schliessen

Filtern

 

Bibliotheken

Hereditary diffuse gastric cancer: updated clinical practice guidelines

Hereditary diffuse gastric cancer (HDGC) is an autosomal dominant cancer syndrome that is characterised by a high prevalence of diffuse gastric cancer and lobular breast cancer. It is largely caused by inactivating germline mutations in the tumour suppressor gene CDH1, although pathogenic variants i... Full description

Journal Title: The lancet oncology 2020-08, Vol.21 (8), p.e386-e397
Main Author: Blair, Vanessa R
Other Authors: McLeod, Maybelle , Carneiro, Fátima , Coit, Daniel G , D'Addario, Johanna L , van Dieren, Jolanda M , Harris, Kirsty L , Hoogerbrugge, Nicoline , Oliveira, Carla , van der Post, Rachel S , Arnold, Julie , Benusiglio, Patrick R , Bisseling, Tanya M , Boussioutas, Alex , Cats, Annemieke , Charlton, Amanda , Schreiber, Karen E Chelcun , Davis, Jeremy L , Pietro, Massimiliano di , Fitzgerald, Rebecca C , Ford, James M , Gamet, Kimberley , Gullo, Irene , Hardwick, Richard H , Huntsman, David G , Kaurah, Pardeep , Kupfer, Sonia S , Latchford, Andrew , Mansfield, Paul F , Nakajima, Takeshi , Parry, Susan , Rossaak, Jeremy , Sugimura, Haruhiko , Svrcek, Magali , Tischkowitz, Marc , Ushijima, Toshikazu , Yamada, Hidetaka , Yang, Han-Kwang , Claydon, Adrian , Figueiredo, Joana , Paringatai, Karyn , Seruca, Raquel , Bougen-Zhukov, Nicola , Brew, Tom , Busija, Simone , Carneiro, Patricia , DeGregorio, Lynn , Fisher, Helen , Gardner, Erin , Godwin, Tanis D , Holm, Katharine N , Humar, Bostjan , Lintott, Caroline J , Monroe, Elizabeth C , Muller, Mark D , Norero, Enrique , Nouri, Yasmin , Paredes, Joana , Sanches, João M , Schulpen, Emily , Ribeiro, Ana S , Sporle, Andrew , Whitworth, James , Zhang, Liying , Reeve, Anthony E , Guilford, Parry
Format: Electronic Article Electronic Article
Language: English
Subjects:
Age
Quelle: Alma/SFX Local Collection
Publisher: England: Elsevier Ltd
ID: ISSN: 1470-2045
Link: https://www.ncbi.nlm.nih.gov/pubmed/32758476
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: cdi_proquest_miscellaneous_2431812048
title: Hereditary diffuse gastric cancer: updated clinical practice guidelines
format: Article
creator:
  • Blair, Vanessa R
  • McLeod, Maybelle
  • Carneiro, Fátima
  • Coit, Daniel G
  • D'Addario, Johanna L
  • van Dieren, Jolanda M
  • Harris, Kirsty L
  • Hoogerbrugge, Nicoline
  • Oliveira, Carla
  • van der Post, Rachel S
  • Arnold, Julie
  • Benusiglio, Patrick R
  • Bisseling, Tanya M
  • Boussioutas, Alex
  • Cats, Annemieke
  • Charlton, Amanda
  • Schreiber, Karen E Chelcun
  • Davis, Jeremy L
  • Pietro, Massimiliano di
  • Fitzgerald, Rebecca C
  • Ford, James M
  • Gamet, Kimberley
  • Gullo, Irene
  • Hardwick, Richard H
  • Huntsman, David G
  • Kaurah, Pardeep
  • Kupfer, Sonia S
  • Latchford, Andrew
  • Mansfield, Paul F
  • Nakajima, Takeshi
  • Parry, Susan
  • Rossaak, Jeremy
  • Sugimura, Haruhiko
  • Svrcek, Magali
  • Tischkowitz, Marc
  • Ushijima, Toshikazu
  • Yamada, Hidetaka
  • Yang, Han-Kwang
  • Claydon, Adrian
  • Figueiredo, Joana
  • Paringatai, Karyn
