Downregulation of genes involved in NFκB activation in peripheral blood mononuclear cells after weight loss is associated with the improvement of insulin sensitivity in individuals with the metabolic syndrome: the GENOBIN study
Journal Title: | Diabetologia 2008-08-30, Vol.51 (11), p.2060-2067 |
Main Author: | de Mello, V. D. F |
Other Authors: | Kolehmainen, M , Pulkkinen, L , Schwab, U , Mager, U , Laaksonen, D. E , Niskanen, L , Gylling, H , Atalay, M , Rauramaa, R , Uusitupa, M |
Format: |
![]() |
Language: |
English |
Subjects: | |
Publisher: | Berlin/Heidelberg: Springer-Verlag |
ID: | ISSN: 0012-186X |
Zum Text: |
SendSend as email
Add to Book BagAdd to Book Bag
Staff View

recordid: | cdi_proquest_miscellaneous_19719239 |
title: | Downregulation of genes involved in NFκB activation in peripheral blood mononuclear cells after weight loss is associated with the improvement of insulin sensitivity in individuals with the metabolic syndrome: the GENOBIN study |
format: | Article |
creator: |
|
subjects: |
|
ispartof: | Diabetologia, 2008-08-30, Vol.51 (11), p.2060-2067 |
description: | Aims/hypothesis The transcription factor nuclear factor-kappa-B (NFκB) is implicated in inflammatory responses, obesity and the metabolic syndrome, while immune cells appear to play a central role in mediating insulin resistance and can be used as a model to study inflammation and its relationship with insulin resistance. In peripheral blood mononuclear cells of overweight participants with the metabolic syndrome, we evaluated (1) the effect of diet-induced weight loss on the expression of genes involved in NFκB activation and (2) their association with insulin sensitivity. The genes studied were: TNF receptors TNFRSF1A and TNFRSF1B , and IL1R1 , TLR4 , TLR2 , ICAM1 , CCL5 and IKBKB . Methods We analysed data from 34 overweight participants with abnormal glucose metabolism and the metabolic syndrome, who were randomised to a weight-reduction ( n = 24) or control group ( n = 10) for 33 weeks. The mRNA expression was measured using real-time PCR. Measures of insulin and glucose homeostasis were assessed by IVGTT and OGTT. Results In general, the genes studied were downregulated after weight loss intervention. The changes in TLR4 , TLR2 , CCL5 and TNFRSF1A mRNA expression were associated with an increase in insulin sensitivity index independently of the change in waist circumference ( p |
language: | eng |
source: | |
identifier: | ISSN: 0012-186X |
fulltext: | no_fulltext |
issn: |
|
url: | Link |
@attributes |
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
PrimoNMBib |
|