A novel intranasal Protollin ™-based measles vaccine induces mucosal and systemic neutralizing antibody responses and cell-mediated immunity in mice

Journal Title:	Vaccine 2005, Vol.23 (11), p.1374-1383
Main Author:	Chabot, Sophie
Other Authors:	Brewer, Angela , Lowell, George , Plante, Martin , Cyr, Sonya , Burt, David S , Ward, Brian J
Format:	Electronic Article
Language:	English
Subjects:	Adjuvants Adjuvants, Immunologic - administration & dosage Adjuvants, Immunologic - pharmacology Administration, Intranasal Animals Antibodies, Viral - immunology Antibody Applied microbiology Biological and medical sciences Children & youth Clinical trials Cysteine Endopeptidases - administration & dosage Cysteine Endopeptidases - pharmacology Drug Combinations Female Fundamental and applied biological sciences. Psychology Human viral diseases IgA Immune system Immunity, Cellular Immunity, Mucosal Immunoglobulin A - analysis Immunoglobulin G - blood Infections Infectious diseases Interferon-gamma Interferon-gamma - biosynthesis Laboratories Leukocytes - immunology Lipopolysaccharides - administration & dosage Lipopolysaccharides - pharmacology Measles Measles - prevention & control Measles Vaccine - administration & dosage Measles Vaccine - immunology Medical research Medical sciences Membranes Mice Mice, Inbred BALB C Microbiology Microscopy Mucosal vaccination Neisseria meningitidis - chemistry Neutralization Neutralization Tests Proteins Shigella flexneri - chemistry Spleen - immunology Studies T-Lymphocytes, Helper-Inducer - immunology Vaccine Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, Subunit - immunology Viral diseases Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye
Quelle:	Alma/SFX Local Collection
Publisher:	Oxford: Elsevier Ltd
ID:	ISSN: 0264-410X
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title:	A novel intranasal Protollin ™-based measles vaccine induces mucosal and systemic neutralizing antibody responses and cell-mediated immunity in mice
format:	Article
creator:	Chabot, Sophie Brewer, Angela Lowell, George Plante, Martin Cyr, Sonya Burt, David S Ward, Brian J
subjects:	Adjuvants Adjuvants, Immunologic - administration & dosage Adjuvants, Immunologic - pharmacology Administration, Intranasal Animals Antibodies, Viral - immunology Antibody Applied microbiology Biological and medical sciences Children & youth Clinical trials Cysteine Endopeptidases - administration & dosage Cysteine Endopeptidases - pharmacology Drug Combinations Female Fundamental and applied biological sciences. Psychology Human viral diseases IgA Immune system Immunity, Cellular Immunity, Mucosal Immunoglobulin A - analysis Immunoglobulin G - blood Infections Infectious diseases Interferon-gamma Interferon-gamma - biosynthesis Laboratories Leukocytes - immunology Lipopolysaccharides - administration & dosage Lipopolysaccharides - pharmacology Measles Measles - prevention & control Measles Vaccine - administration & dosage Measles Vaccine - immunology Medical research Medical sciences Membranes Mice Mice, Inbred BALB C Microbiology Microscopy Mucosal vaccination Neisseria meningitidis - chemistry Neutralization Neutralization Tests Proteins Shigella flexneri - chemistry Spleen - immunology Studies T-Lymphocytes, Helper-Inducer - immunology Vaccine Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, Subunit - immunology Viral diseases Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye
ispartof:	Vaccine, 2005, Vol.23 (11), p.1374-1383
description:	Protollin-MV is a vaccine produced by mixing split measles virus (MV) antigen with the novel adjuvant Protollin ™ ( Neisseria meningitidis outer membrane proteins non-covalently complexed with Shigella flexneri 2a lipopolysaccharide). Intranasal immunization of mice with two or three doses of Protollin-MV induces both serum IgG and mucosal IgA with strong neutralizing activity. There is a dose-dependent shift towards lower IgG 1:IgG 2a ratios and MV-specific IFNγ production in splenocytes. Intranasal Protollin-MV can therefore induce systemic and mucosal neutralizing antibody responses as well as elicit a balanced T H1/T H2-type response.
language:	eng
source:	Alma/SFX Local Collection
identifier:	ISSN: 0264-410X
fulltext:	fulltext
issn:	0264-410X 1873-2518
url:	Link