  • Seruca, Raquel
  • Bougen-Zhukov, Nicola
  • Brew, Tom
  • Busija, Simone
  • Carneiro, Patricia
  • DeGregorio, Lynn
  • Fisher, Helen
  • Gardner, Erin
  • Godwin, Tanis D
  • Holm, Katharine N
  • Humar, Bostjan
  • Lintott, Caroline J
  • Monroe, Elizabeth C
  • Muller, Mark D
  • Norero, Enrique
  • Nouri, Yasmin
  • Paredes, Joana
  • Sanches, João M
  • Schulpen, Emily
  • Ribeiro, Ana S
  • Sporle, Andrew
  • Whitworth, James
  • Zhang, Liying
  • Reeve, Anthony E
  • Guilford, Parry
subjects:
  • Age
  • Breast cancer
  • Cell adhesion & migration
  • Complications
  • Counseling
  • E-cadherin
  • Family medical history
  • Gastrectomy
  • Gastric cancer
  • Gastroenterology
  • Genetic aspects
  • Genetic screening
  • Health surveillance
  • Humans
  • Laboratories
  • Mutation
  • Neoplastic Syndromes, Hereditary
  • Patients
  • Practice guidelines (Medicine)
  • Signal transduction
  • Stomach cancer
  • Stomach Neoplasms
  • Surgeons
  • Surgery
  • Tumors
ispartof: The lancet oncology, 2020-08, Vol.21 (8), p.e386-e397
description: Hereditary diffuse gastric cancer (HDGC) is an autosomal dominant cancer syndrome that is characterised by a high prevalence of diffuse gastric cancer and lobular breast cancer. It is largely caused by inactivating germline mutations in the tumour suppressor gene CDH1, although pathogenic variants in CTNNA1 occur in a minority of families with HDGC. In this Policy Review, we present updated clinical practice guidelines for HDGC from the International Gastric Cancer Linkage Consortium (IGCLC), which recognise the emerging evidence of variability in gastric cancer risk between families with HDGC, the growing capability of endoscopic and histological surveillance in HDGC, and increased experience of managing long-term sequelae of total gastrectomy in young patients. To redress the balance between the accessibility, cost, and acceptance of genetic testing and the increased identification of pathogenic variant carriers, the HDGC genetic testing criteria have been relaxed, mainly through less restrictive age limits. Prophylactic total gastrectomy remains the recommended option for gastric cancer risk management in pathogenic CDH1 variant carriers. However, there is increasing confidence from the IGCLC that endoscopic surveillance in expert centres can be safely offered to patients who wish to postpone surgery, or to those whose risk of developing gastric cancer is not well defined.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 1470-2045
fulltext: fulltext
issn:
  • 1470-2045
  • 1474-5488
url: Link


@attributes
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
RANK2.7783241
LOCALfalse
PrimoNMBib
record
control
sourceidgale_proqu
recordidTN_cdi_proquest_miscellaneous_2431812048
sourceformatXML
sourcesystemPC
galeidA631471617
sourcerecordidA631471617
originalsourceidFETCH-LOGICAL-c454t-6b17388288fa205f9a36661470008b2f44c3ff9bd2a67fe2be29fc4afc9d5b193
