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Extrathyroidal Extension: Does Strap Muscle Invasion Alone Influence Recurrence and Survival in Patients with Differentiated Thyroid Cancer?

Background According to the 8th edition American Joint Committee on Cancer staging system, extrathyroidal extension (ETE) and primary tumor size remain the principle determinants of T stage. However, impact of gross ETE into strap muscles on survival remains controversial. Patients and Methods A ret... Full description

Journal Title: Annals of surgical oncology 2018-07-18, Vol.25 (11), p.3380-3388
Main Author: Amit, Moran
Other Authors: Boonsripitayanon, Mongkol , Goepfert, Ryan P , Tam, Samantha , Busaidy, Naifa L , Cabanillas, Maria E , Dadu, Ramona , Varghese, Jeena , Waguespack, Steven G , Gross, Neil D , Graham, Paul , Williams, Michelle D , Sturgis, Erich M , Zafereo, Mark E
Format: Electronic Article Electronic Article
Language: English
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Publisher: Cham: Springer International Publishing
ID: ISSN: 1068-9265
Link: https://www.ncbi.nlm.nih.gov/pubmed/30022274
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title: Extrathyroidal Extension: Does Strap Muscle Invasion Alone Influence Recurrence and Survival in Patients with Differentiated Thyroid Cancer?
format: Article
creator:
  • Amit, Moran
  • Boonsripitayanon, Mongkol
  • Goepfert, Ryan P
  • Tam, Samantha
  • Busaidy, Naifa L
  • Cabanillas, Maria E
  • Dadu, Ramona
  • Varghese, Jeena
  • Waguespack, Steven G
  • Gross, Neil D
  • Graham, Paul
  • Williams, Michelle D
  • Sturgis, Erich M
  • Zafereo, Mark E
subjects:
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Carcinoma, Papillary - mortality
  • Carcinoma, Papillary - pathology
  • Carcinoma, Papillary - surgery
  • Female
  • Follow-Up Studies
  • Head and Neck Oncology
  • Humans
  • Lymphatic Metastasis
  • Male
  • Medicine
  • Medicine & Public Health
  • Middle Aged
  • Multivariate analysis
  • Muscle Neoplasms - mortality
  • Muscle Neoplasms - pathology
  • Muscle Neoplasms - surgery
  • Muscles
  • Neck Muscles - pathology
  • Neck Muscles - surgery
  • Neoplasm Invasiveness
  • Neoplasm Recurrence, Local - mortality
  • Neoplasm Recurrence, Local - pathology
  • Neoplasm Recurrence, Local - surgery
  • Oncology
  • Prognosis
  • Retrospective Studies
  • Statistical analysis
  • Surgery
  • Surgical Oncology
  • Survival
  • Survival Rate
  • Thyroid
  • Thyroid cancer
  • Thyroid Neoplasms - mortality
  • Thyroid Neoplasms - pathology
  • Thyroid Neoplasms - surgery
  • Thyroidectomy - mortality
  • Young Adult
ispartof: Annals of surgical oncology, 2018-07-18, Vol.25 (11), p.3380-3388
description: Background According to the 8th edition American Joint Committee on Cancer staging system, extrathyroidal extension (ETE) and primary tumor size remain the principle determinants of T stage. However, impact of gross ETE into strap muscles on survival remains controversial. Patients and Methods A retrospective review of 2084 patients with ≤ 4 cm nonmetastatic differentiated thyroid cancer who underwent surgery between 2000 and 2015 was conducted. Patients were divided into three groups according to degree of ETE: no ETE (group 1), ETE into perithyroidal soft tissue (group 2), and gross ETE into strap muscle (group 3). Survivals were analyzed using Kaplan–Meier method and compared using log-rank test. Factors predictive of survival were analyzed using Cox proportional hazard model. Results Ten-year disease-free survival (DFS) of patients in groups 1–3 was 90, 82, and 83%, respectively ( p  = 0.003). On multivariate analysis, age ≥ 55 years, male sex, and pathologic N1b category predicted significantly worse DFS, while ETE into perithyroidal soft tissue or gross strap muscle invasion did not predict worse DFS. Overall survival ( p  = 0.957) and disease-specific survival ( p  =0.910) were not significantly different between the three groups. There was a statistically significant difference in locoregional recurrence-free survival between groups 1 and 2 [HR 2.02, 95% CI 1.06–3.94]. Conclusion Gross strap muscle invasion may not be an important survival prognostic factor for staging purposes. Although both gross strap muscle invasion and perithyroidal soft tissue extension may be predictive for locoregional recurrence, the distinction between them may not be as important for postoperative risk stratification.
