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Prevalence of abdominal cystic echinococcosis in rural Bulgaria, Romania, and Turkey: a cross-sectional, ultrasound-based, population study from the HERACLES project

Cystic echinococcosis is a neglected zoonotic infection that is distributed worldwide and prioritised by WHO for control efforts. The burden of human cystic echinococcosis is poorly understood in most endemic regions, including eastern Europe. We aimed to estimate the prevalence of abdominal cystic... Full description

Journal Title: The Lancet infectious diseases 2018, Vol.18 (7), p.769-778
Main Author: Tamarozzi, Francesca
Other Authors: Akhan, Okan , Cretu, Carmen Michaela , Vutova, Kamenna , Akinci, Devrim , Chipeva, Rossitza , Ciftci, Turkmen , Constantin, Corina Manuela , Fabiani, Massimo , Golemanov, Branimir , Janta, Denisa , Mihailescu, Patricia , Muhtarov, Marin , Orsten, Serra , Petrutescu, Marius , Pezzotti, Patrizio , Popa, Alexandru Cosmin , Popa, Loredana Gabriela , Popa, Mircea Ioan , Velev, Valeri , Siles-Lucas, Mar , Brunetti, Enrico , Casulli, Adriano
Format: Electronic Article Electronic Article
Language: English
Subjects:
Age
Sex
Quelle: Alma/SFX Local Collection
Publisher: United States: Elsevier Ltd
ID: ISSN: 1473-3099
Link: https://www.ncbi.nlm.nih.gov/pubmed/29793823
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title: Prevalence of abdominal cystic echinococcosis in rural Bulgaria, Romania, and Turkey: a cross-sectional, ultrasound-based, population study from the HERACLES project
format: Article
creator:
  • Tamarozzi, Francesca
  • Akhan, Okan
  • Cretu, Carmen Michaela
  • Vutova, Kamenna
  • Akinci, Devrim
  • Chipeva, Rossitza
  • Ciftci, Turkmen
  • Constantin, Corina Manuela
  • Fabiani, Massimo
  • Golemanov, Branimir
  • Janta, Denisa
  • Mihailescu, Patricia
  • Muhtarov, Marin
  • Orsten, Serra
  • Petrutescu, Marius
  • Pezzotti, Patrizio
  • Popa, Alexandru Cosmin
  • Popa, Loredana Gabriela
  • Popa, Mircea Ioan
  • Velev, Valeri
  • Siles-Lucas, Mar
  • Brunetti, Enrico
  • Casulli, Adriano
subjects:
  • Abdomen
  • Abdomen - diagnostic imaging
  • Age
  • Analysis
  • Animals
  • Bulgaria - epidemiology
  • Children
  • Communities
  • Cross sections
  • Cross-Sectional Studies
  • Cysts
  • Disease
  • Echinococcosis
  • Echinococcosis - diagnostic imaging
  • Echinococcosis - epidemiology
  • Echinococcus granulosus
  • Estimates
  • Female
  • Hospitals
  • Humans
  • Incidence
  • Infections
  • Lesions
  • Male
  • Missing data
  • Mosques
  • Population
  • Population studies
  • Population Surveillance
  • Prevalence
  • Public health
  • Romania - epidemiology
  • Rural areas
  • Rural Population - statistics & numerical data
  • Screening
  • Sex
  • Studies
  • Turkey - epidemiology
  • Ultrasonic imaging
  • Ultrasonography
  • Ultrasound
  • Zoonoses
  • Zoonoses - epidemiology
ispartof: The Lancet infectious diseases, 2018, Vol.18 (7), p.769-778
description: Cystic echinococcosis is a neglected zoonotic infection that is distributed worldwide and prioritised by WHO for control efforts. The burden of human cystic echinococcosis is poorly understood in most endemic regions, including eastern Europe. We aimed to estimate the prevalence of abdominal cystic echinococcosis in rural areas of Bulgaria, Romania, and Turkey. We did a cross-sectional ultrasound-based survey that recruited volunteers from 50 villages in rural areas of Bulgaria, Romania, and Turkey. These villages were in provinces with annual hospital incidence of cystic echinococcosis within the mid-range for the respective countries. All people who attended a session were allowed to participate if they agreed to be screened. Abdominal ultrasound screening sessions were hosted in public community structures such as community halls, primary health-care centres, schools, and mosques. Lesions were classified using an adapted WHO classification. We reported the prevalence of abdominal cystic echinococcosis adjusted by sex and age through direct standardisation, using the country's rural population as a reference. From July 1, 2014, to Aug 3, 2015, 24 693 individuals presented to screening sessions and 24 687 underwent ultrasound screening. We