addsrcrecordideNqFkdFr1jAUxYMobvv0T1AKvsyHziRN0lQQGWNuwsAH9Tmkyc24o19Tk1bwvzf9OieKIIEmHH7ncm4PIS8YPWOUqTefmWhpzamQp5y-bihnXd09IsdFFrUUWj8-vDfkiJzkfEcpaxmVT8lRw1upRauOydU1JPA42_Sj8hjCkqG6tXlO6CpnRwfpbbVM3s7gKzfgiM4O1ZSsm9EVckEPRYX8jDwJdsjw_P7eka8fLr9cXNc3n64-Xpzf1E5IMdeqZ22jNdc6WE5l6GyjlFpzUqp7HoRwTQhd77lVbQDeA--CEza4zsuedc2OnG5zpxS_LZBns8fsYBjsCHHJhouGaVZ21gV99Rd6F5c0lnQrRWnLlWx-U7d2AINjiHPZbh1qzlVTkjFVIu_I2T-ocjzs0cURAhb9D4PcDC7FnBMEMyXcl79sGDVrgeZQoFnbKR9zKNCs-728D730e_APrl-NFeDdBow2OcwPQFpMtGgSTDHjHIuy9OOqjkOZr5ThXHLFiv_95ofS0neEZLJDKEV7TOBm4yP-J-JPWzq-EA
sourcetypeAggregation Database
isCDItrue
recordtypearticle
pqid2430072653
display
typearticle
titleHereditary diffuse gastric cancer: updated clinical practice guidelines
sourceAlma/SFX Local Collection
creatorBlair, Vanessa R ; McLeod, Maybelle ; Carneiro, Fátima ; Coit, Daniel G ; D'Addario, Johanna L ; van Dieren, Jolanda M ; Harris, Kirsty L ; Hoogerbrugge, Nicoline ; Oliveira, Carla ; van der Post, Rachel S ; Arnold, Julie ; Benusiglio, Patrick R ; Bisseling, Tanya M ; Boussioutas, Alex ; Cats, Annemieke ; Charlton, Amanda ; Schreiber, Karen E Chelcun ; Davis, Jeremy L ; Pietro, Massimiliano di ; Fitzgerald, Rebecca C ; Ford, James M ; Gamet, Kimberley ; Gullo, Irene ; Hardwick, Richard H ; Huntsman, David G ; Kaurah, Pardeep ; Kupfer, Sonia S ; Latchford, Andrew ; Mansfield, Paul F ; Nakajima, Takeshi ; Parry, Susan ; Rossaak, Jeremy ; Sugimura, Haruhiko ; Svrcek, Magali ; Tischkowitz, Marc ; Ushijima, Toshikazu ; Yamada, Hidetaka ; Yang, Han-Kwang ; Claydon, Adrian ; Figueiredo, Joana ; Paringatai, Karyn ; Seruca, Raquel ; Bougen-Zhukov, Nicola ; Brew, Tom ; Busija, Simone ; Carneiro, Patricia ; DeGregorio, Lynn ; Fisher, Helen ; Gardner, Erin ; Godwin, Tanis D ; Holm, Katharine N ; Humar, Bostjan ; Lintott, Caroline J ; Monroe, Elizabeth C ; Muller, Mark D ; Norero, Enrique ; Nouri, Yasmin ; Paredes, Joana ; Sanches, João M ; Schulpen, Emily ; Ribeiro, Ana S ; Sporle, Andrew ; Whitworth, James ; Zhang, Liying ; Reeve, Anthony E ; Guilford, Parry
creatorcontribBlair, Vanessa R ; McLeod, Maybelle ; Carneiro, Fátima ; Coit, Daniel G ; D'Addario, Johanna L ; van Dieren, Jolanda M ; Harris, Kirsty L ; Hoogerbrugge, Nicoline ; Oliveira, Carla ; van der Post, Rachel S ; Arnold, Julie ; Benusiglio, Patrick R ; Bisseling, Tanya M ; Boussioutas, Alex ; Cats, Annemieke ; Charlton, Amanda ; Schreiber, Karen E Chelcun ; Davis, Jeremy L ; Pietro, Massimiliano di ; Fitzgerald, Rebecca C ; Ford, James M ; Gamet, Kimberley ; Gullo, Irene ; Hardwick, Richard H ; Huntsman, David G ; Kaurah, Pardeep ; Kupfer, Sonia S ; Latchford, Andrew ; Mansfield, Paul F ; Nakajima, Takeshi ; Parry, Susan ; Rossaak, Jeremy ; Sugimura, Haruhiko ; Svrcek, Magali ; Tischkowitz, Marc ; Ushijima, Toshikazu ; Yamada, Hidetaka ; Yang, Han-Kwang ; Claydon, Adrian ; Figueiredo, Joana ; Paringatai, Karyn ; Seruca, Raquel ; Bougen-Zhukov, Nicola ; Brew, Tom ; Busija, Simone ; Carneiro, Patricia ; DeGregorio, Lynn ; Fisher, Helen ; Gardner, Erin ; Godwin, Tanis D ; Holm, Katharine N ; Humar, Bostjan ; Lintott, Caroline J ; Monroe, Elizabeth C ; Muller, Mark D ; Norero, Enrique ; Nouri, Yasmin ; Paredes, Joana ; Sanches, João M ; Schulpen, Emily ; Ribeiro, Ana S ; Sporle, Andrew ; Whitworth, James ; Zhang, Liying ; Reeve, Anthony E ; Guilford, Parry
