schliessen

Filtern

 

Bibliotheken

Mesangial C4d deposition may predict progression of kidney disease in pediatric patients with IgA nephropathy

Background Data on the risk factors for chronic kidney disease in children with immunoglobulin A nephropathy (IgAN) are scarce. This study was aimed at investigating whether glomerular C4d immunostaining is a prognostic marker in pediatric IgAN. Methods In this retrospective cohort study, 47 patient... Full description

Journal Title: Pediatric nephrology (Berlin West), 2017-02-23, Vol.32 (7), p.1211-1220
Main Author: Fabiano, Rafaela Cabral Gonçalves
Other Authors: de Almeida Araújo, Stanley , Bambirra, Eduardo Alves , Oliveira, Eduardo Araújo , Simões e Silva, Ana Cristina , Pinheiro, Sérgio Veloso Brant
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Berlin/Heidelberg: Springer Berlin Heidelberg
ID: ISSN: 0931-041X
Link: https://www.ncbi.nlm.nih.gov/pubmed/28233100
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: cdi_proquest_miscellaneous_1872580861
title: Mesangial C4d deposition may predict progression of kidney disease in pediatric patients with IgA nephropathy
format: Article
creator:
  • Fabiano, Rafaela Cabral Gonçalves
  • de Almeida Araújo, Stanley
  • Bambirra, Eduardo Alves
  • Oliveira, Eduardo Araújo
  • Simões e Silva, Ana Cristina
  • Pinheiro, Sérgio Veloso Brant
subjects:
  • Biological markers
  • Biomarkers - analysis
  • Biomarkers - metabolism
  • Biopsy
  • Child
  • Children
  • Chronic kidney failure
  • Complement C4b - analysis
  • Complement C4b - metabolism
  • Complications and side effects
  • Development and progression
  • Disease Progression
  • End-stage renal disease
  • Epidermal growth factor receptors
  • Female
  • Follow-Up Studies
  • Glomerular Filtration Rate
  • Glomerular Mesangium - metabolism
  • Glomerular Mesangium - pathology
  • Glomerulonephritis, IGA - pathology
  • Glomerulonephritis, IGA - urine
  • Health aspects
  • Humans
  • IgA nephropathy
  • Immunoglobulin A
  • Immunohistochemistry
  • Kidney diseases
  • Kidney Failure, Chronic - pathology
  • Kidney Failure, Chronic - urine
  • Kidney transplantation
  • Male
  • Medicine
  • Medicine & Public Health
  • Nephrology
  • Original Article
  • Pediatric research
  • Pediatrics
  • Peptide Fragments - analysis
  • Peptide Fragments - metabolism
  • Prognosis
  • Proteinuria
  • Proteinuria - urine
  • Renal function
  • Retrospective Studies
  • Risk Factors
  • Survival
  • Urology
ispartof: Pediatric nephrology (Berlin, West), 2017-02-23, Vol.32 (7), p.1211-1220
description: Background Data on the risk factors for chronic kidney disease in children with immunoglobulin A nephropathy (IgAN) are scarce. This study was aimed at investigating whether glomerular C4d immunostaining is a prognostic marker in pediatric IgAN. Methods In this retrospective cohort study, 47 patients with IgAN biopsied from 1982 to 2010 were evaluated. Immunohistochemistry for C4d was performed in all cases. For analysis, patients were grouped according to positivity or not for C4d in the mesangial area. Primary outcome was a decline in baseline estimated glomerular filtration rate (eGFR) by 50% or more. Results Median follow-up was 8.3 years. Median renal survival was 13.7 years and the probability of a 50% decline in eGFR was 13% over 10 years. Nine children exhibited the primary outcome and 4 developed end-stage renal disease (ESRD). Compared with C4d-negative patients ( n  = 10), C4d-positive patients ( n  = 37) presented higher baseline proteinuria (1.66 ± 0.68 vs 0.47 ± 0.19 g/day/1.73 m 2 , p  
