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Effect of conjugated linoleic acid isomers on insulin resistance and mRNA levels of genes regulating energy metabolism in high-fat–fed rats

We investigated the effects of specific conjugated linoleic acid (CLA) isomers on glucose metabolism and insulin resistance and on mRNA levels of genes important in glucose and lipid metabolism. Sprague-Dawley rats were fed for 8 wk on a high-fat diet (45% kcal from fat) or one of three CLA-suppleme... Full description

Journal Title: Nutrition (Burbank Los Angeles County, Calif.), 2004, Vol.20 (11), p.1008-1017
Main Author: Choi, Joo Sun
Other Authors: Jung, Myeong Ho , Park, Hyun Suh , Song, Jihyun
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: New York, NY: Elsevier Inc
ID: ISSN: 0899-9007
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title: Effect of conjugated linoleic acid isomers on insulin resistance and mRNA levels of genes regulating energy metabolism in high-fat–fed rats
format: Article
creator:
  • Choi, Joo Sun
  • Jung, Myeong Ho
  • Park, Hyun Suh
  • Song, Jihyun
subjects:
  • Acyl coenzyme A oxidase
  • Acyl-CoA Oxidase - metabolism
  • Animals
  • Biological and medical sciences
  • Blood Glucose - metabolism
  • Conjugated linoleic acid
  • Diabetes
  • Diet
  • Dietary Fats - administration & dosage
  • Dietary Fats - pharmacology
  • Energy Metabolism - drug effects
  • Energy Metabolism - physiology
  • Fatty acids
  • Feeding. Feeding behavior
  • Fundamental and applied biological sciences. Psychology
  • Glucose
  • Glucose tolerance test
  • Hyperglycemia
  • Insulin Resistance
  • Insulin sensitivity
  • Ion Channels
  • Linoleic Acids, Conjugated - administration & dosage
  • Linoleic Acids, Conjugated - chemistry
  • Linoleic Acids, Conjugated - pharmacology
  • Lipids - blood
  • Liver - drug effects
  • Liver - metabolism
  • Male
  • Membrane Transport Proteins - metabolism
  • Metabolism
  • Mitochondrial Proteins - metabolism
  • Obesity
  • Protein Isoforms
  • Random Allocation
  • Rats
  • Rats, Sprague-Dawley
  • RNA, Messenger - metabolism
  • Rodents
  • Uncoupling protein
  • Uncoupling Protein 2
  • Vertebrates: anatomy and physiology, studies on body, several organs or systems
ispartof: Nutrition (Burbank, Los Angeles County, Calif.), 2004, Vol.20 (11), p.1008-1017
description: We investigated the effects of specific conjugated linoleic acid (CLA) isomers on glucose metabolism and insulin resistance and on mRNA levels of genes important in glucose and lipid metabolism. Sprague-Dawley rats were fed for 8 wk on a high-fat diet (45% kcal from fat) or one of three CLA-supplemented diets (1% CLA) containing differing isomers of CLA, including a mixture of CLAs (CLA mix), cis-9, trans-11-CLA (C9,T11-CLA), or trans-10, cis-12-CLA (T10,C12-CLA). Compared with the high-fat group, all the CLA groups had enhanced glucose tolerance. Insulin resistance index was significantly lower in the CLA-treated groups. No significant difference could be observed in the level of serum lipids between groups and in the activities of phosphoenolpyruvate carboxylase, glucose-6-phosphatase, and glucokinase. However, C9,T11-CLA and T10,C12-CLA significantly increased acyl coenzyme A oxidase mRNA in skeletal muscle. In addition, C9,T11-CLA increased hepatic acyl coenzyme A oxidase mRNA and skeletal muscle uncoupling protein-2 mRNA. The CLA mix showed intermediate effects on the levels of these genes. The addition of all types of CLA to Sprague-Dawley rats fed a high-fat diet can decrease insulin resistance. Possible mechanisms are increased fat oxidation and energy expenditure by increasing acyl coenzyme A oxidase and uncoupling protein-2 mRNA in the liver and/or skeletal muscle.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0899-9007
fulltext: fulltext
issn:
  • 0899-9007
  • 1873-1244
url: Link


