schliessen

Filtern

 

Bibliotheken

Renal function, atherothrombosis extent, and outcomes in high-risk patients

Background Although prior data showed an association between chronic kidney disease (CKD) and atherothrombotic events, little is known about the risk profile and specific outcomes of atherothrombotic outpatients with CKD. Methods More than 69,000 outpatients at risk of atherothrombotic events were e... Full description

Journal Title: The American heart journal 2009, Vol.158 (1), p.141-148.e1
Main Author: Dumaine, Raphaelle L., MD
Other Authors: Montalescot, Gilles, MD, PhD , Steg, Ph. Gabriel, MD , Ohman, E. Magnus, MD , Eagle, Kim, MD , Bhatt, Deepak L., MD, MPH
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: New York, NY: Mosby, Inc
ID: ISSN: 0002-8703
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: cdi_proquest_miscellaneous_67399455
title: Renal function, atherothrombosis extent, and outcomes in high-risk patients
format: Article
creator:
  • Dumaine, Raphaelle L., MD
  • Montalescot, Gilles, MD, PhD
  • Steg, Ph. Gabriel, MD
  • Ohman, E. Magnus, MD
  • Eagle, Kim, MD
  • Bhatt, Deepak L., MD, MPH
subjects:
  • Abridged Index Medicus
  • Aged
  • Aged, 80 and over
  • Amputation - statistics & numerical data
  • Arterial Occlusive Diseases - diagnosis
  • Arterial Occlusive Diseases - epidemiology
  • Arterial Occlusive Diseases - mortality
  • Atherosclerosis - diagnosis
  • Atherosclerosis - epidemiology
  • Atherosclerosis - mortality
  • Biological and medical sciences
  • Blood pressure
  • Cardiology. Vascular system
  • Cardiovascular
  • Cardiovascular disease
  • Cause of Death
  • Comorbidity
  • Coronary Artery Disease - diagnosis
  • Coronary Artery Disease - epidemiology
  • Coronary Artery Disease - mortality
  • Coronary vessels
  • Creatinine - blood
  • Diabetes
  • Embolism, Cholesterol - diagnosis
  • Embolism, Cholesterol - epidemiology
  • Embolism, Cholesterol - mortality
  • Female
  • Heart Failure - diagnosis
  • Heart Failure - epidemiology
  • Heart Failure - mortality
  • Hemorrhage - diagnosis
  • Hemorrhage - epidemiology
  • Hemorrhage - mortality
  • Humans
  • Hypertension
  • Kidney diseases
  • Kidney Failure, Chronic - diagnosis
  • Kidney Failure, Chronic - epidemiology
  • Kidney Failure, Chronic - mortality
  • Kidney Function Tests
  • Male
  • Medical sciences
  • Middle Aged
  • Patient outcomes
  • Prospective Studies
  • Risk Factors
  • Statistical analysis
  • Statistics as Topic
  • Stroke - diagnosis
  • Stroke - epidemiology
  • Stroke - mortality
  • Variables
ispartof: The American heart journal, 2009, Vol.158 (1), p.141-148.e1
description: Background Although prior data showed an association between chronic kidney disease (CKD) and atherothrombotic events, little is known about the risk profile and specific outcomes of atherothrombotic outpatients with CKD. Methods More than 69,000 outpatients at risk of atherothrombotic events were enrolled in the REACH Registry. Creatinine clearance (CrCl) was available for 51,208 patients divided into 4 groups: normal (CrCl ≥90 mL/min, n = 13,949), mild (60-89 mL/min, n = 19,474), moderate (30-59 mL/min, n = 15,883), and severe CKD (CrCl
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0002-8703
fulltext: fulltext
issn:
  • 0002-8703
  • 1097-6744
url: Link


@attributes
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
RANK2.3920789
LOCALfalse
PrimoNMBib
record
control
sourceidgale_proqu
recordidTN_cdi_proquest_miscellaneous_67399455
sourceformatXML
sourcesystemPC
galeidA202206872
sourcerecordidA202206872
originalsourceidFETCH-LOGICAL-1579t-9679a7aa9541f867cbd6701a87502b132b98b4426eee96606f7297d4ed4505e83
