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Simultaneous cognate epitope recognition by bovine CD4 and CD8 T cells is essential for primary expansion of antigen-specific cytotoxic T-cells following ex vivo stimulation with a candidate Mycobacterium avium subsp. paratuberculosis peptide vaccine

•Antigen presentation to CD4 and CD8 T cells by antigen presenting cells is blocked in the presence of antibody specific for either MHC I or MHC II.•Simultaneous CD4 and CD8 T cell cognate recognition of antigenic epitopes presented by antigen presenting cells is essential for development of CD8 cyt... Full description

Journal Title: Vaccine 2020, Vol.38 (8), p.2016-2025
Main Author: Abdellrazeq, Gaber S
Other Authors: Fry, Lindsay M , Elnaggar, Mahmoud M , Bannantine, John P , Schneider, David A , Chamberlin, William M , Mahmoud, Asmaa H.A , Park, Kun-Taek , Hulubei, Victoria , Davis, William C
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: Netherlands: Elsevier Ltd
ID: ISSN: 0264-410X
Link: https://www.ncbi.nlm.nih.gov/pubmed/31902643
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title: Simultaneous cognate epitope recognition by bovine CD4 and CD8 T cells is essential for primary expansion of antigen-specific cytotoxic T-cells following ex vivo stimulation with a candidate Mycobacterium avium subsp. paratuberculosis peptide vaccine
format: Article
creator:
  • Abdellrazeq, Gaber S
  • Fry, Lindsay M
  • Elnaggar, Mahmoud M
  • Bannantine, John P
  • Schneider, David A
  • Chamberlin, William M
  • Mahmoud, Asmaa H.A
  • Park, Kun-Taek
  • Hulubei, Victoria
  • Davis, William C
subjects:
  • Animals
  • Antigen Presentation
  • Antigen-presenting cells
  • Antigens
  • Bovine
  • Cattle
  • CD4 antigen
  • CD4-Positive T-Lymphocytes - immunology
  • CD8 antigen
  • CD8-Positive T-Lymphocytes - immunology
  • Cells, Cultured
  • Cognate epitope recognition
  • Cytotoxicity
  • Dendritic cells
  • Depletion
  • Epitopes
  • Epitopes - immunology
  • Histocompatibility Antigens Class I - immunology
  • Histocompatibility Antigens Class II - immunology
  • Immunoglobulins
  • Infections
  • Leukocytes (mononuclear)
  • Leukocytes, Mononuclear - immunology
  • Livestock
  • Lymphocytes
  • Lymphocytes T
  • Major histocompatibility complex
  • Membrane proteins
  • Monoclonal antibodies
  • Monocytes
  • Mycobacterium avium
  • Mycobacterium avium subsp. paratuberculosis
  • Mycobacterium avium subsp. paratuberculosis - immunology
  • Paratuberculosis
  • Paratuberculosis - prevention & control
  • Peptides
  • Peripheral blood mononuclear cells
  • Propidium monoazide
  • Recognition
  • Stimulation
  • T cells
  • T-Lymphocytes, Cytotoxic - immunology
  • Tuberculosis Vaccines - immunology
  • Vaccination
  • Vaccines
  • Vaccines, Subunit - immunology
ispartof: Vaccine, 2020, Vol.38 (8), p.2016-2025
description: •Antigen presentation to CD4 and CD8 T cells by antigen presenting cells is blocked in the presence of antibody specific for either MHC I or MHC II.