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Estimating glomerular filtration rate in children: evaluation of creatinine- and cystatin C-based equations

Background Glomerular filtration rate (GFR) estimated by creatinine- and/or cystatin C-based equations (eGFR) is widely used in daily practice. The purpose of our study was to compare new and old eGFR equations with measured GFR (mGFR) by iohexol clearance in a cohort of children with chronic kidney... Full description

Journal Title: Pediatric nephrology (Berlin West), 2018, Vol.34 (2), p.301-311
Main Author: Salvador, Cathrin L
Other Authors: Tøndel, Camilla , Rowe, Alexander D , Bjerre, Anna , Brun, Atle , Brackman, Damien , Mørkrid, Lars
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Berlin/Heidelberg: Springer Berlin Heidelberg
ID: ISSN: 0931-041X
Link: https://www.ncbi.nlm.nih.gov/pubmed/30171354
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title: Estimating glomerular filtration rate in children: evaluation of creatinine- and cystatin C-based equations
format: Article
creator:
  • Salvador, Cathrin L
  • Tøndel, Camilla
  • Rowe, Alexander D
  • Bjerre, Anna
  • Brun, Atle
  • Brackman, Damien
  • Mørkrid, Lars
subjects:
  • Accuracy
  • Adolescent
  • Bias
  • Body height
  • Body Height - physiology
  • Care and treatment
  • Child
  • Child, Preschool
  • Children
  • Chronic kidney failure
  • Cohort Studies
  • Creatinine
  • Creatinine - analysis
  • Creatinine - metabolism
  • Cross-Sectional Studies
  • Cystatin
  • Cystatin C
  • Cystatin C - analysis
  • Cystatin C - metabolism
  • Diagnosis
  • Epidermal growth factor receptors
  • Feasibility Studies
  • Female
  • Glomerular filtration rate
  • Glomerular Filtration Rate - physiology
  • Humans
  • Infant
  • Information systems
  • Infusions, Intravenous
  • Iohexol - administration & dosage
  • Iohexol - metabolism
  • Kidney - physiopathology
  • Male
  • Measurement
  • Medicine
  • Medicine & Public Health
  • Nephrology
  • Original Article
  • Pediatrics
  • Physiological aspects
  • Renal Elimination - physiology
  • Renal Insufficiency, Chronic - blood
  • Renal Insufficiency, Chronic - diagnosis
  • Renal Insufficiency, Chronic - physiopathology
  • Renal Insufficiency, Chronic - urine
  • Urology
  • What’s New in Chronic Kidney Disease
ispartof: Pediatric nephrology (Berlin, West), 2018, Vol.34 (2), p.301-311
description: Background Glomerular filtration rate (GFR) estimated by creatinine- and/or cystatin C-based equations (eGFR) is widely used in daily practice. The purpose of our study was to compare new and old eGFR equations with measured GFR (mGFR) by iohexol clearance in a cohort of children with chronic kidney disease (CKD). Methods We examined 96 children (median age 9.2 years (range 0.25–17.5)) with CKD stages 1–5. A 7-point iohexol clearance (GFR7p) was defined as the reference method (median mGFR 66 mL/min/1.73 m 2 , range 6–153). Ten different eGFR equations, with or without body height, were evaluated: Schwartz bedside , Schwartz CKiD , Schwartz cysC , CAPA, LM REV , (LM REV + CAPA) / 2, FAS crea , FAS cysC , FAS combi , FAS height . The accuracy was evaluated with percentage within 10 and 30% of GFR7p (P10 and P30). Results In the group with mGFR below 60 mL/min/1.73 m 2 , the Schwartz cysC equation had the lowest median bias (interquartile range; IQR) 3.27 (4.80) mL/min/1.73 m 2 and the highest accuracy with P10 of 44% and P30 of 85%. In the group with mGFR above 60 mL/min/1.73 m 2 , the Schwartz CKiD presented with the lowest bias 3.41 (13.1) mL/min/1.73 m 2 and P10 of 62% and P30 of 98%. Overall, the Schwartz cysC had the lowest bias − 1.49 (13.5) mL/min/1.73 m 2 and both Schwartz cysC and Schwartz CKiD showed P30 of 90%. P10 was 44 and 48%, respectively. Conclusions The Schwartz cysC and the combined Schwartz CKiD present with lower bias and higher accuracy as compared to the other equations. The Schwartz cysC equation is a good height-independent alternative to the Schwartz CKiD equation in children and can be reported directly by the laboratory information system. Clinical Trial Registration ClinicalTrials.gov , Identifier NCT01092260, https://clinicaltrials.gov/ct2/show/NCT01092260?term=tondel&rank=2
language: eng
source:
identifier: ISSN: 0931-041X
fulltext: no_fulltext
issn:
  • 0931-041X
  • 1432-198X
url: Link


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titleEstimating glomerular filtration rate in children: evaluation of creatinine- and cystatin C-based equations
creatorSalvador, Cathrin L ; Tøndel, Camilla ; Rowe, Alexander D ; Bjerre, Anna ; Brun, Atle ; Brackman, Damien ; Mørkrid, Lars
creatorcontribSalvador, Cathrin L ; Tøndel, Camilla ; Rowe, Alexander D ; Bjerre, Anna ; Brun, Atle ; Brackman, Damien ; Mørkrid, Lars