addsrcrecordideNp9kl2L1DAUhoso7uzqD_BGCuJe2XqSNknDgrAsfuGC4Ad4F9L0dCezbTMmqbj_3pQZHBxkORchyfMmb_KeLHtGoCRA-OtNqdebkgLIElgJhDzIVgSkKLio64fZCgBo0QioTrLTEDZpymnDH2cnRLIaUq2yT19w0kPez5OJ1k2vch3X6F1ceze2LtiQ4--IU0wbU5e7ORo3YsjtlK_tzbrwNtzmWx1tQsKT7FGvh4BP9-NZ9v3d229XH4rrz-8_Xl1eF4QJGQvJhdRC6-SB9A0Xpu24AKIbwYC2pKKtbNq6phwRJefAe0Gl6GrsagYMm-osO9-du_Xu54whqtEGg8OgJ3RzUFxUUtaMJfDFEbhxs0_vDYowqJnggtQH6kYPqOzUu-i1WY5UlxQoBd4ImqjyP1SqDkdr3IS9Tev_CMhOYLwLwWOvtt6O2t8pAmqJT21Uik8t8SlgKsWXNM_3hud2xO6g2OeVgJd7QAejh97rydjwl6OES0no8nJxdLmxUS8JJ9d2uNfCxU6JKcFfFr0KJqVrsLMeTVSds_eq3xypzWAnm6ze4h2Gw_erQBWor0uHLg0KEqBi7Ef1B66a2xk
sourcetypeAggregation Database
isCDItrue
recordtypearticle
pqid1504576714
display
typearticle
titleRenal function, atherothrombosis extent, and outcomes in high-risk patients
sourceAlma/SFX Local Collection
creatorDumaine, Raphaelle L., MD ; Montalescot, Gilles, MD, PhD ; Steg, Ph. Gabriel, MD ; Ohman, E. Magnus, MD ; Eagle, Kim, MD ; Bhatt, Deepak L., MD, MPH
creatorcontribDumaine, Raphaelle L., MD ; Montalescot, Gilles, MD, PhD ; Steg, Ph. Gabriel, MD ; Ohman, E. Magnus, MD ; Eagle, Kim, MD ; Bhatt, Deepak L., MD, MPH ; on behalf of the REACH Registry Investigators ; REACH Registry Investigators
descriptionBackground Although prior data showed an association between chronic kidney disease (CKD) and atherothrombotic events, little is known about the risk profile and specific outcomes of atherothrombotic outpatients with CKD. Methods More than 69,000 outpatients at risk of atherothrombotic events were enrolled in the REACH Registry. Creatinine clearance (CrCl) was available for 51,208 patients divided into 4 groups: normal (CrCl ≥90 mL/min, n = 13,949), mild (60-89 mL/min, n = 19,474), moderate (30-59 mL/min, n = 15,883), and severe CKD (CrCl <30 mL/min, n = 1902). Baseline characteristics, number of arterial beds overtly affected, medications, overall mortality, cardiovascular death, myocardial infarction, stroke, congestive heart failure, peripheral arterial events, and bleeding events were assessed according to renal function. Results The number of arterial beds affected increased with severity of CKD. However, patients with severe CKD were less likely to receive medications of proven benefit. Severe CKD was an independent correlate of all-cause mortality, cardiovascular mortality, myocardial infarction, congestive heart failure, peripheral arterial revascularization, or amputation. Conclusion One third of outpatients at risk for atherothrombotic events have moderate to severe CKD. They are less likely to receive beneficial therapies despite a higher atherothrombotic burden and worse outcomes.
identifier
0ISSN: 0002-8703
1EISSN: 1097-6744
2DOI: 10.1016/j.ahj.2009.05.011
3PMID: 19540404
4CODEN: AHJOA2
languageeng
publisherNew York, NY: Mosby, Inc
subjectAbridged Index Medicus ; Aged ; Aged, 80 and over ; Amputation - statistics & numerical data ; Arterial Occlusive Diseases - diagnosis ; Arterial Occlusive Diseases - epidemiology ; Arterial Occlusive Diseases - mortality ; Atherosclerosis - diagnosis ; Atherosclerosis - epidemiology ; Atherosclerosis - mortality ; Biological and medical sciences ; Blood pressure ; Cardiology. Vascular system ; Cardiovascular ; Cardiovascular disease ; Cause of Death ; Comorbidity ; Coronary Artery Disease - diagnosis ; Coronary Artery Disease - epidemiology ; Coronary Artery Disease - mortality ; Coronary vessels ; Creatinine - blood ; Diabetes ; Embolism, Cholesterol - diagnosis ; Embolism, Cholesterol - epidemiology ; Embolism, Cholesterol - mortality ; Female ; Heart Failure - diagnosis ; Heart Failure - epidemiology ; Heart Failure - mortality ; Hemorrhage - diagnosis ; Hemorrhage - epidemiology ; Hemorrhage - mortality ; Humans ; Hypertension ; Kidney diseases ; Kidney Failure, Chronic - diagnosis ; Kidney Failure, Chronic - epidemiology ; Kidney Failure, Chronic - mortality ; Kidney Function Tests ; Male ; Medical sciences ; Middle Aged ; Patient outcomes ; Prospective Studies ; Risk Factors ; Statistical analysis ; Statistics as Topic ; Stroke - diagnosis ; Stroke - epidemiology ; Stroke - mortality ; Variables
ispartofThe American heart journal, 2009, Vol.158 (1), p.141-148.e1
rights
0Mosby, Inc.
