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Consumption of garlic and lemon aqueous extracts combination reduces tumor burden by angiogenesis inhibition, apoptosis induction, and immune system modulation

Dietary agents play an important role in cancer prevention and therapy because of their low toxicity and the perception that they are not a medicine. The aim of the present study was to investigate the anticancer effect of the administration of garlic and lemon aqueous extracts against breast cancer... Full description

Journal Title: Nutrition (Burbank Los Angeles County, Calif.), 2017-11, Vol.43-44, p.89-97
Main Author: Talib, Wamidh H
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: United States: Elsevier Inc
ID: ISSN: 0899-9007
Link: https://www.ncbi.nlm.nih.gov/pubmed/28935151
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title: Consumption of garlic and lemon aqueous extracts combination reduces tumor burden by angiogenesis inhibition, apoptosis induction, and immune system modulation
format: Article
creator:
  • Talib, Wamidh H
subjects:
  • Alanine
  • Alanine transaminase
  • Analysis
  • Angiogenesis
  • Angiogenesis inhibition
  • Animal models
  • Animals
  • Anticancer functional food
  • Anticancer properties
  • Anticarcinogenic Agents - administration & dosage
  • Apoptosis
  • Apoptosis - drug effects
  • Apoptosis induction
  • Aspartate transaminase
  • Assaying
  • Breast cancer
  • Cancer
  • Cell Line, Tumor
  • Citrus
  • Citrus fruits
  • Combination therapy
  • Creatinine
  • Diet
  • Drug Synergism
  • Endothelial growth factors
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Fruit - chemistry
  • Functional foods
  • Garlic
  • Garlic - chemistry
  • Immune system
  • Immunity - drug effects
  • Inhibition
  • Interferon
  • Interferon-gamma - blood
  • Interleukin
  • Interleukin 10
  • Interleukin 4
  • Interleukins - blood
  • Mammary Neoplasms, Experimental - drug therapy
  • Mammary Neoplasms, Experimental - immunology
  • Mammary Neoplasms, Experimental - pathology
  • Mice
  • Mice, Inbred BALB C
  • Molecular modelling
  • Neoplasm Transplantation
  • Neovascularization, Pathologic - prevention & control
  • Phytochemicals
  • Phytotherapy
  • Plant Extracts - administration & dosage
  • Plant Tubers - chemistry
  • Prevention
  • Recipes
  • Serum levels
  • Studies
  • Toxicity
  • Tumor Burden - drug effects
  • Tumors
  • Vascular endothelial growth factor
ispartof: Nutrition (Burbank, Los Angeles County, Calif.), 2017-11, Vol.43-44, p.89-97
description: Dietary agents play an important role in cancer prevention and therapy because of their low toxicity and the perception that they are not a medicine. The aim of the present study was to investigate the anticancer effect of the administration of garlic and lemon aqueous extracts against breast cancer implanted in mice. We used 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay to determine the antiproliferative effect of both extracts and their combinations. Isobolographic method was used to calculate the combination index. Balb/C mice were inoculated with EMT6/P breast cancer cells and received intragastric administration of one of three treatments (garlic alone, lemon alone, or a combination of both). Change in tumor size and survival rates were measured. TUNEL assay was used to measure apoptosis and enzyme-linked immunosorbent assay (ELISA) was used to measure vascular endothelial growth factor expression. Serum levels of interferon-γ, interleukin (IL)-2, IL-4, and IL-10 were measured using ELISA and levels of aspartate transaminase, alanine transaminase, and creatinine were determined. The combination of both extracts acts synergistically against breast cancer in mice. Of the treated mice, 80% were cured using this combination. This combination inhibited angiogenesis, induced apoptosis, and caused systemic activation in the immune system. The combination of garlic and lemon aqueous extracts represents a promising option to develop an anticancer food for augmenting conventional anticancer therapies. However, further testing is essential to understand the exact molecular mechanisms of this combination and to test its therapeutic effect against other cancer models. •Dietary agents play an important role in cancer prevention and therapy because of their low toxicity and the perception that they are not a medicine.•Garlic and lemon were tested for their anticancer activities in vitro and in vivo against murine breast cancer.•Garlic and lemon worked synergistically to inhibit breast cancer in vitro and in vivo.•The combination of garlic and lemon can be considered for future development of anticancer food to augment conventional anticancer therapies.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0899-9007
fulltext: fulltext
issn:
  • 0899-9007
  • 1873-1244
url: Link


