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The Relationship of Serum Osteocalcin Concentration to Insulin Secretion, Sensitivity, and Disposal with Hypocaloric Diet and Resistance Training

Context: Bone has recently been described as exhibiting properties of an endocrine organ by producing osteocalcin that increases insulin sensitivity and secretion in animal models. Objective and Design: We aimed to evaluate circulating osteocalcin in association with insulin sensitivity and insulin... Full description

Journal Title: The journal of clinical endocrinology and metabolism 2009, Vol.94 (1), p.237-245
Main Author: Fernández-Real, Jose Manuel
Other Authors: Izquierdo, Mikel , Ortega, Francisco , Gorostiaga, Esteban , Gómez-Ambrosi, Javier , Moreno-Navarrete, Jose Maria , Frühbeck, Gema , Martínez, Cristina , Idoate, Fernando , Salvador, Javier , Forga, Lluis , Ricart, Wifredo , Ibañez, Javier
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Bethesda, MD: Endocrine Society
ID: ISSN: 0021-972X
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title: The Relationship of Serum Osteocalcin Concentration to Insulin Secretion, Sensitivity, and Disposal with Hypocaloric Diet and Resistance Training
format: Article
creator:
  • Fernández-Real, Jose Manuel
  • Izquierdo, Mikel
  • Ortega, Francisco
  • Gorostiaga, Esteban
  • Gómez-Ambrosi, Javier
  • Moreno-Navarrete, Jose Maria
  • Frühbeck, Gema
  • Martínez, Cristina
  • Idoate, Fernando
  • Salvador, Javier
  • Forga, Lluis
  • Ricart, Wifredo
  • Ibañez, Javier
subjects:
  • Abridged Index Medicus
  • Adult
  • Aged
  • Biological and medical sciences
  • Body Mass Index
  • Cross-Sectional Studies
  • Endocrinopathies
  • Energy Intake
  • Feeding. Feeding behavior
  • Female
  • Fundamental and applied biological sciences. Psychology
  • Humans
  • Insulin - metabolism
  • Insulin Resistance
  • Insulin Secretion
  • Insulin sensitivity
  • Longitudinal Studies
  • Male
  • Medical sciences
  • Middle Aged
  • Osteocalcin
  • Osteocalcin - blood
  • Resistance Training
  • Vertebrates: anatomy and physiology, studies on body, several organs or systems
  • Vertebrates: endocrinology
  • Weight Loss
ispartof: The journal of clinical endocrinology and metabolism, 2009, Vol.94 (1), p.237-245
description: Context: Bone has recently been described as exhibiting properties of an endocrine organ by producing osteocalcin that increases insulin sensitivity and secretion in animal models. Objective and Design: We aimed to evaluate circulating osteocalcin in association with insulin sensitivity and insulin secretion in three different studies in nondiabetic subjects: one cross-sectional study in 149 men (using minimal model), and two longitudinal studies in two independent groups (one formed by 26 women, and the other by 9 men and 11 women), after a mean of 7.3 and 16.8% weight loss, and after a mean of 8.7% weight loss plus regular exercise. Results: In the cross-sectional study, circulating osteocalcin was associated with insulin sensitivity, mainly in lean subjects, and with insulin secretion (only in lean subjects). A mean of 16.8%, but not 7.3% weight loss, led to significant increases in circulating osteocalcin. However, a mean of 8.7% weight loss plus regular exercise led to the more pronounced effects on the serum osteocalcin concentration, which increased in parallel to reduced visceral fat mass, unchanged thigh muscle mass, and increased leg strength and force. The postintervention serum levels of osteocalcin were associated with both insulin sensitivity (r = 0.49; P = 0.03) and fasting triglycerides (r = −0.54; P = 0.01). The change in visceral fat was the parameter that best predicted the change in serum osteocalcin, once age, body mass index, and insulin sensitivity changes were controlled for (P = 0.002). Conclusion: Circulating osteocalcin could mediate the role of bone as an endocrine organ in humans. Bone recently exhibited properties of an endocrine organ in animal models. In humans, osteocalcin might also be an active regulator of insulin sensitivity by bone.