descriptionHereditary diffuse gastric cancer (HDGC) is an autosomal dominant cancer syndrome that is characterised by a high prevalence of diffuse gastric cancer and lobular breast cancer. It is largely caused by inactivating germline mutations in the tumour suppressor gene CDH1, although pathogenic variants in CTNNA1 occur in a minority of families with HDGC. In this Policy Review, we present updated clinical practice guidelines for HDGC from the International Gastric Cancer Linkage Consortium (IGCLC), which recognise the emerging evidence of variability in gastric cancer risk between families with HDGC, the growing capability of endoscopic and histological surveillance in HDGC, and increased experience of managing long-term sequelae of total gastrectomy in young patients. To redress the balance between the accessibility, cost, and acceptance of genetic testing and the increased identification of pathogenic variant carriers, the HDGC genetic testing criteria have been relaxed, mainly through less restrictive age limits. Prophylactic total gastrectomy remains the recommended option for gastric cancer risk management in pathogenic CDH1 variant carriers. However, there is increasing confidence from the IGCLC that endoscopic surveillance in expert centres can be safely offered to patients who wish to postpone surgery, or to those whose risk of developing gastric cancer is not well defined.
identifier
0ISSN: 1470-2045
1EISSN: 1474-5488
2DOI: 10.1016/S1470-2045(20)30219-9
3PMID: 32758476
languageeng
publisherEngland: Elsevier Ltd
subjectAge ; Breast cancer ; Cell adhesion & migration ; Complications ; Counseling ; E-cadherin ; Family medical history ; Gastrectomy ; Gastric cancer ; Gastroenterology ; Genetic aspects ; Genetic screening ; Health surveillance ; Humans ; Laboratories ; Mutation ; Neoplastic Syndromes, Hereditary ; Patients ; Practice guidelines (Medicine) ; Signal transduction ; Stomach cancer ; Stomach Neoplasms ; Surgeons ; Surgery ; Tumors
ispartofThe lancet oncology, 2020-08, Vol.21 (8), p.e386-e397
rights
02020 Elsevier Ltd
1info:eu-repo/semantics/closedAccess
2Copyright © 2020 Elsevier Ltd. All rights reserved.
3COPYRIGHT 2020 Elsevier B.V.
42020. Elsevier Ltd
lds50peer_reviewed
oafree_for_read
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
thumbnail$$Usyndetics_thumb_exl
backlink$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32758476$$D View this record in MEDLINE/PubMed
search
creatorcontrib
0Blair, Vanessa R
1McLeod, Maybelle
2Carneiro, Fátima
3Coit, Daniel G
4D'Addario, Johanna L
5van Dieren, Jolanda M
6Harris, Kirsty L
7Hoogerbrugge, Nicoline
8Oliveira, Carla
9van der Post, Rachel S
10Arnold, Julie
11Benusiglio, Patrick R
12Bisseling, Tanya M
13Boussioutas, Alex
14Cats, Annemieke
15Charlton, Amanda
16Schreiber, Karen E Chelcun
17Davis, Jeremy L
18Pietro, Massimiliano di
19Fitzgerald, Rebecca C
20Ford, James M
21Gamet, Kimberley
22Gullo, Irene
23Hardwick, Richard H
24Huntsman, David G
25Kaurah, Pardeep
26Kupfer, Sonia S
27Latchford, Andrew
28Mansfield, Paul F
