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The role of microalbuminuria as a predictor of subclinical cardiovascular events in rheumatoid arthritis patients and its relation to disease activity

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that affects many body tissues and leads to major morbidity and mortality. Renal disease in RA is clinically important because it restricts the management of primary disease and increases mortality. The objectives of this study a... Full description

Journal Title: Clinical rheumatology 2017, Vol.37 (3), p.623-630
Main Author: Nada, D. W
Other Authors: El Morsy, S , Abu-Zaid, M. H , Aboelhawa, M. A , Zakaria, Mohammad A , El Sheikh, E. A , Gaber, R. A
Format: Electronic Article Electronic Article
Language: English
Subjects:
EKG
Publisher: London: Springer London
ID: ISSN: 0770-3198
Link: https://www.ncbi.nlm.nih.gov/pubmed/29063462
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title: The role of microalbuminuria as a predictor of subclinical cardiovascular events in rheumatoid arthritis patients and its relation to disease activity
format: Article
creator:
  • Nada, D. W
  • El Morsy, S
  • Abu-Zaid, M. H
  • Aboelhawa, M. A
  • Zakaria, Mohammad A
  • El Sheikh, E. A
  • Gaber, R. A
subjects:
  • Adult
  • Albuminuria - complications
  • Albuminuria - diagnostic imaging
  • Albuminuria - physiopathology
  • Arthritis
  • Arthritis, Rheumatoid - complications
  • Arthritis, Rheumatoid - diagnostic imaging
  • Arthritis, Rheumatoid - physiopathology
  • Atherosclerosis
  • Atherosclerosis - complications
  • Atherosclerosis - diagnostic imaging
  • Atherosclerosis - physiopathology
  • Brachial Artery - diagnostic imaging
  • Brachial Artery - physiopathology
  • Cardiovascular Diseases - complications
  • Cardiovascular Diseases - diagnostic imaging
  • Cardiovascular Diseases - physiopathology
  • Carotid Intima-Media Thickness
  • Creatinine
  • Echocardiography
  • EKG
  • Endothelium, Vascular - diagnostic imaging
  • Endothelium, Vascular - physiopathology
  • Female
  • Health risk assessment
  • Humans
  • Kidney diseases
  • Kidney Function Tests
  • Lipids
  • Low density lipoprotein
  • Low density lipoproteins
  • Male
  • Medical research
  • Medicine
  • Medicine & Public Health
  • Medicine, Experimental
  • Middle Aged
  • Morbidity
  • Mortality
  • Original Article
  • Renal function
  • Rheumatoid arthritis
  • Rheumatoid factor
  • Rheumatology
  • Severity of Illness Index
ispartof: Clinical rheumatology, 2017, Vol.37 (3), p.623-630
description: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that affects many body tissues and leads to major morbidity and mortality. Renal disease in RA is clinically important because it restricts the management of primary disease and increases mortality. The objectives of this study are to (1) investigate the difference between RA patients with and without microalbuminuria (MAU) and (2) find out the relation between MAU and disease activity as well as subclinical cardiovascular effects. Ninety RA patients were divided into two groups according to the presence of MAU, in addition to 30 healthy volunteers. ESR, hs-CRP, RF, lipid profile, urinary microalbumin, GFR, renal function tests, carotid intima media thickness (cIMT), flow-mediated dilatation of the brachial artery (FMD), ECG, and echocardiographic examination were performed for patients and controls. MAU positive RA patients revealed significantly higher lipid profile, ESR, hs-CRP, DAS 28, cIMT, and lower FMD as well as ECG and echocardiographic abnormalities compared to MAU negative RA patients. Moreover, there was significant positive correlation between MAU and DAS28, hs-CRP, LDL, cIMT as well as negative correlation with FMD%. In our study, all RA patients with MAU had a normal serum creatinine concentration and gave a negative result with Albustix. MAU is significantly correlated with ESR, hs-CRP, lipid profile, cIMT, and FMD% in RA patients; therefore, it can be used as an index to measure disease activity as well as subclinical cardiovascular affection in RA patients.