•Simultaneous CD4 and CD8 T cell cognate recognition of antigenic epitopes presented by antigen presenting cells is essential for development of CD8 cytotoxic T cells. Studies in cattle show CD8 cytotoxic T cells (CTL), with the ability to kill intracellular bacteria, develop following stimulation of monocyte-depleted peripheral blood mononuclear cells (mdPBMC) with antigen presenting cells (APC, i.e. conventional dendritic cells [cDC] and monocyte-derived DC [MoDC]) pulsed with MMP, a membrane protein from Mycobacterium avium subsp. paratuberculosis (Map) encoded by MAP2121c. CTL activity was diminished if CD4 T cells were depleted from mdPBMC before antigen (Ag) presentation by APC, suggesting simultaneous cognate recognition of MMP epitopes presented by MHC I and MHC II molecules to CD4 and CD8 T cells is essential for development of CTL activity. To explore this possibility, studies were conducted with mdPBMC cultures in the presence of monoclonal antibodies (mAbs) specific for MHC class I and MHC class II molecules. The CTL response of mdPBMC to MMP-pulsed APC was completely blocked in the presence of mAbs to both MHC I and II molecules and also blocked in the presence of mAbs to either MHC I or MHC II alone. The results demonstrate simultaneous cognate recognition of Ag by CD4 and CD8 T cells is essential for delivery of CD4 T cell help to CD8 T cells to elicit development of CTL.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0264-410X
fulltext: fulltext
issn:
  • 0264-410X
  • 1873-2518
url: Link


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titleSimultaneous cognate epitope recognition by bovine CD4 and CD8 T cells is essential for primary expansion of antigen-specific cytotoxic T-cells following ex vivo stimulation with a candidate Mycobacterium avium subsp. paratuberculosis peptide vaccine
sourceAlma/SFX Local Collection
creatorAbdellrazeq, Gaber S ; Fry, Lindsay M ; Elnaggar, Mahmoud M ; Bannantine, John P ; Schneider, David A ; Chamberlin, William M ; Mahmoud, Asmaa H.A ; Park, Kun-Taek ; Hulubei, Victoria ; Davis, William C
creatorcontribAbdellrazeq, Gaber S ; Fry, Lindsay M ; Elnaggar, Mahmoud M ; Bannantine, John P ; Schneider, David A ; Chamberlin, William M ; Mahmoud, Asmaa H.A ; Park, Kun-Taek ; Hulubei, Victoria ; Davis, William C
description•Antigen presentation to CD4 and CD8 T cells by antigen presenting cells is blocked in the presence of antibody specific for either MHC I or MHC II.•Simultaneous CD4 and CD8 T cell cognate recognition of antigenic epitopes presented by antigen presenting cells is essential for development of CD8 cytotoxic T cells. Studies in cattle show CD8 cytotoxic T cells (CTL), with the ability to kill intracellular bacteria, develop following stimulation of monocyte-depleted peripheral blood mononuclear cells (mdPBMC) with antigen presenting cells (APC, i.e. conventional dendritic cells [cDC] and monocyte-derived DC [MoDC]) pulsed with MMP, a membrane protein from Mycobacterium avium subsp. paratuberculosis (Map) encoded by MAP2121c. CTL activity was diminished if CD4 T cells were depleted from mdPBMC before antigen (Ag) presentation by APC, suggesting simultaneous cognate recognition of MMP epitopes presented by MHC I and MHC II molecules to CD4 and CD8 T cells is essential for development of CTL activity. To explore this possibility, studies were conducted with mdPBMC cultures in the presence of monoclonal antibodies (mAbs) specific for MHC class I and MHC class II molecules. The CTL response of mdPBMC to MMP-pulsed APC was completely blocked in the presence of mAbs to both MHC I and II molecules and also blocked in the presence of mAbs to either MHC I or MHC II alone. The results demonstrate simultaneous cognate recognition of Ag by CD4 and CD8 T cells is essential for delivery of CD4 T cell help to CD8 T cells to elicit development of CTL.
