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18F-FDG PET and high-resolution MRI co-registration for pre-surgical evaluation of patients with conventional MRI-negative refractory extra-temporal lobe epilepsy

Purpose Epilepsy that originates outside of the temporal lobe can present some of the most challenging problems for surgical therapy, especially for patients with conventional magnetic resonance imaging (MRI)-negative refractory extra-temporal lobe epilepsy (ETLE). This study aimed to evaluate the c... Full description

Journal Title: European journal of nuclear medicine and molecular imaging 2018-04-18, Vol.45 (9), p.1567-1572
Main Author: Ding, Yao
Other Authors: Zhu, Yuankai , Jiang, Biao , Zhou, Yongji , Jin, Bo , Hou, Haifeng , Wu, Shuang , Zhu, Junming , Wang, Zhong Irene , Wong, Chong H , Ding, Meiping , Zhang, Hong , Wang, Shuang , Tian, Mei
Format: Electronic Article Electronic Article
Language: English
Subjects:
NMR
Publisher: Berlin/Heidelberg: Springer Berlin Heidelberg
ID: ISSN: 1619-7070
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recordid: cdi_proquest_miscellaneous_2027597814
title: 18F-FDG PET and high-resolution MRI co-registration for pre-surgical evaluation of patients with conventional MRI-negative refractory extra-temporal lobe epilepsy
format: Article
creator:
  • Ding, Yao
  • Zhu, Yuankai
  • Jiang, Biao
  • Zhou, Yongji
  • Jin, Bo
  • Hou, Haifeng
  • Wu, Shuang
  • Zhu, Junming
  • Wang, Zhong Irene
  • Wong, Chong H
  • Ding, Meiping
  • Zhang, Hong
  • Wang, Shuang
  • Tian, Mei
subjects:
  • Abnormalities
  • Cardiology
  • Clinical decision making
  • Decision making
  • Emission analysis
  • Epilepsy
  • Evaluation
  • Fluorine isotopes
  • High resolution
  • Imaging
  • Lesions
  • Magnetic resonance imaging
  • Medicine
  • Medicine & Public Health
  • NMR
  • Nuclear magnetic resonance
  • Nuclear Medicine
  • Oncology
  • Orthopedics
  • Patients
  • Positron emission
  • Positron emission tomography
  • Radiology
  • Short Communication
  • Surgery
  • Temporal lobe
  • Tomography
ispartof: European journal of nuclear medicine and molecular imaging, 2018-04-18, Vol.45 (9), p.1567-1572
description: Purpose Epilepsy that originates outside of the temporal lobe can present some of the most challenging problems for surgical therapy, especially for patients with conventional magnetic resonance imaging (MRI)-negative refractory extra-temporal lobe epilepsy (ETLE). This study aimed to evaluate the clinical value of pre-surgical 18 F-fluoro-deoxy-glucose positron emission tomography ( 18 F-FDG PET) and high-resolution MRI (HR-MRI) co-registration in patients with conventional MRI-negative refractory ETLE, and compare their surgical outcomes. Methods Sixty-seven patients with conventional MRI-negative refractory ETLE were prospectively included for pre-surgical 18 F-FDG PET and HR-MRI examinations. Under the guidance of 18 F-FDG PET and HR-MRI co-registration, HR-MRI images were re-read. Based on the image result changes from first reading to re-reading, patients were divided into three groups: Change-1 (lesions of subtle abnormality could be identified in re-read), Change-2 (non-specific abnormalities reported in the first reading were considered as lesions on HR-MRI re-read) and No-change. Post-surgical follow-ups were conducted for up to 59 months. Results Visual analysis of 18 F-FDG PET showed focal or regional abnormality in 46 patients (68.6%), while the abnormal rate increased to 94.0% ( P 
language: eng
source:
identifier: ISSN: 1619-7070
fulltext: no_fulltext
issn:
  • 1619-7070
  • 1619-7089
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title18F-FDG PET and high-resolution MRI co-registration for pre-surgical evaluation of patients with conventional MRI-negative refractory extra-temporal lobe epilepsy
creatorDing, Yao ; Zhu, Yuankai ; Jiang, Biao ; Zhou, Yongji ; Jin, Bo ; Hou, Haifeng ; Wu, Shuang ; Zhu, Junming ; Wang, Zhong Irene ; Wong, Chong H ; Ding, Meiping ; Zhang, Hong ; Wang, Shuang ; Tian, Mei
creatorcontribDing, Yao ; Zhu, Yuankai ; Jiang, Biao ; Zhou, Yongji ; Jin, Bo ; Hou, Haifeng ; Wu, Shuang ; Zhu, Junming ; Wang, Zhong Irene ; Wong, Chong H ; Ding, Meiping ; Zhang, Hong ; Wang, Shuang ; Tian, Mei