language: eng
source:
identifier: ISSN: 1068-9265
fulltext: no_fulltext
issn:
  • 1068-9265
  • 1534-4681
url: Link


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titleExtrathyroidal Extension: Does Strap Muscle Invasion Alone Influence Recurrence and Survival in Patients with Differentiated Thyroid Cancer?
creatorAmit, Moran ; Boonsripitayanon, Mongkol ; Goepfert, Ryan P ; Tam, Samantha ; Busaidy, Naifa L ; Cabanillas, Maria E ; Dadu, Ramona ; Varghese, Jeena ; Waguespack, Steven G ; Gross, Neil D ; Graham, Paul ; Williams, Michelle D ; Sturgis, Erich M ; Zafereo, Mark E
creatorcontribAmit, Moran ; Boonsripitayanon, Mongkol ; Goepfert, Ryan P ; Tam, Samantha ; Busaidy, Naifa L ; Cabanillas, Maria E ; Dadu, Ramona ; Varghese, Jeena ; Waguespack, Steven G ; Gross, Neil D ; Graham, Paul ; Williams, Michelle D ; Sturgis, Erich M ; Zafereo, Mark E
descriptionBackground According to the 8th edition American Joint Committee on Cancer staging system, extrathyroidal extension (ETE) and primary tumor size remain the principle determinants of T stage. However, impact of gross ETE into strap muscles on survival remains controversial. Patients and Methods A retrospective review of 2084 patients with ≤ 4 cm nonmetastatic differentiated thyroid cancer who underwent surgery between 2000 and 2015 was conducted. Patients were divided into three groups according to degree of ETE: no ETE (group 1), ETE into perithyroidal soft tissue (group 2), and gross ETE into strap muscle (group 3). Survivals were analyzed using Kaplan–Meier method and compared using log-rank test. Factors predictive of survival were analyzed using Cox proportional hazard model. Results Ten-year disease-free survival (DFS) of patients in groups 1–3 was 90, 82, and 83%, respectively ( p  = 0.003). On multivariate analysis, age ≥ 55 years, male sex, and pathologic N1b category predicted significantly worse DFS, while ETE into perithyroidal soft tissue or gross strap muscle invasion did not predict worse DFS. Overall survival ( p  = 0.957) and disease-specific survival ( p  =0.910) were not significantly different between the three groups. There was a statistically significant difference in locoregional recurrence-free survival between groups 1 and 2 [HR 2.02, 95% CI 1.06–3.94]. Conclusion Gross strap muscle invasion may not be an important survival prognostic factor for staging purposes. Although both gross strap muscle invasion and perithyroidal soft tissue extension may be predictive for locoregional recurrence, the distinction between them may not be as important for postoperative risk stratification.
