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Expression of OATP1B3 determines uptake of Gd-EOB-DTPA in hepatocellular carcinoma

Background Gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) is an MRI contrast agent with perfusion and hepatoselective properties. The purpose of the study was to examine uptake of Gd-EOB-DTPA in the hepatobiliary phase in hepatocellular carcinoma (HCC). Methods A retrospec... Full description

Journal Title: Journal of gastroenterology 2009-04-29, Vol.44 (7), p.793-798
Main Author: Narita, Masato
Other Authors: Hatano, Etsuro , Arizono, Shigeki , Miyagawa-Hayashino, Aya , Isoda, Hiroyoshi , Kitamura, Koji , Taura, Kojiro , Yasuchika, Kentaro , Nitta, Takashi , Ikai, Iwao , Uemoto, Shinji
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Japan: Springer Japan
ID: ISSN: 0944-1174
Link: https://www.ncbi.nlm.nih.gov/pubmed/19404564
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title: Expression of OATP1B3 determines uptake of Gd-EOB-DTPA in hepatocellular carcinoma
format: Article
creator:
  • Narita, Masato
  • Hatano, Etsuro
  • Arizono, Shigeki
  • Miyagawa-Hayashino, Aya
  • Isoda, Hiroyoshi
  • Kitamura, Koji
  • Taura, Kojiro
  • Yasuchika, Kentaro
  • Nitta, Takashi
  • Ikai, Iwao
  • Uemoto, Shinji
subjects:
  • Abdominal Surgery
  • Bile - metabolism
  • Carcinoma, Hepatocellular - diagnosis
  • Carcinoma, Hepatocellular - metabolism
  • Colorectal Surgery
  • Contrast media
  • Contrast Media - metabolism
  • Female
  • Gadolinium DTPA - metabolism
  • Gastroenterology
  • Hepatology
  • Hepatoma
  • Humans
  • Liver cancer
  • Liver Neoplasms - diagnosis
  • Liver Neoplasms - metabolism
  • Magnetic Resonance Imaging - methods
  • Male
  • Medical colleges
  • Medicine
  • Medicine & Public Health
  • Middle Aged
  • Organic Anion Transporters, Sodium-Independent - metabolism
  • Rapid Communication
  • Retrospective Studies
  • Solute Carrier Organic Anion Transporter Family Member 1B3
  • Surgical Oncology
ispartof: Journal of gastroenterology, 2009-04-29, Vol.44 (7), p.793-798
description: Background Gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) is an MRI contrast agent with perfusion and hepatoselective properties. The purpose of the study was to examine uptake of Gd-EOB-DTPA in the hepatobiliary phase in hepatocellular carcinoma (HCC). Methods A retrospective analysis of 22 patients with HCC who underwent preoperative Gd-EOB-DTPA-enhanced MRI was performed. Enhancement ratios (ERs) and expression levels of the organic anion transporter (OATP) 1B3 protein were examined. Results Gd-EOB-DTPA accumulated in the hepatobiliary phase in 6 of the 22 cases. All 6 Gd-EOB-DTPA-positive cases were moderately differentiated HCC, but 11 other moderately differentiated HCCs did not show Gd-EOB-DTPA uptake. Histopathologically, 4 Gd-EOB-DTPA-positive HCCs and 5 Gd-EOB-DTPA-negative HCCs produced bile. HCCs with Gd-EOB-DTPA uptake overexpressed OATP1B3 compared with HCCs without Gd-EOB-DTPA uptake, and OATP1B3 levels were significantly correlated with ERs ( r  = 0.91, P  
language: eng
source:
identifier: ISSN: 0944-1174
fulltext: no_fulltext
issn:
  • 0944-1174
  • 1435-5922
url: Link