12009 Mosby, Inc.
22009 INIST-CNRS
3COPYRIGHT 2009 Elsevier B.V.
4Copyright Elsevier Limited Jul 2009
lds50peer_reviewed
citedbyFETCH-LOGICAL-1579t-9679a7aa9541f867cbd6701a87502b132b98b4426eee96606f7297d4ed4505e83
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
thumbnail$$Usyndetics_thumb_exl
backlink
0$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21699125$$DView record in Pascal Francis
1$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19540404$$D View this record in MEDLINE/PubMed
search
creatorcontrib
0Dumaine, Raphaelle L., MD
1Montalescot, Gilles, MD, PhD
2Steg, Ph. Gabriel, MD
3Ohman, E. Magnus, MD
4Eagle, Kim, MD
5Bhatt, Deepak L., MD, MPH
6on behalf of the REACH Registry Investigators
7REACH Registry Investigators
title
0Renal function, atherothrombosis extent, and outcomes in high-risk patients
1The American heart journal
addtitleAm Heart J
descriptionBackground Although prior data showed an association between chronic kidney disease (CKD) and atherothrombotic events, little is known about the risk profile and specific outcomes of atherothrombotic outpatients with CKD. Methods More than 69,000 outpatients at risk of atherothrombotic events were enrolled in the REACH Registry. Creatinine clearance (CrCl) was available for 51,208 patients divided into 4 groups: normal (CrCl ≥90 mL/min, n = 13,949), mild (60-89 mL/min, n = 19,474), moderate (30-59 mL/min, n = 15,883), and severe CKD (CrCl <30 mL/min, n = 1902). Baseline characteristics, number of arterial beds overtly affected, medications, overall mortality, cardiovascular death, myocardial infarction, stroke, congestive heart failure, peripheral arterial events, and bleeding events were assessed according to renal function. Results The number of arterial beds affected increased with severity of CKD. However, patients with severe CKD were less likely to receive medications of proven benefit. Severe CKD was an independent correlate of all-cause mortality, cardiovascular mortality, myocardial infarction, congestive heart failure, peripheral arterial revascularization, or amputation. Conclusion One third of outpatients at risk for atherothrombotic events have moderate to severe CKD. They are less likely to receive beneficial therapies despite a higher atherothrombotic burden and worse outcomes.
subject
0Abridged Index Medicus
1Aged
2Aged, 80 and over
3Amputation - statistics & numerical data
4Arterial Occlusive Diseases - diagnosis
5Arterial Occlusive Diseases - epidemiology
6Arterial Occlusive Diseases - mortality
7Atherosclerosis - diagnosis
8Atherosclerosis - epidemiology
9Atherosclerosis - mortality
10Biological and medical sciences
11Blood pressure
12Cardiology. Vascular system
13Cardiovascular
14Cardiovascular disease
15Cause of Death
16Comorbidity
17Coronary Artery Disease - diagnosis
18Coronary Artery Disease - epidemiology
19Coronary Artery Disease - mortality
20Coronary vessels
21Creatinine - blood
22Diabetes
23Embolism, Cholesterol - diagnosis
24Embolism, Cholesterol - epidemiology
25Embolism, Cholesterol - mortality
26Female
27Heart Failure - diagnosis
28Heart Failure - epidemiology
29Heart Failure - mortality
30Hemorrhage - diagnosis
31Hemorrhage - epidemiology
32Hemorrhage - mortality
33Humans
34Hypertension
35Kidney diseases
36Kidney Failure, Chronic - diagnosis
37Kidney Failure, Chronic - epidemiology
38Kidney Failure, Chronic - mortality
39Kidney Function Tests
40Male
41Medical sciences
42Middle Aged
43Patient outcomes
44Prospective Studies
45Risk Factors
