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Obesity-Associated Hypertension: New Insights Into Mechanisms

Obesity is strongly associated with hypertension and cardiovascular disease. Several central and peripheral abnormalities that can explain the development or maintenance of high arterial pressure in obesity have been identified. These include activation of the sympathetic nervous system and the reni... Full description

Journal Title: Hypertension 2005-01-01, Vol.45 (1), p.9-14
Main Author: Rahmouni, Kamal
Other Authors: Correia, Marcelo L.G , Haynes, William G , Mark, Allyn L
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Philadelphia, PA: Am Heart Assoc
ID: ISSN: 0194-911X
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recordid: cdi_proquest_miscellaneous_67340641
title: Obesity-Associated Hypertension: New Insights Into Mechanisms
format: Article
creator:
  • Rahmouni, Kamal
  • Correia, Marcelo L.G
  • Haynes, William G
  • Mark, Allyn L
subjects:
  • Adiponectin
  • Aldosterone - physiology
  • Animals
  • Appetite - physiology
  • Arterial hypertension. Arterial hypotension
  • Biological and medical sciences
  • Blood and lymphatic vessels
  • Cardiology. Vascular system
  • Clinical manifestations. Epidemiology. Investigative techniques. Etiology
  • Endothelium, Vascular - physiopathology
  • Energy Metabolism - physiology
  • Ghrelin
  • Humans
  • Hyperinsulinism - physiopathology
  • Hypertension - etiology
  • Hypertension - physiopathology
  • Intercellular Signaling Peptides and Proteins - physiology
  • Kidney - physiopathology
  • Leptin - physiology
  • Medical sciences
  • Metabolic diseases
  • Mice
  • Mice, Mutant Strains
  • Mineralocorticoid Receptor Antagonists - pharmacology
  • Obesity
  • Obesity - complications
  • Obesity - physiopathology
  • Peptide Hormones - physiology
  • Peptide YY - physiology
  • Receptors, Cell Surface - physiology
  • Receptors, Leptin
  • Renin-Angiotensin System - physiology
  • Repressor Proteins - physiology
  • Satiation - physiology
  • Suppressor of Cytokine Signaling 3 Protein
  • Suppressor of Cytokine Signaling Proteins
  • Sympathetic Nervous System - physiopathology
  • Transcription Factors - physiology
ispartof: Hypertension, 2005-01-01, Vol.45 (1), p.9-14
description: Obesity is strongly associated with hypertension and cardiovascular disease. Several central and peripheral abnormalities that can explain the development or maintenance of high arterial pressure in obesity have been identified. These include activation of the sympathetic nervous system and the renin-angiotensin–aldosterone system. Obesity is also associated with endothelial dysfunction and renal functional abnormalities that may play a role in the development of hypertension. The continuing discovery of mechanisms regulating appetite and metabolism is likely to lead to new therapies for obesity-induced hypertension. Better understanding of leptin signaling in the hypothalamus and the mechanisms of leptin resistance should facilitate therapeutic approaches to reverse the phenomenon of selective leptin resistance. Other hunger and satiety signals such as ghrelin and peptide YY are potentially attractive therapeutic strategies for treatment of obesity and its complications. These recent discoveries should lead to novel strategies for treatment of obesity and hypertension.
language: eng
source:
identifier: ISSN: 0194-911X
fulltext: no_fulltext
issn:
  • 0194-911X
  • 1524-4563
url: Link