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languageeng
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subjectAdolescent ; Adult ; Aged ; Aged, 80 and over ; Carcinoma, Papillary - mortality ; Carcinoma, Papillary - pathology ; Carcinoma, Papillary - surgery ; Female ; Follow-Up Studies ; Head and Neck Oncology ; Humans ; Lymphatic Metastasis ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Multivariate analysis ; Muscle Neoplasms - mortality ; Muscle Neoplasms - pathology ; Muscle Neoplasms - surgery ; Muscles ; Neck Muscles - pathology ; Neck Muscles - surgery ; Neoplasm Invasiveness ; Neoplasm Recurrence, Local - mortality ; Neoplasm Recurrence, Local - pathology ; Neoplasm Recurrence, Local - surgery ; Oncology ; Prognosis ; Retrospective Studies ; Statistical analysis ; Surgery ; Surgical Oncology ; Survival ; Survival Rate ; Thyroid ; Thyroid cancer ; Thyroid Neoplasms - mortality ; Thyroid Neoplasms - pathology ; Thyroid Neoplasms - surgery ; Thyroidectomy - mortality ; Young Adult
ispartofAnnals of surgical oncology, 2018-07-18, Vol.25 (11), p.3380-3388
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4Busaidy, Naifa L
5Cabanillas, Maria E
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7Varghese, Jeena
8Waguespack, Steven G
9Gross, Neil D
10Graham, Paul
11Williams, Michelle D
12Sturgis, Erich M
13Zafereo, Mark E
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0Extrathyroidal Extension: Does Strap Muscle Invasion Alone Influence Recurrence and Survival in Patients with Differentiated Thyroid Cancer?
1Annals of surgical oncology
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descriptionBackground According to the 8th edition American Joint Committee on Cancer staging system, extrathyroidal extension (ETE) and primary tumor size remain the principle determinants of T stage. However, impact of gross ETE into strap muscles on survival remains controversial. Patients and Methods A retrospective review of 2084 patients with ≤ 4 cm nonmetastatic differentiated thyroid cancer who underwent surgery between 2000 and 2015 was conducted. Patients were divided into three groups according to degree of ETE: no ETE (group 1), ETE into perithyroidal soft tissue (group 2), and gross ETE into strap muscle (group 3). Survivals were analyzed using Kaplan–Meier method and compared using log-rank test. Factors predictive of survival were analyzed using Cox proportional hazard model. Results Ten-year disease-free survival (DFS) of patients in groups 1–3 was 90, 82, and 83%, respectively ( p  = 0.003). On multivariate analysis, age ≥ 55 years, male sex, and pathologic N1b category predicted significantly worse DFS, while ETE into perithyroidal soft tissue or gross strap muscle invasion did not predict worse DFS. Overall survival ( p  = 0.957) and disease-specific survival ( p  =0.910) were not significantly different between the three groups. There was a statistically significant difference in locoregional recurrence-free survival between groups 1 and 2 [HR 2.02, 95% CI 1.06–3.94]. Conclusion Gross strap muscle invasion may not be an important survival prognostic factor for staging purposes. Although both gross strap muscle invasion and perithyroidal soft tissue extension may be predictive for locoregional recurrence, the distinction between them may not be as important for postoperative risk stratification.
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4Carcinoma, Papillary - mortality
5Carcinoma, Papillary - pathology
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7Female
8Follow-Up Studies
9Head and Neck Oncology
10Humans
11Lymphatic Metastasis
12Male
13Medicine
14Medicine & Public Health
15Middle Aged
16Multivariate analysis
17Muscle Neoplasms - mortality
18Muscle Neoplasms - pathology
19Muscle Neoplasms - surgery
20Muscles
21Neck Muscles - pathology
22Neck Muscles - surgery
23Neoplasm Invasiveness
24Neoplasm Recurrence, Local - mortality
25Neoplasm Recurrence, Local - pathology
26Neoplasm Recurrence, Local - surgery
27Oncology
28Prognosis
29Retrospective Studies
30Statistical analysis
31Surgery
32Surgical Oncology
33Survival
34Survival Rate
35Thyroid
36Thyroid cancer
37Thyroid Neoplasms - mortality
38Thyroid Neoplasms - pathology
39Thyroid Neoplasms - surgery
40Thyroidectomy - mortality
41Young Adult
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titleExtrathyroidal Extension: Does Strap Muscle Invasion Alone Influence Recurrence and Survival in Patients with Differentiated Thyroid Cancer?
