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Determination of Clara cell protein urinary elimination as a marker of tubular dysfunction

Clara cell 16-kDa protein (CC16) is a protein expressed primarily by the bronchial cells. It is rapidly eliminated by glomerular filtration, reabsorbed almost entirely, and catabolized in proximal tubule cells. To date, normal values for urinary CC16 in healthy children have not been determined. We... Full description

Journal Title: Pediatric nephrology (Berlin West), 2009-04-01, Vol.24 (4), p.747-752
Main Author: Martín-Granado, Ascensión
Other Authors: Vázquez-Moncholí, Carmen , Luis-Yanes, María Isabel , López-Méndez, Marisela , García-Nieto, Víctor
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Berlin/Heidelberg: Springer Berlin Heidelberg
ID: ISSN: 0931-041X
Link: https://www.ncbi.nlm.nih.gov/pubmed/19152009
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title: Determination of Clara cell protein urinary elimination as a marker of tubular dysfunction
format: Article
creator:
  • Martín-Granado, Ascensión
  • Vázquez-Moncholí, Carmen
  • Luis-Yanes, María Isabel
  • López-Méndez, Marisela
  • García-Nieto, Víctor
subjects:
  • Acetylglucosaminidase - urine
  • Adolescent
  • beta 2-Microglobulin - urine
  • Biomarkers - urine
  • Child
  • Child, Preschool
  • Creatinine - urine
  • Cyclosporine - therapeutic use
  • Female
  • Humans
  • Immunosuppressive Agents - therapeutic use
  • Infant
  • Kidney Diseases - drug therapy
  • Kidney Diseases - pathology
  • Kidney Diseases - urine
  • Kidney Failure, Chronic - drug therapy
  • Kidney Failure, Chronic - pathology
  • Kidney Failure, Chronic - urine
  • Kidney Tubules, Proximal - metabolism
  • Kidney Tubules, Proximal - pathology
  • Kidney Tubules, Proximal - physiopathology
  • Male
  • Medicine & Public Health
  • Nephrology
  • Original Article
  • Pediatrics
  • Urology
  • Uteroglobin - urine
  • Young Adult
ispartof: Pediatric nephrology (Berlin, West), 2009-04-01, Vol.24 (4), p.747-752
description: Clara cell 16-kDa protein (CC16) is a protein expressed primarily by the bronchial cells. It is rapidly eliminated by glomerular filtration, reabsorbed almost entirely, and catabolized in proximal tubule cells. To date, normal values for urinary CC16 in healthy children have not been determined. We have studied 63 pediatric patients (mean age 8.17 ± 3.91 years) and 31 healthy children (control group; mean age 8.83 ± 3.65 years). In the control group, the CC16/creatinine ratio was 1.22 ± 1.52 μg/g. In 16 out of 31 control children, the value of the ratio was zero. Fourteen patients (22.2%) showed a high CC16/creatinine ratio; in contrast, among these same patients, the ratio N-acetyl-β- d -glucosaminidase (NAG)/creatinine was elevated in seven cases (11.1%) and the ratio β2-microglobulin/creatinine was elevated in seven cases (11.1%). The three parameters were in agreement in 51 patients (80.9%). Among the patients, the CC16/creatinine ratio was correlated with both the β2-microglobulin/creatinina ratio ( r  = 0.76, P  
language: eng
source:
identifier: ISSN: 0931-041X
fulltext: no_fulltext
issn:
  • 0931-041X
  • 1432-198X
url: Link


