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Polymorphisms of mannose-binding lectin-associated serine protease 1 (MASP1) and its relationship with milk performance traits and complement activity in Chinese Holstein cattle

Mannose-binding lectin (MBL)-associated serine protease1 (MASP1) is the central enzyme in the innate immune system, which has biological functions of antibacterial and anti-inflammatory activities. Moreover, MASP1 represents a candidate gene reflecting the complement activity. This study is to inves... Full description

Journal Title: Research in veterinary science 2019-06, Vol.124, p.346-351
Main Author: Zhang, Haiyan
Other Authors: Wei, Yan , Zhang, Fengying , Liu, Yanyan , Wang, Haifeng , Li, Yan , Li, Ge
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: England: Elsevier Ltd
ID: ISSN: 0034-5288
Link: https://www.ncbi.nlm.nih.gov/pubmed/31060014
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recordid: cdi_proquest_miscellaneous_2231899649
title: Polymorphisms of mannose-binding lectin-associated serine protease 1 (MASP1) and its relationship with milk performance traits and complement activity in Chinese Holstein cattle
format: Article
creator:
  • Zhang, Haiyan
  • Wei, Yan
  • Zhang, Fengying
  • Liu, Yanyan
  • Wang, Haifeng
  • Li, Yan
  • Li, Ge
subjects:
  • Analysis
  • Beef cattle
  • Complement activity
  • Dairy cattle
  • DNA sequencing
  • Enzymes
  • Genes
  • Genetic aspects
  • Lectins
  • Mannose-binding lectin-associated serine protease 1 (MASP1)
  • Mastitis
  • Milk
  • Milk performance traits
  • Milk production
  • Monosaccharides
  • Nucleotide sequencing
  • Serine
  • Single nucleotide polymorphisms
  • Single nucleotide polymorphisms (SNPs)
  • Sugars
  • Thrombin
ispartof: Research in veterinary science, 2019-06, Vol.124, p.346-351
description: Mannose-binding lectin (MBL)-associated serine protease1 (MASP1) is the central enzyme in the innate immune system, which has biological functions of antibacterial and anti-inflammatory activities. Moreover, MASP1 represents a candidate gene reflecting the complement activity. This study is to investigate the entire exons of MASP1 in Chinese Holstein cattle with DNA sequencing to identify novel single nucleotide polymorphisms (SNPs). Novel SNPs were identified through gene sequencing and genotyped by the PCR Restriction Fragment Length Polymorphism (PCR-RFLP) and Created Restriction Site PCR (CRS-PCR). The relationship between the milk performance traits and complement activity in Chinese Holstein cattle was analyzed using the General Linear Model (GLM) procedure with the SAS software (version 8.0). Two novel SNPs (i.e., g.5766A > G and g.51228A > C) were detected. The SNP g.5766A > G was located in the first intron and the SNP g.51228A > C was located in the 3′-untranslated regions of MASP1. The polymorphism at g.5766A > G was correlated with protein percentage (P  C had only two genotypes, and this SNP had no significant correlation with CH50, ACH50, fat percentage, protein percentage, 305-day milk yields, or SCS scores. MASP1, reflecting the complement activity, may not be significantly related to mastitis. However, MASP1 could be implemented in the breeding program to improve the production performance of Chinese Holstein cattle. •This report, we scanned the entire exons of MASP1 with DNA sequencing to identify single nucleotide polymorphisms.•We analysised the relationship with milk performance traits and complement activity in Chinese Holstein cattle.•MASP1 could be implemented in breeding programmes to improve the production performance of Chinese Holstein cattle.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0034-5288
fulltext: fulltext
issn:
  • 0034-5288
  • 1532-2661
url: Link


