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Effect of Beta Blockers (Metoprolol or Propranolol) on Effect of Simvastatin in Lowering C-Reactive Protein in Acute Myocardial Infarction

Recent data indicated that statin therapy may fail to reduce the incidence of coronary events in patients concomitantly using β blockers. The aim of the present study was to examine whether the concomitant use of β blockers would modify the anti-inflammatory action of statins. Changes in C-reactive... Full description

Journal Title: The American journal of cardiology 2009, Vol.103 (4), p.461-463
Main Author: Quinaglia e Silva, Jose C., MD
Other Authors: Munhoz, Daniel B , Morato, Tiago N , Gurgel, Augusto , Macedo, Antonio C.T , Sever, Peter, MD, PhD , Sposito, Andrei C., MD, PhD
Format: Electronic Article Electronic Article
Language: English
Subjects:
Abridged Index Medicus
Adrenergic beta-Antagonists - pharmacology
Adrenergic beta-Antagonists - therapeutic use
Aged
Beta blockers
Biological and medical sciences
C-reactive protein
C-Reactive Protein - analysis
Cardiac patients
Cardiology
Cardiology. Vascular system
Cardiovascular
Cohort Studies
Coronary heart disease
Drug therapy
Drug Therapy, Combination
Effectiveness studies
Female
Heart
Heart attack
Heart attacks
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology
Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
Male
Medical sciences
Metoprolol
Metoprolol - pharmacology
Metoprolol - therapeutic use
Middle Aged
Myocardial Infarction - blood
Myocardial Infarction - drug therapy
Myocarditis. Cardiomyopathies
Propranolol - pharmacology
Propranolol - therapeutic use
Propranolol hydrochloride
Simvastatin
Simvastatin - pharmacology
Simvastatin - therapeutic use
Statins
Treatment Outcome
Publisher: New York, NY: Elsevier Inc
ID: ISSN: 0002-9149
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recordid: cdi_proquest_miscellaneous_66887122
title: Effect of Beta Blockers (Metoprolol or Propranolol) on Effect of Simvastatin in Lowering C-Reactive Protein in Acute Myocardial Infarction
format: Article
creator:
  • Quinaglia e Silva, Jose C., MD
  • Munhoz, Daniel B
  • Morato, Tiago N
  • Gurgel, Augusto
  • Macedo, Antonio C.T
  • Sever, Peter, MD, PhD
  • Sposito, Andrei C., MD, PhD
subjects:
  • Abridged Index Medicus
  • Adrenergic beta-Antagonists - pharmacology
  • Adrenergic beta-Antagonists - therapeutic use
  • Aged
  • Beta blockers
  • Biological and medical sciences
  • C-reactive protein
  • C-Reactive Protein - analysis
  • Cardiac patients
  • Cardiology
  • Cardiology. Vascular system
  • Cardiovascular
  • Cohort Studies
  • Coronary heart disease
  • Drug therapy
  • Drug Therapy, Combination
  • Effectiveness studies
  • Female
  • Heart
  • Heart attack
  • Heart attacks
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
  • Male
  • Medical sciences
  • Metoprolol
  • Metoprolol - pharmacology
  • Metoprolol - therapeutic use
  • Middle Aged
  • Myocardial Infarction - blood
  • Myocardial Infarction - drug therapy
  • Myocarditis. Cardiomyopathies
  • Propranolol - pharmacology
  • Propranolol - therapeutic use
  • Propranolol hydrochloride
  • Simvastatin
  • Simvastatin - pharmacology
  • Simvastatin - therapeutic use
  • Statins
  • Treatment Outcome
ispartof: The American journal of cardiology, 2009, Vol.103 (4), p.461-463
