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Early vitamin E supplementation attenuates diabetes-associated vascular dysfunction and the rise in protein kinase C-β in mesenteric artery and ameliorates wall stiffness in femoral artery of Wistar rats

The impact of early vitamin E supplementation on vascular function in diabetes remains unresolved. Therefore, we examined the effects of vitamin E on functional and structural parameters and on chemical markers that are disturbed in diabetes in mesenteric and femoral arteries. Segments of both arter... Full description

Journal Title: Diabetologia 2004, Vol.47 (6), p.1038-1046
Main Author: WIGG, S. J
Other Authors: TARE, M , FORBES, J , COOPER, M. E , THOMAS, M. C , COLEMAN, H. A , PARKINGTON, H. C , O'BRIEN, R. C
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Berlin: Springer
ID: ISSN: 0012-186X
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title: Early vitamin E supplementation attenuates diabetes-associated vascular dysfunction and the rise in protein kinase C-β in mesenteric artery and ameliorates wall stiffness in femoral artery of Wistar rats
format: Article
creator:
  • WIGG, S. J
  • TARE, M
  • FORBES, J
  • COOPER, M. E
  • THOMAS, M. C
  • COLEMAN, H. A
  • PARKINGTON, H. C
  • O'BRIEN, R. C
subjects:
  • Acetylcholine - pharmacology
  • Animals
  • Australia
  • Biological and medical sciences
  • Biomarkers - metabolism
  • Blood Glucose - metabolism
  • Body Weight - drug effects
  • Diabetes Mellitus, Experimental - complications
  • Diabetes Mellitus, Experimental - drug therapy
  • Diabetes Mellitus, Experimental - physiopathology
  • Diabetes. Impaired glucose tolerance
  • Dietary Supplements
  • Dilatation, Pathologic - complications
  • Dilatation, Pathologic - drug therapy
  • Dilatation, Pathologic - physiopathology
  • Drug Administration Schedule
  • Elasticity - drug effects
  • Endocrine pancreas. Apud cells (diseases)
  • Endocrinopathies
  • Endothelium, Vascular - drug effects
  • Endothelium, Vascular - pathology
  • Endothelium, Vascular - physiopathology
  • Femoral Artery - drug effects
  • Femoral Artery - metabolism
  • Femoral Artery - pathology
  • Glycated Hemoglobin A - metabolism
  • Glycation End Products, Advanced - chemistry
  • Glycation End Products, Advanced - metabolism
  • Indomethacin - pharmacology
  • Isoprostanes - metabolism
  • Lipid Metabolism
  • Lipids - classification
  • Male
  • Medical sciences
  • Mesenteric Arteries - drug effects
  • Mesenteric Arteries - enzymology
  • Mesenteric Arteries - pathology
  • Muscle, Smooth, Vascular - physiology
  • NG-Nitroarginine Methyl Ester - pharmacology
  • Protein Kinase C - antagonists & inhibitors
  • Protein Kinase C - chemistry
  • Protein Kinase C - physiology
  • Protein Kinase C beta
  • Rats
  • Rats, Wistar
  • Up-Regulation
  • Vasodilation - physiology
  • Vitamin E - administration & dosage
  • Vitamin E - blood
  • Vitamin E - therapeutic use
ispartof: Diabetologia, 2004, Vol.47 (6), p.1038-1046
description: The impact of early vitamin E supplementation on vascular function in diabetes remains unresolved. Therefore, we examined the effects of vitamin E on functional and structural parameters and on chemical markers that are disturbed in diabetes in mesenteric and femoral arteries. Segments of both arteries, taken from control and 8-week-old streptozotocin diabetic Wistar rats that were treated or not with vitamin E, were mounted on wire and pressure myographs, after which endothelium-dependent and -independent vasodilation was assessed. Passive mechanical wall properties and the localisation and levels of protein kinase C (PKC)-beta(2) and AGE were evaluated in these vessels. Vitamin E supplementation was associated with improved endothelium-dependent and -independent vasodilatation in mesenteric arteries from diabetic rats. Impaired endothelium-dependent vasodilatation in diabetic mesenteric vessels was associated with PKC-beta(2) up-regulation and this was prevented by vitamin E supplementation. Increased AGE accumulation and plasma isoprostane levels in diabetic rats were not changed by vitamin E. In the femoral artery, vitamin E supplementation had no effect on endothelium-dependent or -independent vasodilatation, but did prevent the wall stiffening associated with diabetes. Early vitamin E supplementation has a beneficial effect on diabetes-induced endothelial dysfunction in resistance arteries. This benefit may arise from a direct effect on smooth muscle function, as a result of inhibition of the PKC-beta(2) isoform by vitamin E.
