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Antioxidant vitamin status during pregnancy in relation to cognitive development in the first two years of life

Abstract Objective To investigate the correlation of the antioxidant vitamins status (vitamins A, E and C) during pregnancy and the intellectual development of early childhood. Method A total of 150 paired maternal–neonatal subjects were recruited into the present study. The serum concentrations of... Full description

Journal Title: Early human development 2009, Vol.85 (7), p.421-427
Main Author: Chen, Ke
Other Authors: Zhang, Xuan , Wei, Xiao-ping , Qu, Ping , Liu, You-xue , Li, Ting-yu
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: Amsterdam: Elsevier Ireland Ltd
ID: ISSN: 0378-3782
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recordid: cdi_proquest_miscellaneous_67327051
title: Antioxidant vitamin status during pregnancy in relation to cognitive development in the first two years of life
format: Article
creator:
  • Chen, Ke
  • Zhang, Xuan
  • Wei, Xiao-ping
  • Qu, Ping
  • Liu, You-xue
  • Li, Ting-yu
subjects:
  • Advanced Basic Science
  • Antioxidant vitamins
  • Antioxidants
  • Antioxidants - metabolism
  • Antioxidants - pharmacology
  • Ascorbic Acid - blood
  • Ascorbic Acid - metabolism
  • Ascorbic Acid - pharmacology
  • Biological and medical sciences
  • Child Development
  • Children
  • Cognition
  • Cohort Studies
  • Cord blood
  • Embryology: invertebrates and vertebrates. Teratology
  • Female
  • Fetal Blood - metabolism
  • Follow-Up Studies
  • Fundamental and applied biological sciences. Psychology
  • Humans
  • Infant
  • Infant, Newborn
  • Intellectual development
  • Intelligence Tests
  • Language Development
  • Maternal-Fetal Exchange
  • Neonatal and Perinatal Medicine
  • Pregnancy - blood
  • Pregnant women
  • Vitamin A - blood
  • Vitamin A - metabolism
  • Vitamin A - pharmacology
  • Vitamin E - blood
  • Vitamin E - metabolism
  • Vitamin E - pharmacology
  • Vitamins
ispartof: Early human development, 2009, Vol.85 (7), p.421-427
description: Abstract Objective To investigate the correlation of the antioxidant vitamins status (vitamins A, E and C) during pregnancy and the intellectual development of early childhood. Method A total of 150 paired maternal–neonatal subjects were recruited into the present study. The serum concentrations of antioxidant vitamins (vitamins A, E and C) in maternal blood and cord blood after delivery were determined by high performance liquid chromatography and the intellectual development was evaluated by Gesell Development Schedules (GDS) at two-years-old. Result Children with higher cord serum vitamin E level showed higher scores of motor, adaptive domain and average compared to children with lower cord serum vitamin E level ( p < 0.01 or 0.05), respectively. Cord serum vitamin A level had significant positive correlation with effect on motor DQs ( β = 4.227, p < 0.05), and vitamin E level in cord blood showed a positive relation with motor DQ and average DQ ( β = 0.329 and 0.1875, respectively, p < 0.05) in multiple linear regression model. The language and social DQs were influenced by placental vitamin E transport rate ( β = 3.1968 and 3.0194, respectively, p < 0.05). The placental transport rate of vitamin E also was a protective factor for the prevalence of motor behavior developmental delay [OR: 0.118, 95% confident interval (95% CI), 0.018–0.765, p = 0.0251], personal and social behavior developmental delay (OR: 0.052, 95% CI: 0.004–0.610, p = 0.0185) and average developmental delay (OR: 0.041, 95% CI: 0.003–0.642, p = 0.0229) in logistic multiple regression model. Conclusion Data suggested that vitamin A, E status and vitamin E transfer rate at delivery had beneficial influence on children's cognitive and behavior development quotients.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0378-3782
fulltext: fulltext
issn:
  • 0378-3782
  • 1872-6232
url: Link