description: Recent data indicated that statin therapy may fail to reduce the incidence of coronary events in patients concomitantly using β blockers. The aim of the present study was to examine whether the concomitant use of β blockers would modify the anti-inflammatory action of statins. Changes in C-reactive protein (CRP) between days 1 and 5 after myocardial infarction were evaluated in 189 patients treated with simvastatin alone (S), β blockers alone (B; propranolol or metoprolol), S + B, or neither of these 2 medications (N) in a prospective observational cohort. At baseline, median CRP was lower in the S group (0.40 mg/dl, interquartile range 0.1 to 0.6) than the other groups (B: 0.6 mg/dl, interquartile range 0.4 to 1.6; S + B: 0.5 mg/dl, interquartile range 0.3 to 1.2; and N: 0.6 mg/dl, interquartile range 0.2 to 1.5). By day 5, median CRP was 1.3 mg/dl (interquartile range 0.7 to 2.6), 4.3 (interquartile range 1.6 to 8.8), 4.6 (interquartile range 2.8 to 9.5), and 4.4 (interquartile range 1.9 to 9.9) for the S, B, S + B, and N groups, respectively. After adjusting for loge baseline CRP, the difference in loge CRP between days 1 and 5 was significantly lower in the S group compared with the B (−0.74 ± 0.23 [SE], p = 0.001) or S + B group (−0.99 ± 0.20 [SE], p
language: eng
source:
identifier: ISSN: 0002-9149
fulltext: no_fulltext
issn:
  • 0002-9149
  • 1879-1913
url: Link


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titleEffect of Beta Blockers (Metoprolol or Propranolol) on Effect of Simvastatin in Lowering C-Reactive Protein in Acute Myocardial Infarction
creatorQuinaglia e Silva, Jose C., MD ; Munhoz, Daniel B ; Morato, Tiago N ; Gurgel, Augusto ; Macedo, Antonio C.T ; Sever, Peter, MD, PhD ; Sposito, Andrei C., MD, PhD
creatorcontribQuinaglia e Silva, Jose C., MD ; Munhoz, Daniel B ; Morato, Tiago N ; Gurgel, Augusto ; Macedo, Antonio C.T ; Sever, Peter, MD, PhD ; Sposito, Andrei C., MD, PhD ; Brasilia Heart Study Group
descriptionRecent data indicated that statin therapy may fail to reduce the incidence of coronary events in patients concomitantly using β blockers. The aim of the present study was to examine whether the concomitant use of β blockers would modify the anti-inflammatory action of statins. Changes in C-reactive protein (CRP) between days 1 and 5 after myocardial infarction were evaluated in 189 patients treated with simvastatin alone (S), β blockers alone (B; propranolol or metoprolol), S + B, or neither of these 2 medications (N) in a prospective observational cohort. At baseline, median CRP was lower in the S group (0.40 mg/dl, interquartile range 0.1 to 0.6) than the other groups (B: 0.6 mg/dl, interquartile range 0.4 to 1.6; S + B: 0.5 mg/dl, interquartile range 0.3 to 1.2; and N: 0.6 mg/dl, interquartile range 0.2 to 1.5). By day 5, median CRP was 1.3 mg/dl (interquartile range 0.7 to 2.6), 4.3 (interquartile range 1.6 to 8.8), 4.6 (interquartile range 2.8 to 9.5), and 4.4 (interquartile range 1.9 to 9.9) for the S, B, S + B, and N groups, respectively. After adjusting for loge baseline CRP, the difference in loge CRP between days 1 and 5 was significantly lower in the S group compared with the B (−0.74 ± 0.23 [SE], p = 0.001) or S + B group (−0.99 ± 0.20 [SE], p <0.0001). The significance remained after adjustment for age, gender, and baseline CRP. There was no significant difference in change in CRP between the SB and B groups. In conclusion, the present study confirmed the anti-inflammatory action of statins and showed that concomitant use of β blockers may significantly attenuate this effect.
