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Is Antioxidant Therapy a Viable Alternative for Mild Cognitive Impairment? Examination of the Evidence

Therapeutic interventions for the prodromal stages of dementia are currently being sought with a view to delaying if not preventing disease onset. Uncertainty as to whether cognitive disorder in a given individual will progress towards dementia and adverse drug side effects has led to hesitancy on t... Full description

Journal Title: Dementia and geriatric cognitive disorders 2007-06, Vol.24 (1), p.1-19
Main Author: Ancelin, Marie-Laure
Other Authors: Christen, Yves , Ritchie, Karen
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: Basel, Switzerland: Karger
ID: ISSN: 1420-8008
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recordid: cdi_proquest_miscellaneous_20693297
title: Is Antioxidant Therapy a Viable Alternative for Mild Cognitive Impairment? Examination of the Evidence
format: Article
creator:
  • Ancelin, Marie-Laure
  • Christen, Yves
  • Ritchie, Karen
subjects:
  • Aged
  • Alzheimer Disease - drug therapy
  • Alzheimer Disease - metabolism
  • Amyloid beta-Peptides - metabolism
  • Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy
  • Antioxidants - pharmacology
  • Antioxidants - therapeutic use
  • Biological and medical sciences
  • Blood. Blood coagulation. Reticuloendothelial system
  • Cognition Disorders - drug therapy
  • Cognition Disorders - metabolism
  • Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases
  • Emergency and intensive care: comas and nervous system diseases
  • Flavonoids - pharmacology
  • Flavonoids - therapeutic use
  • Humans
  • Intensive care medicine
  • Medical sciences
  • Neurology
  • Pharmacology. Drug treatments
  • Reactive Oxygen Species - metabolism
  • Review Article
  • Superoxide Dismutase
  • Vitamin E - pharmacology
  • Vitamin E - therapeutic use
  • Wine
ispartof: Dementia and geriatric cognitive disorders, 2007-06, Vol.24 (1), p.1-19
description: Therapeutic interventions for the prodromal stages of dementia are currently being sought with a view to delaying if not preventing disease onset. Uncertainty as to whether cognitive disorder in a given individual will progress towards dementia and adverse drug side effects has led to hesitancy on the part of drug regulators to instigate preventive pharmacotherapies. In this context, antioxidant therapies may provide a low-risk alternative, targeting very early biological changes. While a growing body of knowledge demonstrates both the importance of oxidative stress in the aetiology of dementia and the efficacy of antioxidant treatment in animal and cellular models, studies in humans are presently inconclusive. While some antioxidants, notably flavonoid- or vitamin-rich diets, appear to lower the relative risk for Alzheimer’s disease in humans in observational studies, these results must be interpreted in the light of the biological complexity of the relationship between oxidative stress and neurodegeneration, and the methodological and theoretical shortcomings of studies conducted to date. A clearer understanding of these factors will assist in the interpretation of the results of the intervention studies which are now being undertaken; these studies being the only current means of establishing efficacy for preventive drug treatment of Alzheimer’s disease.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 1420-8008
fulltext: fulltext
issn:
  • 1420-8008
  • 1421-9824
url: Link


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descriptionTherapeutic interventions for the prodromal stages of dementia are currently being sought with a view to delaying if not preventing disease onset. Uncertainty as to whether cognitive disorder in a given individual will progress towards dementia and adverse drug side effects has led to hesitancy on the part of drug regulators to instigate preventive pharmacotherapies. In this context, antioxidant therapies may provide a low-risk alternative, targeting very early biological changes. While a growing body of knowledge demonstrates both the importance of oxidative stress in the aetiology of dementia and the efficacy of antioxidant treatment in animal and cellular models, studies in humans are presently inconclusive. While some antioxidants, notably flavonoid- or vitamin-rich diets, appear to lower the relative risk for Alzheimer’s disease in humans in observational studies, these results must be interpreted in the light of the biological complexity of the relationship between oxidative stress and neurodegeneration, and the methodological and theoretical shortcomings of studies conducted to date. A clearer understanding of these factors will assist in the interpretation of the results of the intervention studies which are now being undertaken; these studies being the only current means of establishing efficacy for preventive drug treatment of Alzheimer’s disease.
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subjectAged ; Alzheimer Disease - drug therapy ; Alzheimer Disease - metabolism ; Amyloid beta-Peptides - metabolism ; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy ; Antioxidants - pharmacology ; Antioxidants - therapeutic use ; Biological and medical sciences ; Blood. Blood coagulation. Reticuloendothelial system ; Cognition Disorders - drug therapy ; Cognition Disorders - metabolism ; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases ; Emergency and intensive care: comas and nervous system diseases ; Flavonoids - pharmacology ; Flavonoids - therapeutic use ; Humans ; Intensive care medicine ; Medical sciences ; Neurology ; Pharmacology. Drug treatments ; Reactive Oxygen Species - metabolism ; Review Article ; Superoxide Dismutase ; Vitamin E - pharmacology ; Vitamin E - therapeutic use ; Wine
ispartofDementia and geriatric cognitive disorders, 2007-06, Vol.24 (1), p.1-19
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descriptionTherapeutic interventions for the prodromal stages of dementia are currently being sought with a view to delaying if not preventing disease onset. Uncertainty as to whether cognitive disorder in a given individual will progress towards dementia and adverse drug side effects has led to hesitancy on the part of drug regulators to instigate preventive pharmacotherapies. In this context, antioxidant therapies may provide a low-risk alternative, targeting very early biological changes. While a growing body of knowledge demonstrates both the importance of oxidative stress in the aetiology of dementia and the efficacy of antioxidant treatment in animal and cellular models, studies in humans are presently inconclusive. While some antioxidants, notably flavonoid- or vitamin-rich diets, appear to lower the relative risk for Alzheimer’s disease in humans in observational studies, these results must be interpreted in the light of the biological complexity of the relationship between oxidative stress and neurodegeneration, and the methodological and theoretical shortcomings of studies conducted to date. A clearer understanding of these factors will assist in the interpretation of the results of the intervention studies which are now being undertaken; these studies being the only current means of establishing efficacy for preventive drug treatment of Alzheimer’s disease.
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8Blood. Blood coagulation. Reticuloendothelial system
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14Flavonoids - therapeutic use
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16Intensive care medicine
17Medical sciences
18Neurology
19Pharmacology. Drug treatments
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abstractTherapeutic interventions for the prodromal stages of dementia are currently being sought with a view to delaying if not preventing disease onset. Uncertainty as to whether cognitive disorder in a given individual will progress towards dementia and adverse drug side effects has led to hesitancy on the part of drug regulators to instigate preventive pharmacotherapies. In this context, antioxidant therapies may provide a low-risk alternative, targeting very early biological changes. While a growing body of knowledge demonstrates both the importance of oxidative stress in the aetiology of dementia and the efficacy of antioxidant treatment in animal and cellular models, studies in humans are presently inconclusive. While some antioxidants, notably flavonoid- or vitamin-rich diets, appear to lower the relative risk for Alzheimer’s disease in humans in observational studies, these results must be interpreted in the light of the biological complexity of the relationship between oxidative stress and neurodegeneration, and the methodological and theoretical shortcomings of studies conducted to date. A clearer understanding of these factors will assist in the interpretation of the results of the intervention studies which are now being undertaken; these studies being the only current means of establishing efficacy for preventive drug treatment of Alzheimer’s disease.
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