language: eng
source:
identifier: ISSN: 0012-186X
fulltext: no_fulltext
issn:
  • 0012-186X
  • 1432-0428
url: Link


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titleEarly vitamin E supplementation attenuates diabetes-associated vascular dysfunction and the rise in protein kinase C-β in mesenteric artery and ameliorates wall stiffness in femoral artery of Wistar rats
creatorWIGG, S. J ; TARE, M ; FORBES, J ; COOPER, M. E ; THOMAS, M. C ; COLEMAN, H. A ; PARKINGTON, H. C ; O'BRIEN, R. C
creatorcontribWIGG, S. J ; TARE, M ; FORBES, J ; COOPER, M. E ; THOMAS, M. C ; COLEMAN, H. A ; PARKINGTON, H. C ; O'BRIEN, R. C
descriptionThe impact of early vitamin E supplementation on vascular function in diabetes remains unresolved. Therefore, we examined the effects of vitamin E on functional and structural parameters and on chemical markers that are disturbed in diabetes in mesenteric and femoral arteries. Segments of both arteries, taken from control and 8-week-old streptozotocin diabetic Wistar rats that were treated or not with vitamin E, were mounted on wire and pressure myographs, after which endothelium-dependent and -independent vasodilation was assessed. Passive mechanical wall properties and the localisation and levels of protein kinase C (PKC)-beta(2) and AGE were evaluated in these vessels. Vitamin E supplementation was associated with improved endothelium-dependent and -independent vasodilatation in mesenteric arteries from diabetic rats. Impaired endothelium-dependent vasodilatation in diabetic mesenteric vessels was associated with PKC-beta(2) up-regulation and this was prevented by vitamin E supplementation. Increased AGE accumulation and plasma isoprostane levels in diabetic rats were not changed by vitamin E. In the femoral artery, vitamin E supplementation had no effect on endothelium-dependent or -independent vasodilatation, but did prevent the wall stiffening associated with diabetes. Early vitamin E supplementation has a beneficial effect on diabetes-induced endothelial dysfunction in resistance arteries. This benefit may arise from a direct effect on smooth muscle function, as a result of inhibition of the PKC-beta(2) isoform by vitamin E.
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0ISSN: 0012-186X
1EISSN: 1432-0428
2DOI: 10.1007/s00125-004-1411-x
3PMID: 15184978
languageeng
publisherBerlin: Springer
subjectAcetylcholine - pharmacology ; Animals ; Australia ; Biological and medical sciences ; Biomarkers - metabolism ; Blood Glucose - metabolism ; Body Weight - drug effects ; Diabetes Mellitus, Experimental - complications ; Diabetes Mellitus, Experimental - drug therapy ; Diabetes Mellitus, Experimental - physiopathology ; Diabetes. Impaired glucose tolerance ; Dietary Supplements ; Dilatation, Pathologic - complications ; Dilatation, Pathologic - drug therapy ; Dilatation, Pathologic - physiopathology ; Drug Administration Schedule ; Elasticity - drug effects ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Endothelium, Vascular - drug effects ; Endothelium, Vascular - pathology ; Endothelium, Vascular - physiopathology ; Femoral Artery - drug effects ; Femoral Artery - metabolism ; Femoral Artery - pathology ; Glycated Hemoglobin A - metabolism ; Glycation End Products, Advanced - chemistry ; Glycation End Products, Advanced - metabolism ; Indomethacin - pharmacology ; Isoprostanes - metabolism ; Lipid Metabolism ; Lipids - classification ; Male ; Medical sciences ; Mesenteric Arteries - drug effects ; Mesenteric Arteries - enzymology ; Mesenteric Arteries - pathology ; Muscle, Smooth, Vascular - physiology ; NG-Nitroarginine Methyl Ester - pharmacology ; Protein Kinase C - antagonists & inhibitors ; Protein Kinase C - chemistry ; Protein Kinase C - physiology ; Protein Kinase C beta ; Rats ; Rats, Wistar ; Up-Regulation ; Vasodilation - physiology ; Vitamin E - administration & dosage ; Vitamin E - blood ; Vitamin E - therapeutic use
ispartofDiabetologia, 2004, Vol.47 (6), p.1038-1046
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0WIGG, S. J
1TARE, M