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1EISSN: 1873-2518
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3PMID: 31902643
languageeng
publisherNetherlands: Elsevier Ltd
subjectAnimals ; Antigen Presentation ; Antigen-presenting cells ; Antigens ; Bovine ; Cattle ; CD4 antigen ; CD4-Positive T-Lymphocytes - immunology ; CD8 antigen ; CD8-Positive T-Lymphocytes - immunology ; Cells, Cultured ; Cognate epitope recognition ; Cytotoxicity ; Dendritic cells ; Depletion ; Epitopes ; Epitopes - immunology ; Histocompatibility Antigens Class I - immunology ; Histocompatibility Antigens Class II - immunology ; Immunoglobulins ; Infections ; Leukocytes (mononuclear) ; Leukocytes, Mononuclear - immunology ; Livestock ; Lymphocytes ; Lymphocytes T ; Major histocompatibility complex ; Membrane proteins ; Monoclonal antibodies ; Monocytes ; Mycobacterium avium ; Mycobacterium avium subsp. paratuberculosis ; Mycobacterium avium subsp. paratuberculosis - immunology ; Paratuberculosis ; Paratuberculosis - prevention & control ; Peptides ; Peripheral blood mononuclear cells ; Propidium monoazide ; Recognition ; Stimulation ; T cells ; T-Lymphocytes, Cytotoxic - immunology ; Tuberculosis Vaccines - immunology ; Vaccination ; Vaccines ; Vaccines, Subunit - immunology
ispartofVaccine, 2020, Vol.38 (8), p.2016-2025
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0Abdellrazeq, Gaber S
1Fry, Lindsay M
2Elnaggar, Mahmoud M
3Bannantine, John P
4Schneider, David A
5Chamberlin, William M
6Mahmoud, Asmaa H.A
7Park, Kun-Taek
8Hulubei, Victoria
9Davis, William C
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0Simultaneous cognate epitope recognition by bovine CD4 and CD8 T cells is essential for primary expansion of antigen-specific cytotoxic T-cells following ex vivo stimulation with a candidate Mycobacterium avium subsp. paratuberculosis peptide vaccine
1Vaccine
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description•Antigen presentation to CD4 and CD8 T cells by antigen presenting cells is blocked in the presence of antibody specific for either MHC I or MHC II.•Simultaneous CD4 and CD8 T cell cognate recognition of antigenic epitopes presented by antigen presenting cells is essential for development of CD8 cytotoxic T cells. Studies in cattle show CD8 cytotoxic T cells (CTL), with the ability to kill intracellular bacteria, develop following stimulation of monocyte-depleted peripheral blood mononuclear cells (mdPBMC) with antigen presenting cells (APC, i.e. conventional dendritic cells [cDC] and monocyte-derived DC [MoDC]) pulsed with MMP, a membrane protein from Mycobacterium avium subsp. paratuberculosis (Map) encoded by MAP2121c. CTL activity was diminished if CD4 T cells were depleted from mdPBMC before antigen (Ag) presentation by APC, suggesting simultaneous cognate recognition of MMP epitopes presented by MHC I and MHC II molecules to CD4 and CD8 T cells is essential for development of CTL activity. To explore this possibility, studies were conducted with mdPBMC cultures in the presence of monoclonal antibodies (mAbs) specific for MHC class I and MHC class II molecules. The CTL response of mdPBMC to MMP-pulsed APC was completely blocked in the presence of mAbs to both MHC I and II molecules and also blocked in the presence of mAbs to either MHC I or MHC II alone. The results demonstrate simultaneous cognate recognition of Ag by CD4 and CD8 T cells is essential for delivery of CD4 T cell help to CD8 T cells to elicit development of CTL.
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0Animals
1Antigen Presentation
2Antigen-presenting cells
3Antigens
4Bovine
5Cattle
6CD4 antigen
7CD4-Positive T-Lymphocytes - immunology
8CD8 antigen
9CD8-Positive T-Lymphocytes - immunology
10Cells, Cultured
11Cognate epitope recognition
12Cytotoxicity
13Dendritic cells
14Depletion
15Epitopes
16Epitopes - immunology
17Histocompatibility Antigens Class I - immunology
18Histocompatibility Antigens Class II - immunology
19Immunoglobulins
20Infections
21Leukocytes (mononuclear)
22Leukocytes, Mononuclear - immunology
23Livestock
24Lymphocytes
25Lymphocytes T
26Major histocompatibility complex
27Membrane proteins
28Monoclonal antibodies
29Monocytes
30Mycobacterium avium
31Mycobacterium avium subsp. paratuberculosis
32Mycobacterium avium subsp. paratuberculosis - immunology
33Paratuberculosis
34Paratuberculosis - prevention & control
35Peptides
36Peripheral blood mononuclear cells
37Propidium monoazide
38Recognition
39Stimulation