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titleDetermination of Clara cell protein urinary elimination as a marker of tubular dysfunction
creatorMartín-Granado, Ascensión ; Vázquez-Moncholí, Carmen ; Luis-Yanes, María Isabel ; López-Méndez, Marisela ; García-Nieto, Víctor
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descriptionClara cell 16-kDa protein (CC16) is a protein expressed primarily by the bronchial cells. It is rapidly eliminated by glomerular filtration, reabsorbed almost entirely, and catabolized in proximal tubule cells. To date, normal values for urinary CC16 in healthy children have not been determined. We have studied 63 pediatric patients (mean age 8.17 ± 3.91 years) and 31 healthy children (control group; mean age 8.83 ± 3.65 years). In the control group, the CC16/creatinine ratio was 1.22 ± 1.52 μg/g. In 16 out of 31 control children, the value of the ratio was zero. Fourteen patients (22.2%) showed a high CC16/creatinine ratio; in contrast, among these same patients, the ratio N-acetyl-β- d -glucosaminidase (NAG)/creatinine was elevated in seven cases (11.1%) and the ratio β2-microglobulin/creatinine was elevated in seven cases (11.1%). The three parameters were in agreement in 51 patients (80.9%). Among the patients, the CC16/creatinine ratio was correlated with both the β2-microglobulin/creatinina ratio ( r  = 0.76, P  < 0.001) and the NAG/creatinine ratio ( r  = 0.6, P < 0.001). Our findings indicate that CC16 is a good marker of proximal tubular function in childhood. The highest observed values were in children with proximal tubulopathies, in children with chronic renal failure, and in those treated with cyclosporine.
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subjectAcetylglucosaminidase - urine ; Adolescent ; beta 2-Microglobulin - urine ; Biomarkers - urine ; Child ; Child, Preschool ; Creatinine - urine ; Cyclosporine - therapeutic use ; Female ; Humans ; Immunosuppressive Agents - therapeutic use ; Infant ; Kidney Diseases - drug therapy ; Kidney Diseases - pathology ; Kidney Diseases - urine ; Kidney Failure, Chronic - drug therapy ; Kidney Failure, Chronic - pathology ; Kidney Failure, Chronic - urine ; Kidney Tubules, Proximal - metabolism ; Kidney Tubules, Proximal - pathology ; Kidney Tubules, Proximal - physiopathology ; Male ; Medicine & Public Health ; Nephrology ; Original Article ; Pediatrics ; Urology ; Uteroglobin - urine ; Young Adult
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descriptionClara cell 16-kDa protein (CC16) is a protein expressed primarily by the bronchial cells. It is rapidly eliminated by glomerular filtration, reabsorbed almost entirely, and catabolized in proximal tubule cells. To date, normal values for urinary CC16 in healthy children have not been determined. We have studied 63 pediatric patients (mean age 8.17 ± 3.91 years) and 31 healthy children (control group; mean age 8.83 ± 3.65 years). In the control group, the CC16/creatinine ratio was 1.22 ± 1.52 μg/g. In 16 out of 31 control children, the value of the ratio was zero. Fourteen patients (22.2%) showed a high CC16/creatinine ratio; in contrast, among these same patients, the ratio N-acetyl-β- d -glucosaminidase (NAG)/creatinine was elevated in seven cases (11.1%) and the ratio β2-microglobulin/creatinine was elevated in seven cases (11.1%). The three parameters were in agreement in 51 patients (80.9%). Among the patients, the CC16/creatinine ratio was correlated with both the β2-microglobulin/creatinina ratio ( r  = 0.76, P  < 0.001) and the NAG/creatinine ratio ( r  = 0.6, P < 0.001). Our findings indicate that CC16 is a good marker of proximal tubular function in childhood. The highest observed values were in children with proximal tubulopathies, in children with chronic renal failure, and in those treated with cyclosporine.
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1Adolescent
2beta 2-Microglobulin - urine
3Biomarkers - urine
4Child
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6Creatinine - urine
7Cyclosporine - therapeutic use
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10Immunosuppressive Agents - therapeutic use
11Infant
12Kidney Diseases - drug therapy
13Kidney Diseases - pathology
14Kidney Diseases - urine
15Kidney Failure, Chronic - drug therapy
16Kidney Failure, Chronic - pathology
17Kidney Failure, Chronic - urine
18Kidney Tubules, Proximal - metabolism
19Kidney Tubules, Proximal - pathology
20Kidney Tubules, Proximal - physiopathology
21Male
22Medicine & Public Health
23Nephrology
24Original Article
25Pediatrics
26Urology
27Uteroglobin - urine
28Young Adult
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7Cyclosporine - therapeutic use
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abstractClara cell 16-kDa protein (CC16) is a protein expressed primarily by the bronchial cells. It is rapidly eliminated by glomerular filtration, reabsorbed almost entirely, and catabolized in proximal tubule cells. To date, normal values for urinary CC16 in healthy children have not been determined. We have studied 63 pediatric patients (mean age 8.17 ± 3.91 years) and 31 healthy children (control group; mean age 8.83 ± 3.65 years). In the control group, the CC16/creatinine ratio was 1.22 ± 1.52 μg/g. In 16 out of 31 control children, the value of the ratio was zero. Fourteen patients (22.2%) showed a high CC16/creatinine ratio; in contrast, among these same patients, the ratio N-acetyl-β- d -glucosaminidase (NAG)/creatinine was elevated in seven cases (11.1%) and the ratio β2-microglobulin/creatinine was elevated in seven cases (11.1%). The three parameters were in agreement in 51 patients (80.9%). Among the patients, the CC16/creatinine ratio was correlated with both the β2-microglobulin/creatinina ratio ( r  = 0.76, P  < 0.001) and the NAG/creatinine ratio ( r  = 0.6, P < 0.001). Our findings indicate that CC16 is a good marker of proximal tubular function in childhood. The highest observed values were in children with proximal tubulopathies, in children with chronic renal failure, and in those treated with cyclosporine.
copBerlin/Heidelberg
pubSpringer Berlin Heidelberg
pmid19152009
doi10.1007/s00467-008-1078-5