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Maternal determinants of infant immunity: Implications for effective immunization and maternal-child health

[...]maternal immunization strategies could be refined and improved by better understanding the mechanisms underlying maternal and infant immunity to pathogens, especially the elements that influence responses to vaccines in pregnant women, maternal antibody transfer, and adaptive immune responses t... Full description

Journal Title: Vaccine 2020, Vol.38 (28), p.4491-4494
Main Author: Pasetti, Marcela F
Other Authors: Ackerman, Margaret E , Hoen, Annie G , Alter, Galit , Tsang, John S , Marchant, Arnaud
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: Netherlands: Elsevier Ltd
ID: ISSN: 0264-410X
Link: https://www.ncbi.nlm.nih.gov/pubmed/32111530
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recordid: cdi_proquest_miscellaneous_2369435123
title: Maternal determinants of infant immunity: Implications for effective immunization and maternal-child health
format: Article
creator:
  • Pasetti, Marcela F
  • Ackerman, Margaret E
  • Hoen, Annie G
  • Alter, Galit
  • Tsang, John S
  • Marchant, Arnaud
subjects:
  • Adaptive immunity
  • Antibodies
  • Antigens
  • Babies
  • Breast milk
  • Breastfeeding & lactation
  • Child
  • Child Health
  • Childrens health
  • Cytokines
  • Humans
  • Immune response
  • Immune status
  • Immune system
  • Immunity
  • Immunization
  • Immunology
  • Infant
  • Infants
  • Infections
  • Infectious diseases
  • Influenza
  • Interrogation
  • Maternal & child health
  • Microbial activity
  • Microorganisms
  • Milk
  • Mothers
  • Newborn babies
  • Pathogens
  • Placenta
  • Pregnancy
  • Proteomics
  • Transcription
  • Vaccination
  • Vaccines
  • Whooping cough
  • Womens health
ispartof: Vaccine, 2020, Vol.38 (28), p.4491-4494
description: [...]maternal immunization strategies could be refined and improved by better understanding the mechanisms underlying maternal and infant immunity to pathogens, especially the elements that influence responses to vaccines in pregnant women, maternal antibody transfer, and adaptive immune responses to vaccine antigens in infants. A holistic approach focused on the mother-infant dyad as one entity from conception through 2 years of age, in-depth interrogation and integrative analysis of potential health determinants such as microbial communities; transcriptional, proteomic, and cellular states, and their interactions, is necessary to define the rich interactions within the maternal-child unit, refine clinical practices, and uncover novel actionable targets for intervention. The full and large-scale potential of maternal vaccination can only be appreciated by a combination of efficacy/effectiveness studies with longitudinal analyses of maternal immunity and immunological components conveyed via placenta and breast milk.4 Interactions of maternal antibodies with the infant immune system Maternal antibodies provide protection against infectious agents but can also influence infant vaccine responses. Defining the principles underlying antibody-dependent immunity in early life and the influence of maternal antibodies on infant immune responses to vaccine antigens is essential to harness integrated maternal and infant immunization strategies.5 Toward a systems immunology approach to maternal immunization Beyond antibodies, little is known about other immune correlates and determinants of effective immunization in pregnant women and infants, as well as about how other maternal immune-related components (e.g. cells, cytokines, and other molecules shared via placenta and/or breast milk) may interact and shape the immune status and health of the infant.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0264-410X
fulltext: fulltext
issn:
  • 0264-410X
  • 1873-2518
url: Link


