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Molecular aspects of cancer chemopreventive and therapeutic efficacies of tea and tea polyphenols

The natural dietary product tea (Camellia sinensis) and its bioactive polyphenols such as epigallocatechin gallate (EGCG) and theaflavin (TF) demonstrated potential anticancer effects in different preclinical and clinical studies. The aim of the present review was to understand the molecular mechani... Full description

Journal Title: Nutrition (Burbank Los Angeles County, Calif.), 2017-11, Vol.43-44, p.8-15
Main Author: Sur, Subhayan
Other Authors: Panda, Chinmay Kumar
Format: Electronic Article Electronic Article
Language: English
Subjects:
DNA
RNA
Tea
Quelle: Alma/SFX Local Collection
Publisher: United States: Elsevier Inc
ID: ISSN: 0899-9007
Link: https://www.ncbi.nlm.nih.gov/pubmed/28935149
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recordid: cdi_proquest_miscellaneous_1942676443
title: Molecular aspects of cancer chemopreventive and therapeutic efficacies of tea and tea polyphenols
format: Article
creator:
  • Sur, Subhayan
  • Panda, Chinmay Kumar
subjects:
  • Analysis
  • Angiogenesis
  • Animals
  • Anticancer properties
  • Anticarcinogenic Agents - administration & dosage
  • Antioxidants
  • Apoptosis
  • Biflavonoids - administration & dosage
  • Cancer
  • Cancer prevention
  • Cancer therapies
  • Cancer therapy
  • Carcinogenesis
  • Carcinogens
  • Care and treatment
  • Catechin
  • Catechin - administration & dosage
  • Catechin - analogs & derivatives
  • Cell culture
  • Cell cycle
  • Chemotherapy
  • Cloning
  • Deoxyribonucleic acid
  • Detoxification
  • Development and progression
  • Diet
  • Disease prevention
  • DNA
  • Drinking water
  • Enzymes
  • Epigallocatechin gallate
  • Epigallocatechin-3-gallate
  • Epigenesis, Genetic - drug effects
  • Health aspects
  • Humans
  • In vivo methods and tests
  • Liver
  • Metabolic Detoxication, Phase I
  • Metabolism
  • Molecular modelling
  • Neoplasms - drug therapy
  • Neoplasms - prevention & control
  • Nucleic Acids - metabolism
  • Oncology, Experimental
  • Organs
  • Pancreas
  • Phytotherapy
  • Polyphenols
  • Polyphenols - administration & dosage
  • Polyphenols - metabolism
  • Population
  • Prevention
  • Prostate
  • Proteins
  • Proteins - metabolism
  • Research
  • Ribonucleic acid
  • RNA
  • Rodents
  • Stem cells
  • Stomach
  • Tea
  • Tea - chemistry
  • Theaflavin
  • Therapy
ispartof: Nutrition (Burbank, Los Angeles County, Calif.), 2017-11, Vol.43-44, p.8-15
description: The natural dietary product tea (Camellia sinensis) and its bioactive polyphenols such as epigallocatechin gallate (EGCG) and theaflavin (TF) demonstrated potential anticancer effects in different preclinical and clinical studies. The aim of the present review was to understand the molecular mechanisms of the tea and tea polyphenol-mediated cancer prevention and therapy. In the setting of in vivo cancer prevention studies, administration of the tea and tea polyphenols at preinitiation stages only showed partial prevention, whereas continuous administration showed potential effect in restriction of carcinogenesis in the body's multiple organs at early premalignant stages throughout the experiment. Similar to different in vitro cancer cell models, treatment after initiation stages showed potential therapeutic efficacy in vivo. But, the mechanisms of prevention and therapy were found to be similar regardless of tea and its polyphenols. They mainly serve as antioxidants and induce the detoxification system, thereby inhibiting carcinogen metabolism and cancer initiation. Additionally, they could inhibit self-renewal, proliferation, and survival of the tumor-initiating population in restriction of the carcinogenesis progression from cancer initiation and promotion. This might be a result of the modulation of membrane organization, interaction with DNA/RNA/proteins and epigenetic modifications, as well as regulation of cellular replicative potential by the tea polyphenols. [Display omitted] •We reviewed cancer preventive and therapeutic mechanisms by tea and tea polyphenols.•Tea and tea polyphenols could restrict the progression of carcinogenesis in vivo in the early dysplastic stages.•Tea and tea polyphenols serve as antioxidants and induce the detoxification system during restriction.•Tea and tea polyphenols inhibit self-renewal, proliferation, and survival of tumor-initiating clones.•Tea polyphenols interact with or modify different cellular targets of the membrane to nucleus.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0899-9007
fulltext: fulltext
issn:
  • 0899-9007
  • 1873-1244
url: Link


