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CCR5 targeted SIV vaccination strategy preventing or inhibiting SIV infection

Cell-surface CCR5 is a major coreceptor with CD4 glycoprotein, mediating cellular entry of CCR5 strains of HIV-1 or SIV. We targeted the SIV CCR5 coreceptor in a combined CCR5–SIV antigen immunization strategy. Rhesus macaques were immunized i.m. with the 70 kDa heat shock protein (HSP70) covalently... Full description

Journal Title: Vaccine 2004, Vol.22 (23), p.2974-2984
Main Author: Bogers, W.M.J.M
Other Authors: Bergmeier, L.A , Oostermeijer, H , Haaft, P. ten , Wang, Y , Kelly, C.G , Singh, M , Heeney, J.L , Lehner, T
Format: Electronic Article Electronic Article
Language: English
Subjects:
HIV
SIV
Quelle: Alma/SFX Local Collection
Publisher: Oxford: Elsevier Ltd
ID: ISSN: 0264-410X
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title: CCR5 targeted SIV vaccination strategy preventing or inhibiting SIV infection
format: Article
creator:
  • Bogers, W.M.J.M
  • Bergmeier, L.A
  • Oostermeijer, H
  • Haaft, P. ten
  • Wang, Y
  • Kelly, C.G
  • Singh, M
  • Heeney, J.L
  • Lehner, T
subjects:
  • Amino Acid Sequence
  • Animals
  • Antibodies, Viral - analysis
  • Antibodies, Viral - biosynthesis
  • Antigens, Surface - immunology
  • Antigens, Viral - immunology
  • Applied microbiology
  • Biological and medical sciences
  • CCR5
  • CD4-Positive T-Lymphocytes - immunology
  • CD8-Positive T-Lymphocytes - immunology
  • Cell growth
  • Charitable foundations
  • Chemokines
  • Disease transmission
  • Fundamental and applied biological sciences. Psychology
  • Gene Products, rex - genetics
  • Gene Products, rex - immunology
  • HIV
  • HSP70 Heat-Shock Proteins - metabolism
  • Human immunodeficiency virus
  • Human immunodeficiency virus 1
  • Immune system
  • Immunization Schedule
  • Immunoglobulin A - analysis
  • Immunoglobulin A - biosynthesis
  • Immunoglobulin G - analysis
  • Immunoglobulin G - biosynthesis
  • Infections
  • Kinetics
  • Lymphocytes
  • Macaca mulatta
  • Membrane Glycoproteins - genetics
  • Membrane Glycoproteins - immunology
  • Microbiology
  • Miscellaneous
  • Molecular Sequence Data
  • Mycobacterium tuberculosis - immunology
  • Peptides
  • Primates
  • Proteins
  • Receptors, CCR5 - immunology
  • SAIDS Vaccines - therapeutic use
  • Simian Acquired Immunodeficiency Syndrome - immunology
  • Simian Acquired Immunodeficiency Syndrome - prevention & control
  • Simian immunodeficiency virus
  • SIV
  • T-Lymphocytes - immunology
  • Vaccine
  • Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
  • Viral Envelope Proteins - genetics
  • Viral Envelope Proteins - immunology
  • Virology
ispartof: Vaccine, 2004, Vol.22 (23), p.2974-2984
description: Cell-surface CCR5 is a major coreceptor with CD4 glycoprotein, mediating cellular entry of CCR5 strains of HIV-1 or SIV. We targeted the SIV CCR5 coreceptor in a combined CCR5–SIV antigen immunization strategy. Rhesus macaques were immunized i.m. with the 70 kDa heat shock protein (HSP70) covalently linked to the CCR5 peptides, SIV gp120 and p27. Intravenous challenge with SIVmac 8980 prevented SIV infection or decreased the viral load with the CCR5-SIV combined vaccine. CC chemokines and antibodies which block and downmodulate CCR5 were induced, as well as immune responses to the subunit SIV antigens. This novel vaccination strategy complements cognate immunity to SIV with innate immunity to the CCR5 coreceptor of SIV.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0264-410X
fulltext: fulltext
issn:
  • 0264-410X
  • 1873-2518
url: Link