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0ISSN: 0002-9149
1EISSN: 1879-1913
2DOI: 10.1016/j.amjcard.2008.10.007
3PMID: 19195502
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languageeng
publisherNew York, NY: Elsevier Inc
subjectAbridged Index Medicus ; Adrenergic beta-Antagonists - pharmacology ; Adrenergic beta-Antagonists - therapeutic use ; Aged ; Beta blockers ; Biological and medical sciences ; C-reactive protein ; C-Reactive Protein - analysis ; Cardiac patients ; Cardiology ; Cardiology. Vascular system ; Cardiovascular ; Cohort Studies ; Coronary heart disease ; Drug therapy ; Drug Therapy, Combination ; Effectiveness studies ; Female ; Heart ; Heart attack ; Heart attacks ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology ; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use ; Male ; Medical sciences ; Metoprolol ; Metoprolol - pharmacology ; Metoprolol - therapeutic use ; Middle Aged ; Myocardial Infarction - blood ; Myocardial Infarction - drug therapy ; Myocarditis. Cardiomyopathies ; Propranolol - pharmacology ; Propranolol - therapeutic use ; Propranolol hydrochloride ; Simvastatin ; Simvastatin - pharmacology ; Simvastatin - therapeutic use ; Statins ; Treatment Outcome
ispartofThe American journal of cardiology, 2009, Vol.103 (4), p.461-463
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0Quinaglia e Silva, Jose C., MD
1Munhoz, Daniel B
2Morato, Tiago N
3Gurgel, Augusto
4Macedo, Antonio C.T
5Sever, Peter, MD, PhD
6Sposito, Andrei C., MD, PhD
7Brasilia Heart Study Group
title
0Effect of Beta Blockers (Metoprolol or Propranolol) on Effect of Simvastatin in Lowering C-Reactive Protein in Acute Myocardial Infarction
1The American journal of cardiology
addtitleAm J Cardiol
descriptionRecent data indicated that statin therapy may fail to reduce the incidence of coronary events in patients concomitantly using β blockers. The aim of the present study was to examine whether the concomitant use of β blockers would modify the anti-inflammatory action of statins. Changes in C-reactive protein (CRP) between days 1 and 5 after myocardial infarction were evaluated in 189 patients treated with simvastatin alone (S), β blockers alone (B; propranolol or metoprolol), S + B, or neither of these 2 medications (N) in a prospective observational cohort. At baseline, median CRP was lower in the S group (0.40 mg/dl, interquartile range 0.1 to 0.6) than the other groups (B: 0.6 mg/dl, interquartile range 0.4 to 1.6; S + B: 0.5 mg/dl, interquartile range 0.3 to 1.2; and N: 0.6 mg/dl, interquartile range 0.2 to 1.5). By day 5, median CRP was 1.3 mg/dl (interquartile range 0.7 to 2.6), 4.3 (interquartile range 1.6 to 8.8), 4.6 (interquartile range 2.8 to 9.5), and 4.4 (interquartile range 1.9 to 9.9) for the S, B, S + B, and N groups, respectively. After adjusting for loge baseline CRP, the difference in loge CRP between days 1 and 5 was significantly lower in the S group compared with the B (−0.74 ± 0.23 [SE], p = 0.001) or S + B group (−0.99 ± 0.20 [SE], p <0.0001). The significance remained after adjustment for age, gender, and baseline CRP. There was no significant difference in change in CRP between the SB and B groups. In conclusion, the present study confirmed the anti-inflammatory action of statins and showed that concomitant use of β blockers may significantly attenuate this effect.