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titlePolymorphisms of mannose-binding lectin-associated serine protease 1 (MASP1) and its relationship with milk performance traits and complement activity in Chinese Holstein cattle
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creatorZhang, Haiyan ; Wei, Yan ; Zhang, Fengying ; Liu, Yanyan ; Wang, Haifeng ; Li, Yan ; Li, Ge
creatorcontribZhang, Haiyan ; Wei, Yan ; Zhang, Fengying ; Liu, Yanyan ; Wang, Haifeng ; Li, Yan ; Li, Ge
descriptionMannose-binding lectin (MBL)-associated serine protease1 (MASP1) is the central enzyme in the innate immune system, which has biological functions of antibacterial and anti-inflammatory activities. Moreover, MASP1 represents a candidate gene reflecting the complement activity. This study is to investigate the entire exons of MASP1 in Chinese Holstein cattle with DNA sequencing to identify novel single nucleotide polymorphisms (SNPs). Novel SNPs were identified through gene sequencing and genotyped by the PCR Restriction Fragment Length Polymorphism (PCR-RFLP) and Created Restriction Site PCR (CRS-PCR). The relationship between the milk performance traits and complement activity in Chinese Holstein cattle was analyzed using the General Linear Model (GLM) procedure with the SAS software (version 8.0). Two novel SNPs (i.e., g.5766A > G and g.51228A > C) were detected. The SNP g.5766A > G was located in the first intron and the SNP g.51228A > C was located in the 3′-untranslated regions of MASP1. The polymorphism at g.5766A > G was correlated with protein percentage (P < 0.05). Moreover, the polymorphism at g.51228A > C had only two genotypes, and this SNP had no significant correlation with CH50, ACH50, fat percentage, protein percentage, 305-day milk yields, or SCS scores. MASP1, reflecting the complement activity, may not be significantly related to mastitis. However, MASP1 could be implemented in the breeding program to improve the production performance of Chinese Holstein cattle. •This report, we scanned the entire exons of MASP1 with DNA sequencing to identify single nucleotide polymorphisms.•We analysised the relationship with milk performance traits and complement activity in Chinese Holstein cattle.•MASP1 could be implemented in breeding programmes to improve the production performance of Chinese Holstein cattle.
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subjectAnalysis ; Beef cattle ; Complement activity ; Dairy cattle ; DNA sequencing ; Enzymes ; Genes ; Genetic aspects ; Lectins ; Mannose-binding lectin-associated serine protease 1 (MASP1) ; Mastitis ; Milk ; Milk performance traits ; Milk production ; Monosaccharides ; Nucleotide sequencing ; Serine ; Single nucleotide polymorphisms ; Single nucleotide polymorphisms (SNPs) ; Sugars ; Thrombin
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descriptionMannose-binding lectin (MBL)-associated serine protease1 (MASP1) is the central enzyme in the innate immune system, which has biological functions of antibacterial and anti-inflammatory activities. Moreover, MASP1 represents a candidate gene reflecting the complement activity. This study is to investigate the entire exons of MASP1 in Chinese Holstein cattle with DNA sequencing to identify novel single nucleotide polymorphisms (SNPs). Novel SNPs were identified through gene sequencing and genotyped by the PCR Restriction Fragment Length Polymorphism (PCR-RFLP) and Created Restriction Site PCR (CRS-PCR). The relationship between the milk performance traits and complement activity in Chinese Holstein cattle was analyzed using the General Linear Model (GLM) procedure with the SAS software (version 8.0). Two novel SNPs (i.e., g.5766A > G and g.51228A > C) were detected. The SNP g.5766A > G was located in the first intron and the SNP g.51228A > C was located in the 3′-untranslated regions of MASP1. The polymorphism at g.5766A > G was correlated with protein percentage (P < 0.05). Moreover, the polymorphism at g.51228A > C had only two genotypes, and this SNP had no significant correlation with CH50, ACH50, fat percentage, protein percentage, 305-day milk yields, or SCS scores. MASP1, reflecting the complement activity, may not be significantly related to mastitis. However, MASP1 could be implemented in the breeding program to improve the production performance of Chinese Holstein cattle. •This report, we scanned the entire exons of MASP1 with DNA sequencing to identify single nucleotide polymorphisms.•We analysised the relationship with milk performance traits and complement activity in Chinese Holstein cattle.•MASP1 could be implemented in breeding programmes to improve the production performance of Chinese Holstein cattle.
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abstractMannose-binding lectin (MBL)-associated serine protease1 (MASP1) is the central enzyme in the innate immune system, which has biological functions of antibacterial and anti-inflammatory activities. Moreover, MASP1 represents a candidate gene reflecting the complement activity. This study is to investigate the entire exons of MASP1 in Chinese Holstein cattle with DNA sequencing to identify novel single nucleotide polymorphisms (SNPs). Novel SNPs were identified through gene sequencing and genotyped by the PCR Restriction Fragment Length Polymorphism (PCR-RFLP) and Created Restriction Site PCR (CRS-PCR). The relationship between the milk performance traits and complement activity in Chinese Holstein cattle was analyzed using the General Linear Model (GLM) procedure with the SAS software (version 8.0). Two novel SNPs (i.e., g.5766A > G and g.51228A > C) were detected. The SNP g.5766A > G was located in the first intron and the SNP g.51228A > C was located in the 3′-untranslated regions of MASP1. The polymorphism at g.5766A > G was correlated with protein percentage (P < 0.05). Moreover, the polymorphism at g.51228A > C had only two genotypes, and this SNP had no significant correlation with CH50, ACH50, fat percentage, protein percentage, 305-day milk yields, or SCS scores. MASP1, reflecting the complement activity, may not be significantly related to mastitis. However, MASP1 could be implemented in the breeding program to improve the production performance of Chinese Holstein cattle. •This report, we scanned the entire exons of MASP1 with DNA sequencing to identify single nucleotide polymorphisms.•We analysised the relationship with milk performance traits and complement activity in Chinese Holstein cattle.•MASP1 could be implemented in breeding programmes to improve the production performance of Chinese Holstein cattle.
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pubElsevier Ltd
pmid31060014
doi10.1016/j.rvsc.2019.04.017