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Associations of Circulating C-Reactive Protein and Interleukin-6 with Cancer Risk: Findings from Two Prospective Cohorts and a Meta-Analysis

Objective We investigated the associations of circulating C-reactive protein (CRP) and interleukin-6 (IL-6) with cancer risk. Methods We examined the associations of CRP and IL-6 with incident cancer in two prospective cohorts, the British Women's Heart and Health Study (4,286 women aged 60-80) and... Full description

Journal Title: Cancer causes & control 2009, Vol.20 (1), p.15-26
Main Author: Heikkilä, Katriina
Other Authors: Harris, Ross , Lowe, Gordon , Rumley, Ann , Yarnell, John , Gallacher, John , Ben-Shlomo, Yoav , Ebrahim, Shah , Lawlor, Debbie A
Format: Electronic Article Electronic Article
Language: English
Subjects:
Aged
Aged, 80 and over
Biological markers
Biomedical and Life Sciences
Biomedicine
Breast cancer
Breast Neoplasms - epidemiology
C-reactive protein
C-Reactive Protein - metabolism
Cancer
Cancer Research
Cohort Studies
Colorectal cancer
Colorectal Neoplasms - epidemiology
Epidemiology
Female
general
Genetic aspects
Health aspects
Hematology
Humans
Inflammation
Interleukin-6
Interleukin-6 - blood
Lung neoplasms
Lung Neoplasms - epidemiology
Middle Aged
Neoplasms - epidemiology
Oncology
Original Paper
Ovarian cancer
Prospective Studies
Prostate cancer
Public Health
Risk Factors
Tobacco smoking
Publisher: Dordrecht: Springer
ID: ISSN: 0957-5243
Link: https://www.ncbi.nlm.nih.gov/pubmed/18704713
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recordid: cdi_proquest_miscellaneous_66818516
title: Associations of Circulating C-Reactive Protein and Interleukin-6 with Cancer Risk: Findings from Two Prospective Cohorts and a Meta-Analysis
format: Article
creator:
  • Heikkilä, Katriina
  • Harris, Ross
  • Lowe, Gordon
  • Rumley, Ann
  • Yarnell, John
  • Gallacher, John
  • Ben-Shlomo, Yoav
  • Ebrahim, Shah
  • Lawlor, Debbie A
subjects:
  • Aged
  • Aged, 80 and over
  • Biological markers
  • Biomedical and Life Sciences
  • Biomedicine
  • Breast cancer
  • Breast Neoplasms - epidemiology
  • C-reactive protein
  • C-Reactive Protein - metabolism
  • Cancer
  • Cancer Research
  • Cohort Studies
  • Colorectal cancer
  • Colorectal Neoplasms - epidemiology
  • Epidemiology
  • Female
  • general
  • Genetic aspects
  • Health aspects
  • Hematology
  • Humans
  • Inflammation
  • Interleukin-6
  • Interleukin-6 - blood
  • Lung neoplasms
  • Lung Neoplasms - epidemiology
  • Middle Aged
  • Neoplasms - epidemiology
  • Oncology
  • Original Paper
  • Ovarian cancer
  • Prospective Studies
  • Prostate cancer
  • Public Health
  • Risk Factors
  • Tobacco smoking
ispartof: Cancer causes & control, 2009, Vol.20 (1), p.15-26
description: Objective We investigated the associations of circulating C-reactive protein (CRP) and interleukin-6 (IL-6) with cancer risk. Methods We examined the associations of CRP and IL-6 with incident cancer in two prospective cohorts, the British Women's Heart and Health Study (4,286 women aged 60-80) and the Caerphilly Cohort (2,398 men aged 45–59) using Cox regression and pooled our findings with previous prospective studies' in fixed and random effects meta-analyses. Results CRP and IL-6 were associated with some incident cancers in our cohorts, but the numbers of cancer cases were small. In our meta-analyses elevated CRP was associated with an increased overall risk of cancer (random effects estimate (RE): 1.10, 95% CI: 1.02, 1.18) and lung cancer (RE: 1.32, 95% CI: 1.08, 1.61). Its associations with colorectal (RE: 1.09, 95% CI: 0.98, 1.21) and breast cancer risks (RE: 1.10, 95% CI: 0.97, 1.26) were weaker. CRP appeared unrelated to prostate cancer risk (RE: 1.00 0.88, 1.13). IL-6 was associated with increased lung and breast cancer risks and decreased prostate cancer risk, and was unrelated to colorectal cancer risk. Conclusions Our findings suggest an etiological role for CRP and IL-6 in some cancers. Further large prospective and genetic studies would help to better understand this role.
