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Plasma concentrations of 8-hydroxy-2′-deoxyguanosine and risk of kidney disease and death in individuals with type 1 diabetes

Aims/hypothesis Oxidative stress is involved in the pathogenesis of diabetic kidney disease. We evaluated the association between 8-hydroxy-2′-deoxyguanosine (8-OHdG), a marker of DNA oxidative damage, and end-stage renal disease (ESRD) or death in individuals with type 1 diabetes. Methods Plasma 8-... Full description

Journal Title: Diabetologia 2017, Vol.61 (4), p.977-984
Main Author: Sanchez, Manuel
Other Authors: Roussel, Ronan , Hadjadj, Samy , Moutairou, Abdul , Marre, Michel , Velho, Gilberto , Mohammedi, Kamel
Format: Electronic Article Electronic Article
Language: English
Subjects:
DNA
Publisher: Berlin/Heidelberg: Springer Berlin Heidelberg
ID: ISSN: 0012-186X
Link: https://www.ncbi.nlm.nih.gov/pubmed/29185011
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title: Plasma concentrations of 8-hydroxy-2′-deoxyguanosine and risk of kidney disease and death in individuals with type 1 diabetes
format: Article
creator:
  • Sanchez, Manuel
  • Roussel, Ronan
  • Hadjadj, Samy
  • Moutairou, Abdul
  • Marre, Michel
  • Velho, Gilberto
  • Mohammedi, Kamel
subjects:
  • Adult
  • Albumin
  • Article
  • Chronic kidney failure
  • Clinical outcomes
  • Cross-Sectional Studies
  • Death
  • Deoxyguanosine
  • Deoxyguanosine - analogs & derivatives
  • Deoxyguanosine - blood
  • Deoxyribonucleic acid
  • Development and progression
  • Diabetes
  • Diabetes mellitus
  • Diabetes Mellitus, Type 1 - blood
  • Diabetes Mellitus, Type 1 - complications
  • Diabetes Mellitus, Type 1 - mortality
  • DNA
  • DNA Damage
  • End-stage renal disease
  • Epidermal growth factor receptors
  • Female
  • Follow-Up Studies
  • Glomerular Filtration Rate
  • Health risk assessment
  • Human Physiology
  • Humans
  • Internal Medicine
  • Kidney diseases
  • Kidney Failure, Chronic - blood
  • Kidney Failure, Chronic - complications
  • Kidney Failure, Chronic - mortality
  • Male
  • Medicine
  • Medicine & Public Health
  • Metabolic Diseases
  • Middle Aged
  • Mortality
  • Oxidative Stress
  • Oxygen - chemistry
  • Prospective Studies
  • Risk Factors
  • Sensitivity and Specificity
  • Type 1 diabetes
ispartof: Diabetologia, 2017, Vol.61 (4), p.977-984
description: Aims/hypothesis Oxidative stress is involved in the pathogenesis of diabetic kidney disease. We evaluated the association between 8-hydroxy-2′-deoxyguanosine (8-OHdG), a marker of DNA oxidative damage, and end-stage renal disease (ESRD) or death in individuals with type 1 diabetes. Methods Plasma 8-OHdG concentrations were measured at baseline in participants with type 1 diabetes from GENEDIAB ( n  = 348) and GENESIS ( n  = 571) cohorts. A follow-up was conducted in 205 and 499 participants for a mean ± SD duration of 8.9 ± 2.3 years and 5.2 ± 1.9 years, respectively. We tested associations between 8-OHdG concentrations and urinary albumin concentration (UAC) or eGFR at baseline, and the risk of ESRD or all-cause mortality during follow-up. Analyses were performed in pooled cohorts. Results The highest UAC (geometric mean [95% CI]) was observed in the third 8-OHdG tertile (tertile 1, 9 [6, 13] mg/l; tertile 2, 10 [7, 16] mg/l; tertile 3, 16 [10, 25] mg/l; p  = 0.36 for tertile 1 vs tertile 2 and p  = 0.003 for tertile 3 vs tertile 1) after adjustment for potential confounding covariates. The lowest eGFR (mean [95% CI]) was observed in the third tertile (tertile 1, 87 [82, 93] ml min −1 1.73 m −2 ; tertile 2, 88 [82, 94] ml min −1 1.73 m −2 ; tertile 3, 74 [68, 80] ml min −1 1.73 m −2 ; p  = 0.61 for tertile 1 vs tertile 2; p  
language: eng
source:
identifier: ISSN: 0012-186X
fulltext: no_fulltext
issn:
  • 0012-186X
  • 1432-0428
url: Link


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titlePlasma concentrations of 8-hydroxy-2′-deoxyguanosine and risk of kidney disease and death in individuals with type 1 diabetes