descriptionBackground Glomerular filtration rate (GFR) estimated by creatinine- and/or cystatin C-based equations (eGFR) is widely used in daily practice. The purpose of our study was to compare new and old eGFR equations with measured GFR (mGFR) by iohexol clearance in a cohort of children with chronic kidney disease (CKD). Methods We examined 96 children (median age 9.2 years (range 0.25–17.5)) with CKD stages 1–5. A 7-point iohexol clearance (GFR7p) was defined as the reference method (median mGFR 66 mL/min/1.73 m 2 , range 6–153). Ten different eGFR equations, with or without body height, were evaluated: Schwartz bedside , Schwartz CKiD , Schwartz cysC , CAPA, LM REV , (LM REV + CAPA) / 2, FAS crea , FAS cysC , FAS combi , FAS height . The accuracy was evaluated with percentage within 10 and 30% of GFR7p (P10 and P30). Results In the group with mGFR below 60 mL/min/1.73 m 2 , the Schwartz cysC equation had the lowest median bias (interquartile range; IQR) 3.27 (4.80) mL/min/1.73 m 2 and the highest accuracy with P10 of 44% and P30 of 85%. In the group with mGFR above 60 mL/min/1.73 m 2 , the Schwartz CKiD presented with the lowest bias 3.41 (13.1) mL/min/1.73 m 2 and P10 of 62% and P30 of 98%. Overall, the Schwartz cysC had the lowest bias − 1.49 (13.5) mL/min/1.73 m 2 and both Schwartz cysC and Schwartz CKiD showed P30 of 90%. P10 was 44 and 48%, respectively. Conclusions The Schwartz cysC and the combined Schwartz CKiD present with lower bias and higher accuracy as compared to the other equations. The Schwartz cysC equation is a good height-independent alternative to the Schwartz CKiD equation in children and can be reported directly by the laboratory information system. Clinical Trial Registration ClinicalTrials.gov , Identifier NCT01092260, https://clinicaltrials.gov/ct2/show/NCT01092260?term=tondel&rank=2
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subjectAccuracy ; Adolescent ; Bias ; Body height ; Body Height - physiology ; Care and treatment ; Child ; Child, Preschool ; Children ; Chronic kidney failure ; Cohort Studies ; Creatinine ; Creatinine - analysis ; Creatinine - metabolism ; Cross-Sectional Studies ; Cystatin ; Cystatin C ; Cystatin C - analysis ; Cystatin C - metabolism ; Diagnosis ; Epidermal growth factor receptors ; Feasibility Studies ; Female ; Glomerular filtration rate ; Glomerular Filtration Rate - physiology ; Humans ; Infant ; Information systems ; Infusions, Intravenous ; Iohexol - administration & dosage ; Iohexol - metabolism ; Kidney - physiopathology ; Male ; Measurement ; Medicine ; Medicine & Public Health ; Nephrology ; Original Article ; Pediatrics ; Physiological aspects ; Renal Elimination - physiology ; Renal Insufficiency, Chronic - blood ; Renal Insufficiency, Chronic - diagnosis ; Renal Insufficiency, Chronic - physiopathology ; Renal Insufficiency, Chronic - urine ; Urology ; What’s New in Chronic Kidney Disease
ispartofPediatric nephrology (Berlin, West), 2018, Vol.34 (2), p.301-311
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1Tøndel, Camilla
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4Brun, Atle
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6Mørkrid, Lars
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descriptionBackground Glomerular filtration rate (GFR) estimated by creatinine- and/or cystatin C-based equations (eGFR) is widely used in daily practice. The purpose of our study was to compare new and old eGFR equations with measured GFR (mGFR) by iohexol clearance in a cohort of children with chronic kidney disease (CKD). Methods We examined 96 children (median age 9.2 years (range 0.25–17.5)) with CKD stages 1–5. A 7-point iohexol clearance (GFR7p) was defined as the reference method (median mGFR 66 mL/min/1.73 m 2 , range 6–153). Ten different eGFR equations, with or without body height, were evaluated: Schwartz bedside , Schwartz CKiD , Schwartz cysC , CAPA, LM REV , (LM REV + CAPA) / 2, FAS crea , FAS cysC , FAS combi , FAS height . The accuracy was evaluated with percentage within 10 and 30% of GFR7p (P10 and P30). Results In the group with mGFR below 60 mL/min/1.73 m 2 , the Schwartz cysC equation had the lowest median bias (interquartile range; IQR) 3.27 (4.80) mL/min/1.73 m 2 and the highest accuracy with P10 of 44% and P30 of 85%. In the group with mGFR above 60 mL/min/1.73 m 2 , the Schwartz CKiD presented with the lowest bias 3.41 (13.1) mL/min/1.73 m 2 and P10 of 62% and P30 of 98%. Overall, the Schwartz cysC had the lowest bias − 1.49 (13.5) mL/min/1.73 m 2 and both Schwartz cysC and Schwartz CKiD showed P30 of 90%. P10 was 44 and 48%, respectively. Conclusions The Schwartz cysC and the combined Schwartz CKiD present with lower bias and higher accuracy as compared to the other equations. The Schwartz cysC equation is a good height-independent alternative to the Schwartz CKiD equation in children and can be reported directly by the laboratory information system. Clinical Trial Registration ClinicalTrials.gov , Identifier NCT01092260, https://clinicaltrials.gov/ct2/show/NCT01092260?term=tondel&rank=2