46Statistical analysis
47Statistics as Topic
48Stroke - diagnosis
49Stroke - epidemiology
50Stroke - mortality
51Variables
issn
00002-8703
11097-6744
fulltexttrue
rsrctypearticle
creationdate2009
recordtypearticle
recordideNp9kl2L1DAUhoso7uzqD_BGCuJe2XqSNknDgrAsfuGC4Ad4F9L0dCezbTMmqbj_3pQZHBxkORchyfMmb_KeLHtGoCRA-OtNqdebkgLIElgJhDzIVgSkKLio64fZCgBo0QioTrLTEDZpymnDH2cnRLIaUq2yT19w0kPez5OJ1k2vch3X6F1ceze2LtiQ4--IU0wbU5e7ORo3YsjtlK_tzbrwNtzmWx1tQsKT7FGvh4BP9-NZ9v3d229XH4rrz-8_Xl1eF4QJGQvJhdRC6-SB9A0Xpu24AKIbwYC2pKKtbNq6phwRJefAe0Gl6GrsagYMm-osO9-du_Xu54whqtEGg8OgJ3RzUFxUUtaMJfDFEbhxs0_vDYowqJnggtQH6kYPqOzUu-i1WY5UlxQoBd4ImqjyP1SqDkdr3IS9Tev_CMhOYLwLwWOvtt6O2t8pAmqJT21Uik8t8SlgKsWXNM_3hud2xO6g2OeVgJd7QAejh97rydjwl6OES0no8nJxdLmxUS8JJ9d2uNfCxU6JKcFfFr0KJqVrsLMeTVSds_eq3xypzWAnm6ze4h2Gw_erQBWor0uHLg0KEqBi7Ef1B66a2xk
startdate2009
enddate2009
creator
0Dumaine, Raphaelle L., MD
1Montalescot, Gilles, MD, PhD
2Steg, Ph. Gabriel, MD
3Ohman, E. Magnus, MD
4Eagle, Kim, MD
5Bhatt, Deepak L., MD, MPH
general
0Mosby, Inc
1Mosby
2Elsevier B.V
3Elsevier Limited
scope
0IQODW
1CGR
2CUY
3CVF
4ECM
5EIF
6NPM
7AAYXX
8CITATION
9BSHEE
103V.
117QO
127RV
137TS
147X7
157XB
1688C
1788E
188AO
198C1
208FD
218FI
228FJ
238FK
248G5
25ABUWG
26AN0
27AZQEC
28BENPR
29DWQXO
30FR3
31FYUFA
32GHDGH
33GNUQQ
34GUQSH
35K9.
36KB0
37M0S
38M0T
39M1P
40M2O
41MBDVC
42NAPCQ
43P64
44PADUT
45PQEST
46PQQKQ
47PQUKI
48PRINS
49Q9U
507X8
sort
creationdate2009
titleRenal function, atherothrombosis extent, and outcomes in high-risk patients
authorDumaine, Raphaelle L., MD ; Montalescot, Gilles, MD, PhD ; Steg, Ph. Gabriel, MD ; Ohman, E. Magnus, MD ; Eagle, Kim, MD ; Bhatt, Deepak L., MD, MPH
facets
frbrtype5
frbrgroupidcdi_FETCH-LOGICAL-1579t-9679a7aa9541f867cbd6701a87502b132b98b4426eee96606f7297d4ed4505e83
rsrctypearticles
prefilterarticles
languageeng
creationdate2009
topic
0Abridged Index Medicus
1Aged
2Aged, 80 and over
3Amputation - statistics & numerical data
4Arterial Occlusive Diseases - diagnosis
5Arterial Occlusive Diseases - epidemiology
6Arterial Occlusive Diseases - mortality
7Atherosclerosis - diagnosis
8Atherosclerosis - epidemiology
9Atherosclerosis - mortality
10Biological and medical sciences
11Blood pressure
12Cardiology. Vascular system
13Cardiovascular
14Cardiovascular disease
15Cause of Death
16Comorbidity
17Coronary Artery Disease - diagnosis
18Coronary Artery Disease - epidemiology
19Coronary Artery Disease - mortality
20Coronary vessels
21Creatinine - blood
22Diabetes
23Embolism, Cholesterol - diagnosis
24Embolism, Cholesterol - epidemiology
25Embolism, Cholesterol - mortality
26Female
27Heart Failure - diagnosis
28Heart Failure - epidemiology
29Heart Failure - mortality
30Hemorrhage - diagnosis
31Hemorrhage - epidemiology
32Hemorrhage - mortality
33Humans
34Hypertension
35Kidney diseases
36Kidney Failure, Chronic - diagnosis
37Kidney Failure, Chronic - epidemiology
38Kidney Failure, Chronic - mortality
39Kidney Function Tests
40Male
41Medical sciences
42Middle Aged
43Patient outcomes
44Prospective Studies
45Risk Factors
46Statistical analysis
47Statistics as Topic
48Stroke - diagnosis
49Stroke - epidemiology
50Stroke - mortality
51Variables
toplevel
0peer_reviewed
1online_resources
creatorcontrib
0Dumaine, Raphaelle L., MD
1Montalescot, Gilles, MD, PhD
2Steg, Ph. Gabriel, MD
3Ohman, E. Magnus, MD
4Eagle, Kim, MD
5Bhatt, Deepak L., MD, MPH
6on behalf of the REACH Registry Investigators
7REACH Registry Investigators
collection
0Pascal-Francis
1Medline
2MEDLINE
3MEDLINE (Ovid)
4MEDLINE
5MEDLINE