creatorSanchez, Manuel ; Roussel, Ronan ; Hadjadj, Samy ; Moutairou, Abdul ; Marre, Michel ; Velho, Gilberto ; Mohammedi, Kamel
creatorcontribSanchez, Manuel ; Roussel, Ronan ; Hadjadj, Samy ; Moutairou, Abdul ; Marre, Michel ; Velho, Gilberto ; Mohammedi, Kamel
descriptionAims/hypothesis Oxidative stress is involved in the pathogenesis of diabetic kidney disease. We evaluated the association between 8-hydroxy-2′-deoxyguanosine (8-OHdG), a marker of DNA oxidative damage, and end-stage renal disease (ESRD) or death in individuals with type 1 diabetes. Methods Plasma 8-OHdG concentrations were measured at baseline in participants with type 1 diabetes from GENEDIAB ( n  = 348) and GENESIS ( n  = 571) cohorts. A follow-up was conducted in 205 and 499 participants for a mean ± SD duration of 8.9 ± 2.3 years and 5.2 ± 1.9 years, respectively. We tested associations between 8-OHdG concentrations and urinary albumin concentration (UAC) or eGFR at baseline, and the risk of ESRD or all-cause mortality during follow-up. Analyses were performed in pooled cohorts. Results The highest UAC (geometric mean [95% CI]) was observed in the third 8-OHdG tertile (tertile 1, 9 [6, 13] mg/l; tertile 2, 10 [7, 16] mg/l; tertile 3, 16 [10, 25] mg/l; p  = 0.36 for tertile 1 vs tertile 2 and p  = 0.003 for tertile 3 vs tertile 1) after adjustment for potential confounding covariates. The lowest eGFR (mean [95% CI]) was observed in the third tertile (tertile 1, 87 [82, 93] ml min −1 1.73 m −2 ; tertile 2, 88 [82, 94] ml min −1 1.73 m −2 ; tertile 3, 74 [68, 80] ml min −1 1.73 m −2 ; p  = 0.61 for tertile 1 vs tertile 2; p  < 0.001 for tertile 3 vs tertile 1). ESRD and death occurred in 48 and 64 individuals, respectively. The HR for ESRD, but not death, was higher in the third tertile than in the first (tertile 2 vs tertile 1, 1.45 [0.45, 5.04], p  = 0.54; tertile 3 vs tertile 1, 3.05 [1.16, 9.60], p  = 0.02) after multiple adjustments. Conclusions/interpretation Higher plasma concentrations of 8-OHdG were independently associated with increased risk of kidney disease in individuals with type 1 diabetes, suggesting that this marker can be used to evaluate the progression of diabetic kidney disease.
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subjectAdult ; Albumin ; Article ; Chronic kidney failure ; Clinical outcomes ; Cross-Sectional Studies ; Death ; Deoxyguanosine ; Deoxyguanosine - analogs & derivatives ; Deoxyguanosine - blood ; Deoxyribonucleic acid ; Development and progression ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus, Type 1 - blood ; Diabetes Mellitus, Type 1 - complications ; Diabetes Mellitus, Type 1 - mortality ; DNA ; DNA Damage ; End-stage renal disease ; Epidermal growth factor receptors ; Female ; Follow-Up Studies ; Glomerular Filtration Rate ; Health risk assessment ; Human Physiology ; Humans ; Internal Medicine ; Kidney diseases ; Kidney Failure, Chronic - blood ; Kidney Failure, Chronic - complications ; Kidney Failure, Chronic - mortality ; Male ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Middle Aged ; Mortality ; Oxidative Stress ; Oxygen - chemistry ; Prospective Studies ; Risk Factors ; Sensitivity and Specificity ; Type 1 diabetes
ispartofDiabetologia, 2017, Vol.61 (4), p.977-984
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0Springer-Verlag GmbH Germany, part of Springer Nature 2017
1COPYRIGHT 2018 Springer
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3Moutairou, Abdul
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descriptionAims/hypothesis Oxidative stress is involved in the pathogenesis of diabetic kidney disease. We evaluated the association between 8-hydroxy-2′-deoxyguanosine (8-OHdG), a marker of DNA oxidative damage, and end-stage renal disease (ESRD) or death in individuals with type 1 diabetes. Methods Plasma 8-OHdG concentrations were measured at baseline in participants with type 1 diabetes from GENEDIAB ( n  = 348) and GENESIS ( n  = 571) cohorts. A follow-up was conducted in 205 and 499 participants for a mean ± SD duration of 8.9 ± 2.3 years and 5.2 ± 1.9 years, respectively. We tested associations