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Enhanced fatty acid uptake in visceral adipose tissue is not reversed by weight loss in obese individuals with the metabolic syndrome

Aims/hypothesis Obesity causes an imbalance in fat mass distribution between visceral and subcutaneous adipose tissue (AT) depots. We tested the hypothesis that this relates to increased NEFA uptake between these depots in obese compared with healthy participants. Second, we hypothesised that a diet... Full description

Journal Title: Diabetologia 2014-10-21, Vol.58 (1), p.158-164
Main Author: Bucci, Marco
Other Authors: Karmi, Anna C , Iozzo, Patricia , Fielding, Barbara A , Viljanen, Antti , Badeau, Robert M , Borra, Ronald , Saunavaara, Virva , Pham, Tam , Hannukainen, Jarna C , Kalliokoski, Kari , Haaparanta-Solin, Merja , Viljanen, Tapio , Parkkola, Riitta , Frayn, Keith N , Nuutila, Pirjo
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Berlin/Heidelberg: Springer Berlin Heidelberg
ID: ISSN: 0012-186X
Link: https://www.ncbi.nlm.nih.gov/pubmed/25331375
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title: Enhanced fatty acid uptake in visceral adipose tissue is not reversed by weight loss in obese individuals with the metabolic syndrome
format: Article
creator:
  • Bucci, Marco
  • Karmi, Anna C
  • Iozzo, Patricia
  • Fielding, Barbara A
  • Viljanen, Antti
  • Badeau, Robert M
  • Borra, Ronald
  • Saunavaara, Virva
  • Pham, Tam
  • Hannukainen, Jarna C
  • Kalliokoski, Kari
  • Haaparanta-Solin, Merja
  • Viljanen, Tapio
  • Parkkola, Riitta
  • Frayn, Keith N
  • Nuutila, Pirjo
subjects:
  • Adipose tissues
  • Adult
  • Article
  • Caloric Restriction
  • Calorimetry, Indirect
  • Fatty acids
  • Fatty Acids, Nonesterified - metabolism
  • Female
  • Human Physiology
  • Humans
  • Internal Medicine
  • Intra-Abdominal Fat - diagnostic imaging
  • Intra-Abdominal Fat - metabolism
  • Male
  • Medicine
  • Medicine & Public Health
  • Metabolic Diseases
  • Metabolic Syndrome - complications
  • Metabolic Syndrome - metabolism
  • Middle Aged
  • Muscle, Skeletal - diagnostic imaging
  • Muscle, Skeletal - metabolism
  • Obesity
  • Obesity - complications
  • Obesity - diet therapy
  • Obesity - metabolism
  • Physiological aspects
  • Positron-Emission Tomography
  • Radiography
  • Reducing diets
  • Subcutaneous Fat - diagnostic imaging
  • Subcutaneous Fat - metabolism
  • Weight loss
  • Weight Loss - physiology
ispartof: Diabetologia, 2014-10-21, Vol.58 (1), p.158-164
description: Aims/hypothesis Obesity causes an imbalance in fat mass distribution between visceral and subcutaneous adipose tissue (AT) depots. We tested the hypothesis that this relates to increased NEFA uptake between these depots in obese compared with healthy participants. Second, we hypothesised that a diet very low in energy (very low calorie diet [VLCD]) decreases fat mass in obese participants and that this is associated with the decline in NEFA uptake. Methods NEFA uptake in AT depots was measured with [ 18 F]-fluoro-6-thia-heptadecanoic acid ( 18 F-FTHA) and positron emission tomography (PET) in 18 obese participants with the metabolic syndrome before and after a 6 week VLCD. Whole body fat oxidation was measured using indirect calorimetry and [U- 13 C]palmitate. Sixteen non-obese participants were controls. Results Obese participants had >100% higher ( p  
language: eng
source:
identifier: ISSN: 0012-186X
fulltext: no_fulltext
issn:
  • 0012-186X
  • 1432-0428
url: Link


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titleEnhanced fatty acid uptake in visceral adipose tissue is not reversed by weight loss in obese individuals with the metabolic syndrome