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creatorcontribChoi, Joo Sun ; Jung, Myeong Ho ; Park, Hyun Suh ; Song, Jihyun
descriptionWe investigated the effects of specific conjugated linoleic acid (CLA) isomers on glucose metabolism and insulin resistance and on mRNA levels of genes important in glucose and lipid metabolism. Sprague-Dawley rats were fed for 8 wk on a high-fat diet (45% kcal from fat) or one of three CLA-supplemented diets (1% CLA) containing differing isomers of CLA, including a mixture of CLAs (CLA mix), cis-9, trans-11-CLA (C9,T11-CLA), or trans-10, cis-12-CLA (T10,C12-CLA). Compared with the high-fat group, all the CLA groups had enhanced glucose tolerance. Insulin resistance index was significantly lower in the CLA-treated groups. No significant difference could be observed in the level of serum lipids between groups and in the activities of phosphoenolpyruvate carboxylase, glucose-6-phosphatase, and glucokinase. However, C9,T11-CLA and T10,C12-CLA significantly increased acyl coenzyme A oxidase mRNA in skeletal muscle. In addition, C9,T11-CLA increased hepatic acyl coenzyme A oxidase mRNA and skeletal muscle uncoupling protein-2 mRNA. The CLA mix showed intermediate effects on the levels of these genes. The addition of all types of CLA to Sprague-Dawley rats fed a high-fat diet can decrease insulin resistance. Possible mechanisms are increased fat oxidation and energy expenditure by increasing acyl coenzyme A oxidase and uncoupling protein-2 mRNA in the liver and/or skeletal muscle.
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subjectAcyl coenzyme A oxidase ; Acyl-CoA Oxidase - metabolism ; Animals ; Biological and medical sciences ; Blood Glucose - metabolism ; Conjugated linoleic acid ; Diabetes ; Diet ; Dietary Fats - administration & dosage ; Dietary Fats - pharmacology ; Energy Metabolism - drug effects ; Energy Metabolism - physiology ; Fatty acids ; Feeding. Feeding behavior ; Fundamental and applied biological sciences. Psychology ; Glucose ; Glucose tolerance test ; Hyperglycemia ; Insulin Resistance ; Insulin sensitivity ; Ion Channels ; Linoleic Acids, Conjugated - administration & dosage ; Linoleic Acids, Conjugated - chemistry ; Linoleic Acids, Conjugated - pharmacology ; Lipids - blood ; Liver - drug effects ; Liver - metabolism ; Male ; Membrane Transport Proteins - metabolism ; Metabolism ; Mitochondrial Proteins - metabolism ; Obesity ; Protein Isoforms ; Random Allocation ; Rats ; Rats, Sprague-Dawley ; RNA, Messenger - metabolism ; Rodents ; Uncoupling protein ; Uncoupling Protein 2 ; Vertebrates: anatomy and physiology, studies on body, several organs or systems
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descriptionWe investigated the effects of specific conjugated linoleic acid (CLA) isomers on glucose metabolism and insulin resistance and on mRNA levels of genes important in glucose and lipid metabolism. Sprague-Dawley rats were fed for 8 wk on a high-fat diet (45% kcal from fat) or one of three CLA-supplemented diets (1% CLA) containing differing isomers of CLA, including a mixture of CLAs (CLA mix), cis-9, trans-11-CLA (C9,T11-CLA), or trans-10, cis-12-CLA (T10,C12-CLA). Compared with the high-fat group, all the CLA groups had enhanced glucose tolerance. Insulin resistance index was significantly lower in the CLA-treated groups. No significant difference could be observed in the level of serum lipids between groups and in the activities of phosphoenolpyruvate carboxylase, glucose-6-phosphatase, and glucokinase. However, C9,T11-CLA and T10,C12-CLA significantly increased acyl coenzyme A oxidase mRNA in skeletal muscle. In addition, C9,T11-CLA increased hepatic acyl coenzyme A oxidase mRNA and skeletal muscle uncoupling protein-2 mRNA. The CLA mix showed intermediate effects on the levels of these genes. The addition of all types of CLA to Sprague-Dawley rats fed a high-fat diet can decrease insulin resistance. Possible mechanisms are increased fat oxidation and energy expenditure by increasing acyl coenzyme A oxidase and uncoupling protein-2 mRNA in the liver and/or skeletal muscle.
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1Acyl-CoA Oxidase - metabolism
2Animals
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4Blood Glucose - metabolism
5Conjugated linoleic acid
6Diabetes
7Diet
8Dietary Fats - administration & dosage
9Dietary Fats - pharmacology
10Energy Metabolism - drug effects
11Energy Metabolism - physiology
12Fatty acids
13Feeding. Feeding behavior
14Fundamental and applied biological sciences. Psychology
15Glucose
16Glucose tolerance test
17Hyperglycemia
18Insulin Resistance
19Insulin sensitivity
20Ion Channels
21Linoleic Acids, Conjugated - administration & dosage
22Linoleic Acids, Conjugated - chemistry
23Linoleic Acids, Conjugated - pharmacology
24Lipids - blood
25Liver - drug effects
26Liver - metabolism
27Male
28Membrane Transport Proteins - metabolism
29Metabolism
30Mitochondrial Proteins - metabolism
31Obesity
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36RNA, Messenger - metabolism
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abstractWe investigated the effects of specific conjugated linoleic acid (CLA) isomers on glucose metabolism and insulin resistance and on mRNA levels of genes important in glucose and lipid metabolism. Sprague-Dawley rats were fed for 8 wk on a high-fat diet (45% kcal from fat) or one of three CLA-supplemented diets (1% CLA) containing differing isomers of CLA, including a mixture of CLAs (CLA mix), cis-9, trans-11-CLA (C9,T11-CLA), or trans-10, cis-12-CLA (T10,C12-CLA). Compared with the high-fat group, all the CLA groups had enhanced glucose tolerance. Insulin resistance index was significantly lower in the CLA-treated groups. No significant difference could be observed in the level of serum lipids between groups and in the activities of phosphoenolpyruvate carboxylase, glucose-6-phosphatase, and glucokinase. However, C9,T11-CLA and T10,C12-CLA significantly increased acyl coenzyme A oxidase mRNA in skeletal muscle. In addition, C9,T11-CLA increased hepatic acyl coenzyme A oxidase mRNA and skeletal muscle uncoupling protein-2 mRNA. The CLA mix showed intermediate effects on the levels of these genes. The addition of all types of CLA to Sprague-Dawley rats fed a high-fat diet can decrease insulin resistance. Possible mechanisms are increased fat oxidation and energy expenditure by increasing acyl coenzyme A oxidase and uncoupling protein-2 mRNA in the liver and/or skeletal muscle.
copNew York, NY
pubElsevier Inc
pmid15561492
doi10.1016/j.nut.2004.08.009