descriptionPurpose Epilepsy that originates outside of the temporal lobe can present some of the most challenging problems for surgical therapy, especially for patients with conventional magnetic resonance imaging (MRI)-negative refractory extra-temporal lobe epilepsy (ETLE). This study aimed to evaluate the clinical value of pre-surgical 18 F-fluoro-deoxy-glucose positron emission tomography ( 18 F-FDG PET) and high-resolution MRI (HR-MRI) co-registration in patients with conventional MRI-negative refractory ETLE, and compare their surgical outcomes. Methods Sixty-seven patients with conventional MRI-negative refractory ETLE were prospectively included for pre-surgical 18 F-FDG PET and HR-MRI examinations. Under the guidance of 18 F-FDG PET and HR-MRI co-registration, HR-MRI images were re-read. Based on the image result changes from first reading to re-reading, patients were divided into three groups: Change-1 (lesions of subtle abnormality could be identified in re-read), Change-2 (non-specific abnormalities reported in the first reading were considered as lesions on HR-MRI re-read) and No-change. Post-surgical follow-ups were conducted for up to 59 months. Results Visual analysis of 18 F-FDG PET showed focal or regional abnormality in 46 patients (68.6%), while the abnormal rate increased to 94.0% ( P < 0.05 ) by co-registration. Of the 67 patients, 46.3% of them were identified as Change-1, and 11.9% as Change-2 after co-registration and HR-MRI re-read. Patients with Change-1 and -2 were more likely to be recommended to receive surgical resection ( P  < 0.001). In the 17 post-surgical patients, 88% had good outcomes, whereas 11.7% had poor outcomes during our study period. Conclusion Pre-surgical evaluation by co-registration of 18 F-FDG PET and HR-MRI could improve the identification of the epileptogenic onset zone (EOZ), and may further guide the surgical decision-making and improve the outcome of the refractory ETLE with normal conventional MRI; therefore, it should be recommended as a standard procedure for pre-surgical evaluation of these patients.
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subjectAbnormalities ; Cardiology ; Clinical decision making ; Decision making ; Emission analysis ; Epilepsy ; Evaluation ; Fluorine isotopes ; High resolution ; Imaging ; Lesions ; Magnetic resonance imaging ; Medicine ; Medicine & Public Health ; NMR ; Nuclear magnetic resonance ; Nuclear Medicine ; Oncology ; Orthopedics ; Patients ; Positron emission ; Positron emission tomography ; Radiology ; Short Communication ; Surgery ; Temporal lobe ; Tomography
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title
018F-FDG PET and high-resolution MRI co-registration for pre-surgical evaluation of patients with conventional MRI-negative refractory extra-temporal lobe epilepsy
1European journal of nuclear medicine and molecular imaging
addtitleEur J Nucl Med Mol Imaging
descriptionPurpose Epilepsy that originates outside of the temporal lobe can present some of the most challenging problems for surgical therapy, especially for patients with conventional magnetic resonance imaging (MRI)-negative refractory extra-temporal lobe epilepsy (ETLE). This study aimed to evaluate the clinical value of pre-surgical 18 F-fluoro-deoxy-glucose positron emission tomography ( 18 F-FDG PET) and high-resolution MRI (HR-MRI) co-registration in patients with conventional MRI-negative refractory ETLE, and compare their surgical outcomes. Methods Sixty-seven patients with conventional MRI-negative refractory ETLE were prospectively included for pre-surgical 18 F-FDG PET and HR-MRI examinations. Under the guidance of 18 F-FDG PET and HR-MRI co-registration, HR-MRI images were re-read. Based on the image result changes from first reading to re-reading, patients were divided into three groups: Change-1 (lesions of subtle abnormality could be identified in re-read), Change-2 (non-specific abnormalities reported in the first reading were considered as lesions on HR-MRI re-read) and No-change. Post-surgical follow-ups were conducted for up to 59 months. Results Visual analysis of 18 F-FDG PET showed focal or regional abnormality in 46 patients (68.6%), while the abnormal rate increased to 94.0% ( P < 0.05 ) by co-registration. Of the 67 patients, 46.3% of them were identified as Change-1, and 11.9% as Change-2 after co-registration and HR-MRI re-read. Patients with Change-1 and -2 were more likely to be recommended to receive surgical resection ( P  < 0.001). In the 17 post-surgical patients, 88% had good outcomes, whereas 11.7% had poor outcomes during our study period. Conclusion Pre-surgical evaluation by co-registration of 18 F-FDG PET and HR-MRI could improve the identification of the epileptogenic onset zone (EOZ), and may further guide the surgical decision-making and improve the outcome of the refractory ETLE with normal conventional MRI; therefore, it should be recommended as a standard procedure for pre-surgical evaluation of these patients.
