the leading edge were significantly related to airway EMT activity, while peripheral edge vascularity of squamous cell carcinoma only was significantly related to large airway Rbm vascularity ( P  < 0.05). EGFR- and EMT-related protein expression was markedly high in the peripheral leading edge of NSCLCs and related to tumor characteristics associated with poor prognosis. The relationships between EMT-related tumor biomarker expression and those in the airway epithelium and Rbm provide a background for utility of airway changes in clinical settings.
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1Analysis
2Antigens, CD - biosynthesis
3Antigens, CD - genetics
4Biomarkers, Tumor - biosynthesis
5Biomarkers, Tumor - genetics
6Cadherins - biosynthesis
7Cadherins - genetics
8Carcinoma, Non-Small-Cell Lung - blood supply
9Carcinoma, Non-Small-Cell Lung - genetics
10Carcinoma, Non-Small-Cell Lung - metabolism
11Carcinoma, Non-Small-Cell Lung - pathology
12Collagen
13Epithelial-Mesenchymal Transition - physiology
14Female
15Genetic Heterogeneity
16Hematology
17Humans
18Intermediate filament proteins
19Internal Medicine
20Lung cancer
21Lung cancer, Non-small cell
22Lung diseases, Obstructive
23Lung Diseases, Obstructive - genetics
24Lung Diseases, Obstructive - metabolism
25Lung Diseases, Obstructive - pathology
26Lung Neoplasms - blood supply
27Lung Neoplasms - genetics
28Lung Neoplasms - metabolism
29Lung Neoplasms - pathology
30Male
31Medical colleges
32Medicine
33Medicine & Public Health
34Middle Aged
35Oncology
36Original Paper
37Pathology
38Receptor, Epidermal Growth Factor - biosynthesis
39Receptor, Epidermal Growth Factor - genetics
40S100 Calcium-Binding Protein A4 - biosynthesis
41S100 Calcium-Binding Protein A4 - genetics
42Squamous cell carcinoma
43Stem cells
44Vimentin - biosynthesis
45Vimentin - genetics
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titleEpithelial mesenchymal transition (EMT) and non-small cell lung cancer (NSCLC): a mutual association with airway disease
authorMahmood, Malik Quasir ; Ward, Chris ; Muller, Hans Konrad ; Sohal, Sukhwinder Singh ; Walters, Eugene Haydn
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1Analysis
2Antigens, CD - biosynthesis
3Antigens, CD - genetics
4Biomarkers, Tumor - biosynthesis
5Biomarkers, Tumor - genetics
6Cadherins - biosynthesis
7Cadherins - genetics
8Carcinoma, Non-Small-Cell Lung - blood supply
9Carcinoma, Non-Small-Cell Lung - genetics
10Carcinoma, Non-Small-Cell Lung - metabolism
11Carcinoma, Non-Small-Cell Lung - pathology
12Collagen
13Epithelial-Mesenchymal Transition - physiology
14Female
15Genetic Heterogeneity
16Hematology
17Humans
18Intermediate filament proteins
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20Lung cancer
21Lung cancer, Non-small cell
22Lung diseases, Obstructive
23Lung Diseases, Obstructive - genetics
24Lung Diseases, Obstructive - metabolism
25Lung Diseases, Obstructive - pathology
26Lung Neoplasms - blood supply
27Lung Neoplasms - genetics
28Lung Neoplasms - metabolism
29Lung Neoplasms - pathology
30Male
31Medical colleges
32Medicine
33Medicine & Public Health
34Middle Aged
35Oncology
36Original Paper
37Pathology
38Receptor, Epidermal Growth Factor - biosynthesis
39Receptor, Epidermal Growth Factor - genetics
40S100 Calcium-Binding Protein A4 - biosynthesis
41S100 Calcium-Binding Protein A4 - genetics
42Squamous cell carcinoma
43Stem cells
44Vimentin - biosynthesis
45Vimentin - genetics
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abstractNSCLC is a leading cause of morbidity and mortality worldwide. It includes adeno- and squamous cell carcinoma. In the background, COPD and smoking play a vital role in development of NSCLC. Local progression and metastasis of NSCLC has been associated with various mechanisms, but in particular by a process called epithelial mesenchymal transition (EMT), which is implicated in COPD pathogenesis. In this study, we have investigated whether expression of EGFR (activation marker) and S100A4, vimentin and N-cadherin (as EMT) is different both in central and leading edge of NSCLC and to what extent related to EMT activity of both small and large airways, stage and differentiation of NSCLC. We have investigated EMT biomarkers (S100A4, vimentin, and N-cadherin), an epithelial activation marker (EGFR) and a vascularity marker (Type-IV collagen) in surgically resected tissue from patients with NSCLC (adeno- and squamous cell carcinoma), and compared them with expression in the corresponding non-tumorous airways. EGFR, S100A4, vimentin, N-cadherin expression was higher in tumor cells located at the peripheral leading edge of NSCLC when compared with centrally located tumor cells of same subjects ( P  < 0.01). Type-IV collagen-expressing blood vessels were also more at the leading edge in comparison with central parts of NSCLC. EGFR and S100A4 expression was related to differentiation status ( P  < 0.05) and TNM stage ( P  < 0.05) of NSCLC. Moreover, EMT markers in the leading edge were significantly related to airway EMT activity, while peripheral edge vascularity of squamous cell carcinoma only was significantly related to large airway Rbm vascularity ( P  < 0.05). EGFR- and EMT-related protein expression was markedly high in the peripheral leading edge of NSCLCs and related to tumor characteristics associated with poor prognosis. The relationships between EMT-related tumor biomarker expression and those in the airway epithelium and Rbm provide a background for utility of airway changes in clinical settings.
copNew York
pubSpringer US
pmid28197929
doi10.1007/s12032-017-0900-y
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