schliessen

Filtern

 

Bibliotheken

Specific Tumor Characteristics Predict Upstaging in Early-Stage Esophageal Cancer

Background Early-stage esophageal cancer (stages 0–1) has been shown to have relatively good outcomes after local endoscopic or surgical resection. For this reason, neoadjuvant chemoradiation usually is reserved for higher-stage disease. Some early tumors, however, are found after resection to be mo... Full description

Journal Title: Annals of surgical oncology 2018-10-30, Vol.26 (2), p.514-522
Main Author: Haisley, Kelly R
Other Authors: Hart, Christopher M , Kaempf, Andy J , Dash, Nihar R , Dolan, James P , Hunter, John G
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Cham: Springer International Publishing
ID: ISSN: 1068-9265
Link: https://www.ncbi.nlm.nih.gov/pubmed/30377918
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: cdi_proquest_miscellaneous_2127660694
title: Specific Tumor Characteristics Predict Upstaging in Early-Stage Esophageal Cancer
format: Article
creator:
  • Haisley, Kelly R
  • Hart, Christopher M
  • Kaempf, Andy J
  • Dash, Nihar R
  • Dolan, James P
  • Hunter, John G
subjects:
  • Adult
  • Aged
  • Aged, 80 and over
  • Cancer
  • Dysplasia
  • Esophageal cancer
  • Esophageal Neoplasms - pathology
  • Esophageal Neoplasms - surgery
  • Esophagectomy - mortality
  • Esophagus
  • Female
  • Follow-Up Studies
  • Foregut
  • Health risk assessment
  • Humans
  • Male
  • Medicine
  • Medicine & Public Health
  • Middle Aged
  • Neoplasm Staging
  • Oncology
  • Patient Selection
  • Patients
  • Retrospective Studies
  • Risk Factors
  • Surgery
  • Surgical Oncology
  • Survival
  • Survival Rate
  • Tertiary Care Centers
  • Thoracic Oncology
  • Tumors
ispartof: Annals of surgical oncology, 2018-10-30, Vol.26 (2), p.514-522
description: Background Early-stage esophageal cancer (stages 0–1) has been shown to have relatively good outcomes after local endoscopic or surgical resection. For this reason, neoadjuvant chemoradiation usually is reserved for higher-stage disease. Some early tumors, however, are found after resection to be more advanced than predicted based on initial clinical staging, termed pathologic upstaging. Such tumors may have benefited from alternate treatment models had their true stage been known preoperatively. This study aimed to identify high-risk features in early esophageal cancers that might predict tumor upstaging and guide more individualized treatment algorithms. Methods Through retrospective review of a single-institution foregut disease registry, we evaluated patients who underwent esophagectomy for high-grade dysplasia (Tis) or stage 1 esophageal cancer, searching for factors associated with pathologic upstaging. Results The review included 110 patients (88% male, median age at diagnosis, 64.5 years) treated between January 2000 and June 2016. Upstaging occurred for 20.9% of the patients, and was more common for patients with angiolymphatic invasion (odds ratio [OR], 11.07; 95% confidence interval [CI], 2.96–41.44; P  
language: eng
source:
identifier: ISSN: 1068-9265
fulltext: no_fulltext
issn:
  • 1068-9265
  • 1534-4681
url: Link