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0Abridged Index Medicus
1Adrenergic beta-Antagonists - pharmacology
2Adrenergic beta-Antagonists - therapeutic use
3Aged
4Beta blockers
5Biological and medical sciences
6C-reactive protein
7C-Reactive Protein - analysis
8Cardiac patients
9Cardiology
10Cardiology. Vascular system
11Cardiovascular
12Cohort Studies
13Coronary heart disease
14Drug therapy
15Drug Therapy, Combination
16Effectiveness studies
17Female
18Heart
19Heart attack
20Heart attacks
21Humans
22Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology
23Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use
24Male
25Medical sciences
26Metoprolol
27Metoprolol - pharmacology
28Metoprolol - therapeutic use
29Middle Aged
30Myocardial Infarction - blood
31Myocardial Infarction - drug therapy
32Myocarditis. Cardiomyopathies
33Propranolol - pharmacology
34Propranolol - therapeutic use
35Propranolol hydrochloride
36Simvastatin
37Simvastatin - pharmacology
38Simvastatin - therapeutic use
39Statins
40Treatment Outcome
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1Munhoz, Daniel B
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3Gurgel, Augusto
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titleEffect of Beta Blockers (Metoprolol or Propranolol) on Effect of Simvastatin in Lowering C-Reactive Protein in Acute Myocardial Infarction
authorQuinaglia e Silva, Jose C., MD ; Munhoz, Daniel B ; Morato, Tiago N ; Gurgel, Augusto ; Macedo, Antonio C.T ; Sever, Peter, MD, PhD ; Sposito, Andrei C., MD, PhD
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0Abridged Index Medicus
1Adrenergic beta-Antagonists - pharmacology
2Adrenergic beta-Antagonists - therapeutic use
3Aged
4Beta blockers
5Biological and medical sciences
6C-reactive protein
7C-Reactive Protein - analysis
8Cardiac patients
9Cardiology
10Cardiology. Vascular system
11Cardiovascular
12Cohort Studies
13Coronary heart disease
14Drug therapy
15Drug Therapy, Combination
16Effectiveness studies
17Female
18Heart
19Heart attack
20Heart attacks
21Humans
22Hydroxymethylglutaryl-CoA Reductase Inhibitors - pharmacology
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25Medical sciences
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33Propranolol - pharmacology
34Propranolol - therapeutic use
35Propranolol hydrochloride
36Simvastatin
37Simvastatin - pharmacology
38Simvastatin - therapeutic use
39Statins
40Treatment Outcome
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1Munhoz, Daniel B
2Morato, Tiago N
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jtitleThe American journal of cardiology
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date2009
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volume103
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pages461-463
issn0002-9149
eissn1879-1913
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abstractRecent data indicated that statin therapy may fail to reduce the incidence of coronary events in patients concomitantly using β blockers. The aim of the present study was to examine whether the concomitant use of β blockers would modify the anti-inflammatory action of statins. Changes in C-reactive protein (CRP) between days 1 and 5 after myocardial infarction were evaluated in 189 patients treated with simvastatin alone (S), β blockers alone (B; propranolol or metoprolol), S + B, or neither of these 2 medications (N) in a prospective observational cohort. At baseline, median CRP was lower in the S group (0.40 mg/dl, interquartile range 0.1 to 0.6) than the other groups (B: 0.6 mg/dl, interquartile range 0.4 to 1.6; S + B: 0.5 mg/dl, interquartile range 0.3 to 1.2; and N: 0.6 mg/dl, interquartile range 0.2 to 1.5). By day 5, median CRP was 1.3 mg/dl (interquartile range 0.7 to 2.6), 4.3 (interquartile range 1.6 to 8.8), 4.6 (interquartile range 2.8 to 9.5), and 4.4 (interquartile range 1.9 to 9.9) for the S, B, S + B, and N groups, respectively. After adjusting for loge baseline CRP, the difference in loge CRP between days 1 and 5 was significantly lower in the S group compared with the B (−0.74 ± 0.23 [SE], p = 0.001) or S + B group (−0.99 ± 0.20 [SE], p <0.0001). The significance remained after adjustment for age, gender, and baseline CRP. There was no significant difference in change in CRP between the SB and B groups. In conclusion, the present study confirmed the anti-inflammatory action of statins and showed that concomitant use of β blockers may significantly attenuate this effect.
copNew York, NY
pubElsevier Inc
pmid19195502
doi10.1016/j.amjcard.2008.10.007