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descriptionObesity is strongly associated with hypertension and cardiovascular disease. Several central and peripheral abnormalities that can explain the development or maintenance of high arterial pressure in obesity have been identified. These include activation of the sympathetic nervous system and the renin-angiotensin–aldosterone system. Obesity is also associated with endothelial dysfunction and renal functional abnormalities that may play a role in the development of hypertension. The continuing discovery of mechanisms regulating appetite and metabolism is likely to lead to new therapies for obesity-induced hypertension. Better understanding of leptin signaling in the hypothalamus and the mechanisms of leptin resistance should facilitate therapeutic approaches to reverse the phenomenon of selective leptin resistance. Other hunger and satiety signals such as ghrelin and peptide YY are potentially attractive therapeutic strategies for treatment of obesity and its complications. These recent discoveries should lead to novel strategies for treatment of obesity and hypertension.
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subjectAdiponectin ; Aldosterone - physiology ; Animals ; Appetite - physiology ; Arterial hypertension. Arterial hypotension ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Clinical manifestations. Epidemiology. Investigative techniques. Etiology ; Endothelium, Vascular - physiopathology ; Energy Metabolism - physiology ; Ghrelin ; Humans ; Hyperinsulinism - physiopathology ; Hypertension - etiology ; Hypertension - physiopathology ; Intercellular Signaling Peptides and Proteins - physiology ; Kidney - physiopathology ; Leptin - physiology ; Medical sciences ; Metabolic diseases ; Mice ; Mice, Mutant Strains ; Mineralocorticoid Receptor Antagonists - pharmacology ; Obesity ; Obesity - complications ; Obesity - physiopathology ; Peptide Hormones - physiology ; Peptide YY - physiology ; Receptors, Cell Surface - physiology ; Receptors, Leptin ; Renin-Angiotensin System - physiology ; Repressor Proteins - physiology ; Satiation - physiology ; Suppressor of Cytokine Signaling 3 Protein ; Suppressor of Cytokine Signaling Proteins ; Sympathetic Nervous System - physiopathology ; Transcription Factors - physiology
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descriptionObesity is strongly associated with hypertension and cardiovascular disease. Several central and peripheral abnormalities that can explain the development or maintenance of high arterial pressure in obesity have been identified. These include activation of the sympathetic nervous system and the renin-angiotensin–aldosterone system. Obesity is also associated with endothelial dysfunction and renal functional abnormalities that may play a role in the development of hypertension. The continuing discovery of mechanisms regulating appetite and metabolism is likely to lead to new therapies for obesity-induced hypertension. Better understanding of leptin signaling in the hypothalamus and the mechanisms of leptin resistance should facilitate therapeutic approaches to reverse the phenomenon of selective leptin resistance. Other hunger and satiety signals such as ghrelin and peptide YY are potentially attractive therapeutic strategies for treatment of obesity and its complications. These recent discoveries should lead to novel strategies for treatment of obesity and hypertension.
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0Adiponectin
1Aldosterone - physiology
2Animals
3Appetite - physiology
4Arterial hypertension. Arterial hypotension
5Biological and medical sciences
6Blood and lymphatic vessels
7Cardiology. Vascular system
8Clinical manifestations. Epidemiology. Investigative techniques. Etiology
9Endothelium, Vascular - physiopathology
10Energy Metabolism - physiology
11Ghrelin
12Humans
13Hyperinsulinism - physiopathology
14Hypertension - etiology
15Hypertension - physiopathology
16Intercellular Signaling Peptides and Proteins - physiology
17Kidney - physiopathology
18Leptin - physiology
19Medical sciences
20Metabolic diseases
21Mice
22Mice, Mutant Strains
23Mineralocorticoid Receptor Antagonists - pharmacology
24Obesity
25Obesity - complications
26Obesity - physiopathology
27Peptide Hormones - physiology
28Peptide YY - physiology
29Receptors, Cell Surface - physiology
30Receptors, Leptin
31Renin-Angiotensin System - physiology
32Repressor Proteins - physiology
33Satiation - physiology
34Suppressor of Cytokine Signaling 3 Protein
35Suppressor of Cytokine Signaling Proteins
36Sympathetic Nervous System - physiopathology
37Transcription Factors - physiology
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1Aldosterone - physiology
2Animals
3Appetite - physiology
4Arterial hypertension. Arterial hypotension
5Biological and medical sciences
6Blood and lymphatic vessels
7Cardiology. Vascular system
8Clinical manifestations. Epidemiology. Investigative techniques. Etiology
9Endothelium, Vascular - physiopathology
10Energy Metabolism - physiology
11Ghrelin
12Humans
13Hyperinsulinism - physiopathology
14Hypertension - etiology
15Hypertension - physiopathology
16Intercellular Signaling Peptides and Proteins - physiology
17Kidney - physiopathology
18Leptin - physiology
19Medical sciences
20Metabolic diseases
21Mice
22Mice, Mutant Strains
23Mineralocorticoid Receptor Antagonists - pharmacology
24Obesity
25Obesity - complications
26Obesity - physiopathology
27Peptide Hormones - physiology
28Peptide YY - physiology
29Receptors, Cell Surface - physiology
30Receptors, Leptin
31Renin-Angiotensin System - physiology
32Repressor Proteins - physiology
33Satiation - physiology
34Suppressor of Cytokine Signaling 3 Protein
35Suppressor of Cytokine Signaling Proteins
36Sympathetic Nervous System - physiopathology
37Transcription Factors - physiology
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abstractObesity is strongly associated with hypertension and cardiovascular disease. Several central and peripheral abnormalities that can explain the development or maintenance of high arterial pressure in obesity have been identified. These include activation of the sympathetic nervous system and the renin-angiotensin–aldosterone system. Obesity is also associated with endothelial dysfunction and renal functional abnormalities that may play a role in the development of hypertension. The continuing discovery of mechanisms regulating appetite and metabolism is likely to lead to new therapies for obesity-induced hypertension. Better understanding of leptin signaling in the hypothalamus and the mechanisms of leptin resistance should facilitate therapeutic approaches to reverse the phenomenon of selective leptin resistance. Other hunger and satiety signals such as ghrelin and peptide YY are potentially attractive therapeutic strategies for treatment of obesity and its complications. These recent discoveries should lead to novel strategies for treatment of obesity and hypertension.
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