language: eng
source:
identifier: ISSN: 0021-972X
fulltext: no_fulltext
issn:
  • 0021-972X
  • 1945-7197
url: Link


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titleThe Relationship of Serum Osteocalcin Concentration to Insulin Secretion, Sensitivity, and Disposal with Hypocaloric Diet and Resistance Training
creatorFernández-Real, Jose Manuel ; Izquierdo, Mikel ; Ortega, Francisco ; Gorostiaga, Esteban ; Gómez-Ambrosi, Javier ; Moreno-Navarrete, Jose Maria ; Frühbeck, Gema ; Martínez, Cristina ; Idoate, Fernando ; Salvador, Javier ; Forga, Lluis ; Ricart, Wifredo ; Ibañez, Javier
creatorcontribFernández-Real, Jose Manuel ; Izquierdo, Mikel ; Ortega, Francisco ; Gorostiaga, Esteban ; Gómez-Ambrosi, Javier ; Moreno-Navarrete, Jose Maria ; Frühbeck, Gema ; Martínez, Cristina ; Idoate, Fernando ; Salvador, Javier ; Forga, Lluis ; Ricart, Wifredo ; Ibañez, Javier
descriptionContext: Bone has recently been described as exhibiting properties of an endocrine organ by producing osteocalcin that increases insulin sensitivity and secretion in animal models. Objective and Design: We aimed to evaluate circulating osteocalcin in association with insulin sensitivity and insulin secretion in three different studies in nondiabetic subjects: one cross-sectional study in 149 men (using minimal model), and two longitudinal studies in two independent groups (one formed by 26 women, and the other by 9 men and 11 women), after a mean of 7.3 and 16.8% weight loss, and after a mean of 8.7% weight loss plus regular exercise. Results: In the cross-sectional study, circulating osteocalcin was associated with insulin sensitivity, mainly in lean subjects, and with insulin secretion (only in lean subjects). A mean of 16.8%, but not 7.3% weight loss, led to significant increases in circulating osteocalcin. However, a mean of 8.7% weight loss plus regular exercise led to the more pronounced effects on the serum osteocalcin concentration, which increased in parallel to reduced visceral fat mass, unchanged thigh muscle mass, and increased leg strength and force. The postintervention serum levels of osteocalcin were associated with both insulin sensitivity (r = 0.49; P = 0.03) and fasting triglycerides (r = −0.54; P = 0.01). The change in visceral fat was the parameter that best predicted the change in serum osteocalcin, once age, body mass index, and insulin sensitivity changes were controlled for (P = 0.002). Conclusion: Circulating osteocalcin could mediate the role of bone as an endocrine organ in humans. Bone recently exhibited properties of an endocrine organ in animal models. In humans, osteocalcin might also be an active regulator of insulin sensitivity by bone.