creatorBucci, Marco ; Karmi, Anna C ; Iozzo, Patricia ; Fielding, Barbara A ; Viljanen, Antti ; Badeau, Robert M ; Borra, Ronald ; Saunavaara, Virva ; Pham, Tam ; Hannukainen, Jarna C ; Kalliokoski, Kari ; Haaparanta-Solin, Merja ; Viljanen, Tapio ; Parkkola, Riitta ; Frayn, Keith N ; Nuutila, Pirjo
creatorcontribBucci, Marco ; Karmi, Anna C ; Iozzo, Patricia ; Fielding, Barbara A ; Viljanen, Antti ; Badeau, Robert M ; Borra, Ronald ; Saunavaara, Virva ; Pham, Tam ; Hannukainen, Jarna C ; Kalliokoski, Kari ; Haaparanta-Solin, Merja ; Viljanen, Tapio ; Parkkola, Riitta ; Frayn, Keith N ; Nuutila, Pirjo
descriptionAims/hypothesis Obesity causes an imbalance in fat mass distribution between visceral and subcutaneous adipose tissue (AT) depots. We tested the hypothesis that this relates to increased NEFA uptake between these depots in obese compared with healthy participants. Second, we hypothesised that a diet very low in energy (very low calorie diet [VLCD]) decreases fat mass in obese participants and that this is associated with the decline in NEFA uptake. Methods NEFA uptake in AT depots was measured with [ 18 F]-fluoro-6-thia-heptadecanoic acid ( 18 F-FTHA) and positron emission tomography (PET) in 18 obese participants with the metabolic syndrome before and after a 6 week VLCD. Whole body fat oxidation was measured using indirect calorimetry and [U- 13 C]palmitate. Sixteen non-obese participants were controls. Results Obese participants had >100% higher ( p  < 0.0001) NEFA uptake in the visceral and subcutaneous abdominal AT depots than controls. VLCD decreased AT mass in all regions (12% to 21%), but NEFA uptake was decreased significantly (18%; p  < 0.006) only in the femoral AT. Whole body carbohydrate oxidation decreased, while fat oxidation increased. Conclusions/interpretation The data demonstrate that weight loss caused by VLCD does not affect abdominal fasting NEFA uptake rates. We found that visceral fat takes up more NEFAs than subcutaneous AT depots, even after weight loss.
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subjectAdipose tissues ; Adult ; Article ; Caloric Restriction ; Calorimetry, Indirect ; Fatty acids ; Fatty Acids, Nonesterified - metabolism ; Female ; Human Physiology ; Humans ; Internal Medicine ; Intra-Abdominal Fat - diagnostic imaging ; Intra-Abdominal Fat - metabolism ; Male ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Metabolic Syndrome - complications ; Metabolic Syndrome - metabolism ; Middle Aged ; Muscle, Skeletal - diagnostic imaging ; Muscle, Skeletal - metabolism ; Obesity ; Obesity - complications ; Obesity - diet therapy ; Obesity - metabolism ; Physiological aspects ; Positron-Emission Tomography ; Radiography ; Reducing diets ; Subcutaneous Fat - diagnostic imaging ; Subcutaneous Fat - metabolism ; Weight loss ; Weight Loss - physiology
ispartofDiabetologia, 2014-10-21, Vol.58 (1), p.158-164
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1Karmi, Anna C
2Iozzo, Patricia
3Fielding, Barbara A
4Viljanen, Antti
5Badeau, Robert M
6Borra, Ronald
7Saunavaara, Virva
8Pham, Tam
9Hannukainen, Jarna C
10Kalliokoski, Kari
11Haaparanta-Solin, Merja
12Viljanen, Tapio
13Parkkola, Riitta
14Frayn, Keith N
15Nuutila, Pirjo
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descriptionAims/hypothesis Obesity causes an imbalance in fat mass distribution between visceral and subcutaneous adipose tissue (AT) depots. We tested the hypothesis that this relates to increased NEFA uptake between these depots in obese compared with healthy participants. Second, we hypothesised that a diet very low in energy (very low calorie diet [VLCD]) decreases fat mass in obese participants and that this is associated with the decline in NEFA uptake. Methods NEFA uptake in AT depots was measured with [ 18 F]-fluoro-6-thia-heptadecanoic