excluded a further six indivduals due to missing data, leaving 24 681 people in our analysis. Abdominal cystic echinococcosis was detected in 31 of 8602 people screened in Bulgaria, 35 of 7461 screened in Romania, and 53 of 8618 screened in Turkey. The age and sex adjusted prevalence of abdominal cystic echinococcosis was 0·41% (95% CI 0·29–0·58) in Bulgaria, 0·41% (0·26–0·65) in Romania, and 0·59% (0·19–1·85) in Turkey. Active cysts were found in people of all ages, including children, and in all investigated provinces. Our results provide population-based estimates of the prevalence of abdominal cystic echinococcosis. These findings should be useful to support the planning of cost-effective interventions, supporting the WHO roadmap for cystic echinococcosis control. European Union Seventh Framework Programme.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 1473-3099
fulltext: fulltext
issn:
  • 1473-3099
  • 1474-4457
url: Link


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titlePrevalence of abdominal cystic echinococcosis in rural Bulgaria, Romania, and Turkey: a cross-sectional, ultrasound-based, population study from the HERACLES project
sourceAlma/SFX Local Collection
creatorTamarozzi, Francesca ; Akhan, Okan ; Cretu, Carmen Michaela ; Vutova, Kamenna ; Akinci, Devrim ; Chipeva, Rossitza ; Ciftci, Turkmen ; Constantin, Corina Manuela ; Fabiani, Massimo ; Golemanov, Branimir ; Janta, Denisa ; Mihailescu, Patricia ; Muhtarov, Marin ; Orsten, Serra ; Petrutescu, Marius ; Pezzotti, Patrizio ; Popa, Alexandru Cosmin ; Popa, Loredana Gabriela ; Popa, Mircea Ioan ; Velev, Valeri ; Siles-Lucas, Mar ; Brunetti, Enrico ; Casulli, Adriano
creatorcontribTamarozzi, Francesca ; Akhan, Okan ; Cretu, Carmen Michaela ; Vutova, Kamenna ; Akinci, Devrim ; Chipeva, Rossitza ; Ciftci, Turkmen ; Constantin, Corina Manuela ; Fabiani, Massimo ; Golemanov, Branimir ; Janta, Denisa ; Mihailescu, Patricia ; Muhtarov, Marin ; Orsten, Serra ; Petrutescu, Marius ; Pezzotti, Patrizio ; Popa, Alexandru Cosmin ; Popa, Loredana Gabriela ; Popa, Mircea Ioan ; Velev, Valeri ; Siles-Lucas, Mar ; Brunetti, Enrico ; Casulli, Adriano
descriptionCystic echinococcosis is a neglected zoonotic infection that is distributed worldwide and prioritised by WHO for control efforts. The burden of human cystic echinococcosis is poorly understood in most endemic regions, including eastern Europe. We aimed to estimate the prevalence of abdominal cystic echinococcosis in rural areas of Bulgaria, Romania, and Turkey. We did a cross-sectional ultrasound-based survey that recruited volunteers from 50 villages in rural areas of Bulgaria, Romania, and Turkey. These villages were in provinces with annual hospital incidence of cystic echinococcosis within the mid-range for the respective countries. All people who attended a session were allowed to participate if they agreed to be screened. Abdominal ultrasound screening sessions were hosted in public community structures such as community halls, primary health-care centres, schools, and mosques. Lesions were classified using an adapted WHO classification. We reported the prevalence of abdominal cystic echinococcosis adjusted by sex and age through direct standardisation, using the country's rural population as a reference. From July 1, 2014, to Aug 3, 2015, 24 693 individuals presented to screening sessions and 24 687 underwent ultrasound screening. We excluded a further six indivduals due to missing data, leaving 24 681 people in our analysis. Abdominal cystic echinococcosis was detected in 31 of 8602 people screened in Bulgaria, 35 of 7461 screened in Romania, and 53 of 8618 screened in Turkey. The age and sex adjusted prevalence of abdominal cystic echinococcosis was 0·41% (95% CI 0·29–0·58) in Bulgaria, 0·41% (0·26–0·65) in Romania, and 0·59% (0·19–1·85) in Turkey. Active cysts were found in people of all ages, including children, and in all investigated provinces. Our results provide population-based estimates of the prevalence of abdominal cystic echinococcosis. These findings should be useful to support the planning of cost-effective interventions, supporting the WHO roadmap for cystic echinococcosis control. European Union Seventh Framework Programme.