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descriptionThe natural dietary product tea (Camellia sinensis) and its bioactive polyphenols such as epigallocatechin gallate (EGCG) and theaflavin (TF) demonstrated potential anticancer effects in different preclinical and clinical studies. The aim of the present review was to understand the molecular mechanisms of the tea and tea polyphenol-mediated cancer prevention and therapy. In the setting of in vivo cancer prevention studies, administration of the tea and tea polyphenols at preinitiation stages only showed partial prevention, whereas continuous administration showed potential effect in restriction of carcinogenesis in the body's multiple organs at early premalignant stages throughout the experiment. Similar to different in vitro cancer cell models, treatment after initiation stages showed potential therapeutic efficacy in vivo. But, the mechanisms of prevention and therapy were found to be similar regardless of tea and its polyphenols. They mainly serve as antioxidants and induce the detoxification system, thereby inhibiting carcinogen metabolism and cancer initiation. Additionally, they could inhibit self-renewal, proliferation, and survival of the tumor-initiating population in restriction of the carcinogenesis progression from cancer initiation and promotion. This might be a result of the modulation of membrane organization, interaction with DNA/RNA/proteins and epigenetic modifications, as well as regulation of cellular replicative potential by the tea polyphenols. [Display omitted] •We reviewed cancer preventive and therapeutic mechanisms by tea and tea polyphenols.•Tea and tea polyphenols could restrict the progression of carcinogenesis in vivo in the early dysplastic stages.•Tea and tea polyphenols serve as antioxidants and induce the detoxification system during restriction.•Tea and tea polyphenols inhibit self-renewal, proliferation, and survival of tumor-initiating clones.•Tea polyphenols interact with or modify different cellular targets of the membrane to nucleus.
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descriptionThe natural dietary product tea (Camellia sinensis) and its bioactive polyphenols such as epigallocatechin gallate (EGCG) and theaflavin (TF) demonstrated potential anticancer effects in different preclinical and clinical studies. The aim of the present review was to understand the molecular mechanisms of the tea and tea polyphenol-mediated cancer prevention and therapy. In the setting of in vivo cancer prevention studies, administration of the tea and tea polyphenols at preinitiation stages only showed partial prevention, whereas continuous administration showed potential effect in restriction of carcinogenesis in the body's multiple organs at early premalignant stages throughout the experiment. Similar to different in vitro cancer cell models, treatment after initiation stages showed potential therapeutic efficacy in vivo. But, the mechanisms of prevention and therapy were found to be similar regardless of tea and its polyphenols. They mainly serve as antioxidants and induce the detoxification system, thereby inhibiting carcinogen metabolism and cancer initiation. Additionally, they could inhibit self-renewal, proliferation, and survival of the tumor-initiating population in restriction of the carcinogenesis progression from cancer initiation and promotion. This might be a result of the modulation of membrane organization, interaction with DNA/RNA/proteins and epigenetic modifications, as well as regulation of cellular replicative potential by the tea polyphenols. [Display omitted] •We reviewed cancer preventive and therapeutic mechanisms by tea and tea polyphenols.•Tea and tea polyphenols could restrict the progression of carcinogenesis in vivo in the early dysplastic stages.•Tea and tea polyphenols serve as antioxidants and induce the detoxification system during restriction.•Tea and tea polyphenols inhibit self-renewal, proliferation, and survival of tumor-initiating clones.•Tea polyphenols interact with or modify different cellular targets of the membrane to nucleus.
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4Anticarcinogenic Agents - administration & dosage
5Antioxidants
6Apoptosis
7Biflavonoids - administration & dosage
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9Cancer prevention
10Cancer therapies
11Cancer therapy
12Carcinogenesis
13Carcinogens
14Care and treatment
15Catechin
16Catechin - administration & dosage
17Catechin - analogs & derivatives
18Cell culture
19Cell cycle
20Chemotherapy
21Cloning
22Deoxyribonucleic acid
23Detoxification
24Development and progression
25Diet
26Disease prevention
27DNA
28Drinking water
29Enzymes
30Epigallocatechin gallate
31Epigallocatechin-3-gallate
32Epigenesis, Genetic - drug effects
33Health aspects
34Humans
35In vivo methods and tests
36Liver
37Metabolic Detoxication, Phase I
38Metabolism
39Molecular modelling
40Neoplasms - drug therapy
41Neoplasms - prevention & control
42Nucleic Acids - metabolism
43Oncology, Experimental
44Organs
45Pancreas
46Phytotherapy
47Polyphenols
48Polyphenols - administration & dosage
49Polyphenols - metabolism
50Population
51Prevention
52Prostate
53Proteins
54Proteins - metabolism
55Research
56Ribonucleic acid
57RNA
58Rodents
59Stem cells
60Stomach
61Tea
62Tea - chemistry
63Theaflavin
64Therapy
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53Proteins
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abstractThe natural dietary product tea (Camellia sinensis) and its bioactive polyphenols such as epigallocatechin gallate (EGCG) and theaflavin (TF) demonstrated potential anticancer effects in different preclinical and clinical studies. The aim of the present review was to understand the molecular mechanisms of the tea and tea polyphenol-mediated cancer prevention and therapy. In the setting of in vivo cancer prevention studies, administration of the tea and tea polyphenols at preinitiation stages only showed partial prevention, whereas continuous administration showed potential effect in restriction of carcinogenesis in the body's multiple organs at early premalignant stages throughout the experiment. Similar to different in vitro cancer cell models, treatment after initiation stages showed potential therapeutic efficacy in vivo. But, the mechanisms of prevention and therapy were found to be similar regardless of tea and its polyphenols. They mainly serve as antioxidants and induce the detoxification system, thereby inhibiting carcinogen metabolism and cancer initiation. Additionally, they could inhibit self-renewal, proliferation, and survival of the tumor-initiating population in restriction of the carcinogenesis progression from cancer initiation and promotion. This might be a result of the modulation of membrane organization, interaction with DNA/RNA/proteins and epigenetic modifications, as well as regulation of cellular replicative potential by the tea polyphenols. [Display omitted] •We reviewed cancer preventive and therapeutic mechanisms by tea and tea polyphenols.•Tea and tea polyphenols could restrict the progression of carcinogenesis in vivo in the early dysplastic stages.•Tea and tea polyphenols serve as antioxidants and induce the detoxification system during restriction.•Tea and tea polyphenols inhibit self-renewal, proliferation, and survival of tumor-initiating clones.•Tea polyphenols interact with or modify different cellular targets of the membrane to nucleus.
copUnited States
pubElsevier Inc
pmid28935149
doi10.1016/j.nut.2017.06.006