language: eng
source:
identifier: ISSN: 0770-3198
fulltext: no_fulltext
issn:
  • 0770-3198
  • 1434-9949
url: Link


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titleThe role of microalbuminuria as a predictor of subclinical cardiovascular events in rheumatoid arthritis patients and its relation to disease activity
creatorNada, D. W ; El Morsy, S ; Abu-Zaid, M. H ; Aboelhawa, M. A ; Zakaria, Mohammad A ; El Sheikh, E. A ; Gaber, R. A
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descriptionRheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that affects many body tissues and leads to major morbidity and mortality. Renal disease in RA is clinically important because it restricts the management of primary disease and increases mortality. The objectives of this study are to (1) investigate the difference between RA patients with and without microalbuminuria (MAU) and (2) find out the relation between MAU and disease activity as well as subclinical cardiovascular effects. Ninety RA patients were divided into two groups according to the presence of MAU, in addition to 30 healthy volunteers. ESR, hs-CRP, RF, lipid profile, urinary microalbumin, GFR, renal function tests, carotid intima media thickness (cIMT), flow-mediated dilatation of the brachial artery (FMD), ECG, and echocardiographic examination were performed for patients and controls. MAU positive RA patients revealed significantly higher lipid profile, ESR, hs-CRP, DAS 28, cIMT, and lower FMD as well as ECG and echocardiographic abnormalities compared to MAU negative RA patients. Moreover, there was significant positive correlation between MAU and DAS28, hs-CRP, LDL, cIMT as well as negative correlation with FMD%. In our study, all RA patients with MAU had a normal serum creatinine concentration and gave a negative result with Albustix. MAU is significantly correlated with ESR, hs-CRP, lipid profile, cIMT, and FMD% in RA patients; therefore, it can be used as an index to measure disease activity as well as subclinical cardiovascular affection in RA patients.
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subjectAdult ; Albuminuria - complications ; Albuminuria - diagnostic imaging ; Albuminuria - physiopathology ; Arthritis ; Arthritis, Rheumatoid - complications ; Arthritis, Rheumatoid - diagnostic imaging ; Arthritis, Rheumatoid - physiopathology ; Atherosclerosis ; Atherosclerosis - complications ; Atherosclerosis - diagnostic imaging ; Atherosclerosis - physiopathology ; Brachial Artery - diagnostic imaging ; Brachial Artery - physiopathology ; Cardiovascular Diseases - complications ; Cardiovascular Diseases - diagnostic imaging ; Cardiovascular Diseases - physiopathology ; Carotid Intima-Media Thickness ; Creatinine ; Echocardiography ; EKG ; Endothelium, Vascular - diagnostic imaging ; Endothelium, Vascular - physiopathology ; Female ; Health risk assessment ; Humans ; Kidney diseases ; Kidney Function Tests ; Lipids ; Low density lipoprotein ; Low density lipoproteins ; Male ; Medical research ; Medicine ; Medicine & Public Health ; Medicine, Experimental ; Middle Aged ; Morbidity ; Mortality ; Original Article ; Renal function ; Rheumatoid arthritis ; Rheumatoid factor ; Rheumatology ; Severity of Illness Index
ispartofClinical rheumatology, 2017, Vol.37 (3), p.623-630
rights
0International League of Associations for Rheumatology (ILAR) 2017
1COPYRIGHT 2018 Springer
2Clinical Rheumatology is a copyright of Springer, (2017). All Rights Reserved.