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3Body height
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5Care and treatment
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7Child, Preschool
8Children
9Chronic kidney failure
10Cohort Studies
11Creatinine
12Creatinine - analysis
13Creatinine - metabolism
14Cross-Sectional Studies
15Cystatin
16Cystatin C
17Cystatin C - analysis
18Cystatin C - metabolism
19Diagnosis
20Epidermal growth factor receptors
21Feasibility Studies
22Female
23Glomerular filtration rate
24Glomerular Filtration Rate - physiology
25Humans
26Infant
27Information systems
28Infusions, Intravenous
29Iohexol - administration & dosage
30Iohexol - metabolism
31Kidney - physiopathology
32Male
33Measurement
34Medicine
35Medicine & Public Health
36Nephrology
37Original Article
38Pediatrics
39Physiological aspects
40Renal Elimination - physiology
41Renal Insufficiency, Chronic - blood
42Renal Insufficiency, Chronic - diagnosis
43Renal Insufficiency, Chronic - physiopathology
44Renal Insufficiency, Chronic - urine
45Urology
46What’s New in Chronic Kidney Disease
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titleEstimating glomerular filtration rate in children: evaluation of creatinine- and cystatin C-based equations
authorSalvador, Cathrin L ; Tøndel, Camilla ; Rowe, Alexander D ; Bjerre, Anna ; Brun, Atle ; Brackman, Damien ; Mørkrid, Lars
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1Adolescent
2Bias
3Body height
4Body Height - physiology
5Care and treatment
6Child
7Child, Preschool
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9Chronic kidney failure
10Cohort Studies
11Creatinine
12Creatinine - analysis
13Creatinine - metabolism
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19Diagnosis
20Epidermal growth factor receptors
21Feasibility Studies
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23Glomerular filtration rate
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26Infant
27Information systems
28Infusions, Intravenous
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39Physiological aspects
40Renal Elimination - physiology
41Renal Insufficiency, Chronic - blood
42Renal Insufficiency, Chronic - diagnosis
43Renal Insufficiency, Chronic - physiopathology
44Renal Insufficiency, Chronic - urine
45Urology
46What’s New in Chronic Kidney Disease
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1Tøndel, Camilla
2Rowe, Alexander D
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atitleEstimating glomerular filtration rate in children: evaluation of creatinine- and cystatin C-based equations
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date2018-08-31
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volume34
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issn0931-041X
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abstractBackground Glomerular filtration rate (GFR) estimated by creatinine- and/or cystatin C-based equations (eGFR) is widely used in daily practice. The purpose of our study was to compare new and old eGFR equations with measured GFR (mGFR) by iohexol clearance in a cohort of children with chronic kidney disease (CKD). Methods We examined 96 children (median age 9.2 years (range 0.25–17.5)) with CKD stages 1–5. A 7-point iohexol clearance (GFR7p) was defined as the reference method (median mGFR 66 mL/min/1.73 m 2 , range 6–153). Ten different eGFR equations, with or without body height, were evaluated: Schwartz bedside , Schwartz CKiD , Schwartz cysC , CAPA, LM REV , (LM REV + CAPA) / 2, FAS crea , FAS cysC , FAS combi , FAS height . The accuracy was evaluated with percentage within 10 and 30% of GFR7p (P10 and P30). Results In the group with mGFR below 60 mL/min/1.73 m 2 , the Schwartz cysC equation had the lowest median bias (interquartile range; IQR) 3.27 (4.80) mL/min/1.73 m 2 and the highest accuracy with P10 of 44% and P30 of 85%. In the group with mGFR above 60 mL/min/1.73 m 2 , the Schwartz CKiD presented with the lowest bias 3.41 (13.1) mL/min/1.73 m 2 and P10 of 62% and P30 of 98%. Overall, the Schwartz cysC had the lowest bias − 1.49 (13.5) mL/min/1.73 m 2 and both Schwartz cysC and Schwartz CKiD showed P30 of 90%. P10 was 44 and 48%, respectively. Conclusions The Schwartz cysC and the combined Schwartz CKiD present with lower bias and higher accuracy as compared to the other equations. The Schwartz cysC equation is a good height-independent alternative to the Schwartz CKiD equation in children and can be reported directly by the laboratory information system. Clinical Trial Registration ClinicalTrials.gov , Identifier NCT01092260, https://clinicaltrials.gov/ct2/show/NCT01092260?term=tondel&rank=2
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