authorAmit, Moran ; Boonsripitayanon, Mongkol ; Goepfert, Ryan P ; Tam, Samantha ; Busaidy, Naifa L ; Cabanillas, Maria E ; Dadu, Ramona ; Varghese, Jeena ; Waguespack, Steven G ; Gross, Neil D ; Graham, Paul ; Williams, Michelle D ; Sturgis, Erich M ; Zafereo, Mark E
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8Follow-Up Studies
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14Medicine & Public Health
15Middle Aged
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19Muscle Neoplasms - surgery
20Muscles
21Neck Muscles - pathology
22Neck Muscles - surgery
23Neoplasm Invasiveness
24Neoplasm Recurrence, Local - mortality
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26Neoplasm Recurrence, Local - surgery
27Oncology
28Prognosis
29Retrospective Studies
30Statistical analysis
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32Surgical Oncology
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35Thyroid
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37Thyroid Neoplasms - mortality
38Thyroid Neoplasms - pathology
39Thyroid Neoplasms - surgery
40Thyroidectomy - mortality
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1Boonsripitayanon, Mongkol
2Goepfert, Ryan P
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4Busaidy, Naifa L
5Cabanillas, Maria E
6Dadu, Ramona
7Varghese, Jeena
8Waguespack, Steven G
9Gross, Neil D
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1Boonsripitayanon, Mongkol
2Goepfert, Ryan P
3Tam, Samantha
4Busaidy, Naifa L
5Cabanillas, Maria E
6Dadu, Ramona
7Varghese, Jeena
8Waguespack, Steven G
9Gross, Neil D
10Graham, Paul
11Williams, Michelle D
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13Zafereo, Mark E
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atitleExtrathyroidal Extension: Does Strap Muscle Invasion Alone Influence Recurrence and Survival in Patients with Differentiated Thyroid Cancer?
jtitleAnnals of surgical oncology
stitleAnn Surg Oncol
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date2018-07-18
risdate2018
volume25
issue11
spage3380
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pages3380-3388
issn1068-9265
eissn1534-4681
abstractBackground According to the 8th edition American Joint Committee on Cancer staging system, extrathyroidal extension (ETE) and primary tumor size remain the principle determinants of T stage. However, impact of gross ETE into strap muscles on survival remains controversial. Patients and Methods A retrospective review of 2084 patients with ≤ 4 cm nonmetastatic differentiated thyroid cancer who underwent surgery between 2000 and 2015 was conducted. Patients were divided into three groups according to degree of ETE: no ETE (group 1), ETE into perithyroidal soft tissue (group 2), and gross ETE into strap muscle (group 3). Survivals were analyzed using Kaplan–Meier method and compared using log-rank test. Factors predictive of survival were analyzed using Cox proportional hazard model. Results Ten-year disease-free survival (DFS) of patients in groups 1–3 was 90, 82, and 83%, respectively ( p  = 0.003). On multivariate analysis, age ≥ 55 years, male sex, and pathologic N1b category predicted significantly worse DFS, while ETE into perithyroidal soft tissue or gross strap muscle invasion did not predict worse DFS. Overall survival ( p  = 0.957) and disease-specific survival ( p  =0.910) were not significantly different between the three groups. There was a statistically significant difference in locoregional recurrence-free survival between groups 1 and 2 [HR 2.02, 95% CI 1.06–3.94]. Conclusion Gross strap muscle invasion may not be an important survival prognostic factor for staging purposes. Although both gross strap muscle invasion and perithyroidal soft tissue extension may be predictive for locoregional recurrence, the distinction between them may not be as important for postoperative risk stratification.
copCham
pubSpringer International Publishing
pmid30022274
doi10.1245/s10434-018-6563-x