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description[...]maternal immunization strategies could be refined and improved by better understanding the mechanisms underlying maternal and infant immunity to pathogens, especially the elements that influence responses to vaccines in pregnant women, maternal antibody transfer, and adaptive immune responses to vaccine antigens in infants. A holistic approach focused on the mother-infant dyad as one entity from conception through 2 years of age, in-depth interrogation and integrative analysis of potential health determinants such as microbial communities; transcriptional, proteomic, and cellular states, and their interactions, is necessary to define the rich interactions within the maternal-child unit, refine clinical practices, and uncover novel actionable targets for intervention. The full and large-scale potential of maternal vaccination can only be appreciated by a combination of efficacy/effectiveness studies with longitudinal analyses of maternal immunity and immunological components conveyed via placenta and breast milk.4 Interactions of maternal antibodies with the infant immune system Maternal antibodies provide protection against infectious agents but can also influence infant vaccine responses. Defining the principles underlying antibody-dependent immunity in early life and the influence of maternal antibodies on infant immune responses to vaccine antigens is essential to harness integrated maternal and infant immunization strategies.5 Toward a systems immunology approach to maternal immunization Beyond antibodies, little is known about other immune correlates and determinants of effective immunization in pregnant women and infants, as well as about how other maternal immune-related components (e.g. cells, cytokines, and other molecules shared via placenta and/or breast milk) may interact and shape the immune status and health of the infant.
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subjectAdaptive immunity ; Antibodies ; Antigens ; Babies ; Breast milk ; Breastfeeding & lactation ; Child ; Child Health ; Childrens health ; Cytokines ; Humans ; Immune response ; Immune status ; Immune system ; Immunity ; Immunization ; Immunology ; Infant ; Infants ; Infections ; Infectious diseases ; Influenza ; Interrogation ; Maternal & child health ; Microbial activity ; Microorganisms ; Milk ; Mothers ; Newborn babies ; Pathogens ; Placenta ; Pregnancy ; Proteomics ; Transcription ; Vaccination ; Vaccines ; Whooping cough ; Womens health
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description[...]maternal immunization strategies could be refined and improved by better understanding the mechanisms underlying maternal and infant immunity to pathogens, especially the elements that influence responses to vaccines in pregnant women, maternal antibody transfer, and adaptive immune responses to vaccine antigens in infants. A holistic approach focused on the mother-infant dyad as one entity from conception through 2 years of age, in-depth interrogation and integrative analysis of potential health determinants such as microbial communities; transcriptional, proteomic, and cellular states, and their interactions, is necessary to define the rich interactions within the maternal-child unit, refine clinical practices, and uncover novel actionable targets for intervention. The full and large-scale potential of maternal vaccination can only be appreciated by a combination of efficacy/effectiveness studies with longitudinal analyses of maternal immunity and immunological components conveyed via placenta and breast milk.4 Interactions of maternal antibodies with the infant immune system Maternal antibodies provide protection against infectious agents but can also influence infant vaccine responses. Defining the principles underlying antibody-dependent immunity in early life and the influence of maternal antibodies on infant immune responses to vaccine antigens is essential to harness integrated maternal and infant immunization strategies.5 Toward a systems immunology approach to maternal immunization Beyond antibodies, little is known about other immune correlates and determinants of effective immunization in pregnant women and infants, as well as about how other maternal immune-related components (e.g. cells, cytokines, and other molecules shared via placenta and/or breast milk) may interact and shape the immune status and health of the infant.
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19Infections
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28Newborn babies
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36Whooping cough
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abstract[...]maternal immunization strategies could be refined and improved by better understanding the mechanisms underlying maternal and infant immunity to pathogens, especially the elements that influence responses to vaccines in pregnant women, maternal antibody transfer, and adaptive immune responses to vaccine antigens in infants. A holistic approach focused on the mother-infant dyad as one entity from conception through 2 years of age, in-depth interrogation and integrative analysis of potential health determinants such as microbial communities; transcriptional, proteomic, and cellular states, and their interactions, is necessary to define the rich interactions within the maternal-child unit, refine clinical practices, and uncover novel actionable targets for intervention. The full and large-scale potential of maternal vaccination can only be appreciated by a combination of efficacy/effectiveness studies with longitudinal analyses of maternal immunity and immunological components conveyed via placenta and breast milk.4 Interactions of maternal antibodies with the infant immune system Maternal antibodies provide protection against infectious agents but can also influence infant vaccine responses. Defining the principles underlying antibody-dependent immunity in early life and the influence of maternal antibodies on infant immune responses to vaccine antigens is essential to harness integrated maternal and infant immunization strategies.5 Toward a systems immunology approach to maternal immunization Beyond antibodies, little is known about other immune correlates and determinants of effective immunization in pregnant women and infants, as well as about how other maternal immune-related components (e.g. cells, cytokines, and other molecules shared via placenta and/or breast milk) may interact and shape the immune status and health of the infant.
copNetherlands
pubElsevier Ltd
pmid32111530
doi10.1016/j.vaccine.2020.01.056