29Nakajima, Takeshi
30Parry, Susan
31Rossaak, Jeremy
32Sugimura, Haruhiko
33Svrcek, Magali
34Tischkowitz, Marc
35Ushijima, Toshikazu
36Yamada, Hidetaka
37Yang, Han-Kwang
38Claydon, Adrian
39Figueiredo, Joana
40Paringatai, Karyn
41Seruca, Raquel
42Bougen-Zhukov, Nicola
43Brew, Tom
44Busija, Simone
45Carneiro, Patricia
46DeGregorio, Lynn
47Fisher, Helen
48Gardner, Erin
49Godwin, Tanis D
50Holm, Katharine N
51Humar, Bostjan
52Lintott, Caroline J
53Monroe, Elizabeth C
54Muller, Mark D
55Norero, Enrique
56Nouri, Yasmin
57Paredes, Joana
58Sanches, João M
59Schulpen, Emily
60Ribeiro, Ana S
61Sporle, Andrew
62Whitworth, James
63Zhang, Liying
64Reeve, Anthony E
65Guilford, Parry
title
0Hereditary diffuse gastric cancer: updated clinical practice guidelines
1The lancet oncology
addtitleLancet Oncol
descriptionHereditary diffuse gastric cancer (HDGC) is an autosomal dominant cancer syndrome that is characterised by a high prevalence of diffuse gastric cancer and lobular breast cancer. It is largely caused by inactivating germline mutations in the tumour suppressor gene CDH1, although pathogenic variants in CTNNA1 occur in a minority of families with HDGC. In this Policy Review, we present updated clinical practice guidelines for HDGC from the International Gastric Cancer Linkage Consortium (IGCLC), which recognise the emerging evidence of variability in gastric cancer risk between families with HDGC, the growing capability of endoscopic and histological surveillance in HDGC, and increased experience of managing long-term sequelae of total gastrectomy in young patients. To redress the balance between the accessibility, cost, and acceptance of genetic testing and the increased identification of pathogenic variant carriers, the HDGC genetic testing criteria have been relaxed, mainly through less restrictive age limits. Prophylactic total gastrectomy remains the recommended option for gastric cancer risk management in pathogenic CDH1 variant carriers. However, there is increasing confidence from the IGCLC that endoscopic surveillance in expert centres can be safely offered to patients who wish to postpone surgery, or to those whose risk of developing gastric cancer is not well defined.
subject
0Age
1Breast cancer
2Cell adhesion & migration
3Complications
4Counseling
5E-cadherin
6Family medical history
7Gastrectomy
8Gastric cancer
9Gastroenterology
10Genetic aspects
11Genetic screening
12Health surveillance
13Humans
14Laboratories
15Mutation
16Neoplastic Syndromes, Hereditary
17Patients
18Practice guidelines (Medicine)
19Signal transduction
20Stomach cancer
21Stomach Neoplasms
22Surgeons
23Surgery
24Tumors
issn
01470-2045
11474-5488
fulltexttrue
rsrctypearticle
creationdate2020
recordtypearticle
recordideNqFkdFr1jAUxYMobvv0T1AKvsyHziRN0lQQGWNuwsAH9Tmkyc24o19Tk1bwvzf9OieKIIEmHH7ncm4PIS8YPWOUqTefmWhpzamQp5y-bihnXd09IsdFFrUUWj8-vDfkiJzkfEcpaxmVT8lRw1upRauOydU1JPA42_Sj8hjCkqG6tXlO6CpnRwfpbbVM3s7gKzfgiM4O1ZSsm9EVckEPRYX8jDwJdsjw_P7eka8fLr9cXNc3n64-Xpzf1E5IMdeqZ22jNdc6WE5l6GyjlFpzUqp7HoRwTQhd77lVbQDeA--CEza4zsuedc2OnG5zpxS_LZBns8fsYBjsCHHJhouGaVZ21gV99Rd6F5c0lnQrRWnLlWx-U7d2AINjiHPZbh1qzlVTkjFVIu_I2T-ocjzs0cURAhb9D4PcDC7FnBMEMyXcl79sGDVrgeZQoFnbKR9zKNCs-728D730e_APrl-NFeDdBow2OcwPQFpMtGgSTDHjHIuy9OOqjkOZr5ThXHLFiv_95ofS0neEZLJDKEV7TOBm4yP-J-JPWzq-EA