2FORBES, J
3COOPER, M. E
4THOMAS, M. C
5COLEMAN, H. A
6PARKINGTON, H. C
7O'BRIEN, R. C
title
0Early vitamin E supplementation attenuates diabetes-associated vascular dysfunction and the rise in protein kinase C-β in mesenteric artery and ameliorates wall stiffness in femoral artery of Wistar rats
1Diabetologia
addtitleDiabetologia
descriptionThe impact of early vitamin E supplementation on vascular function in diabetes remains unresolved. Therefore, we examined the effects of vitamin E on functional and structural parameters and on chemical markers that are disturbed in diabetes in mesenteric and femoral arteries. Segments of both arteries, taken from control and 8-week-old streptozotocin diabetic Wistar rats that were treated or not with vitamin E, were mounted on wire and pressure myographs, after which endothelium-dependent and -independent vasodilation was assessed. Passive mechanical wall properties and the localisation and levels of protein kinase C (PKC)-beta(2) and AGE were evaluated in these vessels. Vitamin E supplementation was associated with improved endothelium-dependent and -independent vasodilatation in mesenteric arteries from diabetic rats. Impaired endothelium-dependent vasodilatation in diabetic mesenteric vessels was associated with PKC-beta(2) up-regulation and this was prevented by vitamin E supplementation. Increased AGE accumulation and plasma isoprostane levels in diabetic rats were not changed by vitamin E. In the femoral artery, vitamin E supplementation had no effect on endothelium-dependent or -independent vasodilatation, but did prevent the wall stiffening associated with diabetes. Early vitamin E supplementation has a beneficial effect on diabetes-induced endothelial dysfunction in resistance arteries. This benefit may arise from a direct effect on smooth muscle function, as a result of inhibition of the PKC-beta(2) isoform by vitamin E.
subject
0Acetylcholine - pharmacology
1Animals
2Australia
3Biological and medical sciences
4Biomarkers - metabolism
5Blood Glucose - metabolism
6Body Weight - drug effects
7Diabetes Mellitus, Experimental - complications
8Diabetes Mellitus, Experimental - drug therapy
9Diabetes Mellitus, Experimental - physiopathology
10Diabetes. Impaired glucose tolerance
11Dietary Supplements
12Dilatation, Pathologic - complications
13Dilatation, Pathologic - drug therapy
14Dilatation, Pathologic - physiopathology
15Drug Administration Schedule
16Elasticity - drug effects
17Endocrine pancreas. Apud cells (diseases)
18Endocrinopathies
19Endothelium, Vascular - drug effects
20Endothelium, Vascular - pathology
21Endothelium, Vascular - physiopathology
22Femoral Artery - drug effects
23Femoral Artery - metabolism
24Femoral Artery - pathology
25Glycated Hemoglobin A - metabolism
26Glycation End Products, Advanced - chemistry
27Glycation End Products, Advanced - metabolism
28Indomethacin - pharmacology
29Isoprostanes - metabolism
30Lipid Metabolism
31Lipids - classification
32Male
33Medical sciences
34Mesenteric Arteries - drug effects
35Mesenteric Arteries - enzymology
36Mesenteric Arteries - pathology
37Muscle, Smooth, Vascular - physiology
38NG-Nitroarginine Methyl Ester - pharmacology
39Protein Kinase C - antagonists & inhibitors
40Protein Kinase C - chemistry
41Protein Kinase C - physiology
42Protein Kinase C beta
43Rats
44Rats, Wistar
45Up-Regulation
46Vasodilation - physiology
47Vitamin E - administration & dosage
48Vitamin E - blood
49Vitamin E - therapeutic use
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00012-186X
11432-0428
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1TARE, M
2FORBES, J
3COOPER, M. E
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6PARKINGTON, H. C
7O'BRIEN, R. C
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titleEarly vitamin E supplementation attenuates diabetes-associated vascular dysfunction and the rise in protein kinase C-β in mesenteric artery and ameliorates wall stiffness in femoral artery of Wistar rats
authorWIGG, S. J ; TARE, M ; FORBES, J ; COOPER, M. E ; THOMAS, M. C ; COLEMAN, H. A ; PARKINGTON, H. C ; O'BRIEN, R. C
