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Treatment with drugs to lower blood pressure and blood cholesterol based on an individual's absolute cardiovascular risk

In this review, we outline the rationale for targeting blood pressure and blood cholesterol lowering drug treatments to patients at high absolute cardiovascular risk, irrespective of their blood pressure or blood cholesterol levels. Because the specific levels of blood pressure and cholesterol are o... Full description

Journal Title: The Lancet (British edition) 2005, Vol.365 (9457), p.434-441
Main Author: Jackson, Rod
Other Authors: Lawes, Carlene MM , Bennett, Derrick A , Milne, Richard J , Rodgers, Anthony
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: London: Elsevier Ltd
ID: ISSN: 0140-6736
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title: Treatment with drugs to lower blood pressure and blood cholesterol based on an individual's absolute cardiovascular risk
format: Article
creator:
  • Jackson, Rod
  • Lawes, Carlene MM
  • Bennett, Derrick A
  • Milne, Richard J
  • Rodgers, Anthony
subjects:
  • Abridged Index Medicus
  • Adult
  • Aged
  • Atherosclerosis (general aspects, experimental research)
  • Biological and medical sciences
  • Blood and lymphatic vessels
  • Blood Pressure
  • Cardiology. Vascular system
  • Cardiovascular Diseases - etiology
  • Cardiovascular Diseases - prevention & control
  • Cholesterol - blood
  • Female
  • General aspects
  • Humans
  • Hypercholesterolemia - complications
  • Hypercholesterolemia - drug therapy
  • Hypertension - complications
  • Hypertension - drug therapy
  • Male
  • Medical sciences
  • Middle Aged
  • Quality-Adjusted Life Years
  • Risk Assessment
  • Risk Factors
ispartof: The Lancet (British edition), 2005, Vol.365 (9457), p.434-441
description: In this review, we outline the rationale for targeting blood pressure and blood cholesterol lowering drug treatments to patients at high absolute cardiovascular risk, irrespective of their blood pressure or blood cholesterol levels. Because the specific levels of blood pressure and cholesterol are of little clinical relevance when considered in isolation from other risk factors, terms such as hypertension or hypercholesterolaemia have limited value. Separate management guidelines for raised blood pressure and blood cholesterol need to be replaced by integrated cardiovascular risk management guidelines, and absolute cardiovascular risk prediction scores should be used routinely. Since cardiovascular risk factors interact with each other, moderate reductions in several risk factors can be more effective than major reductions in one. An affordable daily pill combining low doses of various drugs could be useful for the many individuals with slightly abnormal cardiovascular risk factors.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0140-6736
fulltext: fulltext
issn:
  • 0140-6736
  • 1474-547X
url: Link


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descriptionIn this review, we outline the rationale for targeting blood pressure and blood cholesterol lowering drug treatments to patients at high absolute cardiovascular risk, irrespective of their blood pressure or blood cholesterol levels. Because the specific levels of blood pressure and cholesterol are of little clinical relevance when considered in isolation from other risk factors, terms such as hypertension or hypercholesterolaemia have limited value. Separate management guidelines for raised blood pressure and blood cholesterol need to be replaced by integrated cardiovascular risk management guidelines, and absolute cardiovascular risk prediction scores should be used routinely. Since cardiovascular risk factors interact with each other, moderate reductions in several risk factors can be more effective than major reductions in one. An affordable daily pill combining low doses of various drugs could be useful for the many individuals with slightly abnormal cardiovascular risk factors.
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subjectAbridged Index Medicus ; Adult ; Aged ; Atherosclerosis (general aspects, experimental research) ; Biological and medical sciences ; Blood and lymphatic vessels ; Blood Pressure ; Cardiology. Vascular system ; Cardiovascular Diseases - etiology ; Cardiovascular Diseases - prevention & control ; Cholesterol - blood ; Female ; General aspects ; Humans ; Hypercholesterolemia - complications ; Hypercholesterolemia - drug therapy ; Hypertension - complications ; Hypertension - drug therapy ; Male ; Medical sciences ; Middle Aged ; Quality-Adjusted Life Years ; Risk Assessment ; Risk Factors
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abstractIn this review, we outline the rationale for targeting blood pressure and blood cholesterol lowering drug treatments to patients at high absolute cardiovascular risk, irrespective of their blood pressure or blood cholesterol levels. Because the specific levels of blood pressure and cholesterol are of little clinical relevance when considered in isolation from other risk factors, terms such as hypertension or hypercholesterolaemia have limited value. Separate management guidelines for raised blood pressure and blood cholesterol need to be replaced by integrated cardiovascular risk management guidelines, and absolute cardiovascular risk prediction scores should be used routinely. Since cardiovascular risk factors interact with each other, moderate reductions in several risk factors can be more effective than major reductions in one. An affordable daily pill combining low doses of various drugs could be useful for the many individuals with slightly abnormal cardiovascular risk factors.
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