language: eng
source:
identifier: ISSN: 0957-5243
fulltext: no_fulltext
issn:
  • 0957-5243
  • 1573-7225
url: Link


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titleAssociations of Circulating C-Reactive Protein and Interleukin-6 with Cancer Risk: Findings from Two Prospective Cohorts and a Meta-Analysis
creatorHeikkilä, Katriina ; Harris, Ross ; Lowe, Gordon ; Rumley, Ann ; Yarnell, John ; Gallacher, John ; Ben-Shlomo, Yoav ; Ebrahim, Shah ; Lawlor, Debbie A
creatorcontribHeikkilä, Katriina ; Harris, Ross ; Lowe, Gordon ; Rumley, Ann ; Yarnell, John ; Gallacher, John ; Ben-Shlomo, Yoav ; Ebrahim, Shah ; Lawlor, Debbie A
descriptionObjective We investigated the associations of circulating C-reactive protein (CRP) and interleukin-6 (IL-6) with cancer risk. Methods We examined the associations of CRP and IL-6 with incident cancer in two prospective cohorts, the British Women's Heart and Health Study (4,286 women aged 60-80) and the Caerphilly Cohort (2,398 men aged 45–59) using Cox regression and pooled our findings with previous prospective studies' in fixed and random effects meta-analyses. Results CRP and IL-6 were associated with some incident cancers in our cohorts, but the numbers of cancer cases were small. In our meta-analyses elevated CRP was associated with an increased overall risk of cancer (random effects estimate (RE): 1.10, 95% CI: 1.02, 1.18) and lung cancer (RE: 1.32, 95% CI: 1.08, 1.61). Its associations with colorectal (RE: 1.09, 95% CI: 0.98, 1.21) and breast cancer risks (RE: 1.10, 95% CI: 0.97, 1.26) were weaker. CRP appeared unrelated to prostate cancer risk (RE: 1.00 0.88, 1.13). IL-6 was associated with increased lung and breast cancer risks and decreased prostate cancer risk, and was unrelated to colorectal cancer risk. Conclusions Our findings suggest an etiological role for CRP and IL-6 in some cancers. Further large prospective and genetic studies would help to better understand this role.
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subjectAged ; Aged, 80 and over ; Biological markers ; Biomedical and Life Sciences ; Biomedicine ; Breast cancer ; Breast Neoplasms - epidemiology ; C-reactive protein ; C-Reactive Protein - metabolism ; Cancer ; Cancer Research ; Cohort Studies ; Colorectal cancer ; Colorectal Neoplasms - epidemiology ; Epidemiology ; Female ; general ; Genetic aspects ; Health aspects ; Hematology ; Humans ; Inflammation ; Interleukin-6 ; Interleukin-6 - blood ; Lung neoplasms ; Lung Neoplasms - epidemiology ; Middle Aged ; Neoplasms - epidemiology ; Oncology ; Original Paper ; Ovarian cancer ; Prospective Studies ; Prostate cancer ; Public Health ; Risk Factors ; Tobacco smoking
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2Lowe, Gordon
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4Yarnell, John
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6Ben-Shlomo, Yoav
7Ebrahim, Shah
8Lawlor, Debbie A
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1Cancer causes & control
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0Cancer Causes Control
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descriptionObjective We investigated the associations of circulating C-reactive protein (CRP) and interleukin-6 (IL-6) with cancer risk. Methods We examined the associations of CRP and IL-6 with incident cancer in two prospective cohorts, the British Women's Heart and Health Study (4,286 women aged 60-80) and the Caerphilly Cohort (2,398 men aged 45–59) using Cox regression and pooled our findings with previous prospective studies' in fixed and random effects meta-analyses. Results CRP and IL-6 were associated with some incident cancers in our cohorts, but the numbers of cancer cases were small. In our meta-analyses elevated CRP was associated with an increased overall risk of cancer (random effects estimate (RE): 1.10, 95% CI: 1.02, 1.18) and lung cancer (RE: 1.32, 95% CI: 1.08, 1.61). Its associations with colorectal (RE: 1.09, 95% CI: 0.98, 1.21) and breast cancer risks (RE: 1.10, 95% CI: 0.97, 1.26) were weaker. CRP appeared unrelated to prostate cancer risk (RE: 1.00 0.88, 1.13). IL-6 was associated with increased lung and breast cancer risks and decreased prostate cancer risk, and was unrelated to colorectal cancer risk. Conclusions Our findings suggest an etiological role for CRP and IL-6 in some cancers. Further large prospective and genetic studies would help to better understand this role.