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descriptionRheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that affects many body tissues and leads to major morbidity and mortality. Renal disease in RA is clinically important because it restricts the management of primary disease and increases mortality. The objectives of this study are to (1) investigate the difference between RA patients with and without microalbuminuria (MAU) and (2) find out the relation between MAU and disease activity as well as subclinical cardiovascular effects. Ninety RA patients were divided into two groups according to the presence of MAU, in addition to 30 healthy volunteers. ESR, hs-CRP, RF, lipid profile, urinary microalbumin, GFR, renal function tests, carotid intima media thickness (cIMT), flow-mediated dilatation of the brachial artery (FMD), ECG, and echocardiographic examination were performed for patients and controls. MAU positive RA patients revealed significantly higher lipid profile, ESR, hs-CRP, DAS 28, cIMT, and lower FMD as well as ECG and echocardiographic abnormalities compared to MAU negative RA patients. Moreover, there was significant positive correlation between MAU and DAS28, hs-CRP, LDL, cIMT as well as negative correlation with FMD%. In our study, all RA patients with MAU had a normal serum creatinine concentration and gave a negative result with Albustix. MAU is significantly correlated with ESR, hs-CRP, lipid profile, cIMT, and FMD% in RA patients; therefore, it can be used as an index to measure disease activity as well as subclinical cardiovascular affection in RA patients.
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1Albuminuria - complications
2Albuminuria - diagnostic imaging
3Albuminuria - physiopathology
4Arthritis
5Arthritis, Rheumatoid - complications
6Arthritis, Rheumatoid - diagnostic imaging
7Arthritis, Rheumatoid - physiopathology
8Atherosclerosis
9Atherosclerosis - complications
10Atherosclerosis - diagnostic imaging
11Atherosclerosis - physiopathology
12Brachial Artery - diagnostic imaging
13Brachial Artery - physiopathology
14Cardiovascular Diseases - complications
15Cardiovascular Diseases - diagnostic imaging
16Cardiovascular Diseases - physiopathology
17Carotid Intima-Media Thickness
18Creatinine
19Echocardiography
20EKG
21Endothelium, Vascular - diagnostic imaging
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24Health risk assessment
25Humans
26Kidney diseases
27Kidney Function Tests
28Lipids
29Low density lipoprotein
30Low density lipoproteins
31Male
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34Medicine & Public Health
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36Middle Aged
37Morbidity
38Mortality
39Original Article
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41Rheumatoid arthritis
42Rheumatoid factor
43Rheumatology
44Severity of Illness Index
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titleThe role of microalbuminuria as a predictor of subclinical cardiovascular events in rheumatoid arthritis patients and its relation to disease activity
authorNada, D. W ; El Morsy, S ; Abu-Zaid, M. H ; Aboelhawa, M. A ; Zakaria, Mohammad A ; El Sheikh, E. A ; Gaber, R. A
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41Rheumatoid arthritis
42Rheumatoid factor
43Rheumatology
44Severity of Illness Index
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atitleThe role of microalbuminuria as a predictor of subclinical cardiovascular events in rheumatoid arthritis patients and its relation to disease activity
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abstractRheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that affects many body tissues and leads to major morbidity and mortality. Renal disease in RA is clinically important because it restricts the management of primary disease and increases mortality. The objectives of this study are to (1) investigate the difference between RA patients with and without microalbuminuria (MAU) and (2) find out the relation between MAU and disease activity as well as subclinical cardiovascular effects. Ninety RA patients were divided into two groups according to the presence of MAU, in addition to 30 healthy volunteers. ESR, hs-CRP, RF, lipid profile, urinary microalbumin, GFR, renal function tests, carotid intima media thickness (cIMT), flow-mediated dilatation of the brachial artery (FMD), ECG, and echocardiographic examination were performed for patients and controls. MAU positive RA patients revealed significantly higher lipid profile, ESR, hs-CRP, DAS 28, cIMT, and lower FMD as well as ECG and echocardiographic abnormalities compared to MAU negative RA patients. Moreover, there was significant positive correlation between MAU and DAS28, hs-CRP, LDL, cIMT as well as negative correlation with FMD%. In our study, all RA patients with MAU had a normal serum creatinine concentration and gave a negative result with Albustix. MAU is significantly correlated with ESR, hs-CRP, lipid profile, cIMT, and FMD% in RA patients; therefore, it can be used as an index to measure disease activity as well as subclinical cardiovascular affection in RA patients.
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pmid29063462
doi10.1007/s10067-017-3849-5