@attributes
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
RANK2.523391
LOCALfalse
PrimoNMBib
record
control
sourceidgale_proqu
recordidTN_cdi_proquest_miscellaneous_2127660694
sourceformatXML
sourcesystemPC
galeidA570568277
sourcerecordidA570568277
originalsourceidFETCH-LOGICAL-c269z-d65d19ad6849a4e888e9a01ee1d90e9d718d3980a9f204273f057f553d66bed40
addsrcrecordideNp1kc1rFTEUxYNYbK3-AW5kwI2baW8y-VyWx6sKBVvarkOa3HlNmS-TmUXfX2-eUxUEySKXk9-5HHII-UDhjDIuzjMF3vAaqK6lBl7vX5ETKorCpaavywxS14ZJcUze5vwEQFUD4g05bqBRylB9Qm5uJ_Sxjb66W_oxVZtHl5yfMcU8R5-r64Qh-rm6n_LsdnHYVXGoti51z_VtEbDa5nF6LIPrqo0bPKZ35Kh1Xcb3L_cpub_c3m2-1lffv3zbXFzVnkmzr4MUgRoXpObGcdRao3FAEWkwgCYoqkNjNDjTMuBMNS0I1QrRBCkfMHA4JZ_XvVMafyyYZ9vH7LHr3IDjki2jTEkJ0hzQT_-gT-OShpLuFwWGKqELdbZSO9ehjUM7zuUrygnYRz8O2MaiXwgFQmqmVDHQ1eDTmHPC1k4p9i49Wwr2UJBdC7KlIHsoyO6L5-NLlOWhx_DH8buRArAVyOVp2GH6m_X_W38C_VOaIg
sourcetypeAggregation Database
isCDItrue
recordtypearticle
pqid2127091758
display
typearticle
titleSpecific Tumor Characteristics Predict Upstaging in Early-Stage Esophageal Cancer
creatorHaisley, Kelly R ; Hart, Christopher M ; Kaempf, Andy J ; Dash, Nihar R ; Dolan, James P ; Hunter, John G
creatorcontribHaisley, Kelly R ; Hart, Christopher M ; Kaempf, Andy J ; Dash, Nihar R ; Dolan, James P ; Hunter, John G
descriptionBackground Early-stage esophageal cancer (stages 0–1) has been shown to have relatively good outcomes after local endoscopic or surgical resection. For this reason, neoadjuvant chemoradiation usually is reserved for higher-stage disease. Some early tumors, however, are found after resection to be more advanced than predicted based on initial clinical staging, termed pathologic upstaging. Such tumors may have benefited from alternate treatment models had their true stage been known preoperatively. This study aimed to identify high-risk features in early esophageal cancers that might predict tumor upstaging and guide more individualized treatment algorithms. Methods Through retrospective review of a single-institution foregut disease registry, we evaluated patients who underwent esophagectomy for high-grade dysplasia (Tis) or stage 1 esophageal cancer, searching for factors associated with pathologic upstaging. Results The review included 110 patients (88% male, median age at diagnosis, 64.5 years) treated between January 2000 and June 2016. Upstaging occurred for 20.9% of the patients, and was more common for patients with angiolymphatic invasion (odds ratio [OR], 11.07; 95% confidence interval [CI], 2.96–41.44; P  < 0.001) or signet-ring features (OR, 23.9; 95% CI, 2.6–216.8; P  = 0.005). In the absence of other predictors, upstaging was associated with decreased overall survival ( P  = 0.006). Conclusions Approximately 20% of patients with early-stage esophageal cancer may be upstaged at resection. Angiolymphatic invasion and signet-ring features may predict tumors likely to be upstaged, resulting in decreased overall survival.
identifier
0ISSN: 1068-9265
1EISSN: 1534-4681
2DOI: 10.1245/s10434-018-6804-z
3PMID: 30377918
languageeng
publisherCham: Springer International Publishing
subjectAdult ; Aged ; Aged, 80 and over ; Cancer ; Dysplasia ; Esophageal cancer ; Esophageal Neoplasms - pathology ; Esophageal Neoplasms - surgery ; Esophagectomy - mortality ; Esophagus ; Female ; Follow-Up Studies ; Foregut ; Health risk assessment ; Humans ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neoplasm Staging ; Oncology ; Patient Selection ; Patients ; Retrospective Studies ; Risk Factors ; Surgery ; Surgical Oncology ; Survival ; Survival Rate ; Tertiary Care Centers ; Thoracic Oncology ; Tumors
ispartofAnnals of surgical oncology, 2018-10-30, Vol.26 (2), p.514-522
rights
0Society of Surgical Oncology 2018
1COPYRIGHT 2019 Springer
2Annals of Surgical Oncology is a copyright of Springer, (2018). All Rights Reserved.
lds50peer_reviewed
citesFETCH-LOGICAL-c269z-d65d19ad6849a4e888e9a01ee1d90e9d718d3980a9f204273f057f553d66bed40