6PubMed
7CrossRef
8Academic OneFile (A&I only)
9ProQuest Central (Corporate)
10Biotechnology Research Abstracts
11Nursing & Allied Health Database
12Physical Education Index
13Health & Medical Collection
14ProQuest Central (purchase pre-March 2016)
15Healthcare Administration Database (Alumni)
16Medical Database (Alumni Edition)
17ProQuest Pharma Collection
18Public Health Database
19Technology Research Database
20Hospital Premium Collection
21Hospital Premium Collection (Alumni Edition)
22ProQuest Central (Alumni) (purchase pre-March 2016)
23Research Library (Alumni Edition)
24ProQuest Central (Alumni Edition)
25British Nursing Database
26ProQuest Central Essentials
27ProQuest Central
28ProQuest Central Korea
29Engineering Research Database
30Health Research Premium Collection
31Health Research Premium Collection (Alumni)
32ProQuest Central Student
33Research Library Prep
34ProQuest Health & Medical Complete (Alumni)
35Nursing & Allied Health Database (Alumni Edition)
36Health & Medical Collection (Alumni Edition)
37Healthcare Administration Database
38Medical Database
39Research Library
40Research Library (Corporate)
41Nursing & Allied Health Premium
42Biotechnology and BioEngineering Abstracts
43Research Library China
44ProQuest One Academic Eastern Edition
45ProQuest One Academic
46ProQuest One Academic UKI Edition
47ProQuest Central China
48ProQuest Central Basic
49MEDLINE - Academic
jtitleThe American heart journal
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
au
0Dumaine, Raphaelle L., MD
1Montalescot, Gilles, MD, PhD
2Steg, Ph. Gabriel, MD
3Ohman, E. Magnus, MD
4Eagle, Kim, MD
5Bhatt, Deepak L., MD, MPH
aucorp
0on behalf of the REACH Registry Investigators
1REACH Registry Investigators
formatjournal
genrearticle
ristypeJOUR
atitleRenal function, atherothrombosis extent, and outcomes in high-risk patients
jtitleThe American heart journal
addtitleAm Heart J
date2009
risdate2009
volume158
issue1
spage141
epage148.e1
pages141-148.e1
issn0002-8703
eissn1097-6744
codenAHJOA2
abstractBackground Although prior data showed an association between chronic kidney disease (CKD) and atherothrombotic events, little is known about the risk profile and specific outcomes of atherothrombotic outpatients with CKD. Methods More than 69,000 outpatients at risk of atherothrombotic events were enrolled in the REACH Registry. Creatinine clearance (CrCl) was available for 51,208 patients divided into 4 groups: normal (CrCl ≥90 mL/min, n = 13,949), mild (60-89 mL/min, n = 19,474), moderate (30-59 mL/min, n = 15,883), and severe CKD (CrCl <30 mL/min, n = 1902). Baseline characteristics, number of arterial beds overtly affected, medications, overall mortality, cardiovascular death, myocardial infarction, stroke, congestive heart failure, peripheral arterial events, and bleeding events were assessed according to renal function. Results The number of arterial beds affected increased with severity of CKD. However, patients with severe CKD were less likely to receive medications of proven benefit. Severe CKD was an independent correlate of all-cause mortality, cardiovascular mortality, myocardial infarction, congestive heart failure, peripheral arterial revascularization, or amputation. Conclusion One third of outpatients at risk for atherothrombotic events have moderate to severe CKD. They are less likely to receive beneficial therapies despite a higher atherothrombotic burden and worse outcomes.
copNew York, NY
pubMosby, Inc
pmid19540404
doi10.1016/j.ahj.2009.05.011