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titleExpression of OATP1B3 determines uptake of Gd-EOB-DTPA in hepatocellular carcinoma
creatorNarita, Masato ; Hatano, Etsuro ; Arizono, Shigeki ; Miyagawa-Hayashino, Aya ; Isoda, Hiroyoshi ; Kitamura, Koji ; Taura, Kojiro ; Yasuchika, Kentaro ; Nitta, Takashi ; Ikai, Iwao ; Uemoto, Shinji
creatorcontribNarita, Masato ; Hatano, Etsuro ; Arizono, Shigeki ; Miyagawa-Hayashino, Aya ; Isoda, Hiroyoshi ; Kitamura, Koji ; Taura, Kojiro ; Yasuchika, Kentaro ; Nitta, Takashi ; Ikai, Iwao ; Uemoto, Shinji
descriptionBackground Gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) is an MRI contrast agent with perfusion and hepatoselective properties. The purpose of the study was to examine uptake of Gd-EOB-DTPA in the hepatobiliary phase in hepatocellular carcinoma (HCC). Methods A retrospective analysis of 22 patients with HCC who underwent preoperative Gd-EOB-DTPA-enhanced MRI was performed. Enhancement ratios (ERs) and expression levels of the organic anion transporter (OATP) 1B3 protein were examined. Results Gd-EOB-DTPA accumulated in the hepatobiliary phase in 6 of the 22 cases. All 6 Gd-EOB-DTPA-positive cases were moderately differentiated HCC, but 11 other moderately differentiated HCCs did not show Gd-EOB-DTPA uptake. Histopathologically, 4 Gd-EOB-DTPA-positive HCCs and 5 Gd-EOB-DTPA-negative HCCs produced bile. HCCs with Gd-EOB-DTPA uptake overexpressed OATP1B3 compared with HCCs without Gd-EOB-DTPA uptake, and OATP1B3 levels were significantly correlated with ERs ( r  = 0.91, P  < 0.0001). Conclusions Uptake of Gd-EOB-DTPA in HCC is determined by expression of OATP1B3 rather than by tumor differentiation or bile production.
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subjectAbdominal Surgery ; Bile - metabolism ; Carcinoma, Hepatocellular - diagnosis ; Carcinoma, Hepatocellular - metabolism ; Colorectal Surgery ; Contrast media ; Contrast Media - metabolism ; Female ; Gadolinium DTPA - metabolism ; Gastroenterology ; Hepatology ; Hepatoma ; Humans ; Liver cancer ; Liver Neoplasms - diagnosis ; Liver Neoplasms - metabolism ; Magnetic Resonance Imaging - methods ; Male ; Medical colleges ; Medicine ; Medicine & Public Health ; Middle Aged ; Organic Anion Transporters, Sodium-Independent - metabolism ; Rapid Communication ; Retrospective Studies ; Solute Carrier Organic Anion Transporter Family Member 1B3 ; Surgical Oncology
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descriptionBackground Gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) is an MRI contrast agent with perfusion and hepatoselective properties. The purpose of the study was to examine uptake of Gd-EOB-DTPA in the hepatobiliary phase in hepatocellular carcinoma (HCC). Methods A retrospective analysis of 22 patients with HCC who underwent preoperative Gd-EOB-DTPA-enhanced MRI was performed. Enhancement ratios (ERs) and expression levels of the organic anion transporter (OATP) 1B3 protein were examined. Results Gd-EOB-DTPA accumulated in the hepatobiliary phase in 6 of the 22 cases. All 6 Gd-EOB-DTPA-positive cases were moderately differentiated HCC, but 11 other moderately differentiated HCCs did not show Gd-EOB-DTPA uptake. Histopathologically, 4 Gd-EOB-DTPA-positive HCCs and 5 Gd-EOB-DTPA-negative HCCs produced bile. HCCs with Gd-EOB-DTPA uptake overexpressed OATP1B3 compared with HCCs without Gd-EOB-DTPA uptake, and OATP1B3 levels were significantly correlated with ERs ( r  = 0.91, P  < 0.0001). Conclusions Uptake of Gd-EOB-DTPA in HCC is determined by expression of OATP1B3 rather than by tumor differentiation or bile production.
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1Bile - metabolism
2Carcinoma, Hepatocellular - diagnosis
3Carcinoma, Hepatocellular - metabolism
4Colorectal Surgery
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8Gadolinium DTPA - metabolism
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16Magnetic Resonance Imaging - methods
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22Organic Anion Transporters, Sodium-Independent - metabolism
23Rapid Communication
24Retrospective Studies
25Solute Carrier Organic Anion Transporter Family Member 1B3
26Surgical Oncology
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titleExpression of OATP1B3 determines uptake of Gd-EOB-DTPA in hepatocellular carcinoma
authorNarita, Masato ; Hatano, Etsuro ; Arizono, Shigeki ; Miyagawa-Hayashino, Aya ; Isoda, Hiroyoshi ; Kitamura, Koji ; Taura, Kojiro ; Yasuchika, Kentaro ; Nitta, Takashi ; Ikai, Iwao ; Uemoto, Shinji
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1Bile - metabolism
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8Gadolinium DTPA - metabolism
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16Magnetic Resonance Imaging - methods
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20Medicine & Public Health
21Middle Aged
22Organic Anion Transporters, Sodium-Independent - metabolism
23Rapid Communication
24Retrospective Studies
25Solute Carrier Organic Anion Transporter Family Member 1B3
26Surgical Oncology
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1Hatano, Etsuro
2Arizono, Shigeki
3Miyagawa-Hayashino, Aya
4Isoda, Hiroyoshi
5Kitamura, Koji
6Taura, Kojiro
7Yasuchika, Kentaro
8Nitta, Takashi
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atitleExpression of OATP1B3 determines uptake of Gd-EOB-DTPA in hepatocellular carcinoma
jtitleJournal of gastroenterology
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date2009-04-29
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volume44
issue7
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issn0944-1174
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abstractBackground Gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) is an MRI contrast agent with perfusion and hepatoselective properties. The purpose of the study was to examine uptake of Gd-EOB-DTPA in the hepatobiliary phase in hepatocellular carcinoma (HCC). Methods A retrospective analysis of 22 patients with HCC who underwent preoperative Gd-EOB-DTPA-enhanced MRI was performed. Enhancement ratios (ERs) and expression levels of the organic anion transporter (OATP) 1B3 protein were examined. Results Gd-EOB-DTPA accumulated in the hepatobiliary phase in 6 of the 22 cases. All 6 Gd-EOB-DTPA-positive cases were moderately differentiated HCC, but 11 other moderately differentiated HCCs did not show Gd-EOB-DTPA uptake. Histopathologically, 4 Gd-EOB-DTPA-positive HCCs and 5 Gd-EOB-DTPA-negative HCCs produced bile. HCCs with Gd-EOB-DTPA uptake overexpressed OATP1B3 compared with HCCs without Gd-EOB-DTPA uptake, and OATP1B3 levels were significantly correlated with ERs ( r  = 0.91, P  < 0.0001). Conclusions Uptake of Gd-EOB-DTPA in HCC is determined by expression of OATP1B3 rather than by tumor differentiation or bile production.
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pubSpringer Japan
pmid19404564
doi10.1007/s00535-009-0056-4
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