links
openurl$$Topenurl_article
thumbnail$$Usyndetics_thumb_exl
backlink$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/30377918$$D View this record in MEDLINE/PubMed
search
creatorcontrib
0Haisley, Kelly R
1Hart, Christopher M
2Kaempf, Andy J
3Dash, Nihar R
4Dolan, James P
5Hunter, John G
title
0Specific Tumor Characteristics Predict Upstaging in Early-Stage Esophageal Cancer
1Annals of surgical oncology
addtitle
0Ann Surg Oncol
1Ann Surg Oncol
descriptionBackground Early-stage esophageal cancer (stages 0–1) has been shown to have relatively good outcomes after local endoscopic or surgical resection. For this reason, neoadjuvant chemoradiation usually is reserved for higher-stage disease. Some early tumors, however, are found after resection to be more advanced than predicted based on initial clinical staging, termed pathologic upstaging. Such tumors may have benefited from alternate treatment models had their true stage been known preoperatively. This study aimed to identify high-risk features in early esophageal cancers that might predict tumor upstaging and guide more individualized treatment algorithms. Methods Through retrospective review of a single-institution foregut disease registry, we evaluated patients who underwent esophagectomy for high-grade dysplasia (Tis) or stage 1 esophageal cancer, searching for factors associated with pathologic upstaging. Results The review included 110 patients (88% male, median age at diagnosis, 64.5 years) treated between January 2000 and June 2016. Upstaging occurred for 20.9% of the patients, and was more common for patients with angiolymphatic invasion (odds ratio [OR], 11.07; 95% confidence interval [CI], 2.96–41.44; P  < 0.001) or signet-ring features (OR, 23.9; 95% CI, 2.6–216.8; P  = 0.005). In the absence of other predictors, upstaging was associated with decreased overall survival ( P  = 0.006). Conclusions Approximately 20% of patients with early-stage esophageal cancer may be upstaged at resection. Angiolymphatic invasion and signet-ring features may predict tumors likely to be upstaged, resulting in decreased overall survival.
subject
0Adult
1Aged
2Aged, 80 and over
3Cancer
4Dysplasia
5Esophageal cancer
6Esophageal Neoplasms - pathology
7Esophageal Neoplasms - surgery
8Esophagectomy - mortality
9Esophagus
10Female
11Follow-Up Studies
12Foregut
13Health risk assessment
14Humans
15Male
16Medicine
17Medicine & Public Health
18Middle Aged
19Neoplasm Staging
20Oncology
21Patient Selection
22Patients
23Retrospective Studies
24Risk Factors
25Surgery
26Surgical Oncology
27Survival
28Survival Rate
29Tertiary Care Centers
30Thoracic Oncology
31Tumors
issn
01068-9265
11534-4681
fulltextfalse
rsrctypearticle
creationdate2018
recordtypearticle
recordideNp1kc1rFTEUxYNYbK3-AW5kwI2baW8y-VyWx6sKBVvarkOa3HlNmS-TmUXfX2-eUxUEySKXk9-5HHII-UDhjDIuzjMF3vAaqK6lBl7vX5ETKorCpaavywxS14ZJcUze5vwEQFUD4g05bqBRylB9Qm5uJ_Sxjb66W_oxVZtHl5yfMcU8R5-r64Qh-rm6n_LsdnHYVXGoti51z_VtEbDa5nF6LIPrqo0bPKZ35Kh1Xcb3L_cpub_c3m2-1lffv3zbXFzVnkmzr4MUgRoXpObGcdRao3FAEWkwgCYoqkNjNDjTMuBMNS0I1QrRBCkfMHA4JZ_XvVMafyyYZ9vH7LHr3IDjki2jTEkJ0hzQT_-gT-OShpLuFwWGKqELdbZSO9ehjUM7zuUrygnYRz8O2MaiXwgFQmqmVDHQ1eDTmHPC1k4p9i49Wwr2UJBdC7KlIHsoyO6L5-NLlOWhx_DH8buRArAVyOVp2GH6m_X_W38C_VOaIg
startdate20181030
enddate20181030
creator
0Haisley, Kelly R
1Hart, Christopher M
2Kaempf, Andy J
3Dash, Nihar R
4Dolan, James P
5Hunter, John G
general
0Springer International Publishing
1Springer
2Springer Nature B.V
scope
0CGR
1CUY
2CVF
3ECM
4EIF
5NPM
6AAYXX
7CITATION
8BSHEE
93V.
107TO
117X7
127XB
1388E
148AO
158FI
168FJ
178FK
18ABUWG
19BENPR
20FYUFA
21GHDGH
22H94
23K9.
24M0S
25M1P
26PQEST
27PQQKQ
28PQUKI
29PRINS
307X8
sort
creationdate20181030
titleSpecific Tumor Characteristics Predict Upstaging in Early-Stage Esophageal Cancer
authorHaisley, Kelly R ; Hart, Christopher M ; Kaempf, Andy J ; Dash, Nihar R ; Dolan, James P ; Hunter, John G
facets
frbrtype5