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A novel intranasal Protollin ™-based measles vaccine induces mucosal and systemic neutralizing antibody responses and cell-mediated immunity in mice

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Alma/SFX Local Collection

creator

Chabot, Sophie ; Brewer, Angela ; Lowell, George ; Plante, Martin ; Cyr, Sonya ; Burt, David S ; Ward, Brian J

creatorcontrib

Chabot, Sophie ; Brewer, Angela ; Lowell, George ; Plante, Martin ; Cyr, Sonya ; Burt, David S ; Ward, Brian J

description

Protollin-MV is a vaccine produced by mixing split measles virus (MV) antigen with the novel adjuvant Protollin ™ ( Neisseria meningitidis outer membrane proteins non-covalently complexed with Shigella flexneri 2a lipopolysaccharide). Intranasal immunization of mice with two or three doses of Protollin-MV induces both serum IgG and mucosal IgA with strong neutralizing activity. There is a dose-dependent shift towards lower IgG 1:IgG 2a ratios and MV-specific IFNγ production in splenocytes. Intranasal Protollin-MV can therefore induce systemic and mucosal neutralizing antibody responses as well as elicit a balanced T H1/T H2-type response.

identifier

0	ISSN: 0264-410X
1	EISSN: 1873-2518
2	DOI: 10.1016/j.vaccine.2004.09.010
3	PMID: 15661386
4	CODEN: VACCDE

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eng

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Oxford: Elsevier Ltd

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0	Chabot, Sophie
1	Brewer, Angela
2	Lowell, George
3	Plante, Martin
4	Cyr, Sonya
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creationdate	2005
title	A novel intranasal Protollin ™-based measles vaccine induces mucosal and systemic neutralizing antibody responses and cell-mediated immunity in mice
author	Chabot, Sophie ; Brewer, Angela ; Lowell, George ; Plante, Martin ; Cyr, Sonya ; Burt, David S ; Ward, Brian J

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2	Adjuvants, Immunologic - pharmacology
3	Administration, Intranasal
4	Animals
5	Antibodies, Viral - immunology
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10	Clinical trials
11	Cysteine Endopeptidases - administration & dosage
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31	Measles
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33	Measles Vaccine - administration & dosage
34	Measles Vaccine - immunology
35	Medical research
36	Medical sciences
37	Membranes
38	Mice
39	Mice, Inbred BALB C
40	Microbiology
41	Microscopy
42	Mucosal vaccination
43	Neisseria meningitidis - chemistry
44	Neutralization
45	Neutralization Tests
46	Proteins
47	Shigella flexneri - chemistry
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49	Studies
50	T-Lymphocytes, Helper-Inducer - immunology
51	Vaccine
52	Vaccines
53	Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
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55	Viral diseases
56	Viral diseases with cutaneous or mucosal lesions and viral diseases of the eye

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jtitle

Vaccine

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fulltext	fulltext

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0	Chabot, Sophie
1	Brewer, Angela
2	Lowell, George
3	Plante, Martin
4	Cyr, Sonya
5	Burt, David S
6	Ward, Brian J

format

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genre

article

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JOUR

atitle

A novel intranasal Protollin ™-based measles vaccine induces mucosal and systemic neutralizing antibody responses and cell-mediated immunity in mice

jtitle

Vaccine

addtitle

Vaccine

date

2005

risdate

2005

volume

issue

spage

1374

epage

1383

pages

1374-1383

issn

0264-410X

eissn

1873-2518

coden

VACCDE

abstract

cop

Oxford

pub

Elsevier Ltd

pmid

15661386

doi

10.1016/j.vaccine.2004.09.010

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Bibliotheken

A novel intranasal Protollin ™-based measles vaccine induces mucosal and systemic neutralizing antibody responses and cell-mediated immunity in mice