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descriptionAbstract Objective To investigate the correlation of the antioxidant vitamins status (vitamins A, E and C) during pregnancy and the intellectual development of early childhood. Method A total of 150 paired maternal–neonatal subjects were recruited into the present study. The serum concentrations of antioxidant vitamins (vitamins A, E and C) in maternal blood and cord blood after delivery were determined by high performance liquid chromatography and the intellectual development was evaluated by Gesell Development Schedules (GDS) at two-years-old. Result Children with higher cord serum vitamin E level showed higher scores of motor, adaptive domain and average compared to children with lower cord serum vitamin E level ( p < 0.01 or 0.05), respectively. Cord serum vitamin A level had significant positive correlation with effect on motor DQs ( β = 4.227, p < 0.05), and vitamin E level in cord blood showed a positive relation with motor DQ and average DQ ( β = 0.329 and 0.1875, respectively, p < 0.05) in multiple linear regression model. The language and social DQs were influenced by placental vitamin E transport rate ( β = 3.1968 and 3.0194, respectively, p < 0.05). The placental transport rate of vitamin E also was a protective factor for the prevalence of motor behavior developmental delay [OR: 0.118, 95% confident interval (95% CI), 0.018–0.765, p = 0.0251], personal and social behavior developmental delay (OR: 0.052, 95% CI: 0.004–0.610, p = 0.0185) and average developmental delay (OR: 0.041, 95% CI: 0.003–0.642, p = 0.0229) in logistic multiple regression model. Conclusion Data suggested that vitamin A, E status and vitamin E transfer rate at delivery had beneficial influence on children's cognitive and behavior development quotients.
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subjectAdvanced Basic Science ; Antioxidant vitamins ; Antioxidants ; Antioxidants - metabolism ; Antioxidants - pharmacology ; Ascorbic Acid - blood ; Ascorbic Acid - metabolism ; Ascorbic Acid - pharmacology ; Biological and medical sciences ; Child Development ; Children ; Cognition ; Cohort Studies ; Cord blood ; Embryology: invertebrates and vertebrates. Teratology ; Female ; Fetal Blood - metabolism ; Follow-Up Studies ; Fundamental and applied biological sciences. Psychology ; Humans ; Infant ; Infant, Newborn ; Intellectual development ; Intelligence Tests ; Language Development ; Maternal-Fetal Exchange ; Neonatal and Perinatal Medicine ; Pregnancy - blood ; Pregnant women ; Vitamin A - blood ; Vitamin A - metabolism ; Vitamin A - pharmacology ; Vitamin E - blood ; Vitamin E - metabolism ; Vitamin E - pharmacology ; Vitamins
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descriptionAbstract Objective To investigate the correlation of the antioxidant vitamins status (vitamins A, E and C) during pregnancy and the intellectual development of early childhood. Method A total of 150 paired maternal–neonatal subjects were recruited into the present study. The serum concentrations of antioxidant vitamins (vitamins A, E and C) in maternal blood and cord blood after delivery were determined by high performance liquid chromatography and the intellectual development was evaluated by Gesell Development Schedules (GDS) at two-years-old. Result Children with higher cord serum vitamin E level showed higher scores of motor, adaptive domain and average compared to children with lower cord serum vitamin E level ( p < 0.01 or 0.05), respectively. Cord serum vitamin A level had significant positive correlation with effect on motor DQs ( β = 4.227, p < 0.05), and vitamin E level in cord blood showed a positive relation with motor DQ and average DQ ( β = 0.329 and 0.1875, respectively, p < 0.05) in multiple linear regression model. The language and social DQs were influenced by placental vitamin E transport rate ( β = 3.1968 and 3.0194, respectively, p < 0.05). The placental transport rate of vitamin E also was a protective factor for the prevalence of motor behavior developmental delay [OR: 0.118, 95% confident interval (95% CI), 0.018–0.765, p = 0.0251], personal and social behavior developmental delay (OR: 0.052, 95% CI: 0.004–0.610, p = 0.0185) and average developmental delay (OR: 0.041, 95% CI: 0.003–0.642, p = 0.0229) in logistic multiple regression model. Conclusion Data suggested that vitamin A, E status and vitamin E transfer rate at delivery had beneficial influence on children's cognitive and behavior development quotients.
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5Ascorbic Acid - blood
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8Biological and medical sciences
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24Language Development
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30Vitamin A - metabolism
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abstractAbstract Objective To investigate the correlation of the antioxidant vitamins status (vitamins A, E and C) during pregnancy and the intellectual development of early childhood. Method A total of 150 paired maternal–neonatal subjects were recruited into the present study. The serum concentrations of antioxidant vitamins (vitamins A, E and C) in maternal blood and cord blood after delivery were determined by high performance liquid chromatography and the intellectual development was evaluated by Gesell Development Schedules (GDS) at two-years-old. Result Children with higher cord serum vitamin E level showed higher scores of motor, adaptive domain and average compared to children with lower cord serum vitamin E level ( p < 0.01 or 0.05), respectively. Cord serum vitamin A level had significant positive correlation with effect on motor DQs ( β = 4.227, p < 0.05), and vitamin E level in cord blood showed a positive relation with motor DQ and average DQ ( β = 0.329 and 0.1875, respectively, p < 0.05) in multiple linear regression model. The language and social DQs were influenced by placental vitamin E transport rate ( β = 3.1968 and 3.0194, respectively, p < 0.05). The placental transport rate of vitamin E also was a protective factor for the prevalence of motor behavior developmental delay [OR: 0.118, 95% confident interval (95% CI), 0.018–0.765, p = 0.0251], personal and social behavior developmental delay (OR: 0.052, 95% CI: 0.004–0.610, p = 0.0185) and average developmental delay (OR: 0.041, 95% CI: 0.003–0.642, p = 0.0229) in logistic multiple regression model. Conclusion Data suggested that vitamin A, E status and vitamin E transfer rate at delivery had beneficial influence on children's cognitive and behavior development quotients.
copAmsterdam
pubElsevier Ireland Ltd
pmid19286336
doi10.1016/j.earlhumdev.2009.02.001