startdate202008
enddate202008
creator
0Blair, Vanessa R
1McLeod, Maybelle
2Carneiro, Fátima
3Coit, Daniel G
4D'Addario, Johanna L
5van Dieren, Jolanda M
6Harris, Kirsty L
7Hoogerbrugge, Nicoline
8Oliveira, Carla
9van der Post, Rachel S
10Arnold, Julie
11Benusiglio, Patrick R
12Bisseling, Tanya M
13Boussioutas, Alex
14Cats, Annemieke
15Charlton, Amanda
16Schreiber, Karen E Chelcun
17Davis, Jeremy L
18Pietro, Massimiliano di
19Fitzgerald, Rebecca C
20Ford, James M
21Gamet, Kimberley
22Gullo, Irene
23Hardwick, Richard H
24Huntsman, David G
25Kaurah, Pardeep
26Kupfer, Sonia S
27Latchford, Andrew
28Mansfield, Paul F
29Nakajima, Takeshi
30Parry, Susan
31Rossaak, Jeremy
32Sugimura, Haruhiko
33Svrcek, Magali
34Tischkowitz, Marc
35Ushijima, Toshikazu
36Yamada, Hidetaka
37Yang, Han-Kwang
38Claydon, Adrian
39Figueiredo, Joana
40Paringatai, Karyn
41Seruca, Raquel
42Bougen-Zhukov, Nicola
43Brew, Tom
44Busija, Simone
45Carneiro, Patricia
46DeGregorio, Lynn
47Fisher, Helen
48Gardner, Erin
49Godwin, Tanis D
50Holm, Katharine N
51Humar, Bostjan
52Lintott, Caroline J
53Monroe, Elizabeth C
54Muller, Mark D
55Norero, Enrique
56Nouri, Yasmin
57Paredes, Joana
58Sanches, João M
59Schulpen, Emily
60Ribeiro, Ana S
61Sporle, Andrew
62Whitworth, James
63Zhang, Liying
64Reeve, Anthony E
65Guilford, Parry
general
0Elsevier Ltd
1Elsevier B.V
2Elsevier Limited
scope
05DI
15DJ
2QVL
3CGR
4CUY
5CVF
6ECM
7EIF
8NPM
9AAYXX
10CITATION
11BSHEE
120TZ
133V.
147RV
157TO
167X7
177XB
1888E
198AO
208C1
218C2
228FI
238FJ
248FK
25ABUWG
26BENPR
27FYUFA
28GHDGH
29H94
30K9.
31KB0
32M0S
33M1P
34NAPCQ
35PQEST
36PQQKQ
37PQUKI
38PRINS
397X8
sort
creationdate202008
titleHereditary diffuse gastric cancer: updated clinical practice guidelines
authorBlair, Vanessa R ; McLeod, Maybelle ; Carneiro, Fátima ; Coit, Daniel G ; D'Addario, Johanna L ; van Dieren, Jolanda M ; Harris, Kirsty L ; Hoogerbrugge, Nicoline ; Oliveira, Carla ; van der Post, Rachel S ; Arnold, Julie ; Benusiglio, Patrick R ; Bisseling, Tanya M ; Boussioutas, Alex ; Cats, Annemieke ; Charlton, Amanda ; Schreiber, Karen E Chelcun ; Davis, Jeremy L ; Pietro, Massimiliano di ; Fitzgerald, Rebecca C ; Ford, James M ; Gamet, Kimberley ; Gullo, Irene ; Hardwick, Richard H ; Huntsman, David G ; Kaurah, Pardeep ; Kupfer, Sonia S ; Latchford, Andrew ; Mansfield, Paul F ; Nakajima, Takeshi ; Parry, Susan ; Rossaak, Jeremy ; Sugimura, Haruhiko ; Svrcek, Magali ; Tischkowitz, Marc ; Ushijima, Toshikazu ; Yamada, Hidetaka ; Yang, Han-Kwang ; Claydon, Adrian ; Figueiredo, Joana ; Paringatai, Karyn ; Seruca, Raquel ; Bougen-Zhukov, Nicola ; Brew, Tom ; Busija, Simone ; Carneiro, Patricia ; DeGregorio, Lynn ; Fisher, Helen ; Gardner, Erin ; Godwin, Tanis D ; Holm, Katharine N ; Humar, Bostjan ; Lintott, Caroline J ; Monroe, Elizabeth C ; Muller, Mark D ; Norero, Enrique ; Nouri, Yasmin ; Paredes, Joana ; Sanches, João M ; Schulpen, Emily ; Ribeiro, Ana S ; Sporle, Andrew ; Whitworth, James ; Zhang, Liying ; Reeve, Anthony E ; Guilford, Parry