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5Epilepsy
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16Nuclear Medicine
17Oncology
18Orthopedics
19Patients
20Positron emission
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25Temporal lobe
26Tomography
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title18F-FDG PET and high-resolution MRI co-registration for pre-surgical evaluation of patients with conventional MRI-negative refractory extra-temporal lobe epilepsy
authorDing, Yao ; Zhu, Yuankai ; Jiang, Biao ; Zhou, Yongji ; Jin, Bo ; Hou, Haifeng ; Wu, Shuang ; Zhu, Junming ; Wang, Zhong Irene ; Wong, Chong H ; Ding, Meiping ; Zhang, Hong ; Wang, Shuang ; Tian, Mei
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atitle18F-FDG PET and high-resolution MRI co-registration for pre-surgical evaluation of patients with conventional MRI-negative refractory extra-temporal lobe epilepsy
jtitleEuropean journal of nuclear medicine and molecular imaging
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date2018-04-18
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abstractPurpose Epilepsy that originates outside of the temporal lobe can present some of the most challenging problems for surgical therapy, especially for patients with conventional magnetic resonance imaging (MRI)-negative refractory extra-temporal lobe epilepsy (ETLE). This study aimed to evaluate the clinical value of pre-surgical 18 F-fluoro-deoxy-glucose positron emission tomography ( 18 F-FDG PET) and high-resolution MRI (HR-MRI) co-registration in patients with conventional MRI-negative refractory ETLE, and compare their surgical outcomes. Methods Sixty-seven patients with conventional MRI-negative refractory ETLE were prospectively included for pre-surgical 18 F-FDG PET and HR-MRI examinations. Under the guidance of 18 F-FDG PET and HR-MRI co-registration, HR-MRI images were re-read. Based on the image result changes from first reading to re-reading, patients were divided into three groups: Change-1 (lesions of subtle abnormality could be identified in re-read), Change-2 (non-specific abnormalities reported in the first reading were considered as lesions on HR-MRI re-read) and No-change. Post-surgical follow-ups were conducted for up to 59 months. Results Visual analysis of 18 F-FDG PET showed focal or regional abnormality in 46 patients (68.6%), while the abnormal rate increased to 94.0% ( P < 0.05 ) by co-registration. Of the 67 patients, 46.3% of them were identified as Change-1, and 11.9% as Change-2 after co-registration and HR-MRI re-read. Patients with Change-1 and -2 were more likely to be recommended to receive surgical resection ( P  < 0.001). In the 17 post-surgical patients, 88% had good outcomes, whereas 11.7% had poor outcomes during our study period. Conclusion Pre-surgical evaluation by co-registration of 18 F-FDG PET and HR-MRI could improve the identification of the epileptogenic onset zone (EOZ), and may further guide the surgical decision-making and improve the outcome of the refractory ETLE with normal conventional MRI; therefore, it should be recommended as a standard procedure for pre-surgical evaluation of these patients.
copBerlin/Heidelberg
pubSpringer Berlin Heidelberg
doi10.1007/s00259-018-4017-0