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The Excitatory Neuronal Network of the C2 Barrel Column in Mouse Primary Somatosensory Cortex

Local microcircuits within neocortical columns form key determinants of sensory processing. Here, we investigate the excitatory synaptic neuronal network of an anatomically defined cortical column, the C2 barrel column of mouse primary somatosensory cortex. This cortical column is known to process t... Full description

Journal Title: Neuron (Cambridge Mass.), 2009, Vol.61 (2), p.301-316
Main Author: Lefort, Sandrine
Other Authors: Tomm, Christian , Floyd Sarria, J.-C , Petersen, Carl C.H
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: United States: Elsevier Inc
ID: ISSN: 0896-6273
Link: https://www.ncbi.nlm.nih.gov/pubmed/19186171
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recordid: cdi_proquest_miscellaneous_66878144
title: The Excitatory Neuronal Network of the C2 Barrel Column in Mouse Primary Somatosensory Cortex
format: Article
creator:
  • Lefort, Sandrine
  • Tomm, Christian
  • Floyd Sarria, J.-C
  • Petersen, Carl C.H
subjects:
  • Action Potentials - physiology
  • Afferent Pathways - cytology
  • Afferent Pathways - physiology
  • Animals
  • Atmospheric turbulence
  • Brain
  • Circuits
  • Excitatory Postsynaptic Potentials - physiology
  • Experiments
  • Fluorescent Dyes
  • Mechanoreceptors - cytology
  • Mechanoreceptors - physiology
  • Mice
  • Mice, Inbred C57BL
  • Nerve Net - cytology
  • Nerve Net - physiology
  • Neural Pathways - cytology
  • Neural Pathways - physiology
  • Neurons
  • Neurons - cytology
  • Neurons - physiology
  • Neuroscience(all)
  • Neurosciences
  • Organ Culture Techniques
  • Patch-Clamp Techniques
  • Somatosensory Cortex - cytology
  • Somatosensory Cortex - physiology
  • Staining and Labeling
  • Synapses - physiology
  • Synapses - ultrastructure
  • Synaptic Transmission - physiology
  • SYSNEURO
  • Touch - physiology
  • Trigeminal Nerve - cytology
  • Trigeminal Nerve - physiology
  • Vibrissae - cytology
  • Vibrissae - physiology
ispartof: Neuron (Cambridge, Mass.), 2009, Vol.61 (2), p.301-316
description: Local microcircuits within neocortical columns form key determinants of sensory processing. Here, we investigate the excitatory synaptic neuronal network of an anatomically defined cortical column, the C2 barrel column of mouse primary somatosensory cortex. This cortical column is known to process tactile information related to the C2 whisker. Through multiple simultaneous whole-cell recordings, we quantify connectivity maps between individual excitatory neurons located across all cortical layers of the C2 barrel column. Synaptic connectivity depended strongly upon somatic laminar location of both presynaptic and postsynaptic neurons, providing definitive evidence for layer-specific signaling pathways. The strongest excitatory influence upon the cortical column was provided by presynaptic layer 4 neurons. In all layers we found rare large-amplitude synaptic connections, which are likely to contribute strongly to reliable information processing. Our data set provides the first functional description of the excitatory synaptic wiring diagram of a physiologically relevant and anatomically well-defined cortical column at single-cell resolution.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0896-6273
fulltext: fulltext
issn:
  • 0896-6273
  • 1097-4199
url: Link


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descriptionLocal microcircuits within neocortical columns form key determinants of sensory processing. Here, we investigate the excitatory synaptic neuronal network of an anatomically defined cortical column, the C2 barrel column of mouse primary somatosensory cortex. This cortical column is known to process tactile information related to the C2 whisker. Through multiple simultaneous whole-cell recordings, we quantify connectivity maps between individual excitatory neurons located across all cortical layers of the C2 barrel column. Synaptic connectivity depended strongly upon somatic laminar location of both presynaptic and postsynaptic neurons, providing definitive evidence for layer-specific signaling pathways. The strongest excitatory influence upon the cortical column was provided by presynaptic layer 4 neurons. In all layers we found rare large-amplitude synaptic connections, which are likely to contribute strongly to reliable information processing. Our data set provides the first functional description of the excitatory synaptic wiring diagram of a physiologically relevant and anatomically well-defined cortical column at single-cell resolution.
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languageeng
publisherUnited States: Elsevier Inc
subjectAction Potentials - physiology ; Afferent Pathways - cytology ; Afferent Pathways - physiology ; Animals ; Atmospheric turbulence ; Brain ; Circuits ; Excitatory Postsynaptic Potentials - physiology ; Experiments ; Fluorescent Dyes ; Mechanoreceptors - cytology ; Mechanoreceptors - physiology ; Mice ; Mice, Inbred C57BL ; Nerve Net - cytology ; Nerve Net - physiology ; Neural Pathways - cytology ; Neural Pathways - physiology ; Neurons ; Neurons - cytology ; Neurons - physiology ; Neuroscience(all) ; Neurosciences ; Organ Culture Techniques ; Patch-Clamp Techniques ; Somatosensory Cortex - cytology ; Somatosensory Cortex - physiology ; Staining and Labeling ; Synapses - physiology ; Synapses - ultrastructure ; Synaptic Transmission - physiology ; SYSNEURO ; Touch - physiology ; Trigeminal Nerve - cytology ; Trigeminal Nerve - physiology ; Vibrissae - cytology ; Vibrissae - physiology
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abstractLocal microcircuits within neocortical columns form key determinants of sensory processing. Here, we investigate the excitatory synaptic neuronal network of an anatomically defined cortical column, the C2 barrel column of mouse primary somatosensory cortex. This cortical column is known to process tactile information related to the C2 whisker. Through multiple simultaneous whole-cell recordings, we quantify connectivity maps between individual excitatory neurons located across all cortical layers of the C2 barrel column. Synaptic connectivity depended strongly upon somatic laminar location of both presynaptic and postsynaptic neurons, providing definitive evidence for layer-specific signaling pathways. The strongest excitatory influence upon the cortical column was provided by presynaptic layer 4 neurons. In all layers we found rare large-amplitude synaptic connections, which are likely to contribute strongly to reliable information processing. Our data set provides the first functional description of the excitatory synaptic wiring diagram of a physiologically relevant and anatomically well-defined cortical column at single-cell resolution.
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