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0Acetylcholine - pharmacology
1Animals
2Australia
3Biological and medical sciences
4Biomarkers - metabolism
5Blood Glucose - metabolism
6Body Weight - drug effects
7Diabetes Mellitus, Experimental - complications
8Diabetes Mellitus, Experimental - drug therapy
9Diabetes Mellitus, Experimental - physiopathology
10Diabetes. Impaired glucose tolerance
11Dietary Supplements
12Dilatation, Pathologic - complications
13Dilatation, Pathologic - drug therapy
14Dilatation, Pathologic - physiopathology
15Drug Administration Schedule
16Elasticity - drug effects
17Endocrine pancreas. Apud cells (diseases)
18Endocrinopathies
19Endothelium, Vascular - drug effects
20Endothelium, Vascular - pathology
21Endothelium, Vascular - physiopathology
22Femoral Artery - drug effects
23Femoral Artery - metabolism
24Femoral Artery - pathology
25Glycated Hemoglobin A - metabolism
26Glycation End Products, Advanced - chemistry
27Glycation End Products, Advanced - metabolism
28Indomethacin - pharmacology
29Isoprostanes - metabolism
30Lipid Metabolism
31Lipids - classification
32Male
33Medical sciences
34Mesenteric Arteries - drug effects
35Mesenteric Arteries - enzymology
36Mesenteric Arteries - pathology
37Muscle, Smooth, Vascular - physiology
38NG-Nitroarginine Methyl Ester - pharmacology
39Protein Kinase C - antagonists & inhibitors
40Protein Kinase C - chemistry
41Protein Kinase C - physiology
42Protein Kinase C beta
43Rats
44Rats, Wistar
45Up-Regulation
46Vasodilation - physiology
47Vitamin E - administration & dosage
48Vitamin E - blood
49Vitamin E - therapeutic use
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1TARE, M
2FORBES, J
3COOPER, M. E
4THOMAS, M. C
5COLEMAN, H. A
6PARKINGTON, H. C
7O'BRIEN, R. C
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1TARE, M
2FORBES, J
3COOPER, M. E
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7O'BRIEN, R. C
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atitleEarly vitamin E supplementation attenuates diabetes-associated vascular dysfunction and the rise in protein kinase C-β in mesenteric artery and ameliorates wall stiffness in femoral artery of Wistar rats
jtitleDiabetologia
addtitleDiabetologia
date2004
risdate2004
volume47
issue6
spage1038
epage1046
pages1038-1046
issn0012-186X
eissn1432-0428
abstractThe impact of early vitamin E supplementation on vascular function in diabetes remains unresolved. Therefore, we examined the effects of vitamin E on functional and structural parameters and on chemical markers that are disturbed in diabetes in mesenteric and femoral arteries. Segments of both arteries, taken from control and 8-week-old streptozotocin diabetic Wistar rats that were treated or not with vitamin E, were mounted on wire and pressure myographs, after which endothelium-dependent and -independent vasodilation was assessed. Passive mechanical wall properties and the localisation and levels of protein kinase C (PKC)-beta(2) and AGE were evaluated in these vessels. Vitamin E supplementation was associated with improved endothelium-dependent and -independent vasodilatation in mesenteric arteries from diabetic rats. Impaired endothelium-dependent vasodilatation in diabetic mesenteric vessels was associated with PKC-beta(2) up-regulation and this was prevented by vitamin E supplementation. Increased AGE accumulation and plasma isoprostane levels in diabetic rats were not changed by vitamin E. In the femoral artery, vitamin E supplementation had no effect on endothelium-dependent or -independent vasodilatation, but did prevent the wall stiffening associated with diabetes. Early vitamin E supplementation has a beneficial effect on diabetes-induced endothelial dysfunction in resistance arteries. This benefit may arise from a direct effect on smooth muscle function, as a result of inhibition of the PKC-beta(2) isoform by vitamin E.
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pmid15184978
doi10.1007/s00125-004-1411-x
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