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Mood variations decoded from multi-site intracranial human brain activity

The ability to decode mood state over time from neural activity could enable closed-loop systems to treat neuropsychiatric disorders. However, this decoding has not been demonstrated, partly owing to the difficulty of modeling distributed mood-relevant neural dynamics while dealing with the sparsity... Full description

Journal Title: Nature biotechnology 2018, Vol.36 (10), p.954-961
Main Author: Sani, Omid G
Other Authors: Yang, Yuxiao , Lee, Morgan B , Dawes, Heather E , Chang, Edward F , Shanechi, Maryam M
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: United States: Nature Publishing Group
ID: ISSN: 1087-0156
Link: https://www.ncbi.nlm.nih.gov/pubmed/30199076
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recordid: cdi_proquest_miscellaneous_2101911615
title: Mood variations decoded from multi-site intracranial human brain activity
format: Article
creator:
  • Sani, Omid G
  • Yang, Yuxiao
  • Lee, Morgan B
  • Dawes, Heather E
  • Chang, Edward F
  • Shanechi, Maryam M
subjects:
  • Affect - physiology
  • Affective disorders
  • Aged
  • Analysis
  • Brain
  • Brain - physiology
  • Brain Mapping - methods
  • Decoders
  • Decoding
  • Drug therapy
  • Dynamic models
  • Emotional disorders
  • Epilepsy
  • Feasibility studies
  • Female
  • Human performance
  • Human subjects
  • Humans
  • Male
  • Medical imaging
  • Mental disorders
  • Middle Aged
  • Modelling
  • Models
  • Models, Biological
  • Models, Neurological
  • Monitoring, Physiologic - instrumentation
  • Monitoring, Physiologic - methods
  • Mood
  • Mood disorders
  • Neurophysiology
  • Signal Processing, Computer-Assisted
  • Sparsity
  • Variation
  • Young Adult
ispartof: Nature biotechnology, 2018, Vol.36 (10), p.954-961
description: The ability to decode mood state over time from neural activity could enable closed-loop systems to treat neuropsychiatric disorders. However, this decoding has not been demonstrated, partly owing to the difficulty of modeling distributed mood-relevant neural dynamics while dealing with the sparsity of mood state measurements. Here we develop a modeling framework to decode mood state variations from multi-site intracranial recordings in seven human subjects with epilepsy who self-reported their mood state intermittently over multiple days. We built dynamic neural encoding models of mood state and corresponding decoders for each individual and demonstrated that mood state variations over time can be decoded from neural activity. Across subjects, the decoders largely recruited neural signals from limbic regions, whose spectro-spatial features were tuned to mood variations. The dynamic models also provided an analytical tool to compute the timescales of the decoded mood state. These results provide an initial line of evidence indicating the feasibility of mood state decoding.
language: eng
source:
identifier: ISSN: 1087-0156
fulltext: no_fulltext
issn:
  • 1087-0156
  • 1546-1696
url: Link


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titleMood variations decoded from multi-site intracranial human brain activity
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descriptionThe ability to decode mood state over time from neural activity could enable closed-loop systems to treat neuropsychiatric disorders. However, this decoding has not been demonstrated, partly owing to the difficulty of modeling distributed mood-relevant neural dynamics while dealing with the sparsity of mood state measurements. Here we develop a modeling framework to decode mood state variations from multi-site intracranial recordings in seven human subjects with epilepsy who self-reported their mood state intermittently over multiple days. We built dynamic neural encoding models of mood state and corresponding decoders for each individual and demonstrated that mood state variations over time can be decoded from neural activity. Across subjects, the decoders largely recruited neural signals from limbic regions, whose spectro-spatial features were tuned to mood variations. The dynamic models also provided an analytical tool to compute the timescales of the decoded mood state. These results provide an initial line of evidence indicating the feasibility of mood state decoding.
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subjectAffect - physiology ; Affective disorders ; Aged ; Analysis ; Brain ; Brain - physiology ; Brain Mapping - methods ; Decoders ; Decoding ; Drug therapy ; Dynamic models ; Emotional disorders ; Epilepsy ; Feasibility studies ; Female ; Human performance ; Human subjects ; Humans ; Male ; Medical imaging ; Mental disorders ; Middle Aged ; Modelling ; Models ; Models, Biological ; Models, Neurological ; Monitoring, Physiologic - instrumentation ; Monitoring, Physiologic - methods ; Mood ; Mood disorders ; Neurophysiology ; Signal Processing, Computer-Assisted ; Sparsity ; Variation ; Young Adult
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abstractThe ability to decode mood state over time from neural activity could enable closed-loop systems to treat neuropsychiatric disorders. However, this decoding has not been demonstrated, partly owing to the difficulty of modeling distributed mood-relevant neural dynamics while dealing with the sparsity of mood state measurements. Here we develop a modeling framework to decode mood state variations from multi-site intracranial recordings in seven human subjects with epilepsy who self-reported their mood state intermittently over multiple days. We built dynamic neural encoding models of mood state and corresponding decoders for each individual and demonstrated that mood state variations over time can be decoded from neural activity. Across subjects, the decoders largely recruited neural signals from limbic regions, whose spectro-spatial features were tuned to mood variations. The dynamic models also provided an analytical tool to compute the timescales of the decoded mood state. These results provide an initial line of evidence indicating the feasibility of mood state decoding.
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