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Potential impact of maternal vaccination on life-threatening respiratory syncytial virus infection during infancy

Respiratory syncytial virus (RSV) infection is an important cause of infant mortality. Here, we estimated the potential impact of maternal vaccination against RSV on life-threatening RSV infection in infants. We developed a mathematical model for maternal vaccine-induced antibody dynamics and used c... Full description

Journal Title: Vaccine 2018-07-25, Vol.36 (31), p.4693-4700
Main Author: Scheltema, Nienke M
Other Authors: Kavelaars, Xynthia M , Thorburn, Kentigern , Hennus, Marije P , van Woensel, Job B , van der Ent, Cornelis K , Borghans, José A.M , Bont, Louis J , Drylewicz, Julia
Format: Electronic Article Electronic Article
Language: English
Subjects:
RSV
Quelle: Alma/SFX Local Collection
Publisher: Netherlands: Elsevier Ltd
ID: ISSN: 0264-410X
Link: https://www.ncbi.nlm.nih.gov/pubmed/29941327
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title: Potential impact of maternal vaccination on life-threatening respiratory syncytial virus infection during infancy
format: Article
creator:
  • Scheltema, Nienke M
  • Kavelaars, Xynthia M
  • Thorburn, Kentigern
  • Hennus, Marije P
  • van Woensel, Job B
  • van der Ent, Cornelis K
  • Borghans, José A.M
  • Bont, Louis J
  • Drylewicz, Julia
subjects:
  • Analysis
  • Antibodies, Viral - blood
  • Antibody Formation
  • Children
  • Development and progression
  • Female
  • Gestational age
  • Hospitalization
  • Humans
  • Immunization
  • Infant
  • Infant mortality
  • Infant, Newborn
  • Infants
  • Infections
  • Life-threatening infections
  • Male
  • Maternal vaccination
  • Mathematical model
  • Mathematical models
  • Medical research
  • Medicine, Experimental
  • Models
  • Models, Theoretical
  • Mortality
  • Netherlands - epidemiology
  • Patient outcomes
  • Pregnancy
  • Respiratory syncytial virus
  • Respiratory Syncytial Virus Infections - epidemiology
  • Respiratory Syncytial Virus Infections - mortality
  • Respiratory Syncytial Virus Infections - prevention & control
  • Respiratory Syncytial Virus Vaccines - administration & dosage
  • Respiratory Syncytial Virus Vaccines - immunology
  • RSV
  • Survival Analysis
  • United Kingdom - epidemiology
  • Vaccination
  • Vaccination - methods
  • Vaccines
  • Virus diseases
  • Viruses
ispartof: Vaccine, 2018-07-25, Vol.36 (31), p.4693-4700
description: Respiratory syncytial virus (RSV) infection is an important cause of infant mortality. Here, we estimated the potential impact of maternal vaccination against RSV on life-threatening RSV infection in infants. We developed a mathematical model for maternal vaccine-induced antibody dynamics and used characteristics of a maternal RSV vaccine currently in phase 3 of clinical development. The model was applied to data from two cohorts of children younger than 12 months with RSV-related paediatric intensive care unit (PICU) admission in the United Kingdom (n = 370) and the Netherlands (n = 167), and a cohort of 211 children younger than 12 months with RSV-related in-hospital death from 20 countries worldwide. Our model predicted that, depending on vaccine efficiency, maternal vaccination at 30 weeks’ gestational age could have prevented 62–75% of RSV-related PICU admissions in the United Kingdom and 76–87% in the Netherlands. For the global mortality cohort, the model predicted that maternal vaccination could have prevented 29–48% of RSV-related in-hospital deaths. Preterm children and children with comorbidities were predicted to benefit less than (healthy) term children. Maternal vaccination against RSV may substantially decrease life-threatening RSV infections in infants.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0264-410X
fulltext: fulltext
issn:
  • 0264-410X
  • 1873-2518
url: Link