language: eng
source:
identifier: ISSN: 0931-041X
fulltext: no_fulltext
issn:
  • 0931-041X
  • 1432-198X
url: Link


@attributes
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
RANK2.5492449
LOCALfalse
PrimoNMBib
record
control
sourceidgale_proqu
recordidTN_cdi_proquest_miscellaneous_1872580861
sourceformatXML
sourcesystemPC
galeidA551032837
sourcerecordidA551032837
originalsourceidFETCH-LOGICAL-c484t-a8aea1500aa2f584e0e2c30642277fe64d0ebf21460acb440dde5a024f5957bd0
addsrcrecordideNp9kk-LFDEQxYMo7uzoB_AiAUH20mslne7OHIfBPwsrXhT2FjKd6pms3UmbZJD-9qYZdWeXVXIoKH7vVVF5hLxicMkAmncRQNRNAawpyppBMT0hCyZKXrCVvHlKFrAqWQGC3ZyR8xhvAUBWsn5OzrjkZZktFmT4jFG7ndU93QhDDY4-2mS9o4Oe6BjQ2Dbl6ncBY5z7vqPfrXE4UWMj6ojUOjpmTqdgWzrqZNGlSH_atKdXuzV1OO6Dz_399II863Qf8eXvuiTfPrz_uvlUXH_5eLVZXxetkCIVWmrUrALQmneVFAjI2xJqwXnTdFgLA7jtOBM16HYrBBiDlQYuumpVNVsDS3Jx9M2L_zhgTGqwscW-1w79ISomG15JkPloS_LmAXrrD8Hl7RRbAWM1r5vVHbXTPSrrOp-CbmdTta4qBiWXZZOpy0eo_AwOtvUOO5v79wSvHxGoU-DtCbBH3ad99P1h_qF434kdwTb4GAN2agx20GFSDNQcFnUMi8phUXNY1HQ3fTxsBzR_FX_SkYHmgWlrk55n5zVt_19rflTGbOp2GE6u-k_RLyJ02Qk
sourcetypeAggregation Database
isCDItrue
recordtypearticle
pqid1901162679
display
typearticle
titleMesangial C4d deposition may predict progression of kidney disease in pediatric patients with IgA nephropathy
creatorFabiano, Rafaela Cabral Gonçalves ; de Almeida Araújo, Stanley ; Bambirra, Eduardo Alves ; Oliveira, Eduardo Araújo ; Simões e Silva, Ana Cristina ; Pinheiro, Sérgio Veloso Brant
creatorcontribFabiano, Rafaela Cabral Gonçalves ; de Almeida Araújo, Stanley ; Bambirra, Eduardo Alves ; Oliveira, Eduardo Araújo ; Simões e Silva, Ana Cristina ; Pinheiro, Sérgio Veloso Brant
descriptionBackground Data on the risk factors for chronic kidney disease in children with immunoglobulin A nephropathy (IgAN) are scarce. This study was aimed at investigating whether glomerular C4d immunostaining is a prognostic marker in pediatric IgAN. Methods In this retrospective cohort study, 47 patients with IgAN biopsied from 1982 to 2010 were evaluated. Immunohistochemistry for C4d was performed in all cases. For analysis, patients were grouped according to positivity or not for C4d in the mesangial area. Primary outcome was a decline in baseline estimated glomerular filtration rate (eGFR) by 50% or more. Results Median follow-up was 8.3 years. Median renal survival was 13.7 years and the probability of a 50% decline in eGFR was 13% over 10 years. Nine children exhibited the primary outcome and 4 developed end-stage renal disease (ESRD). Compared with C4d-negative patients ( n  = 10), C4d-positive patients ( n  = 37) presented higher baseline proteinuria (1.66 ± 0.68 vs 0.47 ± 0.19 g/day/1.73 m 2 , p  < 0.001), a progressive decline in eGFR (−10.04 ± 19.38 vs 1.70 ± 18.51 ml/min/1.73 m 2 /year; p  = 0.045), and more frequently achieved the primary outcome (50.0 vs 10.8%, p  = 0.013), and ESRD (30.0 vs 2.7%, p  = 0.026). No difference was observed in Oxford classification variables. Baseline proteinuria, endocapillary hypercellularity and mesangial C4d deposition were associated with primary outcome in univariate analysis. Proteinuria and mesangial C4d deposition at baseline independently predicted the decline in eGFR. Renal survival was significantly reduced in C4d-positive patients (8.6 vs 15.1 years in C4d-negative patients, p  < 0.001). Conclusions In this exclusively pediatric cohort, positivity for C4d in the mesangial area was an independent predictor of renal function deterioration in IgAN.