frbrgroupidcdi_FETCH-LOGICAL-c269z-d65d19ad6849a4e888e9a01ee1d90e9d718d3980a9f204273f057f553d66bed40
rsrctypearticles
prefilterarticles
languageeng
creationdate2018
topic
0Adult
1Aged
2Aged, 80 and over
3Cancer
4Dysplasia
5Esophageal cancer
6Esophageal Neoplasms - pathology
7Esophageal Neoplasms - surgery
8Esophagectomy - mortality
9Esophagus
10Female
11Follow-Up Studies
12Foregut
13Health risk assessment
14Humans
15Male
16Medicine
17Medicine & Public Health
18Middle Aged
19Neoplasm Staging
20Oncology
21Patient Selection
22Patients
23Retrospective Studies
24Risk Factors
25Surgery
26Surgical Oncology
27Survival
28Survival Rate
29Tertiary Care Centers
30Thoracic Oncology
31Tumors
toplevelpeer_reviewed
creatorcontrib
0Haisley, Kelly R
1Hart, Christopher M
2Kaempf, Andy J
3Dash, Nihar R
4Dolan, James P
5Hunter, John G
collection
0Medline
1MEDLINE
2MEDLINE (Ovid)
3MEDLINE
4MEDLINE
5PubMed
6CrossRef
7Academic OneFile (A&I only)
8ProQuest Central (Corporate)
9Oncogenes and Growth Factors Abstracts
10Health & Medical Collection
11ProQuest Central (purchase pre-March 2016)
12Medical Database (Alumni Edition)
13ProQuest Pharma Collection
14Hospital Premium Collection
15Hospital Premium Collection (Alumni Edition)
16ProQuest Central (Alumni) (purchase pre-March 2016)
17ProQuest Central (Alumni Edition)
18ProQuest Central
19Health Research Premium Collection
20Health Research Premium Collection (Alumni)
21AIDS and Cancer Research Abstracts
22ProQuest Health & Medical Complete (Alumni)
23Health & Medical Collection (Alumni Edition)
24Medical Database
25ProQuest One Academic Eastern Edition
26ProQuest One Academic
27ProQuest One Academic UKI Edition
28ProQuest Central China
29MEDLINE - Academic
jtitleAnnals of surgical oncology
delivery
delcategoryRemote Search Resource
fulltextno_fulltext
addata
au
0Haisley, Kelly R
1Hart, Christopher M
2Kaempf, Andy J
3Dash, Nihar R
4Dolan, James P
5Hunter, John G
formatjournal
genrearticle
ristypeJOUR
atitleSpecific Tumor Characteristics Predict Upstaging in Early-Stage Esophageal Cancer
jtitleAnnals of surgical oncology
stitleAnn Surg Oncol
addtitleAnn Surg Oncol
date2018-10-30
risdate2018
volume26
issue2
spage514
epage522
pages514-522
issn1068-9265
eissn1534-4681
abstractBackground Early-stage esophageal cancer (stages 0–1) has been shown to have relatively good outcomes after local endoscopic or surgical resection. For this reason, neoadjuvant chemoradiation usually is reserved for higher-stage disease. Some early tumors, however, are found after resection to be more advanced than predicted based on initial clinical staging, termed pathologic upstaging. Such tumors may have benefited from alternate treatment models had their true stage been known preoperatively. This study aimed to identify high-risk features in early esophageal cancers that might predict tumor upstaging and guide more individualized treatment algorithms. Methods Through retrospective review of a single-institution foregut disease registry, we evaluated patients who underwent esophagectomy for high-grade dysplasia (Tis) or stage 1 esophageal cancer, searching for factors associated with pathologic upstaging. Results The review included 110 patients (88% male, median age at diagnosis, 64.5 years) treated between January 2000 and June 2016. Upstaging occurred for 20.9% of the patients, and was more common for patients with angiolymphatic invasion (odds ratio [OR], 11.07; 95% confidence interval [CI], 2.96–41.44; P  < 0.001) or signet-ring features (OR, 23.9; 95% CI, 2.6–216.8; P  = 0.005). In the absence of other predictors, upstaging was associated with decreased overall survival ( P  = 0.006). Conclusions Approximately 20% of patients with early-stage esophageal cancer may be upstaged at resection. Angiolymphatic invasion and signet-ring features may predict tumors likely to be upstaged, resulting in decreased overall survival.
copCham
pubSpringer International Publishing
pmid30377918
doi10.1245/s10434-018-6804-z