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descriptionDietary agents play an important role in cancer prevention and therapy because of their low toxicity and the perception that they are not a medicine. The aim of the present study was to investigate the anticancer effect of the administration of garlic and lemon aqueous extracts against breast cancer implanted in mice. We used 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay to determine the antiproliferative effect of both extracts and their combinations. Isobolographic method was used to calculate the combination index. Balb/C mice were inoculated with EMT6/P breast cancer cells and received intragastric administration of one of three treatments (garlic alone, lemon alone, or a combination of both). Change in tumor size and survival rates were measured. TUNEL assay was used to measure apoptosis and enzyme-linked immunosorbent assay (ELISA) was used to measure vascular endothelial growth factor expression. Serum levels of interferon-γ, interleukin (IL)-2, IL-4, and IL-10 were measured using ELISA and levels of aspartate transaminase, alanine transaminase, and creatinine were determined. The combination of both extracts acts synergistically against breast cancer in mice. Of the treated mice, 80% were cured using this combination. This combination inhibited angiogenesis, induced apoptosis, and caused systemic activation in the immune system. The combination of garlic and lemon aqueous extracts represents a promising option to develop an anticancer food for augmenting conventional anticancer therapies. However, further testing is essential to understand the exact molecular mechanisms of this combination and to test its therapeutic effect against other cancer models. •Dietary agents play an important role in cancer prevention and therapy because of their low toxicity and the perception that they are not a medicine.•Garlic and lemon were tested for their anticancer activities in vitro and in vivo against murine breast cancer.•Garlic and lemon worked synergistically to inhibit breast cancer in vitro and in vivo.•The combination of garlic and lemon can be considered for future development of anticancer food to augment conventional anticancer therapies.
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languageeng
publisherUnited States: Elsevier Inc
subjectAlanine ; Alanine transaminase ; Analysis ; Angiogenesis ; Angiogenesis inhibition ; Animal models ; Animals ; Anticancer functional food ; Anticancer properties ; Anticarcinogenic Agents - administration & dosage ; Apoptosis ; Apoptosis - drug effects ; Apoptosis induction ; Aspartate transaminase ; Assaying ; Breast cancer ; Cancer ; Cell Line, Tumor ; Citrus ; Citrus fruits ; Combination therapy ; Creatinine ; Diet ; Drug Synergism ; Endothelial growth factors ; Enzyme-Linked Immunosorbent Assay ; Female ; Fruit - chemistry ; Functional foods ; Garlic ; Garlic - chemistry ; Immune system ; Immunity - drug effects ; Inhibition ; Interferon ; Interferon-gamma - blood ; Interleukin ; Interleukin 10 ; Interleukin 4 ; Interleukins - blood ; Mammary Neoplasms, Experimental - drug therapy ; Mammary Neoplasms, Experimental - immunology ; Mammary Neoplasms, Experimental - pathology ; Mice ; Mice, Inbred BALB C ; Molecular modelling ; Neoplasm Transplantation ; Neovascularization, Pathologic - prevention & control ; Phytochemicals ; Phytotherapy ; Plant Extracts - administration & dosage ; Plant Tubers - chemistry ; Prevention ; Recipes ; Serum levels ; Studies ; Toxicity ; Tumor Burden - drug effects ; Tumors ; Vascular endothelial growth factor
ispartofNutrition (Burbank, Los Angeles County, Calif.), 2017-11, Vol.43-44, p.89-97
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descriptionDietary agents play an important role in cancer prevention and therapy because of their low toxicity and the perception that they are not a medicine. The aim of the present study was to investigate the anticancer effect of the administration of garlic and lemon aqueous extracts against breast cancer implanted in mice. We used 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay to determine the antiproliferative effect of both extracts and their combinations. Isobolographic method was used to calculate the combination index. Balb/C mice were inoculated with EMT6/P breast cancer cells and received intragastric administration of one of three treatments (garlic alone, lemon alone, or a combination of both). Change in tumor size and survival rates were measured. TUNEL assay was used to measure apoptosis and enzyme-linked immunosorbent assay (ELISA) was used to measure vascular endothelial growth factor expression. Serum levels of interferon-γ, interleukin (IL)-2, IL-4, and IL-10 were measured using ELISA and levels of aspartate transaminase, alanine transaminase, and creatinine were determined. The combination of both extracts acts synergistically against breast cancer in mice. Of the treated mice, 80% were cured using this combination. This combination inhibited angiogenesis, induced apoptosis, and caused systemic activation in the immune system. The combination of garlic and lemon aqueous extracts represents a promising option to develop an anticancer food for augmenting conventional anticancer therapies. However, further testing is essential to understand the exact molecular mechanisms of this combination and to test its therapeutic effect against other cancer models. •Dietary agents play an important role in cancer prevention and therapy because of their low toxicity and the perception that they are not a medicine.•Garlic and lemon were tested for their anticancer activities in vitro and in vivo against murine breast cancer.•Garlic and lemon worked synergistically to inhibit breast cancer in vitro and in vivo.•The combination of garlic and lemon can be considered for future development of anticancer food to augment conventional anticancer therapies.
