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Looking and listening to light: the evolution of whole-body photonic imaging

Optical imaging of live animals has grown into an important tool in biomedical research as advances in photonic technology and reporter strategies have led to widespread exploration of biological processes in vivo. Although much attention has been paid to microscopy, macroscopic imaging has allowed... Full description

Journal Title: Nature biotechnology 2005-03, Vol.23 (3), p.313-320
Main Author: Ntziachristos, Vasilis
Other Authors: Ripoll, Jorge , Wang, Lihong V , Weissleder, Ralph
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: New York, NY: Nature
ID: ISSN: 1087-0156
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title: Looking and listening to light: the evolution of whole-body photonic imaging
format: Article
creator:
  • Ntziachristos, Vasilis
  • Ripoll, Jorge
  • Wang, Lihong V
  • Weissleder, Ralph
subjects:
  • Biological and medical sciences
  • Biotechnology
  • Fundamental and applied biological sciences. Psychology
  • Image Enhancement - methods
  • Imaging, Three-Dimensional - methods
  • Imaging, Three-Dimensional - trends
  • Luminescent Measurements - methods
  • Luminescent Measurements - trends
  • Microscopy, Fluorescence - methods
  • Microscopy, Fluorescence - trends
  • Photons
  • Tomography, Optical - methods
  • Tomography, Optical - trends
  • Ultrasonography - methods
  • Ultrasonography - trends
ispartof: Nature biotechnology, 2005-03, Vol.23 (3), p.313-320
description: Optical imaging of live animals has grown into an important tool in biomedical research as advances in photonic technology and reporter strategies have led to widespread exploration of biological processes in vivo. Although much attention has been paid to microscopy, macroscopic imaging has allowed small-animal imaging with larger fields of view (from several millimeters to several centimeters depending on implementation). Photographic methods have been the mainstay for fluorescence and bioluminescence macroscopy in whole animals, but emphasis is shifting to photonic methods that use tomographic principles to noninvasively image optical contrast at depths of several millimeters to centimeters with high sensitivity and sub-millimeter to millimeter resolution. Recent theoretical and instrumentation advances allow the use of large data sets and multiple projections and offer practical systems for quantitative, three-dimensional whole-body images. For photonic imaging to fully realize its potential, however, further progress will be needed in refining optical inversion methods and data acquisition techniques.
language: eng
source:
identifier: ISSN: 1087-0156
fulltext: no_fulltext
issn:
  • 1087-0156
  • 1546-1696
url: Link


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descriptionOptical imaging of live animals has grown into an important tool in biomedical research as advances in photonic technology and reporter strategies have led to widespread exploration of biological processes in vivo. Although much attention has been paid to microscopy, macroscopic imaging has allowed small-animal imaging with larger fields of view (from several millimeters to several centimeters depending on implementation). Photographic methods have been the mainstay for fluorescence and bioluminescence macroscopy in whole animals, but emphasis is shifting to photonic methods that use tomographic principles to noninvasively image optical contrast at depths of several millimeters to centimeters with high sensitivity and sub-millimeter to millimeter resolution. Recent theoretical and instrumentation advances allow the use of large data sets and multiple projections and offer practical systems for quantitative, three-dimensional whole-body images. For photonic imaging to fully realize its potential, however, further progress will be needed in refining optical inversion methods and data acquisition techniques.
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subjectBiological and medical sciences ; Biotechnology ; Fundamental and applied biological sciences. Psychology ; Image Enhancement - methods ; Imaging, Three-Dimensional - methods ; Imaging, Three-Dimensional - trends ; Luminescent Measurements - methods ; Luminescent Measurements - trends ; Microscopy, Fluorescence - methods ; Microscopy, Fluorescence - trends ; Photons ; Tomography, Optical - methods ; Tomography, Optical - trends ; Ultrasonography - methods ; Ultrasonography - trends
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abstractOptical imaging of live animals has grown into an important tool in biomedical research as advances in photonic technology and reporter strategies have led to widespread exploration of biological processes in vivo. Although much attention has been paid to microscopy, macroscopic imaging has allowed small-animal imaging with larger fields of view (from several millimeters to several centimeters depending on implementation). Photographic methods have been the mainstay for fluorescence and bioluminescence macroscopy in whole animals, but emphasis is shifting to photonic methods that use tomographic principles to noninvasively image optical contrast at depths of several millimeters to centimeters with high sensitivity and sub-millimeter to millimeter resolution. Recent theoretical and instrumentation advances allow the use of large data sets and multiple projections and offer practical systems for quantitative, three-dimensional whole-body images. For photonic imaging to fully realize its potential, however, further progress will be needed in refining optical inversion methods and data acquisition techniques.
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