identifier
0ISSN: 0931-041X
1EISSN: 1432-198X
2DOI: 10.1007/s00467-017-3610-y
3PMID: 28233100
languageeng
publisherBerlin/Heidelberg: Springer Berlin Heidelberg
subjectBiological markers ; Biomarkers - analysis ; Biomarkers - metabolism ; Biopsy ; Child ; Children ; Chronic kidney failure ; Complement C4b - analysis ; Complement C4b - metabolism ; Complications and side effects ; Development and progression ; Disease Progression ; End-stage renal disease ; Epidermal growth factor receptors ; Female ; Follow-Up Studies ; Glomerular Filtration Rate ; Glomerular Mesangium - metabolism ; Glomerular Mesangium - pathology ; Glomerulonephritis, IGA - pathology ; Glomerulonephritis, IGA - urine ; Health aspects ; Humans ; IgA nephropathy ; Immunoglobulin A ; Immunohistochemistry ; Kidney diseases ; Kidney Failure, Chronic - pathology ; Kidney Failure, Chronic - urine ; Kidney transplantation ; Male ; Medicine ; Medicine & Public Health ; Nephrology ; Original Article ; Pediatric research ; Pediatrics ; Peptide Fragments - analysis ; Peptide Fragments - metabolism ; Prognosis ; Proteinuria ; Proteinuria - urine ; Renal function ; Retrospective Studies ; Risk Factors ; Survival ; Urology
ispartofPediatric nephrology (Berlin, West), 2017-02-23, Vol.32 (7), p.1211-1220
rights
0IPNA 2017
1COPYRIGHT 2017 Springer
2Pediatric Nephrology is a copyright of Springer, 2017.
lds50peer_reviewed
citedbyFETCH-LOGICAL-c484t-a8aea1500aa2f584e0e2c30642277fe64d0ebf21460acb440dde5a024f5957bd0
citesFETCH-LOGICAL-c484t-a8aea1500aa2f584e0e2c30642277fe64d0ebf21460acb440dde5a024f5957bd0
links
openurl$$Topenurl_article
thumbnail$$Usyndetics_thumb_exl
backlink$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28233100$$D View this record in MEDLINE/PubMed
search
creatorcontrib
0Fabiano, Rafaela Cabral Gonçalves
1de Almeida Araújo, Stanley
2Bambirra, Eduardo Alves
3Oliveira, Eduardo Araújo
4Simões e Silva, Ana Cristina
5Pinheiro, Sérgio Veloso Brant
title
0Mesangial C4d deposition may predict progression of kidney disease in pediatric patients with IgA nephropathy
1Pediatric nephrology (Berlin, West)
addtitle
0Pediatr Nephrol
1Pediatr Nephrol
descriptionBackground Data on the risk factors for chronic kidney disease in children with immunoglobulin A nephropathy (IgAN) are scarce. This study was aimed at investigating whether glomerular C4d immunostaining is a prognostic marker in pediatric IgAN. Methods In this retrospective cohort study, 47 patients with IgAN biopsied from 1982 to 2010 were evaluated. Immunohistochemistry for C4d was performed in all cases. For analysis, patients were grouped according to positivity or not for C4d in the mesangial area. Primary outcome was a decline in baseline estimated glomerular filtration rate (eGFR) by 50% or more. Results Median follow-up was 8.3 years. Median renal survival was 13.7 years and the probability of a 50% decline in eGFR was 13% over 10 years. Nine children exhibited the primary outcome and 4 developed end-stage renal disease (ESRD). Compared with C4d-negative patients ( n  = 10), C4d-positive patients ( n  = 37) presented higher baseline proteinuria (1.66 ± 0.68 vs 0.47 ± 0.19 g/day/1.73 m 2 , p  < 0.001), a progressive decline in eGFR (−10.04 ± 19.38 vs 1.70 ± 18.51 ml/min/1.73 m 2 /year; p  = 0.045), and more frequently achieved the primary outcome (50.0 vs 10.8%, p  = 0.013), and ESRD (30.0 vs 2.7%, p  = 0.026). No difference was observed in Oxford classification variables. Baseline proteinuria, endocapillary hypercellularity and mesangial C4d deposition were associated with primary outcome in univariate analysis. Proteinuria and mesangial C4d deposition at baseline independently predicted the decline in eGFR. Renal survival was significantly reduced in C4d-positive patients (8.6 vs 15.1 years in C4d-negative patients, p  < 0.001). Conclusions In this exclusively pediatric cohort, positivity for C4d in the mesangial area was an independent predictor of renal function deterioration in IgAN.