between 8-OHdG concentrations and urinary albumin concentration (UAC) or eGFR at baseline, and the risk of ESRD or all-cause mortality during follow-up. Analyses were performed in pooled cohorts. Results The highest UAC (geometric mean [95% CI]) was observed in the third 8-OHdG tertile (tertile 1, 9 [6, 13] mg/l; tertile 2, 10 [7, 16] mg/l; tertile 3, 16 [10, 25] mg/l; p  = 0.36 for tertile 1 vs tertile 2 and p  = 0.003 for tertile 3 vs tertile 1) after adjustment for potential confounding covariates. The lowest eGFR (mean [95% CI]) was observed in the third tertile (tertile 1, 87 [82, 93] ml min −1 1.73 m −2 ; tertile 2, 88 [82, 94] ml min −1 1.73 m −2 ; tertile 3, 74 [68, 80] ml min −1 1.73 m −2 ; p  = 0.61 for tertile 1 vs tertile 2; p  < 0.001 for tertile 3 vs tertile 1). ESRD and death occurred in 48 and 64 individuals, respectively. The HR for ESRD, but not death, was higher in the third tertile than in the first (tertile 2 vs tertile 1, 1.45 [0.45, 5.04], p  = 0.54; tertile 3 vs tertile 1, 3.05 [1.16, 9.60], p  = 0.02) after multiple adjustments. Conclusions/interpretation Higher plasma concentrations of 8-OHdG were independently associated with increased risk of kidney disease in individuals with type 1 diabetes, suggesting that this marker can be used to evaluate the progression of diabetic kidney disease.
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10Deoxyribonucleic acid
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15Diabetes Mellitus, Type 1 - complications
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19End-stage renal disease
20Epidermal growth factor receptors
21Female
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23Glomerular Filtration Rate
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titlePlasma concentrations of 8-hydroxy-2′-deoxyguanosine and risk of kidney disease and death in individuals with type 1 diabetes
authorSanchez, Manuel ; Roussel, Ronan ; Hadjadj, Samy ; Moutairou, Abdul ; Marre, Michel ; Velho, Gilberto ; Mohammedi, Kamel
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abstractAims/hypothesis Oxidative stress is involved in the pathogenesis of diabetic kidney disease. We evaluated the association between 8-hydroxy-2′-deoxyguanosine (8-OHdG), a marker of DNA oxidative damage, and end-stage renal disease (ESRD) or death in individuals with type 1 diabetes. Methods Plasma 8-OHdG concentrations were measured at baseline in participants with type 1 diabetes from GENEDIAB ( n  = 348) and GENESIS ( n  = 571) cohorts. A follow-up was conducted in 205 and 499 participants for a mean ± SD duration of 8.9 ± 2.3 years and 5.2 ± 1.9 years, respectively. We tested associations between 8-OHdG concentrations and urinary albumin concentration (UAC) or eGFR at baseline, and the risk of ESRD or all-cause mortality during follow-up. Analyses were performed in pooled cohorts. Results The highest UAC (geometric mean [95% CI]) was observed in the third 8-OHdG tertile (tertile 1, 9 [6, 13] mg/l; tertile 2, 10 [7, 16] mg/l; tertile 3, 16 [10, 25] mg/l; p  = 0.36 for tertile 1 vs tertile 2 and p  = 0.003 for tertile 3 vs tertile 1) after adjustment for potential confounding covariates. The lowest eGFR (mean [95% CI]) was observed in the third tertile (tertile 1, 87 [82, 93] ml min −1 1.73 m −2 ; tertile 2, 88 [82, 94] ml min −1 1.73 m −2 ; tertile 3, 74 [68, 80] ml min −1 1.73 m −2 ; p  = 0.61 for tertile 1 vs tertile 2; p  < 0.001 for tertile 3 vs tertile 1). ESRD and death occurred in 48 and 64 individuals, respectively. The HR for ESRD, but not death, was higher in the third tertile than in the first (tertile 2 vs tertile 1, 1.45 [0.45, 5.04], p  = 0.54; tertile 3 vs tertile 1, 3.05 [1.16, 9.60], p  = 0.02) after multiple adjustments. Conclusions/interpretation Higher plasma concentrations of 8-OHdG were independently associated with increased risk of kidney disease in individuals with type 1 diabetes, suggesting that this marker can be used to evaluate the progression of diabetic kidney disease.
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