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0Alanine
1Alanine transaminase
2Analysis
3Angiogenesis
4Angiogenesis inhibition
5Animal models
6Animals
7Anticancer functional food
8Anticancer properties
9Anticarcinogenic Agents - administration & dosage
10Apoptosis
11Apoptosis - drug effects
12Apoptosis induction
13Aspartate transaminase
14Assaying
15Breast cancer
16Cancer
17Cell Line, Tumor
18Citrus
19Citrus fruits
20Combination therapy
21Creatinine
22Diet
23Drug Synergism
24Endothelial growth factors
25Enzyme-Linked Immunosorbent Assay
26Female
27Fruit - chemistry
28Functional foods
29Garlic
30Garlic - chemistry
31Immune system
32Immunity - drug effects
33Inhibition
34Interferon
35Interferon-gamma - blood
36Interleukin
37Interleukin 10
38Interleukin 4
39Interleukins - blood
40Mammary Neoplasms, Experimental - drug therapy
41Mammary Neoplasms, Experimental - immunology
42Mammary Neoplasms, Experimental - pathology
43Mice
44Mice, Inbred BALB C
45Molecular modelling
46Neoplasm Transplantation
47Neovascularization, Pathologic - prevention & control
48Phytochemicals
49Phytotherapy
50Plant Extracts - administration & dosage
51Plant Tubers - chemistry
52Prevention
53Recipes
54Serum levels
55Studies
56Toxicity
57Tumor Burden - drug effects
58Tumors
59Vascular endothelial growth factor
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abstractDietary agents play an important role in cancer prevention and therapy because of their low toxicity and the perception that they are not a medicine. The aim of the present study was to investigate the anticancer effect of the administration of garlic and lemon aqueous extracts against breast cancer implanted in mice. We used 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay to determine the antiproliferative effect of both extracts and their combinations. Isobolographic method was used to calculate the combination index. Balb/C mice were inoculated with EMT6/P breast cancer cells and received intragastric administration of one of three treatments (garlic alone, lemon alone, or a combination of both). Change in tumor size and survival rates were measured. TUNEL assay was used to measure apoptosis and enzyme-linked immunosorbent assay (ELISA) was used to measure vascular endothelial growth factor expression. Serum levels of interferon-γ, interleukin (IL)-2, IL-4, and IL-10 were measured using ELISA and levels of aspartate transaminase, alanine transaminase, and creatinine were determined. The combination of both extracts acts synergistically against breast cancer in mice. Of the treated mice, 80% were cured using this combination. This combination inhibited angiogenesis, induced apoptosis, and caused systemic activation in the immune system. The combination of garlic and lemon aqueous extracts represents a promising option to develop an anticancer food for augmenting conventional anticancer therapies. However, further testing is essential to understand the exact molecular mechanisms of this combination and to test its therapeutic effect against other cancer models. •Dietary agents play an important role in cancer prevention and therapy because of their low toxicity and the perception that they are not a medicine.•Garlic and lemon were tested for their anticancer activities in vitro and in vivo against murine breast cancer.•Garlic and lemon worked synergistically to inhibit breast cancer in vitro and in vivo.•The combination of garlic and lemon can be considered for future development of anticancer food to augment conventional anticancer therapies.
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pmid28935151
doi10.1016/j.nut.2017.06.015