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titlePotential impact of maternal vaccination on life-threatening respiratory syncytial virus infection during infancy
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creatorScheltema, Nienke M ; Kavelaars, Xynthia M ; Thorburn, Kentigern ; Hennus, Marije P ; van Woensel, Job B ; van der Ent, Cornelis K ; Borghans, José A.M ; Bont, Louis J ; Drylewicz, Julia
creatorcontribScheltema, Nienke M ; Kavelaars, Xynthia M ; Thorburn, Kentigern ; Hennus, Marije P ; van Woensel, Job B ; van der Ent, Cornelis K ; Borghans, José A.M ; Bont, Louis J ; Drylewicz, Julia
descriptionRespiratory syncytial virus (RSV) infection is an important cause of infant mortality. Here, we estimated the potential impact of maternal vaccination against RSV on life-threatening RSV infection in infants. We developed a mathematical model for maternal vaccine-induced antibody dynamics and used characteristics of a maternal RSV vaccine currently in phase 3 of clinical development. The model was applied to data from two cohorts of children younger than 12 months with RSV-related paediatric intensive care unit (PICU) admission in the United Kingdom (n = 370) and the Netherlands (n = 167), and a cohort of 211 children younger than 12 months with RSV-related in-hospital death from 20 countries worldwide. Our model predicted that, depending on vaccine efficiency, maternal vaccination at 30 weeks’ gestational age could have prevented 62–75% of RSV-related PICU admissions in the United Kingdom and 76–87% in the Netherlands. For the global mortality cohort, the model predicted that maternal vaccination could have prevented 29–48% of RSV-related in-hospital deaths. Preterm children and children with comorbidities were predicted to benefit less than (healthy) term children. Maternal vaccination against RSV may substantially decrease life-threatening RSV infections in infants.
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subjectAnalysis ; Antibodies, Viral - blood ; Antibody Formation ; Children ; Development and progression ; Female ; Gestational age ; Hospitalization ; Humans ; Immunization ; Infant ; Infant mortality ; Infant, Newborn ; Infants ; Infections ; Life-threatening infections ; Male ; Maternal vaccination ; Mathematical model ; Mathematical models ; Medical research ; Medicine, Experimental ; Models ; Models, Theoretical ; Mortality ; Netherlands - epidemiology ; Patient outcomes ; Pregnancy ; Respiratory syncytial virus ; Respiratory Syncytial Virus Infections - epidemiology ; Respiratory Syncytial Virus Infections - mortality ; Respiratory Syncytial Virus Infections - prevention & control ; Respiratory Syncytial Virus Vaccines - administration & dosage ; Respiratory Syncytial Virus Vaccines - immunology ; RSV ; Survival Analysis ; United Kingdom - epidemiology ; Vaccination ; Vaccination - methods ; Vaccines ; Virus diseases ; Viruses
ispartofVaccine, 2018-07-25, Vol.36 (31), p.4693-4700
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descriptionRespiratory syncytial virus (RSV) infection is an important cause of infant mortality. Here, we estimated the potential impact of maternal vaccination against RSV on life-threatening RSV infection in infants. We developed a mathematical model for maternal vaccine-induced antibody dynamics and used characteristics of a maternal RSV vaccine currently in phase 3 of clinical development. The model was applied to data from two cohorts of children younger than 12 months with RSV-related paediatric intensive care unit (PICU) admission in the United Kingdom (n = 370) and the Netherlands (n = 167), and a cohort of 211 children younger than 12 months with RSV-related in-hospital death from 20 countries worldwide. Our model predicted that, depending on vaccine efficiency, maternal vaccination at 30 weeks’ gestational age could have prevented 62–75% of RSV-related PICU admissions in the United Kingdom and 76–87% in the Netherlands. For the global mortality cohort, the model predicted that maternal vaccination could have prevented 29–48% of RSV-related in-hospital deaths. Preterm children and children with comorbidities were predicted to benefit less than (healthy) term children. Maternal vaccination against RSV may substantially decrease life-threatening RSV infections in infants.
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6Gestational age
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9Immunization
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11Infant mortality
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19Mathematical models
20Medical research
21Medicine, Experimental
22Models
23Models, Theoretical
24Mortality
25Netherlands - epidemiology
26Patient outcomes
27Pregnancy
28Respiratory syncytial virus
29Respiratory Syncytial Virus Infections - epidemiology
30Respiratory Syncytial Virus Infections - mortality
31Respiratory Syncytial Virus Infections - prevention & control
32Respiratory Syncytial Virus Vaccines - administration & dosage
33Respiratory Syncytial Virus Vaccines - immunology
34RSV
35Survival Analysis
36United Kingdom - epidemiology
37Vaccination
38Vaccination - methods
39Vaccines
40Virus diseases
41Viruses
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titlePotential impact of maternal vaccination on life-threatening respiratory syncytial virus infection during infancy
authorScheltema, Nienke M ; Kavelaars, Xynthia M ; Thorburn, Kentigern ; Hennus, Marije P ; van Woensel, Job B ; van der Ent, Cornelis K ; Borghans, José A.M ; Bont, Louis J ; Drylewicz, Julia
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6Borghans, José A.M
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abstractRespiratory syncytial virus (RSV) infection is an important cause of infant mortality. Here, we estimated the potential impact of maternal vaccination against RSV on life-threatening RSV infection in infants. We developed a mathematical model for maternal vaccine-induced antibody dynamics and used characteristics of a maternal RSV vaccine currently in phase 3 of clinical development. The model was applied to data from two cohorts of children younger than 12 months with RSV-related paediatric intensive care unit (PICU) admission in the United Kingdom (n = 370) and the Netherlands (n = 167), and a cohort of 211 children younger than 12 months with RSV-related in-hospital death from 20 countries worldwide. Our model predicted that, depending on vaccine efficiency, maternal vaccination at 30 weeks’ gestational age could have prevented 62–75% of RSV-related PICU admissions in the United Kingdom and 76–87% in the Netherlands. For the global mortality cohort, the model predicted that maternal vaccination could have prevented 29–48% of RSV-related in-hospital deaths. Preterm children and children with comorbidities were predicted to benefit less than (healthy) term children. Maternal vaccination against RSV may substantially decrease life-threatening RSV infections in infants.
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pmid29941327
doi10.1016/j.vaccine.2018.06.021
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