subject
0Biological markers
1Biomarkers - analysis
2Biomarkers - metabolism
3Biopsy
4Child
5Children
6Chronic kidney failure
7Complement C4b - analysis
8Complement C4b - metabolism
9Complications and side effects
10Development and progression
11Disease Progression
12End-stage renal disease
13Epidermal growth factor receptors
14Female
15Follow-Up Studies
16Glomerular Filtration Rate
17Glomerular Mesangium - metabolism
18Glomerular Mesangium - pathology
19Glomerulonephritis, IGA - pathology
20Glomerulonephritis, IGA - urine
21Health aspects
22Humans
23IgA nephropathy
24Immunoglobulin A
25Immunohistochemistry
26Kidney diseases
27Kidney Failure, Chronic - pathology
28Kidney Failure, Chronic - urine
29Kidney transplantation
30Male
31Medicine
32Medicine & Public Health
33Nephrology
34Original Article
35Pediatric research
36Pediatrics
37Peptide Fragments - analysis
38Peptide Fragments - metabolism
39Prognosis
40Proteinuria
41Proteinuria - urine
42Renal function
43Retrospective Studies
44Risk Factors
45Survival
46Urology
issn
00931-041X
11432-198X
fulltextfalse
rsrctypearticle
creationdate2017
recordtypearticle
recordideNp9kk-LFDEQxYMo7uzoB_AiAUH20mslne7OHIfBPwsrXhT2FjKd6pms3UmbZJD-9qYZdWeXVXIoKH7vVVF5hLxicMkAmncRQNRNAawpyppBMT0hCyZKXrCVvHlKFrAqWQGC3ZyR8xhvAUBWsn5OzrjkZZktFmT4jFG7ndU93QhDDY4-2mS9o4Oe6BjQ2Dbl6ncBY5z7vqPfrXE4UWMj6ojUOjpmTqdgWzrqZNGlSH_atKdXuzV1OO6Dz_399II863Qf8eXvuiTfPrz_uvlUXH_5eLVZXxetkCIVWmrUrALQmneVFAjI2xJqwXnTdFgLA7jtOBM16HYrBBiDlQYuumpVNVsDS3Jx9M2L_zhgTGqwscW-1w79ISomG15JkPloS_LmAXrrD8Hl7RRbAWM1r5vVHbXTPSrrOp-CbmdTta4qBiWXZZOpy0eo_AwOtvUOO5v79wSvHxGoU-DtCbBH3ad99P1h_qF434kdwTb4GAN2agx20GFSDNQcFnUMi8phUXNY1HQ3fTxsBzR_FX_SkYHmgWlrk55n5zVt_19rflTGbOp2GE6u-k_RLyJ02Qk
startdate20170223
enddate20170223
creator
0Fabiano, Rafaela Cabral Gonçalves
1de Almeida Araújo, Stanley
2Bambirra, Eduardo Alves
3Oliveira, Eduardo Araújo
4Simões e Silva, Ana Cristina
5Pinheiro, Sérgio Veloso Brant
general
0Springer Berlin Heidelberg
1Springer
2Springer Nature B.V
scope
0CGR
1CUY
2CVF
3ECM
4EIF
5NPM
6AAYXX
7CITATION
8IOF
93V.
107QP
117RV
127X7
137XB
1488E
158AO
168FI
178FJ
188FK
19ABUWG
20AZQEC
21BENPR
22FYUFA
23GHDGH
24K9-
25K9.
26KB0
27M0R
28M0S
29M1P
30NAPCQ
31PQEST
32PQQKQ
33PQUKI
34PRINS
357X8
sort
creationdate20170223
titleMesangial C4d deposition may predict progression of kidney disease in pediatric patients with IgA nephropathy
authorFabiano, Rafaela Cabral Gonçalves ; de Almeida Araújo, Stanley ; Bambirra, Eduardo Alves ; Oliveira, Eduardo Araújo ; Simões e Silva, Ana Cristina ; Pinheiro, Sérgio Veloso Brant
facets
frbrtype5
frbrgroupidcdi_FETCH-LOGICAL-c484t-a8aea1500aa2f584e0e2c30642277fe64d0ebf21460acb440dde5a024f5957bd0
rsrctypearticles
prefilterarticles
languageeng
creationdate2017
topic
0Biological markers
1Biomarkers - analysis
2Biomarkers - metabolism
3Biopsy
4Child
5Children
6Chronic kidney failure
7Complement C4b - analysis
8Complement C4b - metabolism
9Complications and side effects
10Development and progression
11Disease Progression
12End-stage renal disease
13Epidermal growth factor receptors
14Female
15Follow-Up Studies
16Glomerular Filtration Rate
17Glomerular Mesangium - metabolism
18Glomerular Mesangium - pathology
19Glomerulonephritis, IGA - pathology
20Glomerulonephritis, IGA - urine
21Health aspects
22Humans
23IgA nephropathy
24Immunoglobulin A
25Immunohistochemistry
26Kidney diseases
27Kidney Failure, Chronic - pathology
28Kidney Failure, Chronic - urine
29Kidney transplantation
30Male
31Medicine
32Medicine & Public Health
33Nephrology
34Original Article
35Pediatric research
36Pediatrics
37Peptide Fragments - analysis
38Peptide Fragments - metabolism
39Prognosis
40Proteinuria
41Proteinuria - urine
42Renal function
43Retrospective Studies
44Risk Factors
45Survival
46Urology
toplevelpeer_reviewed
creatorcontrib