acid ( 18 F-FTHA) and positron emission tomography (PET) in 18 obese participants with the metabolic syndrome before and after a 6 week VLCD. Whole body fat oxidation was measured using indirect calorimetry and [U- 13 C]palmitate. Sixteen non-obese participants were controls. Results Obese participants had >100% higher ( p  < 0.0001) NEFA uptake in the visceral and subcutaneous abdominal AT depots than controls. VLCD decreased AT mass in all regions (12% to 21%), but NEFA uptake was decreased significantly (18%; p  < 0.006) only in the femoral AT. Whole body carbohydrate oxidation decreased, while fat oxidation increased. Conclusions/interpretation The data demonstrate that weight loss caused by VLCD does not affect abdominal fasting NEFA uptake rates. We found that visceral fat takes up more NEFAs than subcutaneous AT depots, even after weight loss.
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24Obesity - diet therapy
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29Reducing diets
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32Weight loss
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titleEnhanced fatty acid uptake in visceral adipose tissue is not reversed by weight loss in obese individuals with the metabolic syndrome
authorBucci, Marco ; Karmi, Anna C ; Iozzo, Patricia ; Fielding, Barbara A ; Viljanen, Antti ; Badeau, Robert M ; Borra, Ronald ; Saunavaara, Virva ; Pham, Tam ; Hannukainen, Jarna C ; Kalliokoski, Kari ; Haaparanta-Solin, Merja ; Viljanen, Tapio ; Parkkola, Riitta ; Frayn, Keith N ; Nuutila, Pirjo
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8Human Physiology
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32Weight loss
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8Pham, Tam
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atitleEnhanced fatty acid uptake in visceral adipose tissue is not reversed by weight loss in obese individuals with the metabolic syndrome
jtitleDiabetologia
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date2014-10-21
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volume58
issue1
spage158
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pages158-164
issn0012-186X
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abstractAims/hypothesis Obesity causes an imbalance in fat mass distribution between visceral and subcutaneous adipose tissue (AT) depots. We tested the hypothesis that this relates to increased NEFA uptake between these depots in obese compared with healthy participants. Second, we hypothesised that a diet very low in energy (very low calorie diet [VLCD]) decreases fat mass in obese participants and that this is associated with the decline in NEFA uptake. Methods NEFA uptake in AT depots was measured with [ 18 F]-fluoro-6-thia-heptadecanoic acid ( 18 F-FTHA) and positron emission tomography (PET) in 18 obese participants with the metabolic syndrome before and after a 6 week VLCD. Whole body fat oxidation was measured using indirect calorimetry and [U- 13 C]palmitate. Sixteen non-obese participants were controls. Results Obese participants had >100% higher ( p  < 0.0001) NEFA uptake in the visceral and subcutaneous abdominal AT depots than controls. VLCD decreased AT mass in all regions (12% to 21%), but NEFA uptake was decreased significantly (18%; p  < 0.006) only in the femoral AT. Whole body carbohydrate oxidation decreased, while fat oxidation increased. Conclusions/interpretation The data demonstrate that weight loss caused by VLCD does not affect abdominal fasting NEFA uptake rates. We found that visceral fat takes up more NEFAs than subcutaneous AT depots, even after weight loss.
copBerlin/Heidelberg
pubSpringer Berlin Heidelberg
pmid25331375
doi10.1007/s00125-014-3402-x