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subjectAbridged Index Medicus ; Adult ; Aged ; Biological and medical sciences ; Body Mass Index ; Cross-Sectional Studies ; Endocrinopathies ; Energy Intake ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Insulin - metabolism ; Insulin Resistance ; Insulin Secretion ; Insulin sensitivity ; Longitudinal Studies ; Male ; Medical sciences ; Middle Aged ; Osteocalcin ; Osteocalcin - blood ; Resistance Training ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vertebrates: endocrinology ; Weight Loss
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1Izquierdo, Mikel
2Ortega, Francisco
3Gorostiaga, Esteban
4Gómez-Ambrosi, Javier
5Moreno-Navarrete, Jose Maria
6Frühbeck, Gema
7Martínez, Cristina
8Idoate, Fernando
9Salvador, Javier
10Forga, Lluis
11Ricart, Wifredo
12Ibañez, Javier
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descriptionContext: Bone has recently been described as exhibiting properties of an endocrine organ by producing osteocalcin that increases insulin sensitivity and secretion in animal models. Objective and Design: We aimed to evaluate circulating osteocalcin in association with insulin sensitivity and insulin secretion in three different studies in nondiabetic subjects: one cross-sectional study in 149 men (using minimal model), and two longitudinal studies in two independent groups (one formed by 26 women, and the other by 9 men and 11 women), after a mean of 7.3 and 16.8% weight loss, and after a mean of 8.7% weight loss plus regular exercise. Results: In the cross-sectional study, circulating osteocalcin was associated with insulin sensitivity, mainly in lean subjects, and with insulin secretion (only in lean subjects). A mean of 16.8%, but not 7.3% weight loss, led to significant increases in circulating osteocalcin. However, a mean of 8.7% weight loss plus regular exercise led to the more pronounced effects on the serum osteocalcin concentration, which increased in parallel to reduced visceral fat mass, unchanged thigh muscle mass, and increased leg strength and force. The postintervention serum levels of osteocalcin were associated with both insulin sensitivity (r = 0.49; P = 0.03) and fasting triglycerides (r = −0.54; P = 0.01). The change in visceral fat was the parameter that best predicted the change in serum osteocalcin, once age, body mass index, and insulin sensitivity changes were controlled for (P = 0.002). Conclusion: Circulating osteocalcin could mediate the role of bone as an endocrine organ in humans. Bone recently exhibited properties of an endocrine organ in animal models. In humans, osteocalcin might also be an active regulator of insulin sensitivity by bone.
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titleThe Relationship of Serum Osteocalcin Concentration to Insulin Secretion, Sensitivity, and Disposal with Hypocaloric Diet and Resistance Training
authorFernández-Real, Jose Manuel ; Izquierdo, Mikel ; Ortega, Francisco ; Gorostiaga, Esteban ; Gómez-Ambrosi, Javier ; Moreno-Navarrete, Jose Maria ; Frühbeck, Gema ; Martínez, Cristina ; Idoate, Fernando ; Salvador, Javier ; Forga, Lluis ; Ricart, Wifredo ; Ibañez, Javier
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6Frühbeck, Gema
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8Idoate, Fernando
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abstractContext: Bone has recently been described as exhibiting properties of an endocrine organ by producing osteocalcin that increases insulin sensitivity and secretion in animal models. Objective and Design: We aimed to evaluate circulating osteocalcin in association with insulin sensitivity and insulin secretion in three different studies in nondiabetic subjects: one cross-sectional study in 149 men (using minimal model), and two longitudinal studies in two independent groups (one formed by 26 women, and the other by 9 men and 11 women), after a mean of 7.3 and 16.8% weight loss, and after a mean of 8.7% weight loss plus regular exercise. Results: In the cross-sectional study, circulating osteocalcin was associated with insulin sensitivity, mainly in lean subjects, and with insulin secretion (only in lean subjects). A mean of 16.8%, but not 7.3% weight loss, led to significant increases in circulating osteocalcin. However, a mean of 8.7% weight loss plus regular exercise led to the more pronounced effects on the serum osteocalcin concentration, which increased in parallel to reduced visceral fat mass, unchanged thigh muscle mass, and increased leg strength and force. The postintervention serum levels of osteocalcin were associated with both insulin sensitivity (r = 0.49; P = 0.03) and fasting triglycerides (r = −0.54; P = 0.01). The change in visceral fat was the parameter that best predicted the change in serum osteocalcin, once age, body mass index, and insulin sensitivity changes were controlled for (P = 0.002). Conclusion: Circulating osteocalcin could mediate the role of bone as an endocrine organ in humans. Bone recently exhibited properties of an endocrine organ in animal models. In humans, osteocalcin might also be an active regulator of insulin sensitivity by bone.
copBethesda, MD
pubEndocrine Society
pmid18854399
doi10.1210/jc.2008-0270
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