facets
frbrtype5
frbrgroupidcdi_FETCH-LOGICAL-c454t-6b17388288fa205f9a36661470008b2f44c3ff9bd2a67fe2be29fc4afc9d5b193
rsrctypearticles
prefilterarticles
languageeng
creationdate2020
topic
0Age
1Breast cancer
2Cell adhesion & migration
3Complications
4Counseling
5E-cadherin
6Family medical history
7Gastrectomy
8Gastric cancer
9Gastroenterology
10Genetic aspects
11Genetic screening
12Health surveillance
13Humans
14Laboratories
15Mutation
16Neoplastic Syndromes, Hereditary
17Patients
18Practice guidelines (Medicine)
19Signal transduction
20Stomach cancer
21Stomach Neoplasms
22Surgeons
23Surgery
24Tumors
toplevel
0peer_reviewed
1online_resources
creatorcontrib
0Blair, Vanessa R
1McLeod, Maybelle
2Carneiro, Fátima
3Coit, Daniel G
4D'Addario, Johanna L
5van Dieren, Jolanda M
6Harris, Kirsty L
7Hoogerbrugge, Nicoline
8Oliveira, Carla
9van der Post, Rachel S
10Arnold, Julie
11Benusiglio, Patrick R
12Bisseling, Tanya M
13Boussioutas, Alex
14Cats, Annemieke
15Charlton, Amanda
16Schreiber, Karen E Chelcun
17Davis, Jeremy L
18Pietro, Massimiliano di
19Fitzgerald, Rebecca C
20Ford, James M
21Gamet, Kimberley
22Gullo, Irene
23Hardwick, Richard H
24Huntsman, David G
25Kaurah, Pardeep
26Kupfer, Sonia S
27Latchford, Andrew
28Mansfield, Paul F
29Nakajima, Takeshi
30Parry, Susan
31Rossaak, Jeremy
32Sugimura, Haruhiko
33Svrcek, Magali
34Tischkowitz, Marc
35Ushijima, Toshikazu
36Yamada, Hidetaka
37Yang, Han-Kwang
38Claydon, Adrian
39Figueiredo, Joana
40Paringatai, Karyn
41Seruca, Raquel
42Bougen-Zhukov, Nicola
43Brew, Tom
44Busija, Simone
45Carneiro, Patricia
46DeGregorio, Lynn
47Fisher, Helen
48Gardner, Erin
49Godwin, Tanis D
50Holm, Katharine N
51Humar, Bostjan
52Lintott, Caroline J
53Monroe, Elizabeth C
54Muller, Mark D
55Norero, Enrique
56Nouri, Yasmin
57Paredes, Joana
58Sanches, João M
59Schulpen, Emily
60Ribeiro, Ana S
61Sporle, Andrew
62Whitworth, James
63Zhang, Liying
64Reeve, Anthony E
65Guilford, Parry
collection
0NARCIS
1NARCIS: Datasets
2NARCIS:Publications
3Medline
4MEDLINE
5MEDLINE (Ovid)
6MEDLINE
7MEDLINE
8PubMed
9CrossRef
10Academic OneFile (A&I only)
11Pharma and Biotech Premium PRO
12ProQuest Central (Corporate)
13Nursing & Allied Health Database
14Oncogenes and Growth Factors Abstracts
15Health & Medical Collection
16ProQuest Central (purchase pre-March 2016)
17Medical Database (Alumni Edition)
18ProQuest Pharma Collection
19Public Health Database
20Lancet Titles
21Hospital Premium Collection
22Hospital Premium Collection (Alumni Edition)
23ProQuest Central (Alumni) (purchase pre-March 2016)
24ProQuest Central (Alumni Edition)
25ProQuest Central
26Health Research Premium Collection
27Health Research Premium Collection (Alumni)
28AIDS and Cancer Research Abstracts
29ProQuest Health & Medical Complete (Alumni)
30Nursing & Allied Health Database (Alumni Edition)
31Health & Medical Collection (Alumni Edition)
32Medical Database
33Nursing & Allied Health Premium
34ProQuest One Academic Eastern Edition
35ProQuest One Academic
36ProQuest One Academic UKI Edition
37ProQuest Central China
38MEDLINE - Academic
