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Corrective effect of flavonoid-containing preparation Extralife on the development of Parkinson's syndrome

Oral administration of flavonoid-containing preparation Extralife (daily dose 40 mg/kg) to animals with modeled Parkinson's syndrome considerably improved their survival and the main diagnostic and nosological parameters characterizing the state of locomotor functions. The preparation decreased anim... Full description

Journal Title: Bulletin of experimental biology and medicine 2007-07, Vol.144 (1), p.42-45
Main Author: Luk'yanova, L D
Other Authors: Storozheva, Z I , Proshin, A T
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: United States: Springer
ID: ISSN: 0007-4888
Link: https://www.ncbi.nlm.nih.gov/pubmed/18256748
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title: Corrective effect of flavonoid-containing preparation Extralife on the development of Parkinson's syndrome
format: Article
creator:
  • Luk'yanova, L D
  • Storozheva, Z I
  • Proshin, A T
subjects:
  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
  • Aging
  • Animals
  • Bioflavonoids
  • Flavones
  • Flavonoids
  • Flavonoids - therapeutic use
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Motor Activity - drug effects
  • Parkinson's disease
  • Parkinsonian Disorders - prevention & control
  • Physiological aspects
  • Phytotherapy
  • Plant Extracts - therapeutic use
  • Rosaceae - chemistry
ispartof: Bulletin of experimental biology and medicine, 2007-07, Vol.144 (1), p.42-45
description: Oral administration of flavonoid-containing preparation Extralife (daily dose 40 mg/kg) to animals with modeled Parkinson's syndrome considerably improved their survival and the main diagnostic and nosological parameters characterizing the state of locomotor functions. The preparation decreased animal mortality, rigidity, disturbances in dynamic muscular work and coordination of movements, and reduced oligokinesia. Experimental data confirm the involvement of mitochondrial enzyme complex I dysfunction in the pathogenesis of the disease and showed the possibility of by-passing this site of the respiratory chain with Extralife.
language: eng
source:
identifier: ISSN: 0007-4888
fulltext: no_fulltext
issn:
  • 0007-4888
  • 1573-8221
url: Link


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titleCorrective effect of flavonoid-containing preparation Extralife on the development of Parkinson's syndrome
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descriptionOral administration of flavonoid-containing preparation Extralife (daily dose 40 mg/kg) to animals with modeled Parkinson's syndrome considerably improved their survival and the main diagnostic and nosological parameters characterizing the state of locomotor functions. The preparation decreased animal mortality, rigidity, disturbances in dynamic muscular work and coordination of movements, and reduced oligokinesia. Experimental data confirm the involvement of mitochondrial enzyme complex I dysfunction in the pathogenesis of the disease and showed the possibility of by-passing this site of the respiratory chain with Extralife.
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subject1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine ; Aging ; Animals ; Bioflavonoids ; Flavones ; Flavonoids ; Flavonoids - therapeutic use ; Male ; Mice ; Mice, Inbred C57BL ; Motor Activity - drug effects ; Parkinson's disease ; Parkinsonian Disorders - prevention & control ; Physiological aspects ; Phytotherapy ; Plant Extracts - therapeutic use ; Rosaceae - chemistry
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abstractOral administration of flavonoid-containing preparation Extralife (daily dose 40 mg/kg) to animals with modeled Parkinson's syndrome considerably improved their survival and the main diagnostic and nosological parameters characterizing the state of locomotor functions. The preparation decreased animal mortality, rigidity, disturbances in dynamic muscular work and coordination of movements, and reduced oligokinesia. Experimental data confirm the involvement of mitochondrial enzyme complex I dysfunction in the pathogenesis of the disease and showed the possibility of by-passing this site of the respiratory chain with Extralife.
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doi10.1007/s10517-007-0249-x