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Understanding immunosenescence and its impact on vaccination of older adults

Older adults are more susceptible to viral and bacterial infection, and experience higher incidence and severity of infectious diseases. Although vaccination is the most logical solution in preventing infectious diseases, primary vaccine responses in individuals aged ≥65 years-old fail to generate c... Full description

Journal Title: Vaccine 2020, Vol.38 (52), p.8264-8272
Main Author: Allen, Jessica C
Other Authors: Toapanta, Franklin R , Chen, Wilbur , Tennant, Sharon M
Format: Electronic Article Electronic Article
Language: English
Subjects:
Adaptive immunity
Adaptive systems
Adults
Age
Aged
Aging
Antibodies
Antigen presentation
Bacterial diseases
Bone marrow
Communicable diseases
Cytokines
Disease susceptibility
Humans
Immune
Immune response (cell-mediated)
Immune response (humoral)
Immune System
Immunosenescence
Infectious diseases
Influenza
Lymphatic system
Lymphocytes
Medical colleges
Neutrophils
Older adults
Older people
Pathogens
Population
Prevention
Risk factors
Schedules
Senescence
Streptococcus infections
Thymus gland
Vaccination
Vaccine
Vaccine efficacy
Vaccines
World health
Quelle: Alma/SFX Local Collection
Publisher: Netherlands: Elsevier Ltd
ID: ISSN: 0264-410X
Link: https://www.ncbi.nlm.nih.gov/pubmed/33229108
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recordid: cdi_proquest_miscellaneous_2464149703
title: Understanding immunosenescence and its impact on vaccination of older adults
format: Article
creator:
  • Allen, Jessica C
  • Toapanta, Franklin R
  • Chen, Wilbur
  • Tennant, Sharon M
subjects:
  • Adaptive immunity
  • Adaptive systems
  • Adults
  • Age
  • Aged
  • Aging
  • Antibodies
  • Antigen presentation
  • Bacterial diseases
  • Bone marrow
  • Communicable diseases
  • Cytokines
  • Disease susceptibility
  • Humans
  • Immune
  • Immune response (cell-mediated)
  • Immune response (humoral)
  • Immune System
  • Immunosenescence
  • Infectious diseases
  • Influenza
  • Lymphatic system
  • Lymphocytes
  • Medical colleges
  • Neutrophils
  • Older adults
  • Older people
  • Pathogens
  • Population
  • Prevention
  • Risk factors
  • Schedules
  • Senescence
  • Streptococcus infections
  • Thymus gland
  • Vaccination
  • Vaccine
  • Vaccine efficacy
  • Vaccines
  • World health
ispartof: Vaccine, 2020, Vol.38 (52), p.8264-8272
description: Older adults are more susceptible to viral and bacterial infection, and experience higher incidence and severity of infectious diseases. Although vaccination is the most logical solution in preventing infectious diseases, primary vaccine responses in individuals aged ≥65 years-old fail to generate complete protection. This is presumably attributed to immunosenescence, a term that describes functional differences associated with the immune system and natural age advancement. Both the innate and adaptive immune systems experience age-related impairments that contribute to insufficient protection following vaccination. This review addresses current knowledge of age-related changes that affect vaccine responsiveness; including the deficits in innate cell functions, dampened humoral and cell-mediated immune responses, current vaccination schedules for older adults, and concludes with potential strategies for improving vaccine efficacy specifically for this age group. Due to an age-related decline in immunity and poor vaccine responses, infectious diseases remain a burden among the aged population.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0264-410X
fulltext: fulltext
issn:
  • 0264-410X
  • 1873-2518
url: Link


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descriptionOlder adults are more susceptible to viral and bacterial infection, and experience higher incidence and severity of infectious diseases. Although vaccination is the most logical solution in preventing infectious diseases, primary vaccine responses in individuals aged ≥65 years-old fail to generate complete protection. This is presumably attributed to immunosenescence, a term that describes functional differences associated with the immune system and natural age advancement. Both the innate and adaptive immune systems experience age-related impairments that contribute to insufficient protection following vaccination. This review addresses current knowledge of age-related changes that affect vaccine responsiveness; including the deficits in innate cell functions, dampened humoral and cell-mediated immune responses, current vaccination schedules for older adults, and concludes with potential strategies for improving vaccine efficacy specifically for this age group. Due to an age-related decline in immunity and poor vaccine responses, infectious diseases remain a burden among the aged population.
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subjectAdaptive immunity ; Adaptive systems ; Adults ; Age ; Aged ; Aging ; Antibodies ; Antigen presentation ; Bacterial diseases ; Bone marrow ; Communicable diseases ; Cytokines ; Disease susceptibility ; Humans ; Immune ; Immune response (cell-mediated) ; Immune response (humoral) ; Immune System ; Immunosenescence ; Infectious diseases ; Influenza ; Lymphatic system ; Lymphocytes ; Medical colleges ; Neutrophils ; Older adults ; Older people ; Pathogens ; Population ; Prevention ; Risk factors ; Schedules ; Senescence ; Streptococcus infections ; Thymus gland ; Vaccination ; Vaccine ; Vaccine efficacy ; Vaccines ; World health
ispartofVaccine, 2020, Vol.38 (52), p.8264-8272
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abstractOlder adults are more susceptible to viral and bacterial infection, and experience higher incidence and severity of infectious diseases. Although vaccination is the most logical solution in preventing infectious diseases, primary vaccine responses in individuals aged ≥65 years-old fail to generate complete protection. This is presumably attributed to immunosenescence, a term that describes functional differences associated with the immune system and natural age advancement. Both the innate and adaptive immune systems experience age-related impairments that contribute to insufficient protection following vaccination. This review addresses current knowledge of age-related changes that affect vaccine responsiveness; including the deficits in innate cell functions, dampened humoral and cell-mediated immune responses, current vaccination schedules for older adults, and concludes with potential strategies for improving vaccine efficacy specifically for this age group. Due to an age-related decline in immunity and poor vaccine responses, infectious diseases remain a burden among the aged population.
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