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2Biological markers
3Biomedical and Life Sciences
4Biomedicine
5Breast cancer
6Breast Neoplasms - epidemiology
7C-reactive protein
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9Cancer
10Cancer Research
11Cohort Studies
12Colorectal cancer
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15Female
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17Genetic aspects
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20Humans
21Inflammation
22Interleukin-6
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24Lung neoplasms
25Lung Neoplasms - epidemiology
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28Oncology
29Original Paper
30Ovarian cancer
31Prospective Studies
32Prostate cancer
33Public Health
34Risk Factors
35Tobacco smoking
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titleAssociations of Circulating C-Reactive Protein and Interleukin-6 with Cancer Risk: Findings from Two Prospective Cohorts and a Meta-Analysis
authorHeikkilä, Katriina ; Harris, Ross ; Lowe, Gordon ; Rumley, Ann ; Yarnell, John ; Gallacher, John ; Ben-Shlomo, Yoav ; Ebrahim, Shah ; Lawlor, Debbie A
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0Heikkilä, Katriina
1Harris, Ross
2Lowe, Gordon
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4Yarnell, John
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8Lawlor, Debbie A
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atitleAssociations of Circulating C-Reactive Protein and Interleukin-6 with Cancer Risk: Findings from Two Prospective Cohorts and a Meta-Analysis
jtitleCancer causes & control
stitleCancer Causes Control
addtitleCancer Causes Control
date2009-02-01
risdate2009
volume20
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pages15-26
issn0957-5243
eissn1573-7225
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abstractObjective We investigated the associations of circulating C-reactive protein (CRP) and interleukin-6 (IL-6) with cancer risk. Methods We examined the associations of CRP and IL-6 with incident cancer in two prospective cohorts, the British Women's Heart and Health Study (4,286 women aged 60-80) and the Caerphilly Cohort (2,398 men aged 45–59) using Cox regression and pooled our findings with previous prospective studies' in fixed and random effects meta-analyses. Results CRP and IL-6 were associated with some incident cancers in our cohorts, but the numbers of cancer cases were small. In our meta-analyses elevated CRP was associated with an increased overall risk of cancer (random effects estimate (RE): 1.10, 95% CI: 1.02, 1.18) and lung cancer (RE: 1.32, 95% CI: 1.08, 1.61). Its associations with colorectal (RE: 1.09, 95% CI: 0.98, 1.21) and breast cancer risks (RE: 1.10, 95% CI: 0.97, 1.26) were weaker. CRP appeared unrelated to prostate cancer risk (RE: 1.00 0.88, 1.13). IL-6 was associated with increased lung and breast cancer risks and decreased prostate cancer risk, and was unrelated to colorectal cancer risk. Conclusions Our findings suggest an etiological role for CRP and IL-6 in some cancers. Further large prospective and genetic studies would help to better understand this role.
copDordrecht
pubSpringer
pmid18704713
doi10.1007/s10552-008-9212-z
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