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descriptionCell-surface CCR5 is a major coreceptor with CD4 glycoprotein, mediating cellular entry of CCR5 strains of HIV-1 or SIV. We targeted the SIV CCR5 coreceptor in a combined CCR5–SIV antigen immunization strategy. Rhesus macaques were immunized i.m. with the 70 kDa heat shock protein (HSP70) covalently linked to the CCR5 peptides, SIV gp120 and p27. Intravenous challenge with SIVmac 8980 prevented SIV infection or decreased the viral load with the CCR5-SIV combined vaccine. CC chemokines and antibodies which block and downmodulate CCR5 were induced, as well as immune responses to the subunit SIV antigens. This novel vaccination strategy complements cognate immunity to SIV with innate immunity to the CCR5 coreceptor of SIV.
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1EISSN: 1873-2518
2DOI: 10.1016/j.vaccine.2004.02.050
3PMID: 15356916
4CODEN: VACCDE
languageeng
publisherOxford: Elsevier Ltd
subjectAmino Acid Sequence ; Animals ; Antibodies, Viral - analysis ; Antibodies, Viral - biosynthesis ; Antigens, Surface - immunology ; Antigens, Viral - immunology ; Applied microbiology ; Biological and medical sciences ; CCR5 ; CD4-Positive T-Lymphocytes - immunology ; CD8-Positive T-Lymphocytes - immunology ; Cell growth ; Charitable foundations ; Chemokines ; Disease transmission ; Fundamental and applied biological sciences. Psychology ; Gene Products, rex - genetics ; Gene Products, rex - immunology ; HIV ; HSP70 Heat-Shock Proteins - metabolism ; Human immunodeficiency virus ; Human immunodeficiency virus 1 ; Immune system ; Immunization Schedule ; Immunoglobulin A - analysis ; Immunoglobulin A - biosynthesis ; Immunoglobulin G - analysis ; Immunoglobulin G - biosynthesis ; Infections ; Kinetics ; Lymphocytes ; Macaca mulatta ; Membrane Glycoproteins - genetics ; Membrane Glycoproteins - immunology ; Microbiology ; Miscellaneous ; Molecular Sequence Data ; Mycobacterium tuberculosis - immunology ; Peptides ; Primates ; Proteins ; Receptors, CCR5 - immunology ; SAIDS Vaccines - therapeutic use ; Simian Acquired Immunodeficiency Syndrome - immunology ; Simian Acquired Immunodeficiency Syndrome - prevention & control ; Simian immunodeficiency virus ; SIV ; T-Lymphocytes - immunology ; Vaccine ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) ; Viral Envelope Proteins - genetics ; Viral Envelope Proteins - immunology ; Virology
ispartofVaccine, 2004, Vol.22 (23), p.2974-2984
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1Bergmeier, L.A
2Oostermeijer, H
3Haaft, P. ten
4Wang, Y
5Kelly, C.G
6Singh, M
7Heeney, J.L
8Lehner, T
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descriptionCell-surface CCR5 is a major coreceptor with CD4 glycoprotein, mediating cellular entry of CCR5 strains of HIV-1 or SIV. We targeted the SIV CCR5 coreceptor in a combined CCR5–SIV antigen immunization strategy. Rhesus macaques were immunized i.m. with the 70 kDa heat shock protein (HSP70) covalently linked to the CCR5 peptides, SIV gp120 and p27. Intravenous challenge with SIVmac 8980 prevented SIV infection or decreased the viral load with the CCR5-SIV combined vaccine. CC chemokines and antibodies which block and downmodulate CCR5 were induced, as well as immune responses to the subunit SIV antigens. This novel vaccination strategy complements cognate immunity to SIV with innate immunity to the CCR5 coreceptor of SIV.
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11Cell growth
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16Gene Products, rex - genetics
17Gene Products, rex - immunology
18HIV
19HSP70 Heat-Shock Proteins - metabolism
20Human immunodeficiency virus
21Human immunodeficiency virus 1
22Immune system
23Immunization Schedule
24Immunoglobulin A - analysis
25Immunoglobulin A - biosynthesis
26Immunoglobulin G - analysis
27Immunoglobulin G - biosynthesis
28Infections
29Kinetics
30Lymphocytes
31Macaca mulatta
32Membrane Glycoproteins - genetics
33Membrane Glycoproteins - immunology
34Microbiology
35Miscellaneous
36Molecular Sequence Data
37Mycobacterium tuberculosis - immunology
38Peptides
39Primates
40Proteins
41Receptors, CCR5 - immunology
42SAIDS Vaccines - therapeutic use
43Simian Acquired Immunodeficiency Syndrome - immunology
44Simian Acquired Immunodeficiency Syndrome - prevention & control
45Simian immunodeficiency virus
46SIV
47T-Lymphocytes - immunology
48Vaccine
49Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
50Viral Envelope Proteins - genetics
51Viral Envelope Proteins - immunology
52Virology
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titleCCR5 targeted SIV vaccination strategy preventing or inhibiting SIV infection
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20Human immunodeficiency virus
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31Macaca mulatta
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abstractCell-surface CCR5 is a major coreceptor with CD4 glycoprotein, mediating cellular entry of CCR5 strains of HIV-1 or SIV. We targeted the SIV CCR5 coreceptor in a combined CCR5–SIV antigen immunization strategy. Rhesus macaques were immunized i.m. with the 70 kDa heat shock protein (HSP70) covalently linked to the CCR5 peptides, SIV gp120 and p27. Intravenous challenge with SIVmac 8980 prevented SIV infection or decreased the viral load with the CCR5-SIV combined vaccine. CC chemokines and antibodies which block and downmodulate CCR5 were induced, as well as immune responses to the subunit SIV antigens. This novel vaccination strategy complements cognate immunity to SIV with innate immunity to the CCR5 coreceptor of SIV.
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