40T cells
41T-Lymphocytes, Cytotoxic - immunology
42Tuberculosis Vaccines - immunology
43Vaccination
44Vaccines
45Vaccines, Subunit - immunology
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1Fry, Lindsay M
2Elnaggar, Mahmoud M
3Bannantine, John P
4Schneider, David A
5Chamberlin, William M
6Mahmoud, Asmaa H.A
7Park, Kun-Taek
8Hulubei, Victoria
9Davis, William C
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titleSimultaneous cognate epitope recognition by bovine CD4 and CD8 T cells is essential for primary expansion of antigen-specific cytotoxic T-cells following ex vivo stimulation with a candidate Mycobacterium avium subsp. paratuberculosis peptide vaccine
authorAbdellrazeq, Gaber S ; Fry, Lindsay M ; Elnaggar, Mahmoud M ; Bannantine, John P ; Schneider, David A ; Chamberlin, William M ; Mahmoud, Asmaa H.A ; Park, Kun-Taek ; Hulubei, Victoria ; Davis, William C
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1Antigen Presentation
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3Antigens
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6CD4 antigen
7CD4-Positive T-Lymphocytes - immunology
8CD8 antigen
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13Dendritic cells
14Depletion
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17Histocompatibility Antigens Class I - immunology
18Histocompatibility Antigens Class II - immunology
19Immunoglobulins
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22Leukocytes, Mononuclear - immunology
23Livestock
24Lymphocytes
25Lymphocytes T
26Major histocompatibility complex
27Membrane proteins
28Monoclonal antibodies
29Monocytes
30Mycobacterium avium
31Mycobacterium avium subsp. paratuberculosis
32Mycobacterium avium subsp. paratuberculosis - immunology
33Paratuberculosis
34Paratuberculosis - prevention & control
35Peptides
36Peripheral blood mononuclear cells
37Propidium monoazide
38Recognition
39Stimulation
40T cells
41T-Lymphocytes, Cytotoxic - immunology
42Tuberculosis Vaccines - immunology
43Vaccination
44Vaccines
45Vaccines, Subunit - immunology
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1Fry, Lindsay M
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7Park, Kun-Taek
8Hulubei, Victoria
9Davis, William C
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1Fry, Lindsay M
2Elnaggar, Mahmoud M
3Bannantine, John P
4Schneider, David A
5Chamberlin, William M
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7Park, Kun-Taek
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atitleSimultaneous cognate epitope recognition by bovine CD4 and CD8 T cells is essential for primary expansion of antigen-specific cytotoxic T-cells following ex vivo stimulation with a candidate Mycobacterium avium subsp. paratuberculosis peptide vaccine
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abstract•Antigen presentation to CD4 and CD8 T cells by antigen presenting cells is blocked in the presence of antibody specific for either MHC I or MHC II.•Simultaneous CD4 and CD8 T cell cognate recognition of antigenic epitopes presented by antigen presenting cells is essential for development of CD8 cytotoxic T cells. Studies in cattle show CD8 cytotoxic T cells (CTL), with the ability to kill intracellular bacteria, develop following stimulation of monocyte-depleted peripheral blood mononuclear cells (mdPBMC) with antigen presenting cells (APC, i.e. conventional dendritic cells [cDC] and monocyte-derived DC [MoDC]) pulsed with MMP, a membrane protein from Mycobacterium avium subsp. paratuberculosis (Map) encoded by MAP2121c. CTL activity was diminished if CD4 T cells were depleted from mdPBMC before antigen (Ag) presentation by APC, suggesting simultaneous cognate recognition of MMP epitopes presented by MHC I and MHC II molecules to CD4 and CD8 T cells is essential for development of CTL activity. To explore this possibility, studies were conducted with mdPBMC cultures in the presence of monoclonal antibodies (mAbs) specific for MHC class I and MHC class II molecules. The CTL response of mdPBMC to MMP-pulsed APC was completely blocked in the presence of mAbs to both MHC I and II molecules and also blocked in the presence of mAbs to either MHC I or MHC II alone. The results demonstrate simultaneous cognate recognition of Ag by CD4 and CD8 T cells is essential for delivery of CD4 T cell help to CD8 T cells to elicit development of CTL.
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pubElsevier Ltd
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