0Fabiano, Rafaela Cabral Gonçalves
1de Almeida Araújo, Stanley
2Bambirra, Eduardo Alves
3Oliveira, Eduardo Araújo
4Simões e Silva, Ana Cristina
5Pinheiro, Sérgio Veloso Brant
collection
0Medline
1MEDLINE
2MEDLINE (Ovid)
3MEDLINE
4MEDLINE
5PubMed
6CrossRef
7Gale General OneFile
8ProQuest Central (Corporate)
9Calcium & Calcified Tissue Abstracts
10Nursing & Allied Health Database
11Health & Medical Collection
12ProQuest Central (purchase pre-March 2016)
13Medical Database (Alumni Edition)
14ProQuest Pharma Collection
15Hospital Premium Collection
16Hospital Premium Collection (Alumni Edition)
17ProQuest Central (Alumni) (purchase pre-March 2016)
18ProQuest Central (Alumni Edition)
19ProQuest Central Essentials
20ProQuest Central
21Health Research Premium Collection
22Health Research Premium Collection (Alumni)
23Consumer Health Database (Alumni Edition)
24ProQuest Health & Medical Complete (Alumni)
25Nursing & Allied Health Database (Alumni Edition)
26Consumer Health Database
27Health & Medical Collection (Alumni Edition)
28Medical Database
29Nursing & Allied Health Premium
30ProQuest One Academic Eastern Edition
31ProQuest One Academic
32ProQuest One Academic UKI Edition
33ProQuest Central China
34MEDLINE - Academic
jtitlePediatric nephrology (Berlin, West)
delivery
delcategoryRemote Search Resource
fulltextno_fulltext
addata
au
0Fabiano, Rafaela Cabral Gonçalves
1de Almeida Araújo, Stanley
2Bambirra, Eduardo Alves
3Oliveira, Eduardo Araújo
4Simões e Silva, Ana Cristina
5Pinheiro, Sérgio Veloso Brant
formatjournal
genrearticle
ristypeJOUR
atitleMesangial C4d deposition may predict progression of kidney disease in pediatric patients with IgA nephropathy
jtitlePediatric nephrology (Berlin, West)
stitlePediatr Nephrol
addtitlePediatr Nephrol
date2017-02-23
risdate2017
volume32
issue7
spage1211
epage1220
pages1211-1220
issn0931-041X
eissn1432-198X
abstractBackground Data on the risk factors for chronic kidney disease in children with immunoglobulin A nephropathy (IgAN) are scarce. This study was aimed at investigating whether glomerular C4d immunostaining is a prognostic marker in pediatric IgAN. Methods In this retrospective cohort study, 47 patients with IgAN biopsied from 1982 to 2010 were evaluated. Immunohistochemistry for C4d was performed in all cases. For analysis, patients were grouped according to positivity or not for C4d in the mesangial area. Primary outcome was a decline in baseline estimated glomerular filtration rate (eGFR) by 50% or more. Results Median follow-up was 8.3 years. Median renal survival was 13.7 years and the probability of a 50% decline in eGFR was 13% over 10 years. Nine children exhibited the primary outcome and 4 developed end-stage renal disease (ESRD). Compared with C4d-negative patients ( n  = 10), C4d-positive patients ( n  = 37) presented higher baseline proteinuria (1.66 ± 0.68 vs 0.47 ± 0.19 g/day/1.73 m 2 , p  < 0.001), a progressive decline in eGFR (−10.04 ± 19.38 vs 1.70 ± 18.51 ml/min/1.73 m 2 /year; p  = 0.045), and more frequently achieved the primary outcome (50.0 vs 10.8%, p  = 0.013), and ESRD (30.0 vs 2.7%, p  = 0.026). No difference was observed in Oxford classification variables. Baseline proteinuria, endocapillary hypercellularity and mesangial C4d deposition were associated with primary outcome in univariate analysis. Proteinuria and mesangial C4d deposition at baseline independently predicted the decline in eGFR. Renal survival was significantly reduced in C4d-positive patients (8.6 vs 15.1 years in C4d-negative patients, p  < 0.001). Conclusions In this exclusively pediatric cohort, positivity for C4d in the mesangial area was an independent predictor of renal function deterioration in IgAN.
copBerlin/Heidelberg
pubSpringer Berlin Heidelberg
pmid28233100
doi10.1007/s00467-017-3610-y