jtitleThe lancet oncology
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
au
0Blair, Vanessa R
1McLeod, Maybelle
2Carneiro, Fátima
3Coit, Daniel G
4D'Addario, Johanna L
5van Dieren, Jolanda M
6Harris, Kirsty L
7Hoogerbrugge, Nicoline
8Oliveira, Carla
9van der Post, Rachel S
10Arnold, Julie
11Benusiglio, Patrick R
12Bisseling, Tanya M
13Boussioutas, Alex
14Cats, Annemieke
15Charlton, Amanda
16Schreiber, Karen E Chelcun
17Davis, Jeremy L
18Pietro, Massimiliano di
19Fitzgerald, Rebecca C
20Ford, James M
21Gamet, Kimberley
22Gullo, Irene
23Hardwick, Richard H
24Huntsman, David G
25Kaurah, Pardeep
26Kupfer, Sonia S
27Latchford, Andrew
28Mansfield, Paul F
29Nakajima, Takeshi
30Parry, Susan
31Rossaak, Jeremy
32Sugimura, Haruhiko
33Svrcek, Magali
34Tischkowitz, Marc
35Ushijima, Toshikazu
36Yamada, Hidetaka
37Yang, Han-Kwang
38Claydon, Adrian
39Figueiredo, Joana
40Paringatai, Karyn
41Seruca, Raquel
42Bougen-Zhukov, Nicola
43Brew, Tom
44Busija, Simone
45Carneiro, Patricia
46DeGregorio, Lynn
47Fisher, Helen
48Gardner, Erin
49Godwin, Tanis D
50Holm, Katharine N
51Humar, Bostjan
52Lintott, Caroline J
53Monroe, Elizabeth C
54Muller, Mark D
55Norero, Enrique
56Nouri, Yasmin
57Paredes, Joana
58Sanches, João M
59Schulpen, Emily
60Ribeiro, Ana S
61Sporle, Andrew
62Whitworth, James
63Zhang, Liying
64Reeve, Anthony E
65Guilford, Parry
formatjournal
genrearticle
ristypeJOUR
atitleHereditary diffuse gastric cancer: updated clinical practice guidelines
jtitleThe lancet oncology
addtitleLancet Oncol
date2020-08
risdate2020
volume21
issue8
spagee386
epagee397
pagese386-e397
issn1470-2045
eissn1474-5488
abstractHereditary diffuse gastric cancer (HDGC) is an autosomal dominant cancer syndrome that is characterised by a high prevalence of diffuse gastric cancer and lobular breast cancer. It is largely caused by inactivating germline mutations in the tumour suppressor gene CDH1, although pathogenic variants in CTNNA1 occur in a minority of families with HDGC. In this Policy Review, we present updated clinical practice guidelines for HDGC from the International Gastric Cancer Linkage Consortium (IGCLC), which recognise the emerging evidence of variability in gastric cancer risk between families with HDGC, the growing capability of endoscopic and histological surveillance in HDGC, and increased experience of managing long-term sequelae of total gastrectomy in young patients. To redress the balance between the accessibility, cost, and acceptance of genetic testing and the increased identification of pathogenic variant carriers, the HDGC genetic testing criteria have been relaxed, mainly through less restrictive age limits. Prophylactic total gastrectomy remains the recommended option for gastric cancer risk management in pathogenic CDH1 variant carriers. However, there is increasing confidence from the IGCLC that endoscopic surveillance in expert centres can be safely offered to patients who wish to postpone surgery, or to those whose risk of developing gastric cancer is not well defined.
copEngland
pubElsevier Ltd
pmid32758476
doi10.1016/S1470-2045(20)30219-9
oafree_for_read