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subjectAbdomen ; Abdomen - diagnostic imaging ; Age ; Analysis ; Animals ; Bulgaria - epidemiology ; Children ; Communities ; Cross sections ; Cross-Sectional Studies ; Cysts ; Disease ; Echinococcosis ; Echinococcosis - diagnostic imaging ; Echinococcosis - epidemiology ; Echinococcus granulosus ; Estimates ; Female ; Hospitals ; Humans ; Incidence ; Infections ; Lesions ; Male ; Missing data ; Mosques ; Population ; Population studies ; Population Surveillance ; Prevalence ; Public health ; Romania - epidemiology ; Rural areas ; Rural Population - statistics & numerical data ; Screening ; Sex ; Studies ; Turkey - epidemiology ; Ultrasonic imaging ; Ultrasonography ; Ultrasound ; Zoonoses ; Zoonoses - epidemiology
ispartofThe Lancet infectious diseases, 2018, Vol.18 (7), p.769-778
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7Constantin, Corina Manuela
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17Popa, Loredana Gabriela
18Popa, Mircea Ioan
19Velev, Valeri
20Siles-Lucas, Mar
21Brunetti, Enrico
22Casulli, Adriano
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0Prevalence of abdominal cystic echinococcosis in rural Bulgaria, Romania, and Turkey: a cross-sectional, ultrasound-based, population study from the HERACLES project
1The Lancet infectious diseases
addtitleLancet Infect Dis
descriptionCystic echinococcosis is a neglected zoonotic infection that is distributed worldwide and prioritised by WHO for control efforts. The burden of human cystic echinococcosis is poorly understood in most endemic regions, including eastern Europe. We aimed to estimate the prevalence of abdominal cystic echinococcosis in rural areas of Bulgaria, Romania, and Turkey. We did a cross-sectional ultrasound-based survey that recruited volunteers from 50 villages in rural areas of Bulgaria, Romania, and Turkey. These villages were in provinces with annual hospital incidence of cystic echinococcosis within the mid-range for the respective countries. All people who attended a session were allowed to participate if they agreed to be screened. Abdominal ultrasound screening sessions were hosted in public community structures such as community halls, primary health-care centres, schools, and mosques. Lesions were classified using an adapted WHO classification. We reported the prevalence of abdominal cystic echinococcosis adjusted by sex and age through direct standardisation, using the country's rural population as a reference. From July 1, 2014, to Aug 3, 2015, 24 693 individuals presented to screening sessions and 24 687 underwent ultrasound screening. We excluded a further six indivduals due to missing data, leaving 24 681 people in our analysis. Abdominal cystic echinococcosis was detected in 31 of 8602 people screened in Bulgaria, 35 of 7461 screened in Romania, and 53 of 8618 screened in Turkey. The age and sex adjusted prevalence of abdominal cystic echinococcosis was 0·41% (95% CI 0·29–0·58) in Bulgaria, 0·41% (0·26–0·65) in Romania, and 0·59% (0·19–1·85) in Turkey. Active cysts were found in people of all ages, including children, and in all investigated provinces. Our results provide population-based estimates of the prevalence of abdominal cystic echinococcosis. These findings should be useful to support the planning of cost-effective interventions, supporting the WHO roadmap for cystic echinococcosis control. European Union Seventh Framework Programme.
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titlePrevalence of abdominal cystic echinococcosis in rural Bulgaria, Romania, and Turkey: a cross-sectional, ultrasound-based, population study from the HERACLES project
authorTamarozzi, Francesca ; Akhan, Okan ; Cretu, Carmen Michaela ; Vutova, Kamenna ; Akinci, Devrim ; Chipeva, Rossitza ; Ciftci, Turkmen ; Constantin, Corina Manuela ; Fabiani, Massimo ; Golemanov, Branimir ; Janta, Denisa ; Mihailescu, Patricia ; Muhtarov, Marin ; Orsten, Serra ; Petrutescu, Marius ; Pezzotti, Patrizio ; Popa, Alexandru Cosmin ; Popa, Loredana Gabriela ; Popa, Mircea Ioan ; Velev, Valeri ; Siles-Lucas, Mar ; Brunetti, Enrico ; Casulli, Adriano
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abstractCystic echinococcosis is a neglected zoonotic infection that is distributed worldwide and prioritised by WHO for control efforts. The burden of human cystic echinococcosis is poorly understood in most endemic regions, including eastern Europe. We aimed to estimate the prevalence of abdominal cystic echinococcosis in rural areas of Bulgaria, Romania, and Turkey. We did a cross-sectional ultrasound-based survey that recruited volunteers from 50 villages in rural areas of Bulgaria, Romania, and Turkey. These villages were in provinces with annual hospital incidence of cystic echinococcosis within the mid-range for the respective countries. All people who attended a session were allowed to participate if they agreed to be screened. Abdominal ultrasound screening sessions were hosted in public community structures such as community halls, primary health-care centres, schools, and mosques. Lesions were classified using an adapted WHO classification. We reported the prevalence of abdominal cystic echinococcosis adjusted by sex and age through direct standardisation, using the country's rural population as a reference. From July 1, 2014, to Aug 3, 2015, 24 693 individuals presented to screening sessions and 24 687 underwent ultrasound screening. We excluded a further six indivduals due to missing data, leaving 24 681 people in our analysis. Abdominal cystic echinococcosis was detected in 31 of 8602 people screened in Bulgaria, 35 of 7461 screened in Romania, and 53 of 8618 screened in Turkey. The age and sex adjusted prevalence of abdominal cystic echinococcosis was 0·41% (95% CI 0·29–0·58) in Bulgaria, 0·41% (0·26–0·65) in Romania, and 0·59% (0·19–1·85) in Turkey. Active cysts were found in people of all ages, including children, and in all investigated provinces. Our results provide population-based estimates of the prevalence of abdominal cystic echinococcosis. These findings should be useful to support the planning of cost-effective interventions, supporting the WHO roadmap for cystic echinococcosis control. European Union Seventh Framework Programme.
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pubElsevier Ltd
pmid29793823
doi10.1016/S1473-3099(18)30221-4