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Methodological issues with the assessment of voluntary activation using transcranial magnetic stimulation in the knee extensors

Purpose The assessment of voluntary activation of the knee extensors using transcranial magnetic stimulation (VA TMS ) is routinely performed to assess the supraspinal function. Yet methodological scrutiny of the technique is scarce. The aim of the present study was to examine face validity and reli... Full description

Journal Title: European journal of applied physiology 2019, Vol.119 (4), p.991-1005
Main Author: Dekerle, Jeanne
Other Authors: Ansdell, P , Schäfer, L , Greenhouse-Tucknott, A , Wrightson, J
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Berlin/Heidelberg: Springer Berlin Heidelberg
ID: ISSN: 1439-6319
Link: https://www.ncbi.nlm.nih.gov/pubmed/30746563
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title: Methodological issues with the assessment of voluntary activation using transcranial magnetic stimulation in the knee extensors
format: Article
creator:
  • Dekerle, Jeanne
  • Ansdell, P
  • Schäfer, L
  • Greenhouse-Tucknott, A
  • Wrightson, J
subjects:
  • Biomedical and Life Sciences
  • Biomedicine
  • Contraction
  • Fatigue
  • Human Physiology
  • Isometric
  • Knee
  • Magnetic fields
  • Occupational Medicine/Industrial Medicine
  • Original Article
  • Sports Medicine
  • Statistical analysis
  • Transcranial magnetic stimulation
ispartof: European journal of applied physiology, 2019, Vol.119 (4), p.991-1005
description: Purpose The assessment of voluntary activation of the knee extensors using transcranial magnetic stimulation (VA TMS ) is routinely performed to assess the supraspinal function. Yet methodological scrutiny of the technique is scarce. The aim of the present study was to examine face validity and reliability of VA TMS and its two main determinants (superimposed twitch during a maximal voluntary contraction [SIT 100% ] and estimated resting twitch [ERT]). Methods SIT 100%, ERT, and VA TMS were measured on ten healthy males (age 24 ± 5 years) before and following intermittent isometric fatiguing exercise on two separate occasions. Results The findings indicated issues regarding the accuracy of ERT and suggested a three-point relationship should not be used to determine ERT. Reliabilities for VA TMS , SIT 100%, and ERT were acceptable pre- but much weaker post-exercise (especially for SIT 100% ). Despite statistically significant changes in main neuromuscular variables following the intermittent isometric fatiguing exercise ( P  
language: eng
source:
identifier: ISSN: 1439-6319
fulltext: no_fulltext
issn:
  • 1439-6319
  • 1439-6327
url: Link


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creatorDekerle, Jeanne ; Ansdell, P ; Schäfer, L ; Greenhouse-Tucknott, A ; Wrightson, J
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descriptionPurpose The assessment of voluntary activation of the knee extensors using transcranial magnetic stimulation (VA TMS ) is routinely performed to assess the supraspinal function. Yet methodological scrutiny of the technique is scarce. The aim of the present study was to examine face validity and reliability of VA TMS and its two main determinants (superimposed twitch during a maximal voluntary contraction [SIT 100% ] and estimated resting twitch [ERT]). Methods SIT 100%, ERT, and VA TMS were measured on ten healthy males (age 24 ± 5 years) before and following intermittent isometric fatiguing exercise on two separate occasions. Results The findings indicated issues regarding the accuracy of ERT and suggested a three-point relationship should not be used to determine ERT. Reliabilities for VA TMS , SIT 100%, and ERT were acceptable pre- but much weaker post-exercise (especially for SIT 100% ). Despite statistically significant changes in main neuromuscular variables following the intermittent isometric fatiguing exercise ( P  < 0.05), when post-exercise reliability was considered, the exercise effect on VA TMS was smaller than the smallest detectable change in 18 of the 20 individual tests performed, and for the whole sample for one of two visits. Finally, maximal voluntary contraction was reduced significantly following the neuromuscular assessment (NMA) pre-exercise but recovered during the NMA post-exercise. Conclusion This is the first study to demonstrate a lack of sensitivity of key neuromuscular measurements to exercise and to evidence both presence of neuromuscular fatigue following the NMA in itself, and recovery of the neuromuscular function during the NMA post-exercise. These results challenge the face validity of this routinely used protocol.
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subjectBiomedical and Life Sciences ; Biomedicine ; Contraction ; Fatigue ; Human Physiology ; Isometric ; Knee ; Magnetic fields ; Occupational Medicine/Industrial Medicine ; Original Article ; Sports Medicine ; Statistical analysis ; Transcranial magnetic stimulation
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descriptionPurpose The assessment of voluntary activation of the knee extensors using transcranial magnetic stimulation (VA TMS ) is routinely performed to assess the supraspinal function. Yet methodological scrutiny of the technique is scarce. The aim of the present study was to examine face validity and reliability of VA TMS and its two main determinants (superimposed twitch during a maximal voluntary contraction [SIT 100% ] and estimated resting twitch [ERT]). Methods SIT 100%, ERT, and VA TMS were measured on ten healthy males (age 24 ± 5 years) before and following intermittent isometric fatiguing exercise on two separate occasions. Results The findings indicated issues regarding the accuracy of ERT and suggested a three-point relationship should not be used to determine ERT. Reliabilities for VA TMS , SIT 100%, and ERT were acceptable pre- but much weaker post-exercise (especially for SIT 100% ). Despite statistically significant changes in main neuromuscular variables following the intermittent isometric fatiguing exercise ( P  < 0.05), when post-exercise reliability was considered, the exercise effect on VA TMS was smaller than the smallest detectable change in 18 of the 20 individual tests performed, and for the whole sample for one of two visits. Finally, maximal voluntary contraction was reduced significantly following the neuromuscular assessment (NMA) pre-exercise but recovered during the NMA post-exercise. Conclusion This is the first study to demonstrate a lack of sensitivity of key neuromuscular measurements to exercise and to evidence both presence of neuromuscular fatigue following the NMA in itself, and recovery of the neuromuscular function during the NMA post-exercise. These results challenge the face validity of this routinely used protocol.
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abstractPurpose The assessment of voluntary activation of the knee extensors using transcranial magnetic stimulation (VA TMS ) is routinely performed to assess the supraspinal function. Yet methodological scrutiny of the technique is scarce. The aim of the present study was to examine face validity and reliability of VA TMS and its two main determinants (superimposed twitch during a maximal voluntary contraction [SIT 100% ] and estimated resting twitch [ERT]). Methods SIT 100%, ERT, and VA TMS were measured on ten healthy males (age 24 ± 5 years) before and following intermittent isometric fatiguing exercise on two separate occasions. Results The findings indicated issues regarding the accuracy of ERT and suggested a three-point relationship should not be used to determine ERT. Reliabilities for VA TMS , SIT 100%, and ERT were acceptable pre- but much weaker post-exercise (especially for SIT 100% ). Despite statistically significant changes in main neuromuscular variables following the intermittent isometric fatiguing exercise ( P  < 0.05), when post-exercise reliability was considered, the exercise effect on VA TMS was smaller than the smallest detectable change in 18 of the 20 individual tests performed, and for the whole sample for one of two visits. Finally, maximal voluntary contraction was reduced significantly following the neuromuscular assessment (NMA) pre-exercise but recovered during the NMA post-exercise. Conclusion This is the first study to demonstrate a lack of sensitivity of key neuromuscular measurements to exercise and to evidence both presence of neuromuscular fatigue following the NMA in itself, and recovery of the neuromuscular function during the NMA post-exercise. These results challenge the face validity of this routinely used protocol.
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